ATE527269T1 - 3-substituierte ä1,2,3ü-benzotriazinonverbindung zur förderung der glutamatergen synapsenreaktionen - Google Patents

3-substituierte ä1,2,3ü-benzotriazinonverbindung zur förderung der glutamatergen synapsenreaktionen

Info

Publication number
ATE527269T1
ATE527269T1 AT07868093T AT07868093T ATE527269T1 AT E527269 T1 ATE527269 T1 AT E527269T1 AT 07868093 T AT07868093 T AT 07868093T AT 07868093 T AT07868093 T AT 07868093T AT E527269 T1 ATE527269 T1 AT E527269T1
Authority
AT
Austria
Prior art keywords
promoting
reactions
substituted
glutamatergic synapse
benzotriazinone
Prior art date
Application number
AT07868093T
Other languages
English (en)
Inventor
Alexis Cordi
Gary Rogers
Rudolf Mueller
Original Assignee
Cortex Pharma Inc
Servier Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cortex Pharma Inc, Servier Lab filed Critical Cortex Pharma Inc
Application granted granted Critical
Publication of ATE527269T1 publication Critical patent/ATE527269T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
AT07868093T 2007-01-03 2007-12-28 3-substituierte ä1,2,3ü-benzotriazinonverbindung zur förderung der glutamatergen synapsenreaktionen ATE527269T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US87850307P 2007-01-03 2007-01-03
US92143307P 2007-04-02 2007-04-02
PCT/US2007/026416 WO2008085506A1 (en) 2007-01-03 2007-12-28 3-substituted-[1,2,3]-benzotriazinone compound for enhancing glutamatergic synaptic responses

Publications (1)

Publication Number Publication Date
ATE527269T1 true ATE527269T1 (de) 2011-10-15

Family

ID=39608956

Family Applications (1)

Application Number Title Priority Date Filing Date
AT07868093T ATE527269T1 (de) 2007-01-03 2007-12-28 3-substituierte ä1,2,3ü-benzotriazinonverbindung zur förderung der glutamatergen synapsenreaktionen

Country Status (38)

Country Link
US (1) US8173644B2 (de)
EP (1) EP2144506B1 (de)
JP (1) JP5139446B2 (de)
CN (1) CN101616592B (de)
AP (1) AP2502A (de)
AR (1) AR064740A1 (de)
AT (1) ATE527269T1 (de)
AU (1) AU2007342365B2 (de)
BR (1) BRPI0720749A2 (de)
CA (1) CA2674460C (de)
CR (1) CR10906A (de)
CU (1) CU23804B7 (de)
CY (1) CY1112493T1 (de)
DK (1) DK2144506T3 (de)
EA (1) EA017437B1 (de)
EC (1) ECSP099499A (de)
ES (1) ES2374995T3 (de)
GE (1) GEP20125438B (de)
GT (1) GT200900189A (de)
HK (1) HK1140105A1 (de)
HN (1) HN2009001268A (de)
HR (1) HRP20110970T1 (de)
IL (1) IL199651A (de)
MA (1) MA31160B1 (de)
ME (1) ME00819B (de)
MX (1) MX2009007242A (de)
MY (1) MY154877A (de)
NI (1) NI200900131A (de)
NZ (1) NZ578293A (de)
PL (1) PL2144506T3 (de)
PT (1) PT2144506E (de)
RS (1) RS52108B (de)
SG (1) SG163545A1 (de)
SI (1) SI2144506T1 (de)
SV (1) SV2009003322A (de)
TN (1) TN2009000277A1 (de)
WO (1) WO2008085506A1 (de)
ZA (1) ZA200904826B (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2007342364A1 (en) * 2007-01-03 2008-07-17 Cortex Pharmaceuticals, Inc. 3-substituted-[1,2,3]benzotriazinone compounds for enhancing glutamatergic synaptic responses
US8013003B2 (en) 2007-05-17 2011-09-06 Cortex Pharmaceuticals, Inc. Di-substituted amides for enhancing glutamatergic synaptic responses
SG163526A1 (en) 2007-08-10 2010-08-30 Cortex Pharma Inc Bicyclic amides for enhancing glutamatergic synaptic responses
US8119632B2 (en) 2007-08-10 2012-02-21 Cortex Pharmaceuticals, Inc. Bicyclic amide derivatives for enhancing glutamatergic synaptic responses
US20110257186A1 (en) * 2010-04-15 2011-10-20 Staubli Ursula V Compositions and methods for treating visual disorders
EP2784065B1 (de) 2011-11-22 2016-10-05 Beijing Medisan Technology Co. Ltd. Glycinwiederaufnahmehemmer und verwendung davon
FR3019464B1 (fr) * 2014-04-07 2016-05-06 Servier Lab Nouvelle association entre le 8-cyclopropyl-3-[2-(3-fluorophenyl)ethyl]-7,8-dihydro-3h-[1,3]oxazino[6,5-g] [1,2,3]benzotriazine-4,9-dione et un inhibiteur de l'acetylcholinesterase et les compositions pharmaceutiques qui la contiennent
FR3034019B1 (fr) * 2015-03-26 2017-03-17 Servier Lab Nouvelle association entre le 8-cyclopropyl-3-[2-(3-fluorophenyl)ethyl]-7,8-dihydro-3h-[1,3]oxazino[6,5-g] [1,2,3]benzotriazine-4,9-dione et un antidepresseur et les compositions pharmaceutiques qui la contiennent
AU2016284654B9 (en) 2015-06-26 2020-05-21 Takeda Pharmaceutical Company Limited 2,3-dihydro-4h-1,3-benzoxazin-4-one derivatives as modulators of cholinergic muscarinic M1 receptor
CN106226509B (zh) * 2016-08-12 2019-09-06 中国人民解放军第四军医大学 一种在小鼠前扣带回皮层诱发dse现象的方法

