DK2305625T3 - Fremgangsmåde til fremstilling af benzaldehydforbindelse - Google Patents

Fremgangsmåde til fremstilling af benzaldehydforbindelse Download PDF

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Publication number
DK2305625T3
DK2305625T3 DK09766602.8T DK09766602T DK2305625T3 DK 2305625 T3 DK2305625 T3 DK 2305625T3 DK 09766602 T DK09766602 T DK 09766602T DK 2305625 T3 DK2305625 T3 DK 2305625T3
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Denmark
Prior art keywords
compound
group
benzaldehyde
preparation process
alkaline earth
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Application number
DK09766602.8T
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English (en)
Inventor
Yoshio Onogawa
Kazuyoshi Yamanaka
Masaji Hirota
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Sumitomo Chemical Co
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Publication of DK2305625T3 publication Critical patent/DK2305625T3/da

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
    • C07C41/01—Preparation of ethers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
    • C07C41/01—Preparation of ethers
    • C07C41/16—Preparation of ethers by reaction of esters of mineral or organic acids with hydroxy or O-metal groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/30—Compounds having groups
    • C07C43/315—Compounds having groups containing oxygen atoms singly bound to carbon atoms not being acetal carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/42—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by hydrolysis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/51—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition
    • C07C45/52—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition by dehydration and rearrangement involving two hydroxy groups in the same molecule
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C47/00—Compounds having —CHO groups
    • C07C47/52—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings
    • C07C47/575—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/18—Radicals substituted by singly bound oxygen or sulfur atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Claims (6)

1. Fremgangsmåde til fremstilling af en tilsvarende acetalforbindelse der omfatter omsætning af benzalhalogenidforbindelse som vist med formel (1)
(i) (hvor, Q betegner et hydrogenatom eller halogenatom, X betegner et halogenatom, og Ar betegner en phenylgruppe eventuelt substitueret med mindst én gruppe valgt fra gruppen bestående af alkylgrupper med 1 til 4 carbonatomer og halogenatomer) og en alkoholforbindelse i tilstedeværelse af mindst én jordalkalimetalforbindelse valgt fra gruppen bestående af jordalkalimetaloxider, alkaliske jordalkalimetalhydroxider og alkaliske jordmetalcarbonater.
2. Fremstillingsfremgangsmåde ifølge krav 1, hvor alkoholforbindelsen er en monovalent alkoholforbindelse med 1 til 6 carbonatomer eller en divalent alkoholforbindelse med 2 til 6 carbonatomer.
(3) (hvor, Q og Ar betegner hver den samme betydning som beskrevet ovenfor) der omfatter opnåelse af en acetalforbindelse ved fremstillingsfremgangsmåden ifølge et hvilket som helst af kravene 1 til 13, og omsætte den resulterende acetalforbindelse og vand i tilstedeværelse af en syre.
15. Fremstillingsfremgangsmåde ifølge krav 1, hvor benzalhalogenidforbindelsen som vist med formel (1) er en benzalhalogenidforbindelse opnået ved omsætning af en forbindelse som vist med formel (4)
3. Fremstillingsfremgangsmåde ifølge krav 1, hvor alkoholforbindelsen er en divalent alkoholforbindelse med 2 til 6 carbonatomer.
(4) (hvor, Q og X betegner hver den samme betydning som beskrevet ovenfor, og Y betegner et halogenatom) og en phenolforbindelse som vist med formel (5)
4. Fremstillingsfremgangsmåde ifølge krav 3, hvor den divalente alkoholforbindelse er en 1,2-diolforbindelse.
5. Fremstillingsfremgangsmåde ifølge krav 4, hvor 1-2-diolforbindelsen er ethylenglycol.
6. Fremstillingsfremgangsmåde ifølge krav 1, hvor jordalkalimetallet er calcium.
7. Fremstillingsfremgangsmåde ifølge krav 1, hvor jordalkalimetalforbindelsen er et alkalisk jordmetalcarbonat.
8. Fremstillingsfremgangsmåde ifølge krav 7, hvor jordalkalimetalcarbonatet er calciumcarbonat.
9. Fremstillingsfremgangsmåde ifølge krav 1, hvor syren er en Bronsted-syre.
10. Fremstillingsfremgangsmåde ifølge krav 9, hvor Bronsted-syren er saltsyre.
11. Fremstillingsfremgangsnnåde ifølge krav 1, hvor X betegner et chloratom.
12. Fremstillingsfremgangsmåde ifølge krav 1, hvor Ar betegner en phenylgruppe substitueret med mindst én alkylgruppe med 1 til 4 carbonatomer.
13. Fremstillingsfremgangsmåde ifølge krav 12, hvor phenylgruppen substitueret med mindst én alkylgruppe med 1 til 4 carbonatomer er en 2,5-dimethylphenylgruppe.
14. Fremgangsmåde til fremstilling af en benzaldehydforbindelse som vist med formel (3)
(5) (hvor, Ar har den samme betydning som beskrevet ovenfor) i tilstedeværelse af en base.
16. 2-(2,5-dimethylphenoxymethyl)benzaldehyd-ethylenglycolacetal.
DK09766602.8T 2008-06-16 2009-06-09 Fremgangsmåde til fremstilling af benzaldehydforbindelse DK2305625T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2008157213A JP5314330B2 (ja) 2008-06-16 2008-06-16 ２−（アリールオキシメチル）ベンズアルデヒドの製造方法およびその中間体
PCT/JP2009/060817 WO2009154154A1 (ja) 2008-06-16 2009-06-09 ベンズアルデヒド化合物の製造方法

