DK2003104T3 - Reagens til organisk syntese og fremgangsmåde til organisk syntesereaktion med reagenset - Google Patents

Reagens til organisk syntese og fremgangsmåde til organisk syntesereaktion med reagenset Download PDF

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Publication number
DK2003104T3
DK2003104T3 DK07714522.5T DK07714522T DK2003104T3 DK 2003104 T3 DK2003104 T3 DK 2003104T3 DK 07714522 T DK07714522 T DK 07714522T DK 2003104 T3 DK2003104 T3 DK 2003104T3
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Denmark
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reagent
organic synthesis
reaction
compound
solvent
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DK07714522.5T
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English (en)
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Kazuhiro Chiba
Shokaku Kim
Yusuke Kono
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Jitsubo Co Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/96—Esters of carbonic or haloformic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C217/56—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms
    • C07C217/58—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms with amino groups and the six-membered aromatic ring, or the condensed ring system containing that ring, bound to the same carbon atom of the carbon chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C265/00—Derivatives of isocyanic acid
    • C07C265/12—Derivatives of isocyanic acid having isocyanate groups bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C275/32—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms
    • C07C275/34—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms having nitrogen atoms of urea groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C281/00—Derivatives of carbonic acid containing functional groups covered by groups C07C269/00 - C07C279/00 in which at least one nitrogen atom of these functional groups is further bound to another nitrogen atom not being part of a nitro or nitroso group
    • C07C281/20—Derivatives of carbonic acid containing functional groups covered by groups C07C269/00 - C07C279/00 in which at least one nitrogen atom of these functional groups is further bound to another nitrogen atom not being part of a nitro or nitroso group the two nitrogen atoms of the functional groups being doubly-bound to each other, e.g. azoformamide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/08—Preparation of carboxylic acid esters by reacting carboxylic acids or symmetrical anhydrides with the hydroxy or O-metal group of organic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C07D233/60—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms with hydrocarbon radicals, substituted by oxygen or sulfur atoms, attached to ring nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/50—Organo-phosphines
    • C07F9/5022—Aromatic phosphines (P-C aromatic linkage)

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Peptides Or Proteins (AREA)

Claims (5)

1. Reagens til organisk syntese, som kan anvendes til organiske syntesereaktioner, vist i den følgende kemiske formel (1), og med den egenskab, at det kan ændre sig reversibelt fra en flydende fasetilstand til en fast fasetilstand i henhold til ændringer i mindst en udvalgt fra gruppen bestående af opløsningssammensætning og opløsningstemperatur:
- (1 ) hvor R2 og R* er en docosyloxygruppe (C22H45O-), R1; R3 og R5 er hydrogen og X repræsenterer et aktivt reagenssted vist ved de følgende formler (A), (B), (E), (F), (G), (K), (L), (M) eller (M1):
(A) , (B)
(G),
· · * * (fvf ?,
· · · (M’l hvor Y er en alkylengruppe med et carbonantal på 1 til 10, m og n uafhængigt er 0 eller 1, Za er et chlorinatom eller et brominatom, og Zb er en hy-droxylgruppe, et chlorinatom eller et brominatom.
2. Reagens til organisk syntese ifølge krav 1 udvalgt fra gruppen bestående af de følgende kemiske formler (3), (4), (5), (6), (7), (8) og (9):
(3)
(4)
(5)
(6)
(7)
(S)
(9).
3. Reagens til organisk syntese, som kan anvendes til organiske syntesereaktioner, vist i den følgende Kemisk Formel 2 eller Kemisk Formel 10, og med den egenskab, at det kan ændre sig reversibelt fra en flydende fasetilstand til en fast fasetilstand i henhold til ændringer i mindst en udvalgt fra gruppen bestående af opløsningssammensætning og opløsningstemperatur.
• · · (2)
(10)
4. Fremgangsmåde til organisk syntesereaktion under anvendelse af reagenset til organisk syntese ifølge et af kravene 1 til 3, omfattende et reaktionstrin, hvor der udføres en reaktion, hvor reagenset til organisk syntese opløses i et reaktionssystem, hvor det aktive reagenssted X med Kemisk Formel (1), hydroxymethylgruppen med Kemisk Formel (2) eller det aktive reagenssted med Kemisk Formel (3) til (10) deltager i reaktionen, og efter dette, et separationstrin, hvor reagenset til organisk syntese og et reageret reagens til organisk syntese separeres.
5. Anvendelse af reagenset til organisk syntese ifølge et af kravene 1 til 3 til en organisk syntesereaktion.
DK07714522.5T 2006-03-24 2007-02-19 Reagens til organisk syntese og fremgangsmåde til organisk syntesereaktion med reagenset DK2003104T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2006084019 2006-03-24
PCT/JP2007/052996 WO2007122847A1 (ja) 2006-03-24 2007-02-19 有機合成用試薬、及び当該試薬を用いた有機合成反応方法

