DK1797102T3 - Sammensætning omfattende triarylmethylradikal, der kan anvendes til MRI-diagnostik - Google Patents
Sammensætning omfattende triarylmethylradikal, der kan anvendes til MRI-diagnostik Download PDFInfo
- Publication number
- DK1797102T3 DK1797102T3 DK05771194.7T DK05771194T DK1797102T3 DK 1797102 T3 DK1797102 T3 DK 1797102T3 DK 05771194 T DK05771194 T DK 05771194T DK 1797102 T3 DK1797102 T3 DK 1797102T3
- Authority
- DK
- Denmark
- Prior art keywords
- pyruvate
- pyruvic acid
- radical
- composition
- imaging
- Prior art date
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
- A61K49/1806—Suspensions, emulsions, colloids, dispersions
- A61K49/1815—Suspensions, emulsions, colloids, dispersions compo-inhalant, e.g. breath tests
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves
- A61B5/055—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/10—Organic compounds
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N24/00—Investigating or analyzing materials by the use of nuclear magnetic resonance, electron paramagnetic resonance or other spin effects
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Dispersion Chemistry (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Pathology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Medical Informatics (AREA)
- High Energy & Nuclear Physics (AREA)
- Surgery (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Magnetic Resonance Imaging Apparatus (AREA)
- Cosmetics (AREA)
- Rectifiers (AREA)
Claims (13)
1. Fremgangsmåde til fremstilling afen flydende sammensætning omfattende hyperpolariseret 13C-pyruvat, hvilken fremgangsmåde omfatter a) at danne en flydende blanding omfattende et radikal med formel (I), 13C-pyrodruesyre og/eller 13C-pyruvat og at fryse blandingen;
(i) hvor M betegner hydrogen eller en ækvivalent af en kation; og R1, som er ens eller forskellig, betegner en ligekædet eller forgrenet hydroxy- leret og/eller alkoxyleret Ci-C4-carbonhydridgruppe b) at øge 13C-kernepolariseringen af pyrodruesyre og/eller pyruvat i blandingen via DNP; c) at tilsætte en puffer og en base til den frosne blanding for at opløse den og omdanne 13C-pyrodruesyren til et 13C-pyruvat for at opnå en flydende sammensætning eller, hvis der kun anvendes 13C-pyruvat i trin a), at tilsætte en puffer til den frosne blanding for at opløse den for at opnå en flydende sammensætning; og d) eventuelt at 1]erne radikalet og/eller reaktionsprodukterne deraf fra den flydende sammensætning.
2. Fremgangsmåde ifølge krav 1, hvor radikalet er et radikal med formel (I), hvor M betegner hydrogen eller en ækvivalent af en fysiologisk acceptabel kation, og R1 er ens eller forskellig og betegner hydroxymethyl, hydroxyethyl, eller R1 er ens eller forskellig og betegner en ligekædet eller forgrenet alko-xyleret Ci-C4-carbonhydridgruppe, der bærer en terminal hydroxylgruppe, eller R1 er ens eller forskellig og betegner en ligekædet eller forgrenet alko-xyleret Ci-C4-carbonhydridgruppe.
3. Fremgangsmåde ifølge krav 2, hvor R1 er ens og betegner en ligekædet eller forgrenet alkoxyleret Ci-C4-carbonhydridgruppe, fortrinsvis methoxy, -CH2-OCH3, -CH2-OC2H5 eller -CH2-CH2-OCH3.
4. Fremgangsmåde ifølge krav 1 til 3, hvor 13C-pyrodruesyre og/eller 13C-py-ruvat beriges isotopisk ved C1-positionen, ved C2-positionen, ved C3-posi-tionen, ved C1- og C2-positionen, ved C1- og C3-positionen, ved C2- og C3-positionen eller ved C1-, C2- og C3-positionen, fortrinsvis ved C1-positionen.
