DK2035385T3 - Inhibitorer af akt (proteinkinase B) - Google Patents

Inhibitorer af akt (proteinkinase B)

Info

Publication number
DK2035385T3
DK2035385T3 DK07798410.2T DK07798410T DK2035385T3 DK 2035385 T3 DK2035385 T3 DK 2035385T3 DK 07798410 T DK07798410 T DK 07798410T DK 2035385 T3 DK2035385 T3 DK 2035385T3
Authority
DK
Denmark
Prior art keywords
protein kinase
act inhibitors
inhibitors
act
kinase
Prior art date
Application number
DK07798410.2T
Other languages
English (en)
Inventor
Sajan Joseph
Renhua Li
Michael Ray Myers
Aktham Aburub
Jenny Pingqi Dai
Christopher Randall Schmid
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Application granted granted Critical
Publication of DK2035385T3 publication Critical patent/DK2035385T3/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D217/00Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/045Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05Phenols
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • A61K31/472Non-condensed isoquinolines, e.g. papaverine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/18Antivirals for RNA viruses for HIV
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DK07798410.2T 2006-06-20 2007-06-12 Inhibitorer af akt (proteinkinase B) DK2035385T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US80526006P 2006-06-20 2006-06-20
US88576507P 2007-01-19 2007-01-19
PCT/US2007/070945 WO2007149730A2 (en) 2006-06-20 2007-06-12 Inhibitors of akt (protein kinase b)

Publications (1)

Publication Number Publication Date
DK2035385T3 true DK2035385T3 (da) 2010-03-22

Family

ID=38834248

Family Applications (1)

Application Number Title Priority Date Filing Date
DK07798410.2T DK2035385T3 (da) 2006-06-20 2007-06-12 Inhibitorer af akt (proteinkinase B)

Country Status (28)

Country Link
US (1) US7998977B2 (da)
EP (1) EP2035385B1 (da)
JP (1) JP2009541335A (da)
KR (1) KR101067551B1 (da)
AR (1) AR061240A1 (da)
AT (1) ATE455102T1 (da)
AU (1) AU2007261120A1 (da)
BR (1) BRPI0713136A2 (da)
CA (1) CA2652612A1 (da)
CL (1) CL2007001752A1 (da)
DE (1) DE602007004333D1 (da)
DK (1) DK2035385T3 (da)
DO (1) DOP2008000053A (da)
EA (1) EA015712B1 (da)
EC (1) ECSP088992A (da)
ES (1) ES2336630T3 (da)
HR (1) HRP20100147T1 (da)
IL (1) IL195005A0 (da)
MA (1) MA30757B1 (da)
MX (1) MX2008015904A (da)
NO (1) NO20090289L (da)
PE (1) PE20080338A1 (da)
PL (1) PL2035385T3 (da)
PT (1) PT2035385E (da)
SI (1) SI2035385T1 (da)
TN (1) TNSN08529A1 (da)
TW (1) TW200812970A (da)
WO (1) WO2007149730A2 (da)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5856843B2 (ja) 2008-05-27 2016-02-10 アンピオ ファーマシューティカルズ,インコーポレイテッド ジケトピペラジンを用いた医薬組成物
EP2613786A4 (en) 2010-09-07 2013-10-23 Dmi Acquisition Corp TREATMENT OF DISEASES
WO2013055749A1 (en) 2011-10-10 2013-04-18 Ampio Pharmaceuticals, Inc. Implantable medical devices with increased immune tolerance, and methods for making and implanting
KR102032400B1 (ko) 2011-10-10 2019-10-15 앰피오 파마슈티컬스 인코퍼레이티드 퇴행성 관절 질환의 치료
SG10201605205VA (en) 2011-10-28 2016-08-30 Ampio Pharmaceuticals Inc Treatment of rhinitis
WO2014145729A2 (en) 2013-03-15 2014-09-18 Ampio Pharmaceuticals, Inc. Compositions for the mobilization, homing, expansion and differentiation of stem cells and methods of using the same
KR20160104612A (ko) 2013-07-26 2016-09-05 업데이트 파마 인코포레이트 비산트렌의 치료 효과 개선용 조성물
RU2020136589A (ru) 2014-08-18 2020-12-24 Ампио Фармасьютикалз, Инк. Лечение дегенеративных заболеваний суставов
US10123997B2 (en) * 2015-06-15 2018-11-13 Yong Liao Target for treating hepatitis B virus
US11389512B2 (en) 2015-06-22 2022-07-19 Ampio Pharmaceuticals, Inc. Use of low molecular weight fractions of human serum albumin in treating diseases
US10722484B2 (en) 2016-03-09 2020-07-28 K-Gen, Inc. Methods of cancer treatment
CN115843298B (zh) * 2020-07-22 2024-03-29 南京正大天晴制药有限公司 一种二氢吡啶并[2,3-d]嘧啶酮衍生物的盐及晶型

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL136458A0 (en) 2000-05-30 2001-06-14 Peptor Ltd Protein kinase inhibitors
JP2006521382A (ja) 2003-03-28 2006-09-21 イーライ リリー アンド カンパニー Akt(プロテインキナーゼb)阻害剤
GB0317315D0 (en) 2003-07-24 2003-08-27 Astex Technology Ltd Pharmaceutical compounds
WO2005054202A1 (en) * 2003-11-25 2005-06-16 Eli Lilly And Company 7-phenyl-isoquinoline-5-sulfonylamino derivatives as inhibitors of akt (proteinkinase b)

Also Published As

Publication number Publication date
BRPI0713136A2 (pt) 2012-04-17
WO2007149730A2 (en) 2007-12-27
EP2035385B1 (en) 2010-01-13
DOP2008000053A (es) 2009-01-15
CL2007001752A1 (es) 2008-01-18
KR101067551B1 (ko) 2011-09-27
DE602007004333D1 (de) 2010-03-04
US7998977B2 (en) 2011-08-16
US20090221633A1 (en) 2009-09-03
AU2007261120A1 (en) 2007-12-27
EP2035385A2 (en) 2009-03-18
ES2336630T3 (es) 2010-04-14
SI2035385T1 (sl) 2010-05-31
JP2009541335A (ja) 2009-11-26
EA015712B1 (ru) 2011-10-31
CA2652612A1 (en) 2007-12-27
PE20080338A1 (es) 2008-04-25
ATE455102T1 (de) 2010-01-15
TW200812970A (en) 2008-03-16
KR20090015978A (ko) 2009-02-12
PT2035385E (pt) 2010-03-01
NO20090289L (no) 2009-01-19
WO2007149730A3 (en) 2008-04-24
PL2035385T3 (pl) 2010-06-30
EA200970041A1 (ru) 2009-06-30
HRP20100147T1 (hr) 2010-04-30
MX2008015904A (es) 2009-01-12
IL195005A0 (en) 2009-08-03
AR061240A1 (es) 2008-08-13
MA30757B1 (fr) 2009-10-01
ECSP088992A (es) 2009-01-30
TNSN08529A1 (en) 2010-04-14

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