Publications (1)

Publication Number Publication Date
DK2305625T3 true DK2305625T3 (da) 2015-06-08

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DK09766602.8T DK2305625T3 (da) 2008-06-16 2009-06-09 Fremgangsmåde til fremstilling af benzaldehydforbindelse

Country Status (10)

Country Link
US (1) US8338625B2 (da)
EP (1) EP2305625B1 (da)
JP (1) JP5314330B2 (da)
KR (1) KR101555734B1 (da)
CN (1) CN102123977B (da)
AU (1) AU2009261270B2 (da)
DK (1) DK2305625T3 (da)
IL (1) IL209925A (da)
TW (1) TWI418550B (da)
WO (1) WO2009154154A1 (da)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2009213469B2 (en) * 2008-02-14 2012-12-20 Sumitomo Chemical Company, Limited Process for production of benzaldehyde compound
JP5733052B2 (ja) 2011-06-27 2015-06-10 住友化学株式会社 ２−（アリールオキシメチル）ベンズアルデヒド化合物の製造方法
JP5733055B2 (ja) * 2011-06-29 2015-06-10 住友化学株式会社 ２−（アリールオキシメチル）ベンズアルデヒド化合物の製造方法
WO2013102145A1 (en) 2011-12-28 2013-07-04 Global Blood Therapeutics, Inc. Substituted heteroaryl aldehyde compounds and methods for their use in increasing tissue oxygenation
SI3141542T1 (sl) 2011-12-28 2020-11-30 Global Blood Therapeutics, Inc. Substituirane spojine benzaldehida in metode njihove uporabe pri povečanju oksigenacije tkiva
US8952171B2 (en) 2013-03-15 2015-02-10 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
CN105073728A (zh) 2013-03-15 2015-11-18 全球血液疗法股份有限公司 化合物及其用于调节血红蛋白的用途
US10266551B2 (en) 2013-03-15 2019-04-23 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
WO2014145040A1 (en) 2013-03-15 2014-09-18 Global Blood Therapeutics, Inc. Substituted aldehyde compounds and methods for their use in increasing tissue oxygenation
US9422279B2 (en) 2013-03-15 2016-08-23 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
US9458139B2 (en) 2013-03-15 2016-10-04 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
CN105246477A (zh) 2013-03-15 2016-01-13 全球血液疗法股份有限公司 化合物及其用于调节血红蛋白的用途
KR101971385B1 (ko) 2013-03-15 2019-04-22 글로벌 블러드 테라퓨틱스, 인크. 헤모글로빈 조정을 위한 화합물 및 이의 용도
EA202092627A1 (ru) 2013-11-18 2021-09-30 Глобал Блад Терапьютикс, Инк. Соединения и их применения для модуляции гемоглобина
EA028529B1 (ru) 2014-02-07 2017-11-30 Глобал Блад Терапьютикс, Инк. Кристаллические полиморфные формы свободного основания 2-гидрокси-6-((2-(1-изопропил-1н-пиразол-5-ил)пиридин-3-ил)метокси)бензальдегида
MX2018006832A (es) 2015-12-04 2018-11-09 Global Blood Therapeutics Inc Regimenes de dosificacion de 2-hidroxi-6-((2-(1-isopropil-1h-piraz ol-5-il)-piridin-3-il)-metoxi)-benzaldehido.
TWI663160B (zh) 2016-05-12 2019-06-21 全球血液治療公司 用於合成2-羥基-6-((2-(1-異丙基-1h-吡唑-5-基)-吡啶-3-基)甲氧基)苯甲醛之方法
TWI778983B (zh) 2016-10-12 2022-10-01 美商全球血液治療公司 包含2-羥基-6-((2-(1-異丙基-1h-吡唑-5-基)吡啶-3-基)甲氧基)-苯甲醛之片劑
EP3860975B1 (en) 2018-10-01 2023-10-18 Global Blood Therapeutics, Inc. Modulators of hemoglobin for the treatment of sickle cell disease
CN117720407A (zh) * 2023-12-14 2024-03-19 湖北新南化科技有限公司 废渣的处理方法

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Publication number Publication date
AU2009261270A1 (en) 2009-12-23
US8338625B2 (en) 2012-12-25
TW201004932A (en) 2010-02-01
EP2305625A4 (en) 2014-06-11
IL209925A (en) 2014-06-30
US20110098489A1 (en) 2011-04-28
WO2009154154A1 (ja) 2009-12-23
CN102123977B (zh) 2014-02-26
AU2009261270B2 (en) 2013-01-31
CN102123977A (zh) 2011-07-13
IL209925A0 (en) 2011-02-28
KR101555734B1 (ko) 2015-09-25
EP2305625A1 (en) 2011-04-06
EP2305625B1 (en) 2015-05-13
JP2009298746A (ja) 2009-12-24
TWI418550B (zh) 2013-12-11
KR20110028358A (ko) 2011-03-17
JP5314330B2 (ja) 2013-10-16

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