MX2009007242A - Compuesto de [1,2,3]-benzotriazinona 3-sustituida para mejorar respuestas sinapticas glutamatergicas. - Google Patents

Compuesto de [1,2,3]-benzotriazinona 3-sustituida para mejorar respuestas sinapticas glutamatergicas.

Info

Publication number
MX2009007242A
MX2009007242A MX2009007242A MX2009007242A MX2009007242A MX 2009007242 A MX2009007242 A MX 2009007242A MX 2009007242 A MX2009007242 A MX 2009007242A MX 2009007242 A MX2009007242 A MX 2009007242A MX 2009007242 A MX2009007242 A MX 2009007242A
Authority
MX
Mexico
Prior art keywords
treatment
compound
substituted
synaptic responses
glutamatergic synaptic
Prior art date
Application number
MX2009007242A
Other languages
English (en)
Inventor
Alexis Cordi
Gary Rogers
Rudolf Mueller
Original Assignee
Cortex Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cortex Pharma Inc filed Critical Cortex Pharma Inc
Publication of MX2009007242A publication Critical patent/MX2009007242A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

Esta invención se refiere a la prevención y tratamiento de insuficiencia cerebral, que incluye el mejoramiento del funcionamiento de receptores en sinapsis en redes cerebrales responsables de los comportamientos de orden superior. Estas redes cerebrales están implicadas en las capacidades cognitivas relacionadas con el deterioro de la memoria, como se observa en una gama de demencias, y en los desequilibrios en la actividad neuronal entre diferentes regiones cerebrales, como se sugiere en trastornos tales como la enfermedad de Alzheimer, esquizofrenia y trastornos afectivos. En un aspecto particular, la presente invención se refiere a un compuesto útil para el tratamiento de tales condiciones, y a métodos de uso de este compuesto para tal tratamiento.
MX2009007242A 2007-01-03 2007-12-28 Compuesto de [1,2,3]-benzotriazinona 3-sustituida para mejorar respuestas sinapticas glutamatergicas. MX2009007242A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US87850307P 2007-01-03 2007-01-03
US92143307P 2007-04-02 2007-04-02
PCT/US2007/026416 WO2008085506A1 (en) 2007-01-03 2007-12-28 3-substituted-[1,2,3]-benzotriazinone compound for enhancing glutamatergic synaptic responses

Publications (1)

Publication Number Publication Date
MX2009007242A true MX2009007242A (es) 2009-09-02

Family

ID=39608956

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2009007242A MX2009007242A (es) 2007-01-03 2007-12-28 Compuesto de [1,2,3]-benzotriazinona 3-sustituida para mejorar respuestas sinapticas glutamatergicas.

Country Status (38)

Country Link
US (1) US8173644B2 (es)
EP (1) EP2144506B1 (es)
JP (1) JP5139446B2 (es)
CN (1) CN101616592B (es)
AP (1) AP2502A (es)
AR (1) AR064740A1 (es)
AT (1) ATE527269T1 (es)
AU (1) AU2007342365B2 (es)
BR (1) BRPI0720749A2 (es)
CA (1) CA2674460C (es)
CR (1) CR10906A (es)
CU (1) CU23804B7 (es)
CY (1) CY1112493T1 (es)
DK (1) DK2144506T3 (es)
EA (1) EA017437B1 (es)
EC (1) ECSP099499A (es)
ES (1) ES2374995T3 (es)
GE (1) GEP20125438B (es)
GT (1) GT200900189A (es)
HK (1) HK1140105A1 (es)
HN (1) HN2009001268A (es)
HR (1) HRP20110970T1 (es)
IL (1) IL199651A (es)
MA (1) MA31160B1 (es)
ME (1) ME00819B (es)
MX (1) MX2009007242A (es)
MY (1) MY154877A (es)
NI (1) NI200900131A (es)
NZ (1) NZ578293A (es)
PL (1) PL2144506T3 (es)
PT (1) PT2144506E (es)
RS (1) RS52108B (es)
SG (1) SG163545A1 (es)
SI (1) SI2144506T1 (es)
SV (1) SV2009003322A (es)
TN (1) TN2009000277A1 (es)
WO (1) WO2008085506A1 (es)
ZA (1) ZA200904826B (es)

