DK2144506T3 - 3-substitueret [1,2,3]-benzotriazinonforbindelse til at fremme glutamaterge synaptiske responser - Google Patents

3-substitueret [1,2,3]-benzotriazinonforbindelse til at fremme glutamaterge synaptiske responser

Info

Publication number
DK2144506T3
DK2144506T3 DK07868093.1T DK07868093T DK2144506T3 DK 2144506 T3 DK2144506 T3 DK 2144506T3 DK 07868093 T DK07868093 T DK 07868093T DK 2144506 T3 DK2144506 T3 DK 2144506T3
Authority
DK
Denmark
Prior art keywords
promote
substituted
synaptic responses
glutamatergic synaptic
benzotriazinone
Prior art date
Application number
DK07868093.1T
Other languages
English (en)
Inventor
Rudolf Mueller
Alexis Cordi
Gary Rogers
Original Assignee
Servier Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Servier Lab filed Critical Servier Lab
Application granted granted Critical
Publication of DK2144506T3 publication Critical patent/DK2144506T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
DK07868093.1T 2007-01-03 2007-12-28 3-substitueret [1,2,3]-benzotriazinonforbindelse til at fremme glutamaterge synaptiske responser DK2144506T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US87850307P 2007-01-03 2007-01-03
US92143307P 2007-04-02 2007-04-02
PCT/US2007/026416 WO2008085506A1 (en) 2007-01-03 2007-12-28 3-substituted-[1,2,3]-benzotriazinone compound for enhancing glutamatergic synaptic responses

Publications (1)

Publication Number Publication Date
DK2144506T3 true DK2144506T3 (da) 2012-03-05

Family

ID=39608956

Family Applications (1)

Application Number Title Priority Date Filing Date
DK07868093.1T DK2144506T3 (da) 2007-01-03 2007-12-28 3-substitueret [1,2,3]-benzotriazinonforbindelse til at fremme glutamaterge synaptiske responser

Country Status (38)

Country Link
US (1) US8173644B2 (da)
EP (1) EP2144506B1 (da)
JP (1) JP5139446B2 (da)
CN (1) CN101616592B (da)
AP (1) AP2502A (da)
AR (1) AR064740A1 (da)
AT (1) ATE527269T1 (da)
AU (1) AU2007342365B2 (da)
BR (1) BRPI0720749A2 (da)
CA (1) CA2674460C (da)
CR (1) CR10906A (da)
CU (1) CU23804B7 (da)
CY (1) CY1112493T1 (da)
DK (1) DK2144506T3 (da)
EA (1) EA017437B1 (da)
EC (1) ECSP099499A (da)
ES (1) ES2374995T3 (da)
GE (1) GEP20125438B (da)
GT (1) GT200900189A (da)
HK (1) HK1140105A1 (da)
HN (1) HN2009001268A (da)
HR (1) HRP20110970T1 (da)
IL (1) IL199651A (da)
MA (1) MA31160B1 (da)
ME (1) ME00819B (da)
MX (1) MX2009007242A (da)
MY (1) MY154877A (da)
NI (1) NI200900131A (da)
NZ (1) NZ578293A (da)
PL (1) PL2144506T3 (da)
PT (1) PT2144506E (da)
RS (1) RS52108B (da)
SG (1) SG163545A1 (da)
SI (1) SI2144506T1 (da)
SV (1) SV2009003322A (da)
TN (1) TN2009000277A1 (da)
WO (1) WO2008085506A1 (da)
ZA (1) ZA200904826B (da)

Families Citing this family (10)

