DK1919474T3 - Pyrrolopyridinderivater og anvendelse deraf som PPAR-receptormodulatorer - Google Patents

Pyrrolopyridinderivater og anvendelse deraf som PPAR-receptormodulatorer

Info

Publication number
DK1919474T3
DK1919474T3 DK06808267T DK06808267T DK1919474T3 DK 1919474 T3 DK1919474 T3 DK 1919474T3 DK 06808267 T DK06808267 T DK 06808267T DK 06808267 T DK06808267 T DK 06808267T DK 1919474 T3 DK1919474 T3 DK 1919474T3
Authority
DK
Denmark
Prior art keywords
ppar
alkyl
pyrrolopyridine derivatives
salts
new
Prior art date
Application number
DK06808267T
Other languages
Danish (da)
English (en)
Inventor
Bena Ssa Boubia
Martine Barth
Jean Binet
Pierre Dodey
Christiane Legendre
Olivia Poupardin-Olivier
Original Assignee
Fournier Lab Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fournier Lab Sa filed Critical Fournier Lab Sa
Application granted granted Critical
Publication of DK1919474T3 publication Critical patent/DK1919474T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
    • C07D207/48—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/61—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Neurosurgery (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Endocrinology (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Emergency Medicine (AREA)
  • Rheumatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Vascular Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyrrole Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
DK06808267T 2005-09-01 2006-08-31 Pyrrolopyridinderivater og anvendelse deraf som PPAR-receptormodulatorer DK1919474T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US71345905P 2005-09-01 2005-09-01
FR0510482A FR2890072A1 (fr) 2005-09-01 2005-10-14 Nouveaux composesde pyrrolopyridine
PCT/FR2006/050827 WO2007026104A1 (fr) 2005-09-01 2006-08-31 Derives de pyrrolopyridine et leurs utilisations comme modulateurs des recepteurs ppar

Publications (1)

Publication Number Publication Date
DK1919474T3 true DK1919474T3 (da) 2009-11-09

Family

ID=37735036

Family Applications (1)

Application Number Title Priority Date Filing Date
DK06808267T DK1919474T3 (da) 2005-09-01 2006-08-31 Pyrrolopyridinderivater og anvendelse deraf som PPAR-receptormodulatorer

Country Status (27)

Country Link
US (2) US7557122B2 (ja)
EP (1) EP1919474B1 (ja)
JP (1) JP5232000B2 (ja)
KR (1) KR101289589B1 (ja)
CN (1) CN101242833B (ja)
AT (1) ATE438396T1 (ja)
AU (1) AU2006286348B2 (ja)
BR (1) BRPI0615335A2 (ja)
CA (1) CA2620662C (ja)
DE (1) DE602006008320D1 (ja)
DK (1) DK1919474T3 (ja)
EA (1) EA014185B1 (ja)
ES (1) ES2331336T3 (ja)
FR (1) FR2890072A1 (ja)
HK (1) HK1116698A1 (ja)
HR (1) HRP20090512T1 (ja)
IL (1) IL189189A (ja)
MX (1) MX2008003038A (ja)
MY (1) MY142983A (ja)
NO (1) NO340681B1 (ja)
PL (1) PL1919474T3 (ja)
PT (1) PT1919474E (ja)
SI (1) SI1919474T1 (ja)
TN (1) TNSN08091A1 (ja)
UA (1) UA92026C2 (ja)
WO (1) WO2007026104A1 (ja)
ZA (1) ZA200801885B (ja)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2007145434A (ru) * 2005-05-10 2009-06-20 Вертекс Фармасьютикалз Инкорпорейтед (Us) Бициклические производные в качестве модуляторов ионных каналов
FR2890071B1 (fr) * 2005-08-30 2007-11-09 Fournier Sa Sa Lab Nouveaux composes de l'indole
PE20090159A1 (es) * 2007-03-08 2009-02-21 Plexxikon Inc COMPUESTOS DERIVADOS DE ACIDO INDOL-PROPIONICO COMO MODULADORES PPARs
KR101156845B1 (ko) * 2007-05-21 2012-06-18 에스지엑스 파마슈티컬스, 인코포레이티드 헤테로시클릭 키나제 조절제
FR2955108B1 (fr) 2010-01-08 2012-03-16 Fournier Lab Sa Utilisation de derives de pyrrolopyridine comme activateurs de nurr-1, pour le traitement de la maladie de parkinson
FR2955110A1 (fr) * 2010-01-08 2011-07-15 Fournier Lab Sa Nouveaux derives de type pyrrolopyridine benzoique
US9346798B2 (en) 2012-02-13 2016-05-24 Amgen Inc. Dihydrobenzoxazine and tetrahydroquinoxaline sodium channel inhibitors
WO2013134518A1 (en) 2012-03-09 2013-09-12 Amgen Inc. Sulfamide sodium channel inhibitors
GB201317363D0 (en) * 2013-10-01 2013-11-13 Eisai Ltd Novel compounds
CN103630519A (zh) * 2013-12-03 2014-03-12 华东理工大学 应用pH敏感的比率荧光蛋白检测酶-前药反应的方法
CN108383838B (zh) * 2018-03-31 2020-08-28 浙江药苑生物科技有限公司 一种酰胺类衍生物及其在高血压、高血脂和动脉粥样硬化中的应用
CN108164528B (zh) * 2018-03-31 2019-03-22 杭州巴洛特生物科技有限公司 一种酰胺类衍生物及其在高血压、高血脂和动脉粥样硬化中的应用
CN108456207B (zh) * 2018-03-31 2020-11-20 浙江药苑生物科技有限公司 一种酰胺类衍生物及其在心脑血管方面的应用
CN108218865B (zh) * 2018-03-31 2020-06-26 济南市儿童医院 一种酰胺类衍生物及其在心脑血管方面的应用
CN111793066B (zh) * 2020-07-17 2022-04-08 瀚海新拓(杭州)生物医药有限公司 苯并五元杂环磺酰胺类化合物、其制备方法、药物组合物及应用

