CY1105701T1 - Μεθοδος δια την παρασκευη ενος ενεσιμου φαρμακευτικου σκευασματος - Google Patents
Μεθοδος δια την παρασκευη ενος ενεσιμου φαρμακευτικου σκευασματοςInfo
- Publication number
- CY1105701T1 CY1105701T1 CY20061101464T CY061101464T CY1105701T1 CY 1105701 T1 CY1105701 T1 CY 1105701T1 CY 20061101464 T CY20061101464 T CY 20061101464T CY 061101464 T CY061101464 T CY 061101464T CY 1105701 T1 CY1105701 T1 CY 1105701T1
- Authority
- CY
- Cyprus
- Prior art keywords
- preparation
- active substance
- injectable pharmaceutical
- molecule
- pharmaceutical preparation
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- 239000000825 pharmaceutical preparation Substances 0.000 title abstract 2
- 238000002360 preparation method Methods 0.000 title abstract 2
- 239000013543 active substance Substances 0.000 abstract 4
- 102000014914 Carrier Proteins Human genes 0.000 abstract 1
- 230000027455 binding Effects 0.000 abstract 1
- 108091008324 binding proteins Proteins 0.000 abstract 1
- 210000001124 body fluid Anatomy 0.000 abstract 1
- 239000010839 body fluid Substances 0.000 abstract 1
- 230000001419 dependent effect Effects 0.000 abstract 1
- 230000002452 interceptive effect Effects 0.000 abstract 1
- 230000009149 molecular binding Effects 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/545—Heterocyclic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/643—Albumins, e.g. HSA, BSA, ovalbumin or a Keyhole Limpet Hemocyanin [KHL]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/65—Peptidic linkers, binders or spacers, e.g. peptidic enzyme-labile linkers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Abstract
Η εφεύρεση αφορά μια μέθοδο δια την παρασκευή ενεσίμων φαρμακευτικών σκευασμάτων που περιέχουν μια θεραπευτικώς και/ή διαγνωστικώς δραστική ουσία, η οποία αποτελείται από μια δραστική ύλη, ένα παρεμβαλλόμενο μόριο και τουλάχιστον ένα μόριο δεσμεύσεως πρωτεΐνης και μετά την επαφή με το σώμα δεσμεύεται μέσω του μορίου δεσμεύσεως πρωτεΐνης ομοιοπολικά εις τα συστατικά των υγρών του σώματος ή των ιστών, ούτως ώστε να δίδεται μια μορφή μεταφοράς της δραστικής ύλης η οποία είναι διασπάσιμη εις το σώμα απελευθερώνοντας δραστική ουσία εις εξάρτηση από το pΗ, υδρολυτικώς ή ενζυματικώς.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19926154A DE19926154A1 (de) | 1999-06-09 | 1999-06-09 | Verfahren zur Herstellung einer injizierbaren Arzneimittelzubereitung |
PCT/EP2000/005272 WO2000076551A2 (de) | 1999-06-09 | 2000-06-07 | Verfahren zur herstellung einer injizierbaren arzneimittelzubereitung |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1105701T1 true CY1105701T1 (el) | 2010-12-22 |
Family
ID=7910588
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20061101464T CY1105701T1 (el) | 1999-06-09 | 2006-10-12 | Μεθοδος δια την παρασκευη ενος ενεσιμου φαρμακευτικου σκευασματος |
CY20121100751T CY1113370T1 (el) | 1999-06-09 | 2012-08-22 | Ενεσιμο φαρμακευτικο σκευασμα αποτελουμενο απο ενα κυτταροστατικο και μια μηλεϊνιμιδο ομαδα συνδεομενη δια ενος παρεμβαλλομενου μοριου |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20121100751T CY1113370T1 (el) | 1999-06-09 | 2012-08-22 | Ενεσιμο φαρμακευτικο σκευασμα αποτελουμενο απο ενα κυτταροστατικο και μια μηλεϊνιμιδο ομαδα συνδεομενη δια ενος παρεμβαλλομενου μοριου |
Country Status (13)
Country | Link |
---|---|
US (5) | US7387771B1 (el) |
EP (3) | EP1183050B1 (el) |
JP (5) | JP5517384B2 (el) |
AT (1) | ATE339225T1 (el) |
AU (1) | AU779697B2 (el) |
CA (1) | CA2374964C (el) |