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KR20090098999A (ko) * 2007-01-03 2009-09-18 코텍스 파마슈티칼스, 인크. 글루타메이트에 의한 시냅스 반응을 향상시키기 위한 3-치환된-[1,2,3]벤조트리아지논 화합물
MX2009012430A (es) 2007-05-17 2010-01-14 Cortex Pharma Inc Amidas disustituidas para mejorar las respuestas sinapticas glutamatergicas.
CA2695742C (en) 2007-08-10 2012-11-27 Rudolf Mueller Bicyclic amides for enhancing glutamatergic synaptic responses
US8168632B2 (en) 2007-08-10 2012-05-01 Cortex Pharmaceuticals, Inc. Bicyclic amide derivatives for the treatment of respiratory disorders
US20110257186A1 (en) * 2010-04-15 2011-10-20 Staubli Ursula V Compositions and methods for treating visual disorders
WO2013075624A1 (zh) 2011-11-22 2013-05-30 北京哈三联科技股份有限公司 甘氨酸重摄取抑制剂及其应用
FR3019464B1 (fr) * 2014-04-07 2016-05-06 Servier Lab Nouvelle association entre le 8-cyclopropyl-3-[2-(3-fluorophenyl)ethyl]-7,8-dihydro-3h-[1,3]oxazino[6,5-g] [1,2,3]benzotriazine-4,9-dione et un inhibiteur de l'acetylcholinesterase et les compositions pharmaceutiques qui la contiennent
FR3034019B1 (fr) 2015-03-26 2017-03-17 Servier Lab Nouvelle association entre le 8-cyclopropyl-3-[2-(3-fluorophenyl)ethyl]-7,8-dihydro-3h-[1,3]oxazino[6,5-g] [1,2,3]benzotriazine-4,9-dione et un antidepresseur et les compositions pharmaceutiques qui la contiennent
KR20180019234A (ko) 2015-06-26 2018-02-23 다케다 야쿠힌 고교 가부시키가이샤 콜린성 무스카린 m1 수용체의 조절제로서의 2,3-디히드로-4h-1,3-벤족사진-4-온 유도체
CN106226509B (zh) * 2016-08-12 2019-09-06 中国人民解放军第四军医大学 一种在小鼠前扣带回皮层诱发dse现象的方法

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US3723436A (en) * 1971-02-25 1973-03-27 Sun Oil Co Process for aromatic lactams
DK623586A (da) * 1985-12-27 1987-06-28 Eisai Co Ltd Piperidinderivater eller salte deraf og farmaceutiske kompositioner indeholdende forbindelserne
FR2597103B1 (fr) * 1986-04-15 1988-12-16 Provesan Sa Procede de preparation de derives d'oxazinobenzothiazine 6,6-dioxyde
CA2450801C (en) * 1992-07-24 2009-11-17 The Regent Of The University Of California Drugs that enhance synaptic responses mediated by ampa receptors
US5962477A (en) * 1994-04-12 1999-10-05 Adolor Corporation Screening methods for cytokine inhibitors
ATE174915T1 (de) * 1994-10-31 1999-01-15 Merck Patent Gmbh Benzylpiperidinderivate mit hoher affinität zu bindungsstellen von aminosäure-rezeptoren
US5650409A (en) * 1995-06-02 1997-07-22 Cortex Pharmaceuticals, Inc. Benzoyl piperidines/pyrrolidines for enhancing synaptic response
US5736543A (en) * 1996-04-03 1998-04-07 The Regents Of The University Of California Benzoxazines for enhancing synaptic response
US6030968A (en) * 1996-09-17 2000-02-29 The Regents Of The University Of California Positive AMPA receptor modulation to enhance brain neurotrophic factor expression
US6110935A (en) * 1997-02-13 2000-08-29 The Regents Of The University Of California Benzofurazan compounds for enhancing glutamatergic synaptic responses
US5985871A (en) 1997-12-24 1999-11-16 Cortex Pharmaceuticals, Inc. Benzoxazine compounds for enhancing synaptic response
TR200002427T2 (tr) 1998-02-18 2001-01-22 Neurosearch A/S Yeni bileşikler ve bunların pozitif ampa reseptör modülatörleri olarak kullanımı.
US6713474B2 (en) * 1998-09-18 2004-03-30 Abbott Gmbh & Co. Kg Pyrrolopyrimidines as therapeutic agents
US6303542B1 (en) * 2000-08-18 2001-10-16 Rohm And Haas Company Herbicidal 3-substituted-phenyl-1,2,3-benzotriazin-4-ones
EA011034B1 (ru) * 2001-11-26 2008-12-30 Кортекс Фармасеутикалс, Инк. Соединения карбонилбензоксазина для усиления глутаматергических синаптических ответов
JP2003238555A (ja) * 2002-02-20 2003-08-27 Sumitomo Pharmaceut Co Ltd 細胞死抑制剤
AUPS255202A0 (en) * 2002-05-27 2002-06-13 Monash University Agents and methods for the treatment of disorders associated with motor neuron degeneration
JP2006516283A (ja) * 2003-01-13 2006-06-29 コーテックス ファーマシューティカルズ， インコーポレイテッド 睡眠不足とストレスに起因する知覚衰退の処置方法
GB0317482D0 (en) * 2003-07-25 2003-08-27 Pfizer Ltd Nicotinamide derivatives useful as pde4 inhibitors
CN1897950A (zh) * 2003-10-14 2007-01-17 惠氏公司 稠合芳基和杂芳基衍生物及其使用方法
KR20090098999A (ko) 2007-01-03 2009-09-18 코텍스 파마슈티칼스, 인크. 글루타메이트에 의한 시냅스 반응을 향상시키기 위한 3-치환된-[1,2,3]벤조트리아지논 화합물
MX2009012430A (es) * 2007-05-17 2010-01-14 Cortex Pharma Inc Amidas disustituidas para mejorar las respuestas sinapticas glutamatergicas.
CA2695742C (en) 2007-08-10 2012-11-27 Rudolf Mueller Bicyclic amides for enhancing glutamatergic synaptic responses
MX2010002890A (es) 2007-09-20 2010-07-02 Cortex Pharma Inc 1, 2, 3-triacin -4-onas sustituidas en la posicion 3 y 1, 3- pirimidinonas sustituidas en la posicion 3 para mejorar las respuestas sinapticas glutamatergicas.

