DK2195039T3 - Kirurgisk hydrogel - Google Patents
Kirurgisk hydrogel Download PDFInfo
- Publication number
- DK2195039T3 DK2195039T3 DK08828839.4T DK08828839T DK2195039T3 DK 2195039 T3 DK2195039 T3 DK 2195039T3 DK 08828839 T DK08828839 T DK 08828839T DK 2195039 T3 DK2195039 T3 DK 2195039T3
- Authority
- DK
- Denmark
- Prior art keywords
- polymer
- hydrogel
- chitosan
- derivatised
- aldehyde
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
- A61L26/0052—Mixtures of macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/716—Glucans
- A61K31/721—Dextrans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/716—Glucans
- A61K31/722—Chitin, chitosan
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/738—Cross-linked polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0061—Use of materials characterised by their function or physical properties
- A61L26/008—Hydrogels or hydrocolloids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/04—Macromolecular materials
- A61L31/041—Mixtures of macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L31/145—Hydrogels or hydrocolloids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/04—Materials for stopping bleeding
Claims (15)
- KIRURGISK HYDROGEL1. Polymernetværk omfattende en dicarboxy-derivatiseret chitosan-polymer krydsbundet til en aldehyd-derivatiseret dextran-polymer.
- 2. Polymernetværk ifølge krav 1, hvori den dicarboxy-derivatiserede chitosan-polymer er krydsbundet til den aldehydderivat iserede dextran-polymer gennem den dicarboxy-derivatiserede chitosan-polymers amin-gruppe og den aldehyd-derivatiserede dextran-polymers aldehyd-gruppe.
- 3. Polymernetværk ifølge krav 1 i form af en hydrogel,
- 4. Polymernetværk ifølge krav 2-3, hvori sammensætningen omfatter mellem omtrent 2 vægt-% til 10 vægt-% dicarboxy-derivatiseret chitosan-polymer og mellem omtrent 2 vægt-% til 10 vægt-% aid eh yd e-der i vatiseret dextran-polymer,
- 5. Polymernetværk ifølge krav 1 til i, hvori den dicarboxy-derivatiserede chitosan-polymer er N-succinylchitosan.
- 6. Hydrogel ifølge krav 3 endvidere omfattende en eller flere biologisk aktive agenser.
- 7. Hydrogel ifølge krav 6, hvori den eller de biologisk aktive agenser er udvalgt fra gruppen bestående af plasmaprotein, hormoner, enzymer, antibiotika, antiseptiske agenser, antineoplastiske agenser, antimykotiske agenser, antivirale agenser, antiinflammatoriske agenser, vækstfaktorer, steroider, c e11e s usp e n s i oner, cyt otoxi ne r o g c elleforme r i ng s hæmme r e.
- 8. Hydrogel ifølge krav 3 til anvendelse til forebyggelse eller reducering af adhæsion af væv med tilbøjelighed til adhærencedannelse, til accelerering eller fremme af sårheling eller til standsning af blødning fra et sår.
- 9. Hydrogel ifølge krav 3 til anvendelse i øre-, næse- og halskirurgi.
- 10. Kit omfattende (a) en dicarboxyl-derivatiseret chitosan-polymer og <b> en aldehyd-derivatiseret dextran-polvmer.
- 11, Kit ifølge krav 10, hvori en af eller både (a) og (b) tilvejebringes i separate vandige opløsninger,
- 12, Kit ifølge krav 10 endvidere omfattende en eller flere b i o 1 o g i s k a k t i v e a g e n s e r.
- 13, Kit ifølge krav 10 til anvendelse i øre-, næse- og halskirurgi.
- 14, Hydrogel ifølge krav 3 til anvendelse ved kirurgi i næsehulen eller de paranasale sinusser.
- 15, Kit ifølge krav 10 til anvendelse ved kirurgi i næsehulen eller de paranasale sinusser.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US96841407P | 2007-08-28 | 2007-08-28 | |
PCT/NZ2008/000219 WO2009028965A1 (en) | 2007-08-28 | 2008-08-26 | Surgical hydrogel |
Publications (1)
Publication Number | Publication Date |
---|---|
DK2195039T3 true DK2195039T3 (da) | 2017-01-30 |
Family
ID=40387519
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK08828839.4T DK2195039T3 (da) | 2007-08-28 | 2008-08-26 | Kirurgisk hydrogel |
Country Status (11)
Country | Link |
---|---|
US (2) | US20100291055A1 (da) |
EP (1) | EP2195039B1 (da) |
JP (1) | JP5489999B2 (da) |
KR (1) | KR101610268B1 (da) |
CN (2) | CN104874007A (da) |
AU (1) | AU2008293135B2 (da) |
CA (1) | CA2709546C (da) |
DK (1) | DK2195039T3 (da) |
ES (1) | ES2619181T3 (da) |
NZ (1) | NZ583819A (da) |
WO (1) | WO2009028965A1 (da) |
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2008
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- 2008-08-26 EP EP08828839.4A patent/EP2195039B1/en active Active
- 2008-08-26 ES ES08828839.4T patent/ES2619181T3/es active Active
- 2008-08-26 KR KR1020107006766A patent/KR101610268B1/ko active IP Right Grant
- 2008-08-26 CN CN201510203202.0A patent/CN104874007A/zh active Pending
- 2008-08-26 NZ NZ583819A patent/NZ583819A/xx unknown
- 2008-08-26 US US12/675,329 patent/US20100291055A1/en not_active Abandoned
- 2008-08-26 CA CA2709546A patent/CA2709546C/en not_active Expired - Fee Related
- 2008-08-26 AU AU2008293135A patent/AU2008293135B2/en active Active
- 2008-08-26 JP JP2010522848A patent/JP5489999B2/ja active Active
- 2008-08-26 CN CN200880108319A patent/CN101848739A/zh active Pending
- 2008-08-26 DK DK08828839.4T patent/DK2195039T3/da active
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Also Published As
Publication number | Publication date |
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CN104874007A (zh) | 2015-09-02 |
WO2009028965A1 (en) | 2009-03-05 |
CA2709546A1 (en) | 2009-03-05 |
AU2008293135A1 (en) | 2009-03-05 |
NZ583819A (en) | 2012-08-31 |
KR101610268B1 (ko) | 2016-04-07 |
EP2195039A1 (en) | 2010-06-16 |
ES2619181T3 (es) | 2017-06-23 |
EP2195039B1 (en) | 2016-11-30 |
JP5489999B2 (ja) | 2014-05-14 |
EP2195039A4 (en) | 2013-01-09 |
CA2709546C (en) | 2017-09-26 |
US20100291055A1 (en) | 2010-11-18 |
US8809301B2 (en) | 2014-08-19 |
JP2010537711A (ja) | 2010-12-09 |
KR20100093516A (ko) | 2010-08-25 |
US20130244974A1 (en) | 2013-09-19 |
CN101848739A (zh) | 2010-09-29 |
AU2008293135B2 (en) | 2014-08-07 |
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