RU2010141996A - Ингибитор ммр-2 и/или ммр-9 - Google Patents

Ингибитор ммр-2 и/или ммр-9 Download PDF

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RU2010141996A
RU2010141996A RU2010141996/04A RU2010141996A RU2010141996A RU 2010141996 A RU2010141996 A RU 2010141996A RU 2010141996/04 A RU2010141996/04 A RU 2010141996/04A RU 2010141996 A RU2010141996 A RU 2010141996A RU 2010141996 A RU2010141996 A RU 2010141996A
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mmp
inhibitor
group
substituents
treatment
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RU2010141996/04A
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RU2487131C2 (ru
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Синья МИНАТОГУТИ (JP)
Синья МИНАТОГУТИ
Ясуси ОХНО (JP)
Ясуси ОХНО
Йоуити ЯБУУТИ (JP)
Йоуити ЯБУУТИ
Коунори КОТОСАИ (JP)
Коунори КОТОСАИ
Хисаси НАГАМОТО (JP)
Хисаси НАГАМОТО
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Оцука Фармасьютикал Ко., Лтд. (Jp)
Оцука Фармасьютикал Ко., Лтд.
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Abstract

1. Ингибитор ММР-2 и/или ММР-9, включающий в качестве активного ингредиента, по меньшей мере, одно соединение, выбранное из группы, состоящей из производных тиазола, представленных формулой 1): ! ! где R1 представляет собой фенильную группу, которая может иметь от 1 до 3 низших алкоксигрупп в качестве заместителей у фенильного кольца, и R2 представляет собой пиридильную группу, которая может иметь от 1 до 3 карбоксильных групп в качестве заместителей у пиридинового кольца, и их солей. ! 2. Ингибитор ММР-2 и/или ММР-9 по п.1, где производное тиазола представляет собой 6-[2-(3,4-диэтоксифенил)тиазол-4-ил]пиридин-2-карбоновую кислоту или ее соль. ! 3. Ингибитор ММР-2 и/или ММР-9 по п.1 или 2 для применения при лечении фиброза. ! 4. Ингибитор ММР-2 и/или ММР-9 по п.1 или 2 для применения при лечении легочной эмфиземы.

Claims (4)

1. Ингибитор ММР-2 и/или ММР-9, включающий в качестве активного ингредиента, по меньшей мере, одно соединение, выбранное из группы, состоящей из производных тиазола, представленных формулой 1):
Figure 00000001
где R1 представляет собой фенильную группу, которая может иметь от 1 до 3 низших алкоксигрупп в качестве заместителей у фенильного кольца, и R2 представляет собой пиридильную группу, которая может иметь от 1 до 3 карбоксильных групп в качестве заместителей у пиридинового кольца, и их солей.
2. Ингибитор ММР-2 и/или ММР-9 по п.1, где производное тиазола представляет собой 6-[2-(3,4-диэтоксифенил)тиазол-4-ил]пиридин-2-карбоновую кислоту или ее соль.
3. Ингибитор ММР-2 и/или ММР-9 по п.1 или 2 для применения при лечении фиброза.
4. Ингибитор ММР-2 и/или ММР-9 по п.1 или 2 для применения при лечении легочной эмфиземы.
RU2010141996/04A 2008-03-14 2009-03-13 Ингибитор ммр-2 и/или ммр-9 RU2487131C2 (ru)

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JP2008065455 2008-03-14
JP2008-065455 2008-03-14
PCT/JP2009/055545 WO2009113736A1 (en) 2008-03-14 2009-03-13 Mmp-2 and/or mmp-9 inhibitor

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RU2010141996A true RU2010141996A (ru) 2012-04-20
RU2487131C2 RU2487131C2 (ru) 2013-07-10

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EP (1) EP2280708A1 (ru)
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CN (3) CN103622962A (ru)
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BR (1) BRPI0909288A2 (ru)
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IL (2) IL207816A0 (ru)
MX (1) MX2010010073A (ru)
NZ (1) NZ587591A (ru)
RU (1) RU2487131C2 (ru)
SG (1) SG188852A1 (ru)
TW (1) TWI436767B (ru)
UA (1) UA108979C2 (ru)
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CA2718005A1 (en) 2009-09-17
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ZA201005991B (en) 2011-10-26
AU2009224209A1 (en) 2009-09-17
EP2280708A1 (en) 2011-02-09
BRPI0909288A2 (pt) 2015-08-18
CN103463084A (zh) 2013-12-25
TW200942237A (en) 2009-10-16
KR20100135255A (ko) 2010-12-24
IL207816A0 (en) 2010-12-30
JP2014221839A (ja) 2014-11-27
RU2487131C2 (ru) 2013-07-10
NZ587591A (en) 2012-10-26
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US20110054179A1 (en) 2011-03-03
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