5. Fremgangsmåde ifølge krav 1 til 4, hvor den isotopiske berigelse af 13C-pyrodruesyre og/eller 13C-pyruvat er mindst 75 %, fortrinsvis mindst 90 %.
6. Fremgangsmåde ifølge krav 1 til 5, hvor pufferen er en puffer udvalgt fra gruppen bestående af phosphatpuffer, ACES, PIPES, imidazol/HCI, BES, MOPS, HEPES, TES, TRIS, HEPPS og TRICIN, fortrinsvis udvalgt fra gruppen bestående af phosphatpuffer og TRIS.
7. Fremgangsmåde ifølge krav 1-6, hvor der anvendes 13C-pyrodruesyre i trin a), og hvor pufferen og basen kombineres i en opløsning i trin c).
8. Fremgangsmåde ifølge krav 1-6, hvor der anvendes 13C-pyrodruesyre i trin a), og basen er NaOFI.
9. Fremgangsmåde ifølge krav 1-8, hvor step d) obligatorisk.
10. Fremgangsmåde ifølge krav 9 til fremstilling af en sammensætning til anvendelse som et billedgengivelsemiddel til in wVo-MR-billedgengivelse af en menneskelig eller ikke menneskelig dyrekrop.
11. Sammensætning omfattende 13C-pyrodruesyre og/eller 13C-pyruvat og et radikal med formel (I).
12. Sammensætning ifølge krav 11 omfattende 13C-pyrodruesyre og et radikal med formel (I), hvor M betegner hydrogen eller natrium, og R1 er den samme og betegner -CH2-CH2-OCH3.
13. Anvendelse af sammensætningen ifølge krav 11 og 12 til fremstilling af hyperpolariseret 13C-pyruvat.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NO20043229 | 2004-07-30 | ||
| PCT/NO2005/000281 WO2006011809A1 (en) | 2004-07-30 | 2005-07-28 | Method of producing a composition, composition and its use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1797102T3 true DK1797102T3 (da) | 2015-08-24 |
Family
ID=35058362
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK05771194.7T DK1797102T3 (da) | 2004-07-30 | 2005-07-28 | Sammensætning omfattende triarylmethylradikal, der kan anvendes til MRI-diagnostik |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US9023320B2 (da) |
| EP (1) | EP1797102B1 (da) |
| JP (2) | JP5367265B2 (da) |
| KR (2) | KR20070063504A (da) |
| CN (1) | CN101035796B (da) |
| AU (1) | AU2005267668B2 (da) |
| BR (1) | BRPI0513812B8 (da) |
| CA (1) | CA2575601C (da) |
| DK (1) | DK1797102T3 (da) |
| ES (1) | ES2545260T3 (da) |
| HK (1) | HK1107691A1 (da) |
| IL (1) | IL180897A (da) |
| MX (1) | MX2007001035A (da) |
| NZ (1) | NZ552898A (da) |
| PL (1) | PL1797102T3 (da) |
| RU (1) | RU2374252C2 (da) |
| WO (1) | WO2006011809A1 (da) |
| ZA (1) | ZA200701271B (da) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
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| GB0014463D0 (en) * | 2000-06-14 | 2000-08-09 | Nycomed Amersham Plc | NMR Method |
| KR20070063504A (ko) * | 2004-07-30 | 2007-06-19 | 지이 헬스케어 에이에스 | 조성물의 제조 방법, 조성물 및 그의 용도 |
| KR101372173B1 (ko) * | 2005-12-01 | 2014-03-07 | 지이 헬스케어 에이에스 | 트리틸 라디칼 및 상자성 금속 이온을 사용하는 동적 핵분극화 방법 |
| JP5102221B2 (ja) * | 2005-12-16 | 2012-12-19 | ジーイー・ヘルスケア・アクスイェ・セルスカプ | 過分極カルボン酸塩の製造方法 |
