AU2001284189A1 - Modified release formulation - Google Patents

Modified release formulation

Info

Publication number
AU2001284189A1
AU2001284189A1 AU2001284189A AU8418901A AU2001284189A1 AU 2001284189 A1 AU2001284189 A1 AU 2001284189A1 AU 2001284189 A AU2001284189 A AU 2001284189A AU 8418901 A AU8418901 A AU 8418901A AU 2001284189 A1 AU2001284189 A1 AU 2001284189A1
Authority
AU
Australia
Prior art keywords
water
soluble
modified
modified release
polysaccharide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001284189A
Inventor
Jan-Erik Lofroth
Urban Skantze
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AstraZeneca AB
Original Assignee
AstraZeneca AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by AstraZeneca AB filed Critical AstraZeneca AB
Publication of AU2001284189A1 publication Critical patent/AU2001284189A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin

Abstract

A pharmaceutical modified release formulation comprising a pharmacologically active substance and a modified water-soluble polysaccharide, which modified water-soluble polysaccharide is obtainable by: a) forming a precipitate of a water-soluble polysaccharide by contacting a solution of the water-soluble polysaccharide with a solvent in which the polysaccharide is poorly soluble or insoluble; or b) milling a water-soluble polysaccharide. The modified water-soluble polysaccharides provide modified release formulations with high tablet hardness. Also claimed are a process for preparing the modified release formulation, and the use of the modified water-soluble polysaccharides as an excipient in a pharmaceutical formulation.
AU2001284189A 2000-09-05 2001-08-30 Modified release formulation Abandoned AU2001284189A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SE003125 2000-09-05
SE0003125A SE0003125D0 (en) 2000-09-05 2000-09-05 Modified polymers
PCT/GB2001/003861 WO2002019990A1 (en) 2000-09-05 2001-08-30 Modified release formulation

Publications (1)

Publication Number Publication Date
AU2001284189A1 true AU2001284189A1 (en) 2002-03-22

Family

ID=20280889

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001284189A Abandoned AU2001284189A1 (en) 2000-09-05 2001-08-30 Modified release formulation

Country Status (9)

Country Link
US (1) US20040022850A1 (en)
EP (1) EP1322293B1 (en)
JP (1) JP2004508322A (en)
AT (1) ATE340564T1 (en)
AU (1) AU2001284189A1 (en)
DE (1) DE60123447T2 (en)
ES (1) ES2272527T3 (en)
SE (1) SE0003125D0 (en)
WO (1) WO2002019990A1 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE0201659D0 (en) * 2002-05-31 2002-05-31 Astrazeneca Ab Modified release pharmaceutical formulation
MX2007010660A (en) 2005-03-02 2007-11-07 Hercules Inc Water-soluble, low substitution hydroxyethylcellulose, derivatives thereof, process of making, and uses thereof.
JP5866358B2 (en) * 2010-07-28 2016-02-17 ダウ グローバル テクノロジーズ エルエルシー Method for controlling the release of active ingredients from dosage forms
US20190263938A1 (en) * 2016-09-29 2019-08-29 Sumitomo Seika Chemicals Co., Ltd. Method for producing water-soluble hydroxyethyl cellulose
EP3768378A4 (en) 2018-03-22 2021-11-17 InCarda Therapeutics, Inc. A novel method to slow ventricular rate

