DK2347770T4 - Fremgangsmåde til fremstilling af en injicerbar farmaceutisk tilberedning - Google Patents

Fremgangsmåde til fremstilling af en injicerbar farmaceutisk tilberedning Download PDF

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Publication number
DK2347770T4
DK2347770T4 DK10183870.4T DK10183870T DK2347770T4 DK 2347770 T4 DK2347770 T4 DK 2347770T4 DK 10183870 T DK10183870 T DK 10183870T DK 2347770 T4 DK2347770 T4 DK 2347770T4
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Prior art keywords
drug
spacer
injectable pharmaceutical
preparing
pharmaceutical preparation
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DK10183870.4T
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English (en)
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DK2347770T3 (da
Inventor
Felix Kratz
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Vergell Medical S A
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/545—Heterocyclic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/643—Albumins, e.g. HSA, BSA, ovalbumin or a Keyhole Limpet Hemocyanin [KHL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/65—Peptidic linkers, binders or spacers, e.g. peptidic enzyme-labile linkers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Virology (AREA)
  • Transplantation (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DK10183870.4T 1999-06-09 2000-06-07 Fremgangsmåde til fremstilling af en injicerbar farmaceutisk tilberedning DK2347770T4 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19926154A DE19926154A1 (de) 1999-06-09 1999-06-09 Verfahren zur Herstellung einer injizierbaren Arzneimittelzubereitung
EP06012171A EP1704864B9 (de) 1999-06-09 2000-06-07 Injizierbare Arzneimittelzubereitung bestehend aus einem Zytostatikum und einer durch einen Spacer gebundenen Maleinimidgruppe.

Publications (2)

Publication Number Publication Date
DK2347770T3 DK2347770T3 (da) 2017-07-03
DK2347770T4 true DK2347770T4 (da) 2020-02-03

Family

ID=7910588

Family Applications (3)

Application Number Title Priority Date Filing Date
DK00945721T DK1183050T3 (da) 1999-06-09 2000-06-07 Fremgangsmåde til fremstilling af et injicerbart lægemiddelpræparat
DK10183870.4T DK2347770T4 (da) 1999-06-09 2000-06-07 Fremgangsmåde til fremstilling af en injicerbar farmaceutisk tilberedning
DK06012171.2T DK1704864T3 (da) 1999-06-09 2000-06-07 Injicerbar farmaceutisk tilberedning bestående af et cytostatisk middel og et maleinimid forbundet med en spacer

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DK00945721T DK1183050T3 (da) 1999-06-09 2000-06-07 Fremgangsmåde til fremstilling af et injicerbart lægemiddelpræparat

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK06012171.2T DK1704864T3 (da) 1999-06-09 2000-06-07 Injicerbar farmaceutisk tilberedning bestående af et cytostatisk middel og et maleinimid forbundet med en spacer

Country Status (13)

Country Link
US (5) US7387771B1 (da)
EP (3) EP1704864B9 (da)
JP (5) JP5517384B2 (da)
AT (1) ATE339225T1 (da)
AU (1) AU779697B2 (da)
CA (1) CA2374964C (da)
CY (2) CY1105701T1 (da)
DE (2) DE19926154A1 (da)
DK (3) DK1183050T3 (da)
ES (3) ES2385230T3 (da)
PT (3) PT1183050E (da)
SI (1) SI1704864T1 (da)
WO (1) WO2000076551A2 (da)

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DK1183050T3 (da) 2007-01-02
PT1183050E (pt) 2007-01-31
US20150196573A1 (en) 2015-07-16
US8153581B2 (en) 2012-04-10
US20060233707A1 (en) 2006-10-19
WO2000076551A3 (de) 2001-08-16
DE19926154A1 (de) 2000-12-14
JP2018035191A (ja) 2018-03-08
ES2623017T5 (es) 2020-04-07
CA2374964C (en) 2012-05-22
EP2347770B1 (de) 2017-03-08
JP6573947B2 (ja) 2019-09-11
PT2347770T (pt) 2017-06-20
JP2016047847A (ja) 2016-04-07
US8846602B2 (en) 2014-09-30
JP2014055192A (ja) 2014-03-27
EP1183050A2 (de) 2002-03-06
JP2011173913A (ja) 2011-09-08
CY1113370T1 (el) 2016-06-22
ES2623017T3 (es) 2017-07-10
DK2347770T3 (da) 2017-07-03
ATE339225T1 (de) 2006-10-15
US7387771B1 (en) 2008-06-17
DE50013468D1 (de) 2006-10-26
AU5970900A (en) 2001-01-02
ES2385230T3 (es) 2012-07-19
EP2347770A3 (de) 2011-11-09
EP1183050B1 (de) 2006-09-13
SI1704864T1 (sl) 2012-09-28
EP1704864A2 (de) 2006-09-27
ES2269160T3 (es) 2007-04-01
WO2000076551A2 (de) 2000-12-21
DK1704864T3 (da) 2012-09-03
JP5517384B2 (ja) 2014-06-11
EP2347770B2 (de) 2019-10-23
PT1704864E (pt) 2012-07-02
US20120195832A1 (en) 2012-08-02
JP2003501486A (ja) 2003-01-14
CA2374964A1 (en) 2000-12-21
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US20100215574A1 (en) 2010-08-26
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EP2347770A2 (de) 2011-07-27
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