| JP2009531422A (ja) * | 2006-03-29 | 2009-09-03 | ジーイー・ヘルスケア・アクスイェ・セルスカプ | 過分極カルボン酸塩及びスルホン酸塩の製造方法 |
| KR101502180B1 (ko) | 2006-08-30 | 2015-03-12 | 지이 헬스케어 에이에스 | 동적 핵 분극화 방법 및 이러한 방법에서 사용되는 화합물 및 조성물 |
| WO2008086534A1 (en) | 2007-01-11 | 2008-07-17 | Huntington Medical Research Institutes | Imaging agents and methods of use thereof |
| US20080240998A1 (en) * | 2007-03-28 | 2008-10-02 | Urbahn John A | Fluid path system for dissolution and transport of a hyperpolarized material |
| US8731640B2 (en) | 2007-03-28 | 2014-05-20 | General Electric Company | Fluid path system for dissolution and transport of a hyperpolarized material |
| US7470813B2 (en) | 2007-03-30 | 2008-12-30 | Ge Healthcare Limited | Method for the production of pyruvic acid |
| JP2010529868A (ja) * | 2007-05-17 | 2010-09-02 | ゼネラル・エレクトリック・カンパニイ | 過分極１３ｃ−ピルビン酸塩を含むｍｒ造影剤を用いて腫瘍のグレーディングを行うｍｒ方法 |
| US9227173B2 (en) | 2007-06-22 | 2016-01-05 | General Electric Company | Methods for dynamic filtration of pharmaceutical products |
| JP2010534498A (ja) * | 2007-07-26 | 2010-11-11 | ジーイー・ヘルスケア・ユーケイ・リミテッド | 方法及び該方法で使用するためのイメージング媒体 |
| EP2902041A1 (en) | 2007-12-19 | 2015-08-05 | GE Healthcare Limited | Composition and method for generating a metabolic profile using 13C-MR detection |
| EP2222346B1 (en) * | 2007-12-21 | 2012-02-08 | GE Healthcare Limited | Mr imaging agent, imaging medium and methods of imaging wherein such an imaging medium is used |
| WO2009129265A1 (en) | 2008-04-14 | 2009-10-22 | Huntington Medical Research Institutes | Methods and apparatus for pasadena hyperpolarization |
| US8763410B2 (en) | 2008-04-21 | 2014-07-01 | General Electric Company | Method and apparatus for the dissolution and filtration of a hyperpolarized agent with a neutral dissolution media |
| WO2009133169A1 (en) | 2008-05-02 | 2009-11-05 | General Electric Company | Method of determining alanine transaminase (alt) activity by 13c-mr detection using hyperpolarised 13c-pyruvate |
| EP2414854A1 (en) | 2009-04-02 | 2012-02-08 | GE Healthcare UK Limited | Use of a magnetic resonance imaging medium comprising hyperpolarized 13c pyruvate for the detection of inflammation or infection |
| SG179067A1 (en) | 2009-09-10 | 2012-04-27 | Ge Healthcare Ltd | 13c-mr detection using hyperpolarised 13c-fructose |
| DE102009054956A1 (de) * | 2009-12-18 | 2011-06-22 | Siemens Aktiengesellschaft, 80333 | Magnetresonanztomographie-Bildgebung |
| EP2555803B1 (en) | 2010-04-08 | 2018-09-12 | Bracco Imaging S.p.A | Process for preparing hyperpolarized substrates and method for mri |
| WO2011138269A1 (en) | 2010-05-03 | 2011-11-10 | Ge Healthcare Limited | Hyperpolarized lactate contrast agent for determination of ldh activity |
| US20130149250A1 (en) * | 2011-06-23 | 2013-06-13 | The Regents Of The University Of California | Hyperpolarized agents for mri characterization of redox systems in vivo |