Also Published As

Publication number Publication date
EP2144506A1 (en) 2010-01-20
JP5139446B2 (ja) 2013-02-06
NZ578293A (en) 2012-01-12
EA200900925A1 (ru) 2009-12-30
US8173644B2 (en) 2012-05-08
EP2144506B1 (en) 2011-10-05
CU20090117A7 (es) 2011-10-05
SG163545A1 (en) 2010-08-30
SI2144506T1 (sl) 2012-01-31
EP2144506A4 (en) 2010-05-05
CN101616592B (zh) 2013-06-05
AR064740A1 (es) 2009-04-22
ES2374995T3 (es) 2012-02-23
AU2007342365A1 (en) 2008-07-17
NI200900131A (es) 2010-03-11
HN2009001268A (es) 2011-12-27
RS52108B (en) 2012-08-31
CA2674460C (en) 2014-07-15
ME00819B (me) 2012-03-20
MY154877A (en) 2015-08-14
SV2009003322A (es) 2010-02-05
CR10906A (es) 2009-10-23
HRP20110970T1 (hr) 2012-01-31
IL199651A0 (en) 2010-04-15
WO2008085506A1 (en) 2008-07-17
CY1112493T1 (el) 2015-12-09
PT2144506E (pt) 2011-12-21
GEP20125438B (en) 2012-03-26
TN2009000277A1 (en) 2010-10-18
CA2674460A1 (en) 2008-07-17
AP2502A (en) 2012-10-23
IL199651A (en) 2015-08-31
CU23804B7 (es) 2012-03-15
ECSP099499A (es) 2009-10-30
JP2010514838A (ja) 2010-05-06
ATE527269T1 (de) 2011-10-15
AU2007342365B2 (en) 2012-11-15
ZA200904826B (en) 2010-09-29
AP2009004931A0 (en) 2009-08-31
BRPI0720749A2 (pt) 2014-01-14
EA017437B1 (ru) 2012-12-28
CN101616592A (zh) 2009-12-30
HK1140105A1 (en) 2010-10-08
MA31160B1 (fr) 2010-02-01
MX2009007242A (es) 2009-09-02
US20100137295A1 (en) 2010-06-03
PL2144506T3 (pl) 2012-04-30
GT200900189A (es) 2011-08-02

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