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3965256A (en) * 1972-05-16 1976-06-22 Synergistics Slow release pharmaceutical compositions
JPS5163927A (en) * 1974-11-28 1976-06-02 Shinetsu Chemical Co Ketsugoseiryokonajozaihokaizaino seizohoho
US4097606A (en) * 1975-10-08 1978-06-27 Bristol-Myers Company APAP Tablet containing an alkali metal carboxymethylated starch and processes for manufacturing same
US4063017A (en) * 1976-04-22 1977-12-13 Purdue Research Foundation Porous cellulose beads and the immobilization of enzymes therewith
US4024335A (en) * 1976-05-04 1977-05-17 Union Carbide Corporation Homogeneous hydroxy-alkylation of cellulose
AR241633A1 (en) * 1982-12-30 1992-10-30 Goemar Lab Sa New physiological product extracted from algae and plants, preparation method, extraction apparatus and applications
GB8613689D0 (en) * 1986-06-05 1986-07-09 Euro Celtique Sa Pharmaceutical composition
GB8613688D0 (en) * 1986-06-05 1986-07-09 Euro Celtique Sa Pharmaceutical composition
US4851233A (en) * 1986-10-06 1989-07-25 Warner-Lambert Company Sustained release formulations
FR2634397B2 (en) * 1986-12-31 1991-04-19 Centre Nat Rech Scient PROCESS FOR THE PREPARATION OF DISPERSIBLE COLLOIDAL SYSTEMS OF A PROTEIN IN THE FORM OF NANOPARTICLES
BR8806902A (en) * 1987-04-16 1989-10-31 Christian Bindschaedler PROCESS FOR PREPARING A POOL OF INSOLUBLE POLYMER IN WATER THAT MAY BE REDISPERSED IN A LIQUID PHASE, AS A RESULTING POINT AND ITS USE
US4820522A (en) * 1987-07-27 1989-04-11 Mcneilab, Inc. Oral sustained release acetaminophen formulation and process
US5073380A (en) * 1987-07-27 1991-12-17 Mcneil-Ppc, Inc. Oral sustained release pharmaceutical formulation and process
US5004613A (en) * 1987-07-27 1991-04-02 Mcneil-Ppc, Inc. Oral sustained release pharmaceutical formulation and process
US5066793A (en) * 1987-10-26 1991-11-19 Ciba-Geigy Corporation Finely particulate cellulose esters of aromatic or aromatic-aliphatic carboxylic acids, process for their preparation, and the use thereof
US4892739A (en) * 1988-04-25 1990-01-09 Ciba-Geigy Corporation Osmotic continuous dispensing oral delivery system containing a pharmaceutically acceptable active agent having a improved core membrane adhesion properties
AT395724B (en) * 1990-12-07 1993-02-25 Chemiefaser Lenzing Ag METHOD FOR PRODUCING CELLULOSE MOLDED BODIES
US5550189A (en) * 1992-04-17 1996-08-27 Kimberly-Clark Corporation Modified polysaccharides having improved absorbent properties and process for the preparation thereof
DE69332291T2 (en) * 1992-10-16 2003-07-31 Nippon Shinyaku Co Ltd METHOD FOR PRODUCING WAX MATRICES
WO1994015643A1 (en) * 1992-12-30 1994-07-21 Fmc Corporation Readily available konjac glucomannan sustained release excipient
US5451409A (en) * 1993-11-22 1995-09-19 Rencher; William F. Sustained release matrix system using hydroxyethyl cellulose and hydroxypropyl cellulose polymer blends
EP0804169A4 (en) * 1994-12-01 1998-08-19 Cibus Pharmaceutical Inc Nsaid delivery employing a powdered hydrocolloid gum obtainable from higher plants
MX9704043A (en) * 1994-12-01 1998-02-28 Cibus Pharmaceuticals Inc Sustained-release drug delivery employing a powdered hydrocolloid gum obtainable from higher plants.
US6063402A (en) * 1995-06-07 2000-05-16 Venture Lending, A Division Of Cupertino National Bank Purified galactomannan as an improved pharmaceutical excipient
US6652882B1 (en) * 1997-10-06 2003-11-25 Intellipharmaceutics Corp Controlled release formulation containing bupropion

Also Published As

Publication number Publication date
EP1322293B1 (en) 2006-09-27
EP1322293A1 (en) 2003-07-02
JP2004508322A (en) 2004-03-18
DE60123447D1 (en) 2006-11-09
SE0003125D0 (en) 2000-09-05
ES2272527T3 (en) 2007-05-01
US20040022850A1 (en) 2004-02-05
WO2002019990A1 (en) 2002-03-14
ATE340564T1 (en) 2006-10-15
DE60123447T2 (en) 2007-08-23

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