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DK623586A (da) * 1985-12-27 1987-06-28 Eisai Co Ltd Piperidinderivater eller salte deraf og farmaceutiske kompositioner indeholdende forbindelserne
FR2597103B1 (fr) 1986-04-15 1988-12-16 Provesan Sa Procede de preparation de derives d'oxazinobenzothiazine 6,6-dioxyde
ATE215079T1 (de) 1992-07-24 2002-04-15 Univ California Arzneimittel, die den durch ampa rezeptoren vermittelten synaptischen respons erhöhen
US5962477A (en) * 1994-04-12 1999-10-05 Adolor Corporation Screening methods for cytokine inhibitors
DE59504622D1 (de) * 1994-10-31 1999-02-04 Merck Patent Gmbh Benzylpiperidinderivate mit hoher Affinität zu Bindungsstellen von Aminosäure-Rezeptoren
US5650409A (en) 1995-06-02 1997-07-22 Cortex Pharmaceuticals, Inc. Benzoyl piperidines/pyrrolidines for enhancing synaptic response
US5736543A (en) 1996-04-03 1998-04-07 The Regents Of The University Of California Benzoxazines for enhancing synaptic response
US6030968A (en) 1996-09-17 2000-02-29 The Regents Of The University Of California Positive AMPA receptor modulation to enhance brain neurotrophic factor expression
US6110935A (en) * 1997-02-13 2000-08-29 The Regents Of The University Of California Benzofurazan compounds for enhancing glutamatergic synaptic responses
US5985871A (en) * 1997-12-24 1999-11-16 Cortex Pharmaceuticals, Inc. Benzoxazine compounds for enhancing synaptic response
HUP0101280A3 (en) 1998-02-18 2003-02-28 Neurosearch As Positive ampa receptor modulator compounds and their use
US6713474B2 (en) 1998-09-18 2004-03-30 Abbott Gmbh & Co. Kg Pyrrolopyrimidines as therapeutic agents
US6303542B1 (en) * 2000-08-18 2001-10-16 Rohm And Haas Company Herbicidal 3-substituted-phenyl-1,2,3-benzotriazin-4-ones
EA011034B1 (ru) * 2001-11-26 2008-12-30 Кортекс Фармасеутикалс, Инк. Соединения карбонилбензоксазина для усиления глутаматергических синаптических ответов
JP2003238555A (ja) * 2002-02-20 2003-08-27 Sumitomo Pharmaceut Co Ltd 細胞死抑制剤
AUPS255202A0 (en) * 2002-05-27 2002-06-13 Monash University Agents and methods for the treatment of disorders associated with motor neuron degeneration
KR20050094840A (ko) * 2003-01-13 2005-09-28 코텍스 파마슈티칼스, 인크. 수면 부족 및 스트레스로 인한 인식 저하의 치료방법
GB0317482D0 (en) 2003-07-25 2003-08-27 Pfizer Ltd Nicotinamide derivatives useful as pde4 inhibitors
CN1897950A (zh) 2003-10-14 2007-01-17 惠氏公司 稠合芳基和杂芳基衍生物及其使用方法
AU2007342364A1 (en) 2007-01-03 2008-07-17 Cortex Pharmaceuticals, Inc. 3-substituted-[1,2,3]benzotriazinone compounds for enhancing glutamatergic synaptic responses
US8013003B2 (en) 2007-05-17 2011-09-06 Cortex Pharmaceuticals, Inc. Di-substituted amides for enhancing glutamatergic synaptic responses
SG163526A1 (en) 2007-08-10 2010-08-30 Cortex Pharma Inc Bicyclic amides for enhancing glutamatergic synaptic responses
WO2009038752A2 (en) * 2007-09-20 2009-03-26 Cortex Pharmaceuticals, Inc. 3-substituted 1,2,3-triazin-4-one's and 3-substituted 1,3-pyrimidinone's for enhancing glutamatergic synaptic responses