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US (2) US8093435B2 (da)
EP (1) EP2003104B1 (da)
JP (2) JPWO2007122847A1 (da)
CN (1) CN101405240B (da)
AU (1) AU2007242276A1 (da)
DK (1) DK2003104T3 (da)
ES (1) ES2546808T3 (da)
WO (1) WO2007122847A1 (da)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2003104B1 (en) * 2006-03-24 2015-07-01 Jitsubo Co., Ltd. Reagent for organic synthesis and method of organic synthesis reaction with the reagent
WO2010104169A1 (ja) 2009-03-12 2010-09-16 味の素株式会社 フルオレン化合物
EP2415745A4 (en) 2009-03-30 2014-06-11 Ajinomoto Kk DIPHENYLMETHANE COMPOUND
WO2011078295A1 (ja) 2009-12-25 2011-06-30 味の素株式会社 ベンジル化合物
CN107011132B (zh) * 2010-08-30 2020-11-10 味之素株式会社 含有支链的芳香族化合物
JP6150726B2 (ja) 2011-03-09 2017-06-21 Jitsubo株式会社 新規な非ペプチド性架橋構造を含む架橋ペプチド、ならびに該架橋ペプチドの合成方法および該方法に用いる新規な有機化合物
CN103476784B (zh) 2011-05-17 2017-05-24 味之素株式会社 制备寡核苷酸的方法
WO2012165546A1 (ja) * 2011-05-31 2012-12-06 味の素株式会社 ペプチドの製造方法
JP6011528B2 (ja) 2011-05-31 2016-10-19 味の素株式会社 ペプチドの製造方法
CN102584546A (zh) * 2011-09-26 2012-07-18 盘锦兴福化工有限公司 2,3—二氟苯乙醚的合成方法
US9057712B1 (en) 2011-10-27 2015-06-16 Copilot Ventures Fund Iii Llc Methods of delivery of encapsulated perfluorocarbon taggants
EP2921499B1 (en) 2012-11-14 2020-01-22 Takeda Pharmaceutical Company Limited Method for liquid-phase synthesis of nucleic acids
EP2964608B1 (en) 2013-03-08 2019-08-28 Novartis AG Lipids and lipid compositions for the delivery of active agents
US9504747B2 (en) 2013-03-08 2016-11-29 Novartis Ag Lipids and lipid compositions for the delivery of active agents
EP3015467A4 (en) 2013-05-24 2016-11-02 Ajinomoto Kk PROCESS FOR THE PRODUCTION OF MORPHOLINO-OLIGONUCLEOTIDE
US9365615B2 (en) 2013-09-09 2016-06-14 Jitsubo Co., Ltd. Cross-linked peptides containing non-peptide cross-linked structure, method for synthesizing cross-linked peptides, and novel organic compound used in method
EP3263579B1 (en) 2015-01-21 2022-11-30 Ajinomoto Co., Inc. Precipitation promoter and precipitation method in which same is used
ES2864924T3 (es) * 2015-03-04 2021-10-14 Jitsubo Co Ltd Método de síntesis peptídica
KR101889893B1 (ko) * 2015-06-12 2018-08-22 애니젠 주식회사 선별적 용해도를 갖는 트리페닐메탄 유도체 및 그의 용도
EP3539968B1 (en) 2016-11-11 2021-07-14 Sekisui Medical Co., Ltd. Novel trityl protecting agent
EP3480195A1 (en) 2017-11-07 2019-05-08 Bayer Animal Health GmbH Method for the synthesis of cyclic depsipeptides
CA3081673A1 (en) 2017-11-07 2019-05-16 Bayer Animal Health Gmbh Method for the synthesis of cyclic depsipeptides
WO2019198833A1 (ja) 2018-04-13 2019-10-17 Jitsubo株式会社 ペプチド合成方法
US12024537B2 (en) 2018-05-31 2024-07-02 Sederma Compositions and methods for chemical synthesis
EP3882255A4 (en) 2018-11-16 2022-09-21 Ajinomoto Co., Inc. PROCESS FOR THE PREPARATION OF CYCLIZED PEPTIDE WITH INTRAMOLECULAR S-S BOND
US11827660B2 (en) 2019-02-01 2023-11-28 Sederma Synthesis strategy for gap protecting group
KR20210121181A (ko) 2019-02-28 2021-10-07 후지필름 가부시키가이샤 펩타이드 화합물의 제조 방법, 보호기 형성용 시약, 및 방향족 복소환 화합물
EP4320138A1 (en) 2021-04-09 2024-02-14 Bachem Holding AG Pseudo solid phase protecting group and methods for the synthesis of oligonucleotides and oligonucleotide conjugates
JP7162853B1 (ja) 2021-07-02 2022-10-31 ペプチスター株式会社 液相ペプチド合成用担体結合ペプチドの分析方法

