DK2104682T3 - Diagnose og behandling af alzheimer’s og andre demenssygdomme - Google Patents

Diagnose og behandling af alzheimer’s og andre demenssygdomme Download PDF

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Publication number
DK2104682T3
DK2104682T3 DK08719192.0T DK08719192T DK2104682T3 DK 2104682 T3 DK2104682 T3 DK 2104682T3 DK 08719192 T DK08719192 T DK 08719192T DK 2104682 T3 DK2104682 T3 DK 2104682T3
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seq
amino acid
antibody
sequence
antibodies
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DK08719192.0T
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English (en)
Inventor
Richard Dodel
Michael Bacher
Michael Przybylski
Marilena Manea
Raluca Stefanescu
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Michael Bacher
Dodel Richhard
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Priority claimed from EP07000521A external-priority patent/EP1944315A1/en
Priority claimed from EP07000507A external-priority patent/EP1944314A1/en
Application filed by Michael Bacher, Dodel Richhard filed Critical Michael Bacher
Application granted granted Critical
Publication of DK2104682T3 publication Critical patent/DK2104682T3/da

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Claims (6)

  1. DIAGNOSE OG BEHANDLING AF ALZHEIMER'S OG ANDRE DEMENSSYGDOMME Patentkrav
    1. Isoleret, monoklonalt, humant, anti^-amyloid antistof eller et fragment deraf omfattende et fuldt sæt af seks CDRs, tre CDRs fra den variable tung-kæde region (VH) med aminosyresekvenser med SEQ ID NOs: 15, 23 og 29, og tre CDRs fra den variable let-kæde region (VL) med aminosyresekvenser med SEQ ID NOs: 33, 41 og 45; eller den variable let-kæde region (VL) aminosyresekvens og den variable tungkæde region (VH) aminosyresekevens med henholdsvis SEQ ID NO: 53 og SEQ ID NO: 60, SEQ ID NO: 145 og SEQ ID NO: 60, SEQ ID NO: 51 og SEQ ID NO: 60, SEQ ID NO: 52 og SEQ ID NO: 60, SEQ ID NO: 146 og SEQ ID NO: 60, SEQ ID NO: 53 og SEQ ID NO: 148, SEQ ID NO: 55 og SEQ ID NO: 61, SEQ ID NO: 54 og SEQ ID NO: 61, eller SEQ ID NO: 146 og SEQ ID NO: 61.
  2. 2. Antistoffet eller fragmentet deraf ifølge krav 1, hvor antistoffet binder til dimere former af Αβ med højere affinitet end til monomere former af Αβ.
  3. 3. Antistoffet eller fragmentet deraf ifølge krav 1, hvor antistoffet binder til et peptid omfattende Αβ(21-37) og, hvor antistoffet skærmer aminosyrerester af Αβ(21-37) fra proteolytisk nedbrydning når det er bundet til et Αβ polypeptid omfattende A6(21-37).
  4. 4. Antistoffet eller fragmentet deraf ifølge krav 1, hvor antistoffet binder specifikt til Αβ delvise polypeptider Αβ(12-40) eller Αβ(20-37) når antistoffet er koblet til NHS-aktiveret 6-aminohexansyre-koblet sepharose, men ikke binder specifikt til Αβ(17-28), Αβ(25-35) eller Αβ(31-40) og hvor antistoffet skærmer positioner af Αβ(21-37) fra proteolytisk nedbrydning når det er bundet til et Αβ polypeptid omfattende Αβ(21-37).
  5. 5. Farmaceutisk sammensætning omfattende antistoffet eller fragment deraf ifølge krav 1.
  6. 6. Anvendelse af et antistof eller fragment deraf ifølge et hvilket som helst af kravene 1 til 4 til fremstilling af et medikament for at behandle en demenssygdom eller for at forsinke eller forebygge progression af en demenssygdom, hvor demenssygdommen er valgt fra gruppen bestående af Alzheimers sygdom, Downs syndrom, Lewy body-demens, fronto-temporal demens, cerebral amyloid angiopati og amyloidose.
DK08719192.0T 2007-01-11 2008-01-11 Diagnose og behandling af alzheimer’s og andre demenssygdomme DK2104682T3 (da)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US88452607P 2007-01-11 2007-01-11
US88451307P 2007-01-11 2007-01-11
EP07000521A EP1944315A1 (en) 2007-01-11 2007-01-11 Prophylaxis and therapy of alzheimer's disease and other neurodementing diseases
EP07000507A EP1944314A1 (en) 2007-01-11 2007-01-11 Diagnosis of Alzheimer's disease and other neurodementing disorders
US98167507P 2007-10-22 2007-10-22
US98166707P 2007-10-22 2007-10-22
EP07119002 2007-10-22
EP07119026 2007-10-22
PCT/IB2008/000456 WO2008084402A2 (en) 2007-01-11 2008-01-11 Diagnosis and treatment of alzheimer's and other neurodementing diseases

Publications (1)

Publication Number Publication Date
DK2104682T3 true DK2104682T3 (da) 2017-01-16

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Application Number Title Priority Date Filing Date
DK08719192.0T DK2104682T3 (da) 2007-01-11 2008-01-11 Diagnose og behandling af alzheimer’s og andre demenssygdomme

Country Status (11)

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US (3) US7939075B2 (da)
EP (1) EP2104682B1 (da)
JP (1) JP2010515717A (da)
AU (1) AU2008204335B2 (da)
CA (1) CA2675340C (da)
DK (1) DK2104682T3 (da)
ES (1) ES2610474T3 (da)
PL (1) PL2104682T3 (da)
SI (1) SI2104682T1 (da)
TW (1) TW200844110A (da)
WO (1) WO2008084402A2 (da)

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CA2675340C (en) 2018-07-31
CA2675340A1 (en) 2008-07-17
US8491903B2 (en) 2013-07-23
WO2008084402A8 (en) 2009-08-27
EP2104682B1 (en) 2016-09-21
US20120039897A1 (en) 2012-02-16
US20120040382A1 (en) 2012-02-16
AU2008204335B2 (en) 2013-06-13
US7939075B2 (en) 2011-05-10
PL2104682T3 (pl) 2017-03-31
EP2104682A2 (en) 2009-09-30
JP2010515717A (ja) 2010-05-13
SI2104682T1 (sl) 2017-05-31
WO2008084402A2 (en) 2008-07-17
US20090028869A1 (en) 2009-01-29
WO2008084402A3 (en) 2009-04-09
ES2610474T3 (es) 2017-04-27
AU2008204335A1 (en) 2008-07-17
TW200844110A (en) 2008-11-16

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