Also Published As

Publication number Publication date
HRP20110970T1 (hr) 2012-01-31
NZ578293A (en) 2012-01-12
NI200900131A (es) 2010-03-11
MY154877A (en) 2015-08-14
AU2007342365B2 (en) 2012-11-15
CU23804B7 (es) 2012-03-15
MA31160B1 (fr) 2010-02-01
MX2009007242A (es) 2009-09-02
GT200900189A (es) 2011-08-02
ES2374995T3 (es) 2012-02-23
IL199651A (en) 2015-08-31
EP2144506A1 (de) 2010-01-20
EP2144506A4 (de) 2010-05-05
TN2009000277A1 (en) 2010-10-18
PL2144506T3 (pl) 2012-04-30
IL199651A0 (en) 2010-04-15
RS52108B (en) 2012-08-31
US20100137295A1 (en) 2010-06-03
JP2010514838A (ja) 2010-05-06
CA2674460C (en) 2014-07-15
HN2009001268A (es) 2011-12-27
CR10906A (es) 2009-10-23
ZA200904826B (en) 2010-09-29
HK1140105A1 (en) 2010-10-08
US8173644B2 (en) 2012-05-08
DK2144506T3 (da) 2012-03-05
AP2502A (en) 2012-10-23
CN101616592A (zh) 2009-12-30
CN101616592B (zh) 2013-06-05
CA2674460A1 (en) 2008-07-17
BRPI0720749A2 (pt) 2014-01-14
ECSP099499A (es) 2009-10-30
ME00819B (me) 2012-03-20
EA017437B1 (ru) 2012-12-28
GEP20125438B (en) 2012-03-26
SV2009003322A (es) 2010-02-05
AU2007342365A1 (en) 2008-07-17
AR064740A1 (es) 2009-04-22
SI2144506T1 (sl) 2012-01-31
WO2008085506A1 (en) 2008-07-17
EP2144506B1 (de) 2011-10-05
CY1112493T1 (el) 2015-12-09
CU20090117A7 (es) 2011-10-05
AP2009004931A0 (en) 2009-08-31
SG163545A1 (en) 2010-08-30
EA200900925A1 (ru) 2009-12-30
PT2144506E (pt) 2011-12-21
JP5139446B2 (ja) 2013-02-06

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