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AU2007342364A1 (en) * 2007-01-03 2008-07-17 Cortex Pharmaceuticals, Inc. 3-substituted-[1,2,3]benzotriazinone compounds for enhancing glutamatergic synaptic responses
US8013003B2 (en) 2007-05-17 2011-09-06 Cortex Pharmaceuticals, Inc. Di-substituted amides for enhancing glutamatergic synaptic responses
SG163526A1 (en) 2007-08-10 2010-08-30 Cortex Pharma Inc Bicyclic amides for enhancing glutamatergic synaptic responses
US8119632B2 (en) 2007-08-10 2012-02-21 Cortex Pharmaceuticals, Inc. Bicyclic amide derivatives for enhancing glutamatergic synaptic responses
US20110257186A1 (en) * 2010-04-15 2011-10-20 Staubli Ursula V Compositions and methods for treating visual disorders
EP2784065B1 (en) 2011-11-22 2016-10-05 Beijing Medisan Technology Co. Ltd. Glycine reuptake inhibitor and use thereof
FR3019464B1 (fr) * 2014-04-07 2016-05-06 Servier Lab Nouvelle association entre le 8-cyclopropyl-3-[2-(3-fluorophenyl)ethyl]-7,8-dihydro-3h-[1,3]oxazino[6,5-g] [1,2,3]benzotriazine-4,9-dione et un inhibiteur de l'acetylcholinesterase et les compositions pharmaceutiques qui la contiennent
FR3034019B1 (fr) * 2015-03-26 2017-03-17 Servier Lab Nouvelle association entre le 8-cyclopropyl-3-[2-(3-fluorophenyl)ethyl]-7,8-dihydro-3h-[1,3]oxazino[6,5-g] [1,2,3]benzotriazine-4,9-dione et un antidepresseur et les compositions pharmaceutiques qui la contiennent
AU2016284654B9 (en) 2015-06-26 2020-05-21 Takeda Pharmaceutical Company Limited 2,3-dihydro-4h-1,3-benzoxazin-4-one derivatives as modulators of cholinergic muscarinic M1 receptor
CN106226509B (zh) * 2016-08-12 2019-09-06 中国人民解放军第四军医大学 一种在小鼠前扣带回皮层诱发dse现象的方法

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ATE215079T1 (de) 1992-07-24 2002-04-15 Univ California Arzneimittel, die den durch ampa rezeptoren vermittelten synaptischen respons erhöhen
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US6303542B1 (en) * 2000-08-18 2001-10-16 Rohm And Haas Company Herbicidal 3-substituted-phenyl-1,2,3-benzotriazin-4-ones
EA011034B1 (ru) * 2001-11-26 2008-12-30 Кортекс Фармасеутикалс, Инк. Соединения карбонилбензоксазина для усиления глутаматергических синаптических ответов
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AU2007342364A1 (en) 2007-01-03 2008-07-17 Cortex Pharmaceuticals, Inc. 3-substituted-[1,2,3]benzotriazinone compounds for enhancing glutamatergic synaptic responses
US8013003B2 (en) 2007-05-17 2011-09-06 Cortex Pharmaceuticals, Inc. Di-substituted amides for enhancing glutamatergic synaptic responses
SG163526A1 (en) 2007-08-10 2010-08-30 Cortex Pharma Inc Bicyclic amides for enhancing glutamatergic synaptic responses
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Also Published As

Publication number Publication date
HRP20110970T1 (hr) 2012-01-31
NZ578293A (en) 2012-01-12
NI200900131A (es) 2010-03-11
MY154877A (en) 2015-08-14
AU2007342365B2 (en) 2012-11-15
CU23804B7 (es) 2012-03-15
MA31160B1 (fr) 2010-02-01
GT200900189A (es) 2011-08-02
ES2374995T3 (es) 2012-02-23
IL199651A (en) 2015-08-31
EP2144506A1 (en) 2010-01-20
EP2144506A4 (en) 2010-05-05
TN2009000277A1 (en) 2010-10-18
PL2144506T3 (pl) 2012-04-30
IL199651A0 (en) 2010-04-15
RS52108B (en) 2012-08-31
US20100137295A1 (en) 2010-06-03
JP2010514838A (ja) 2010-05-06
CA2674460C (en) 2014-07-15
HN2009001268A (es) 2011-12-27
CR10906A (es) 2009-10-23
ZA200904826B (en) 2010-09-29
HK1140105A1 (en) 2010-10-08
US8173644B2 (en) 2012-05-08
DK2144506T3 (da) 2012-03-05
AP2502A (en) 2012-10-23
CN101616592A (zh) 2009-12-30
CN101616592B (zh) 2013-06-05
CA2674460A1 (en) 2008-07-17
BRPI0720749A2 (pt) 2014-01-14
ECSP099499A (es) 2009-10-30
ME00819B (me) 2012-03-20
EA017437B1 (ru) 2012-12-28
GEP20125438B (en) 2012-03-26
SV2009003322A (es) 2010-02-05
AU2007342365A1 (en) 2008-07-17
ATE527269T1 (de) 2011-10-15
AR064740A1 (es) 2009-04-22
SI2144506T1 (sl) 2012-01-31
WO2008085506A1 (en) 2008-07-17
EP2144506B1 (en) 2011-10-05
CY1112493T1 (el) 2015-12-09
CU20090117A7 (es) 2011-10-05
AP2009004931A0 (en) 2009-08-31
SG163545A1 (en) 2010-08-30
EA200900925A1 (ru) 2009-12-30
PT2144506E (pt) 2011-12-21
JP5139446B2 (ja) 2013-02-06

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