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4014937A (en) * 1974-08-26 1977-03-29 Pfizer Inc. 3,4-And 3,5-dialkoxyphenethylamines
JPH06239995A (ja) * 1993-02-22 1994-08-30 Matsushita Electric Works Ltd ポリアニリン誘導体およびその製造方法
WO1997042166A1 (fr) 1996-05-02 1997-11-13 Terumo Kabushiki Kaisha Derives amidines et vecteurs de medicaments les contenant
JP2000044493A (ja) * 1998-07-27 2000-02-15 Asahi Chem Ind Co Ltd 化合物ライブラリー合成用保護基
JP2001122889A (ja) * 1999-10-26 2001-05-08 Noguchi Inst 糖脂質アナログ化合物
US6806357B1 (en) 2001-08-20 2004-10-19 University Of Pittsburgh Fluorous nucleophilic substitution of alcohols and reagents for use therein
JP4283469B2 (ja) * 2001-12-19 2009-06-24 独立行政法人科学技術振興機構 相溶性−多相有機溶媒システムによりアミノ酸を逐次的に付加する液相ペプチド合成法
CN1289182C (zh) 2001-08-24 2006-12-13 独立行政法人科学技术振兴机构 相溶性－多相有机溶剂系统
JP2003292494A (ja) 2002-04-01 2003-10-15 Japan Science & Technology Corp 温度依存的集合形態を有するデンドリマー及びそれから成る発光体
JP2004059509A (ja) 2002-07-30 2004-02-26 Nokodai Tlo Kk 液相ペプチド合成用アミノ酸試薬
US20060194948A1 (en) * 2003-02-24 2006-08-31 Kazuhiro Chiba Chemical processes by the use of combinations of solvents capable of taking reversibly homogeneously mixed state and separated state dependently on temperature
JP4360854B2 (ja) 2003-07-08 2009-11-11 テルモ株式会社 グアニジン誘導体およびそれを構成成分とする薬物担体
WO2006104166A1 (ja) 2005-03-29 2006-10-05 National University Corporation, Tokyo University Of Agriculture And Technology 晶析分離用担体及び化合物の分離方法
EP2003104B1 (en) * 2006-03-24 2015-07-01 Jitsubo Co., Ltd. Reagent for organic synthesis and method of organic synthesis reaction with the reagent

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US20120108788A1 (en) 2012-05-03
US8093435B2 (en) 2012-01-10
JP2009185063A (ja) 2009-08-20
US20090299103A1 (en) 2009-12-03
JP5113118B2 (ja) 2013-01-09
US8293948B2 (en) 2012-10-23
EP2003104A9 (en) 2009-04-15
JPWO2007122847A1 (ja) 2009-09-03
ES2546808T3 (es) 2015-09-28
AU2007242276A1 (en) 2007-11-01
EP2003104A4 (en) 2010-01-06
CN101405240B (zh) 2012-07-25
EP2003104A2 (en) 2008-12-17
EP2003104B1 (en) 2015-07-01
WO2007122847A1 (ja) 2007-11-01
CN101405240A (zh) 2009-04-08

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