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU1856997A (en) 1996-02-02 1997-08-22 Merck & Co., Inc. Method for raising hdl cholesterol levels
AU726637B2 (en) 1996-12-13 2000-11-16 Aventis Pharmaceuticals Inc. Sulfonic acid or sulfonylamino N-(heteroaralkyl)-azaheterocyclylamide compounds
CA2400021A1 (en) 2000-02-18 2001-08-23 Merck & Co., Inc. Aryloxyacetic acids for diabetes and lipid disorders
MXPA03007779A (es) 2001-03-14 2004-11-12 Lilly Co Eli Moduladores de los receptores de retinoides x.
JP2005516901A (ja) * 2001-11-19 2005-06-09 ニューロジェン コーポレイション １Ｈ−ピロロ［３，２−ｂ］ピリジン−３−カルボン酸アミド化合物
DE10229777A1 (de) * 2002-07-03 2004-01-29 Bayer Ag Indolin-Phenylsulfonamid-Derivate
DE10300099A1 (de) 2003-01-07 2004-07-15 Bayer Healthcare Ag Indol-Phenylsulfonamid-Derivate
US20050014753A1 (en) * 2003-04-04 2005-01-20 Irm Llc Novel compounds and compositions as protein kinase inhibitors
EP1648867B1 (en) * 2003-07-17 2013-09-04 Plexxikon Inc. Ppar active compounds
DE10335450A1 (de) 2003-08-02 2005-02-17 Bayer Ag Indolin-Sulfanilsäureamide
DE10335449A1 (de) 2003-08-02 2005-02-17 Bayer Healthcare Ag Bicyclische Indolinsulfonamid-Derivate
WO2005056522A2 (en) 2003-12-04 2005-06-23 National Health Research Institutes Indole compounds

