DK2280021T3 - Pharmaceutical formulations comprising insulin complexed to a diketopiperazine - Google Patents
Pharmaceutical formulations comprising insulin complexed to a diketopiperazine Download PDFInfo
- Publication number
- DK2280021T3 DK2280021T3 DK10075475.3T DK10075475T DK2280021T3 DK 2280021 T3 DK2280021 T3 DK 2280021T3 DK 10075475 T DK10075475 T DK 10075475T DK 2280021 T3 DK2280021 T3 DK 2280021T3
- Authority
- DK
- Denmark
- Prior art keywords
- insulin
- diketopiperazine
- microparticles
- composition
- suspension
- Prior art date
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- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 title claims abstract description 336
- 229940125396 insulin Drugs 0.000 title claims abstract description 168
- 108090001061 Insulin Proteins 0.000 title claims abstract description 167
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- BXRNXXXXHLBUKK-UHFFFAOYSA-N piperazine-2,5-dione Chemical compound O=C1CNC(=O)CN1 BXRNXXXXHLBUKK-UHFFFAOYSA-N 0.000 title claims description 64
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- A61K9/167—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
- A61K9/1676—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface having a drug-free core with discrete complete coating layer containing drug
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- C—CHEMISTRY; METALLURGY
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- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/06—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members
- C07D241/08—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
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- C07K1/14—Extraction; Separation; Purification
- C07K1/30—Extraction; Separation; Purification by precipitation
- C07K1/32—Extraction; Separation; Purification by precipitation as complexes
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/605—Glucagons
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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- C07K14/575—Hormones
- C07K14/62—Insulins
Landscapes
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US14143399P | 1999-06-29 | 1999-06-29 | |
| EP07075344.7A EP1808438B1 (en) | 1999-06-29 | 2000-06-29 | Purification and stabilization of peptide and proteins in pharmaceutical agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2280021T3 true DK2280021T3 (en) | 2016-05-02 |
Family
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Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK00945009.9T DK1196430T3 (da) | 1999-06-29 | 2000-06-29 | Rensning og stabilisering af peptider og proteiner i farmaceutiske midler |
| DK10075475.3T DK2280021T3 (en) | 1999-06-29 | 2000-06-29 | Pharmaceutical formulations comprising insulin complexed to a diketopiperazine |
| DK10075474.6T DK2280020T3 (en) | 1999-06-29 | 2000-06-29 | Pharmaceutical formulations comprising a peptide complexed with a diketopiperazine |
| DK07075344.7T DK1808438T3 (da) | 1999-06-29 | 2000-06-29 | Rensning og stabilisering af peptid og proteiner i lægemidler |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK00945009.9T DK1196430T3 (da) | 1999-06-29 | 2000-06-29 | Rensning og stabilisering af peptider og proteiner i farmaceutiske midler |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK10075474.6T DK2280020T3 (en) | 1999-06-29 | 2000-06-29 | Pharmaceutical formulations comprising a peptide complexed with a diketopiperazine |
| DK07075344.7T DK1808438T3 (da) | 1999-06-29 | 2000-06-29 | Rensning og stabilisering af peptid og proteiner i lægemidler |
Country Status (11)
| Country | Link |
|---|---|
| US (7) | US6444226B1 (enExample) |
| EP (5) | EP2280004B1 (enExample) |
| JP (5) | JP4713798B2 (enExample) |
| AT (1) | ATE545652T1 (enExample) |
| AU (3) | AU779986B2 (enExample) |
| CA (1) | CA2377204C (enExample) |
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