CY (2) | CY1105701T1 (el) |
DE (2) | DE19926154A1 (el) |
DK (3) | DK1704864T3 (el) |
ES (3) | ES2623017T5 (el) |
PT (3) | PT1183050E (el) |
SI (1) | SI1704864T1 (el) |
WO (1) | WO2000076551A2 (el) |
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DE19926154A1 (de) * | 1999-06-09 | 2000-12-14 | Ktb Tumorforschungs Gmbh | Verfahren zur Herstellung einer injizierbaren Arzneimittelzubereitung |
DE19926475A1 (de) | 1999-06-10 | 2000-12-14 | Ktb Tumorforschungs Gmbh | Träger-Pharmaka-Konjugate |
EP1235618A2 (en) * | 1999-09-07 | 2002-09-04 | Conjuchem, Inc. | Bioconjugation in vivo to pulmonary or blood components |
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1999
- 1999-06-09 DE DE19926154A patent/DE19926154A1/de not_active Ceased
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2000
- 2000-06-07 AU AU59709/00A patent/AU779697B2/en not_active Expired
- 2000-06-07 AT AT00945721T patent/ATE339225T1/de active
- 2000-06-07 SI SI200031070T patent/SI1704864T1/sl unknown
- 2000-06-07 DE DE50013468T patent/DE50013468D1/de not_active Expired - Lifetime
- 2000-06-07 US US09/980,266 patent/US7387771B1/en not_active Expired - Lifetime
- 2000-06-07 DK DK06012171.2T patent/DK1704864T3/da active
- 2000-06-07 DK DK00945721T patent/DK1183050T3/da active
- 2000-06-07 EP EP00945721A patent/EP1183050B1/de not_active Expired - Lifetime
- 2000-06-07 ES ES10183870T patent/ES2623017T5/es not_active Expired - Lifetime
- 2000-06-07 EP EP10183870.4A patent/EP2347770B2/de not_active Expired - Lifetime
- 2000-06-07 ES ES06012171T patent/ES2385230T3/es not_active Expired - Lifetime
- 2000-06-07 PT PT00945721T patent/PT1183050E/pt unknown
- 2000-06-07 EP EP06012171A patent/EP1704864B9/de not_active Expired - Lifetime
- 2000-06-07 CA CA2374964A patent/CA2374964C/en not_active Expired - Lifetime
- 2000-06-07 ES ES00945721T patent/ES2269160T3/es not_active Expired - Lifetime
- 2000-06-07 PT PT06012171T patent/PT1704864E/pt unknown
- 2000-06-07 WO PCT/EP2000/005272 patent/WO2000076551A2/de active IP Right Grant
- 2000-06-07 JP JP2001502882A patent/JP5517384B2/ja not_active Expired - Lifetime
- 2000-06-07 PT PT101838704T patent/PT2347770T/pt unknown
- 2000-06-07 DK DK10183870.4T patent/DK2347770T4/da active
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2006
- 2006-03-24 US US11/388,733 patent/US20060233707A1/en not_active Abandoned
- 2006-10-12 CY CY20061101464T patent/CY1105701T1/el unknown
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2009
- 2009-10-22 US US12/604,093 patent/US8153581B2/en not_active Expired - Lifetime
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2011
- 2011-04-28 JP JP2011102053A patent/JP5871483B2/ja not_active Expired - Lifetime
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2012
- 2012-03-07 US US13/414,316 patent/US8846602B2/en not_active Expired - Fee Related
- 2012-08-22 CY CY20121100751T patent/CY1113370T1/el unknown
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2013
- 2013-12-26 JP JP2013268998A patent/JP2014055192A/ja not_active Withdrawn
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2014
- 2014-08-26 US US14/469,232 patent/US20150196573A1/en not_active Abandoned
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2015
- 2015-12-24 JP JP2015252087A patent/JP6290166B2/ja not_active Expired - Lifetime
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2017
- 2017-11-07 JP JP2017214959A patent/JP6573947B2/ja not_active Expired - Lifetime
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