Also Published As

Publication number Publication date
TNSN08091A1 (fr) 2009-07-14
MY142983A (en) 2011-02-14
US20080200495A1 (en) 2008-08-21
FR2890072A1 (fr) 2007-03-02
EA014185B1 (ru) 2010-10-29
EP1919474A1 (fr) 2008-05-14
HRP20090512T1 (hr) 2009-12-31
PT1919474E (pt) 2009-10-28
HK1116698A1 (en) 2009-01-02
UA92026C2 (uk) 2010-09-27
EP1919474B1 (fr) 2009-08-05
ZA200801885B (en) 2009-08-26
PL1919474T3 (pl) 2010-03-31
BRPI0615335A2 (pt) 2012-12-11
IL189189A0 (en) 2008-06-05
WO2007026104A1 (fr) 2007-03-08
AU2006286348A1 (en) 2007-03-08
US7728002B2 (en) 2010-06-01
NO340681B1 (no) 2017-05-29
AU2006286348B2 (en) 2012-04-26
SI1919474T1 (sl) 2009-12-31
CA2620662C (fr) 2015-10-06
KR20080039908A (ko) 2008-05-07
DE602006008320D1 (de) 2009-09-17
IL189189A (en) 2013-10-31
CA2620662A1 (fr) 2007-03-08
KR101289589B1 (ko) 2013-07-24
NO20080497L (no) 2008-02-29
JP5232000B2 (ja) 2013-07-10
US7557122B2 (en) 2009-07-07
ES2331336T3 (es) 2009-12-29
ATE438396T1 (de) 2009-08-15
JP2009507007A (ja) 2009-02-19
EA200800352A1 (ru) 2008-06-30
US20090239856A1 (en) 2009-09-24
CN101242833B (zh) 2012-06-27
CN101242833A (zh) 2008-08-13
MX2008003038A (es) 2008-03-24

Similar Documents

Publication Publication Date Title
DK1919474T3 (da) Pyrrolopyridinderivater og anvendelse deraf som PPAR-receptormodulatorer
DK1919869T3 (da) Indolderivater som PPAR-aktivatorer
MY154836A (en) Activating agent for peroxisome prolifrator activated receptor ?
DK1349843T3 (da) Thiazol- og oxazolderivater som aktivatorer af human peroxisom profilerator-aktiverede receptorer
DE60018064D1 (de) Substituierte phenylpropionsäurederivate als agonisten des menschlichen peroxisom-proliferator-aktiverten rezeptors alpha(ppar)
AR056574A1 (es) Derivados de pirazol, composiciones que contienen dichos compuestos y procedimientos de uso
RS52526B (en) OXADIAZOL DERIVATIVES AND THEIR USE AS A POTENTIAL OF METABOTROPIC GLUTAMATE RECEPTORS-842
DK1521744T3 (da) Arylsulfonamidderivater og anvendelse deraf som B1-bradykininreceptorantagonister
NO20054408D0 (no) 3(2-fenyl-oksazol-4-yl-metoksy)-cykloheksylmetoksyeddiksyrederivater og lignende forbindelser som PPAR-modulatorer for behandling av type 2 diabetes og arterosklerose
NO20053561L (no) Mettede kinoksalinderivater og deres anvendelse som metabotrofe og glutamatreseptorligander
NO20051011L (no) Kirale oksazol-arylpropionsyrederivater og anvendelse derav som PPAR agonister
NO20030729L (no) Oksazolyl-arylpropionsyrederivater og deres anvendelse som PPAR-agonister
DK1828125T3 (da) Arylpiperazinderivater og deres anvendelse som selektive ligander for dopaminets D3 receptor
SV2006002109A (es) Una composicion farmaceutica antimicobacteriana
EP1405848A4 (en) TETRAHYDROCHINOLINE DERIVATIVE COMPOUND AND THE COMPOUND OF AN ACTIVE MEDICAMENT CONTAINING ACTIVE SUBSTANCE
AU2003207808A1 (en) Peroxisome proliferator activated receptor modulators
NO20074738L (no) Aktivator for peroksisom-proliferator som aktiverer reseptor delta
RU2010141996A (ru) Ингибитор ммр-2 и/или ммр-9
ES2165410T3 (es) Nuevas 5-(ariloxi-metil)-oxazolinas, su procedimiento de preparacion y las composiciones farmaceuticas que las contienen.
NO20074631L (no) Nye 3-aryl-1,2-benzisoksazolderivater, forbindelser inneholdende de samme og deres anvendelse
NO20043286L (no) Piperidinderivatforbindelser og legemidler inneholdende forbindelsene som den aktive bestanddel
WO2008146917A1 (ja) リンコマイシン誘導体及びこれを有効成分とする抗菌剤
CA2490152A1 (en) Oxazole derivatives and their use as insulin sensitizers
NO20075505L (no) 7-fluor-1,3-dihydro-indol-2-on oksazolidinoner som antibakterielle forbindelser
DK1778655T3 (da) 2-{-3-'2-(phenyl)-oxazol-4-ylmethoxy!-cyclohexylmethoxy}-propionsyrederivater som PPAR-ligander (peroxisomen-proliferator-aktiverede receptorer) til behandling af hyperlipidæmi og diabetes