DK219686A - Fremgangsmaade til bestemmelse af koncentrationen af en fri ligand i en biologisk vaeske - Google Patents
Fremgangsmaade til bestemmelse af koncentrationen af en fri ligand i en biologisk vaeske Download PDFInfo
- Publication number
- DK219686A DK219686A DK219686A DK219686A DK219686A DK 219686 A DK219686 A DK 219686A DK 219686 A DK219686 A DK 219686A DK 219686 A DK219686 A DK 219686A DK 219686 A DK219686 A DK 219686A
- Authority
- DK
- Denmark
- Prior art keywords
- ligand
- concentration
- bound
- free
- protein
- Prior art date
Links
- 239000003446 ligand Substances 0.000 title abstract 17
- 238000000034 method Methods 0.000 title abstract 3
- 239000007788 liquid Substances 0.000 title 1
- 102000014914 Carrier Proteins Human genes 0.000 abstract 5
- 108091008324 binding proteins Proteins 0.000 abstract 5
- 239000000700 radioactive tracer Substances 0.000 abstract 5
- 239000013060 biological fluid Substances 0.000 abstract 3
- 102000004169 proteins and genes Human genes 0.000 abstract 3
- 108090000623 proteins and genes Proteins 0.000 abstract 3
- MUMGGOZAMZWBJJ-DYKIIFRCSA-N Testostosterone Chemical compound O=C1CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 MUMGGOZAMZWBJJ-DYKIIFRCSA-N 0.000 abstract 2
- 239000011230 binding agent Substances 0.000 abstract 2
- GHAFORRTMVIXHS-UHFFFAOYSA-L bromosulfophthalein sodium Chemical compound [Na+].[Na+].C1=C(S([O-])(=O)=O)C(O)=CC=C1C1(C=2C=C(C(O)=CC=2)S([O-])(=O)=O)C(C(Br)=C(Br)C(Br)=C2Br)=C2C(=O)O1 GHAFORRTMVIXHS-UHFFFAOYSA-L 0.000 abstract 2
- 229960001734 sulfobromophthalein Drugs 0.000 abstract 2
- UFBJCMHMOXMLKC-UHFFFAOYSA-N 2,4-dinitrophenol Chemical compound OC1=CC=C([N+]([O-])=O)C=C1[N+]([O-])=O UFBJCMHMOXMLKC-UHFFFAOYSA-N 0.000 abstract 1
- FWEOQOXTVHGIFQ-UHFFFAOYSA-N 8-anilinonaphthalene-1-sulfonic acid Chemical compound C=12C(S(=O)(=O)O)=CC=CC2=CC=CC=1NC1=CC=CC=C1 FWEOQOXTVHGIFQ-UHFFFAOYSA-N 0.000 abstract 1
- YGSDEFSMJLZEOE-UHFFFAOYSA-M salicylate Chemical compound OC1=CC=CC=C1C([O-])=O YGSDEFSMJLZEOE-UHFFFAOYSA-M 0.000 abstract 1
- 229960001860 salicylate Drugs 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 229960003604 testosterone Drugs 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
- G01N33/743—Steroid hormones
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
- G01N33/78—Thyroid gland hormones, e.g. T3, T4, TBH, TBG or their receptors
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Biotechnology (AREA)
- Analytical Chemistry (AREA)
- Cell Biology (AREA)
- Endocrinology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US78485785A | 1985-10-04 | 1985-10-04 | |
| US78485785 | 1985-10-04 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| DK219686D0 DK219686D0 (da) | 1986-05-12 |
| DK219686A true DK219686A (da) | 1987-04-05 |
| DK169365B1 DK169365B1 (da) | 1994-10-10 |
Family
ID=25133738