| EP2766050B1 (en) | 2011-10-12 | 2018-09-05 | Bracco Imaging S.p.A | Process for the preparation of hyperpolarized derivatives for use in mri analysis |
| US9693828B2 (en) | 2011-12-05 | 2017-07-04 | Bracco Imaging S.P.A. | Composition comprising acetic anhydride and a gadolinium complex, and method for the use in hyperpolarisation in MRI analysis |
| JP6507101B2 (ja) | 2013-01-31 | 2019-04-24 | ブラッコ・イメージング・ソシエタ・ペル・アチオニＢｒａｃｃｏ Ｉｍａｇｉｎｇ Ｓ．Ｐ．Ａ． | Ｍｒにおける代謝マーカーとしての過分極エステル |
| EP3016687B1 (en) | 2013-07-01 | 2017-08-09 | Bracco Imaging S.p.A | Hyperpolarized 1-13c-1,1-bis(acetoxy(methyl))-2,2'-cyclopropane as metabolic marker for mr |
| US9874622B2 (en) | 2013-09-27 | 2018-01-23 | General Electric Company | Hyperpolarized media transport vessel |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3851442T2 (de) | 1987-06-23 | 1995-01-19 | Nycomed Innovation Ab | Verbesserungen bei der Bilderzeugung mittels magnetischer Resonanz. |
| GB8817137D0 (en) | 1988-07-19 | 1988-08-24 | Nycomed As | Compositions |
| CA2075818A1 (en) | 1990-02-12 | 1991-08-13 | Mikkel Joergensen | Triarylmethyl radicals and the use of inert carbon free radicals in mri |
| WO1993002711A1 (en) | 1991-08-09 | 1993-02-18 | Nycomed Innovation Ab | Use of persistent free-radicals in magnetic resonance imaging |
| US5728370A (en) | 1993-04-02 | 1998-03-17 | Nycomed Imaging As | Free Radicals |
| ES2175123T3 (es) | 1995-09-08 | 2002-11-16 | Nycomed Imaging As | Procedimiento que sirve para determinar la concentracion de oxigeno enuna muestra. |
| ES2201462T3 (es) | 1997-03-06 | 2004-03-16 | Amersham Health As | Radicales libres de triarilmetilo como agentes mejoradores de la imagen. |
| EP0990168A1 (en) | 1997-06-19 | 2000-04-05 | Nycomed Imaging As | Overhauser magnetic resonance imaging (ormi) method comprising ex vivo polarization of a magnetic resonance (mr) imaging agent |
| US6278893B1 (en) * | 1998-01-05 | 2001-08-21 | Nycomed Imaging As | Method of magnetic resonance imaging of a sample with ex vivo polarization of an MR imaging agent |
| US6232497B1 (en) | 1998-12-23 | 2001-05-15 | Skw Trostberg Aktiengesellschaft | Method for producing alkali metal and alkaline earth metal pyruvates |
| GB0014463D0 (en) | 2000-06-14 | 2000-08-09 | Nycomed Amersham Plc | NMR Method |
| HUP0302425A3 (en) | 2000-11-03 | 2011-04-28 | Ge Healthcare As | Methods and devices for polarised nmr samples |
| US6617169B2 (en) * | 2001-03-30 | 2003-09-09 | Mclean Hospital Corporation | Two-dimensional MR spectroscopy techniques |
| US6486671B1 (en) * | 2001-05-14 | 2002-11-26 | Ge Medical Systems Global Technologies Company Llc | MRI image quality improvement using matrix regularization |
| US6958244B2 (en) * | 2002-04-12 | 2005-10-25 | Bruker Biospin Corp. | Low-conductivity buffers for magnetic resonance measurements |
| KR20070063504A (ko) * | 2004-07-30 | 2007-06-19 | 지이 헬스케어 에이에스 | 조성물의 제조 방법, 조성물 및 그의 용도 |
