DK2055313T3 - Behandling af hæmatologiske maligniteter, der er relateret til cirkulerende tumorceller, ved anvendelse af kimærisk anti-CD20-antistof - Google Patents

Behandling af hæmatologiske maligniteter, der er relateret til cirkulerende tumorceller, ved anvendelse af kimærisk anti-CD20-antistof Download PDF

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DK2055313T3
DK2055313T3 DK09002504.0T DK09002504T DK2055313T3 DK 2055313 T3 DK2055313 T3 DK 2055313T3 DK 09002504 T DK09002504 T DK 09002504T DK 2055313 T3 DK2055313 T3 DK 2055313T3
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antibody
treatment
use according
patients
cll
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DK09002504.0T
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Antonio J Grillo-Lopez
Christine A White
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Biogen Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2887—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
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    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
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    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K38/00—Medicinal preparations containing peptides
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    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/191—Tumor necrosis factors [TNF], e.g. lymphotoxin [LT], i.e. TNF-beta
    • A—HUMAN NECESSITIES
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    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/193—Colony stimulating factors [CSF]
    • A—HUMAN NECESSITIES
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    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A61K38/2026—IL-4
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]
    • A61K38/212—IFN-alpha
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C—CHEMISTRY; METALLURGY
    • C23—COATING METALLIC MATERIAL; COATING MATERIAL WITH METALLIC MATERIAL; CHEMICAL SURFACE TREATMENT; DIFFUSION TREATMENT OF METALLIC MATERIAL; COATING BY VACUUM EVAPORATION, BY SPUTTERING, BY ION IMPLANTATION OR BY CHEMICAL VAPOUR DEPOSITION, IN GENERAL; INHIBITING CORROSION OF METALLIC MATERIAL OR INCRUSTATION IN GENERAL
    • C23C—COATING METALLIC MATERIAL; COATING MATERIAL WITH METALLIC MATERIAL; SURFACE TREATMENT OF METALLIC MATERIAL BY DIFFUSION INTO THE SURFACE, BY CHEMICAL CONVERSION OR SUBSTITUTION; COATING BY VACUUM EVAPORATION, BY SPUTTERING, BY ION IMPLANTATION OR BY CHEMICAL VAPOUR DEPOSITION, IN GENERAL
    • C23C2/00—Hot-dipping or immersion processes for applying the coating material in the molten state without affecting the shape; Apparatus therefor
    • C23C2/04—Hot-dipping or immersion processes for applying the coating material in the molten state without affecting the shape; Apparatus therefor characterised by the coating material
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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
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Claims (16)

1. Anvendelse af et anti-CD20-antistof, omfattende humane konstante gamma 1-regioner, ved fremstilling af et lægemiddel til behandling af kronisk lym-fatisk leukæmi (CLL) hos en human patient, hvor lægemidlet er til administration til den humane patient i en dosis på 500 til 1500 mg/m2.
2. Anvendelse ifølge krav 1, hvor lægemidlet er til anvendelse i kombination med kemoterapi.
3. Anvendelse ifølge krav 1 eller 2, hvor anti-CD20-antistoffet er et kimærisk antistof.
4. Anvendelse ifølge krav 1 eller 2, hvor anti-CD20-antistoffet er et humaniseret antistof.
5. Anvendelse ifølge krav 1 eller 2, hvor anti-CD20-antistoffet er et humant antistof.
6. Anvendelse ifølge krav 1 eller 2, hvor anti-CD20-antistoffet omfatter et CD20-bindende antistoffragment.
7. Anvendelse ifølge krav 3, hvor anti-CD20-antistoffet er rituximab.
8. Anvendelse ifølge et af kravene 1-7, hvor patienten er refraktær overfor en behandling, der tidligere er administreret mod kronisk lymfatisk leukæmi.
9. Anti-CD20-antistof, omfattende humane konstante gamma 1-regioner til anvendelse i en fremgangsmåde til behandling af kronisk lymfatisk leukæmi (CLL) hos en human patient, hvilken fremgangsmåde omfatter at administrere antistoffet til den humane patient i en dosis på 500 til 1500 mg/m2.
10. Antistof til anvendelse ifølge krav 9, hvor fremgangsmåden omfatter at administrere antistoffet i kombination med kemoterapi.
11. Antistof til anvendelse ifølge krav 9 eller 10, hvor anti-CD20-antistoffet er et kimærisk antistof.
12. Antistof til anvendelse ifølge krav 9 eller 10, hvor anti-CD20-antistoffet er et humaniseret antistof.
13. Antistof til anvendelse ifølge krav 9 eller 10, hvor anti-CD20-antistoffet er et humant antistof.
14. Antistof til anvendelse ifølge krav 9 eller 10, hvor anti-CD20-antistoffet omfatter et CD20-bindende antistoffragment.
15. Antistof til anvendelse ifølge krav 11, hvor anti-CD20-antistoffet er rituxi-mab.
16. Antistof til anvendelse ifølge et af kravene 10 til 15, hvor patienten er re-fraktær overfor en behandling, der tidligere er administreret mod kronisk lym-fatisk leukæmi.
DK09002504.0T 1998-11-09 1999-11-09 Behandling af hæmatologiske maligniteter, der er relateret til cirkulerende tumorceller, ved anvendelse af kimærisk anti-CD20-antistof DK2055313T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10765898P 1998-11-09 1998-11-09
EP05022104A EP1616572B1 (en) 1998-11-09 1999-11-09 Chimeric anti-CD20 antibody, rituxan, for use in the treatment of chronic lymphocytic leukemia

Publications (1)

Publication Number Publication Date
DK2055313T3 true DK2055313T3 (da) 2015-07-27

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ID=22317751

Family Applications (2)

Application Number Title Priority Date Filing Date
DK09002504.0T DK2055313T3 (da) 1998-11-09 1999-11-09 Behandling af hæmatologiske maligniteter, der er relateret til cirkulerende tumorceller, ved anvendelse af kimærisk anti-CD20-antistof
DK05022104.3T DK1616572T3 (da) 1998-11-09 1999-11-09 Kimært anti-CD20-antistof, rituxan, til anvendelse i behandling af kronisk lymfatisk leukæmi

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK05022104.3T DK1616572T3 (da) 1998-11-09 1999-11-09 Kimært anti-CD20-antistof, rituxan, til anvendelse i behandling af kronisk lymfatisk leukæmi

Country Status (19)

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US (2) US7682612B1 (da)
EP (7) EP2055313B1 (da)
JP (2) JP4842435B2 (da)
KR (2) KR101092132B1 (da)
CN (2) CN1191850C (da)
AT (1) ATE479443T1 (da)
AU (1) AU761844C (da)
BR (1) BR9915164A (da)
CA (1) CA2350058C (da)
CY (2) CY1111173T1 (da)
DE (1) DE69942727D1 (da)
DK (2) DK2055313T3 (da)
ES (2) ES2351149T3 (da)
HK (1) HK1047043A1 (da)
MX (1) MXPA01004648A (da)
PT (2) PT1616572E (da)
TR (1) TR200101299T2 (da)
WO (1) WO2000027428A1 (da)
ZA (1) ZA200103720B (da)

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