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK219686A DK169365B1 (da) | 1985-10-04 | 1986-05-12 | Fremgangsmåde til bestemmelse af koncentrationen af fri ligand i en biologisk væske |
Country Status (13)
| Country | Link |
|---|---|
| EP (2) | EP0218309B1 (da) |
| JP (2) | JPH081436B2 (da) |
| AT (2) | ATE130435T1 (da) |
| AU (1) | AU602864B2 (da) |
| CA (1) | CA1299984C (da) |
| DE (2) | DE3650437T2 (da) |
| DK (1) | DK169365B1 (da) |
| ES (1) | ES8707342A1 (da) |
| FI (1) | FI92878C (da) |
| IE (1) | IE60715B1 (da) |
| IL (1) | IL79283A (da) |
| NO (1) | NO168002C (da) |
| NZ (1) | NZ216326A (da) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3624464A1 (de) * | 1986-07-19 | 1988-01-28 | Boehringer Mannheim Gmbh | Verfahren zum nachweis eines analyten sowie hierfuer geeignetes mittel |
| US5198340A (en) * | 1991-01-17 | 1993-03-30 | Genentech, Inc. | Assay for free igf-i, igf-ii, and gh levels in body fluids |
| US6159698A (en) * | 1996-07-18 | 2000-12-12 | Dade Behring Marburg Gmbh | Reagents for assays for mycophenolic acid |
| CA2231775A1 (en) | 1996-07-18 | 1998-01-29 | Behringwerke Aktiengesellschaft | Reagents for assays for ligands |
| JP2005283380A (ja) * | 2004-03-30 | 2005-10-13 | Teikoku Hormone Mfg Co Ltd | バイオアベイラブルステロイドホルモンの測定方法 |
| JP5163883B2 (ja) * | 2008-05-30 | 2013-03-13 | 東ソー株式会社 | Ｂ型肝炎ウイルスコア抗原又はそれに対する抗体の測定方法 |
| US20160313310A1 (en) | 2013-12-13 | 2016-10-27 | Siemens Healthcare Diagnostics Inc. | Pretreatment agent in non-agglutination assays |
| JP7472320B2 (ja) * | 2020-12-18 | 2024-04-22 | 中外製薬株式会社 | 動的解析による相対ｆｕ比の測定方法 |
| CN113624982B (zh) * | 2021-08-04 | 2024-11-26 | 深圳市辰纳生物科技有限公司 | 一种睾酮的磁颗粒酶促化学发光免疫检测试剂 |
| JP2025181317A (ja) * | 2024-05-31 | 2025-12-11 | シスメックス株式会社 | トランスサイレチン四量体の検出方法、安定性の評価方法、試薬及び試薬キット |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3928553A (en) * | 1972-03-23 | 1975-12-23 | Univ New York | Radioimmunoassay method for triiodothyronine and thyroxine |
| US4381291A (en) * | 1979-02-23 | 1983-04-26 | Ab Fortia | Measurement of free ligands |
| US4410633A (en) * | 1980-09-25 | 1983-10-18 | Corning Glass Works | Method for the measurement of free thyroxine or 3,5,3'-triiodothyronine in a liquid sample |
| US4430435A (en) * | 1980-12-24 | 1984-02-07 | Burroughs Wellcome Co. | Assay system |
| US4468469A (en) * | 1981-11-04 | 1984-08-28 | Miles Laboratories, Inc. | Substituted phenylacetic acids and salts as TBP blocking agents in iodothyronine immunoassays |
| JPS5886461A (ja) * | 1981-11-04 | 1983-05-24 | マイルス・ラボラトリ−ズ・インコ−ポレ−テツド | 免疫試験用試薬、試験キツト及びそれらを用いる免疫試験法 |
| EP0089806B1 (en) * | 1982-03-22 | 1989-06-28 | AMERSHAM INTERNATIONAL plc | Assay for the free portion of substances in biological fluids |
| GB8317124D0 (en) * | 1983-06-23 | 1983-07-27 | Ekins R P | Free ligand assay |
| US4622293A (en) * | 1983-07-05 | 1986-11-11 | Miles Laboratories, Inc. | Iodothyronine immunoassays employing HMS as TBP blocking agent |
| GB8404843D0 (en) * | 1984-02-24 | 1984-03-28 | Amersham Int Plc | Free analyte assay |