| RU2374253C2 (ru) * | 2004-07-30 | 2009-11-27 | Джи-И Хелткер АС | Радикалы и их применение в качестве парамагнитных агентов в процессе динамической поляризации ядер |
-
2005
- 2005-07-28 KR KR1020077004779A patent/KR20070063504A/ko not_active Application Discontinuation
- 2005-07-28 AU AU2005267668A patent/AU2005267668B2/en not_active Ceased
- 2005-07-28 CN CN2005800334196A patent/CN101035796B/zh active Active
- 2005-07-28 BR BRPI0513812A patent/BRPI0513812B8/pt not_active IP Right Cessation
- 2005-07-28 RU RU2007102843/04A patent/RU2374252C2/ru not_active IP Right Cessation
- 2005-07-28 NZ NZ552898A patent/NZ552898A/en not_active IP Right Cessation
- 2005-07-28 KR KR1020137005588A patent/KR101475635B1/ko not_active IP Right Cessation
- 2005-07-28 CA CA2575601A patent/CA2575601C/en active Active
- 2005-07-28 PL PL05771194T patent/PL1797102T3/pl unknown
- 2005-07-28 DK DK05771194.7T patent/DK1797102T3/da active
- 2005-07-28 JP JP2007523504A patent/JP5367265B2/ja active Active
- 2005-07-28 MX MX2007001035A patent/MX2007001035A/es active IP Right Grant
- 2005-07-28 EP EP05771194.7A patent/EP1797102B1/en active Active
- 2005-07-28 US US11/572,671 patent/US9023320B2/en active Active
- 2005-07-28 ES ES05771194.7T patent/ES2545260T3/es active Active
- 2005-07-28 WO PCT/NO2005/000281 patent/WO2006011809A1/en active Application Filing
- 2005-07-28 US US11/572,679 patent/US20080095713A1/en not_active Abandoned
-
2007
- 2007-01-23 IL IL180897A patent/IL180897A/en active IP Right Grant
- 2007-02-13 ZA ZA200701271A patent/ZA200701271B/en unknown
- 2007-12-05 HK HK07113302.9A patent/HK1107691A1/xx not_active IP Right Cessation
-
2012
- 2012-07-12 JP JP2012156109A patent/JP5745470B2/ja active Active
Also Published As
| Publication number | Publication date |
|---|---|
| WO2006011809A1 (en) | 2006-02-02 |
| BRPI0513812B8 (pt) | 2021-07-27 |
| NZ552898A (en) | 2011-02-25 |
| CN101035796B (zh) | 2011-06-22 |
| KR101475635B1 (ko) | 2014-12-22 |
| IL180897A (en) | 2010-11-30 |
| RU2374252C2 (ru) | 2009-11-27 |
| AU2005267668B2 (en) | 2011-10-20 |
| JP5745470B2 (ja) | 2015-07-08 |
| RU2007102843A (ru) | 2008-09-10 |
| KR20130028989A (ko) | 2013-03-20 |
| ES2545260T3 (es) | 2015-09-09 |
| JP2012236832A (ja) | 2012-12-06 |
| CA2575601C (en) | 2013-05-28 |
| KR20070063504A (ko) | 2007-06-19 |
| ZA200701271B (en) | 2008-05-28 |
| EP1797102A1 (en) | 2007-06-20 |
| CN101035796A (zh) | 2007-09-12 |
| MX2007001035A (es) | 2007-07-11 |
| EP1797102B1 (en) | 2015-05-27 |
| IL180897A0 (en) | 2007-07-04 |
| JP5367265B2 (ja) | 2013-12-11 |
| JP2008508266A (ja) | 2008-03-21 |
| BRPI0513812A (pt) | 2008-05-13 |
| BRPI0513812B1 (pt) | 2017-05-09 |
| US9023320B2 (en) | 2015-05-05 |
| PL1797102T3 (pl) | 2015-10-30 |
| AU2005267668A1 (en) | 2006-02-02 |
| US20080213186A1 (en) | 2008-09-04 |
| CA2575601A1 (en) | 2006-02-02 |
| HK1107691A1 (en) | 2008-04-11 |
| US20080095713A1 (en) | 2008-04-24 |
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