| DE3415818C1 (de) * | 1984-04-27 | 1985-04-18 | Henning Berlin Gmbh Chemie- Und Pharmawerk, 1000 Berlin | Verfahren zur Bestimmung freier Substanzen in biologischen Fluessigkeiten |
| EP0165669A1 (en) * | 1984-05-04 | 1985-12-27 | Corning Glass Works | Improved method of measuring free ligand |
-
1986
- 1986-01-17 DE DE3650437T patent/DE3650437T2/de not_active Expired - Fee Related
- 1986-01-17 AT AT86300336T patent/ATE130435T1/de not_active IP Right Cessation
- 1986-01-17 DE DE3650691T patent/DE3650691T2/de not_active Expired - Fee Related
- 1986-01-17 EP EP86300336A patent/EP0218309B1/en not_active Expired - Lifetime
- 1986-01-17 EP EP95103930A patent/EP0661540B1/en not_active Expired - Lifetime
- 1986-01-17 AT AT95103930T patent/ATE169410T1/de not_active IP Right Cessation
- 1986-05-12 DK DK219686A patent/DK169365B1/da not_active IP Right Cessation
- 1986-05-16 AU AU57521/86A patent/AU602864B2/en not_active Ceased
- 1986-05-28 NZ NZ216326A patent/NZ216326A/xx unknown
- 1986-05-28 ES ES555425A patent/ES8707342A1/es not_active Expired
- 1986-06-04 CA CA000510762A patent/CA1299984C/en not_active Expired - Lifetime
- 1986-06-05 IE IE149586A patent/IE60715B1/en not_active IP Right Cessation
- 1986-06-06 NO NO862278A patent/NO168002C/no not_active IP Right Cessation
- 1986-06-30 IL IL79283A patent/IL79283A/xx not_active IP Right Cessation
- 1986-07-04 JP JP61157772A patent/JPH081436B2/ja not_active Expired - Lifetime
- 1986-08-05 FI FI863186A patent/FI92878C/fi not_active IP Right Cessation
-
1995
- 1995-01-25 JP JP7010194A patent/JP2575338B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| FI92878C (fi) | 1995-01-10 |
| AU5752186A (en) | 1987-04-09 |
| DK169365B1 (da) | 1994-10-10 |
| JPS6283666A (ja) | 1987-04-17 |
| FI863186L (fi) | 1987-04-05 |
| IE861495L (en) | 1987-04-04 |
| DE3650691T2 (de) | 1998-12-10 |
| AU602864B2 (en) | 1990-11-01 |
| NO168002B (no) | 1991-09-23 |
| ATE130435T1 (de) | 1995-12-15 |
| CA1299984C (en) | 1992-05-05 |
| DE3650437T2 (de) | 1996-04-18 |
| IE60715B1 (en) | 1994-08-10 |
| EP0661540B1 (en) | 1998-08-05 |
| IL79283A0 (en) | 1986-09-30 |
| DE3650437D1 (de) | 1995-12-21 |
| JPH07311200A (ja) | 1995-11-28 |
| ES555425A0 (es) | 1987-07-16 |
| JP2575338B2 (ja) | 1997-01-22 |
| JPH081436B2 (ja) | 1996-01-10 |
| EP0218309A2 (en) | 1987-04-15 |
| EP0218309B1 (en) | 1995-11-15 |
| ATE169410T1 (de) | 1998-08-15 |
| ES8707342A1 (es) | 1987-07-16 |
| EP0661540A1 (en) | 1995-07-05 |
| IL79283A (en) | 1991-06-30 |
| DE3650691D1 (de) | 1998-09-10 |
| NO862278D0 (no) | 1986-06-06 |
| DK219686D0 (da) | 1986-05-12 |
| EP0218309A3 (en) | 1988-08-31 |
| NO862278L (no) | 1987-04-06 |
| FI863186A0 (fi) | 1986-08-05 |
| NZ216326A (en) | 1989-02-24 |
| FI92878B (fi) | 1994-09-30 |
| NO168002C (no) | 1992-01-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B1 | Patent granted (law 1993) | ||
| PBP | Patent lapsed |