DK175958B1 - Vævsplasminoaktivator-(t-PA)-variant med zymogene eller fibrinspecifikke eller plasmakoagel-specifikke egenskaber, fremgangsmåde til fremstilling deraf, DNA-sekvens, som koder for varianten, replicerbar udtrykkelsesvektor for denne og værtsceller tran - Google Patents

Vævsplasminoaktivator-(t-PA)-variant med zymogene eller fibrinspecifikke eller plasmakoagel-specifikke egenskaber, fremgangsmåde til fremstilling deraf, DNA-sekvens, som koder for varianten, replicerbar udtrykkelsesvektor for denne og værtsceller tran Download PDF

Info

Publication number
DK175958B1
DK175958B1 DK199100369A DK36991A DK175958B1 DK 175958 B1 DK175958 B1 DK 175958B1 DK 199100369 A DK199100369 A DK 199100369A DK 36991 A DK36991 A DK 36991A DK 175958 B1 DK175958 B1 DK 175958B1
Authority
DK
Denmark
Prior art keywords
variant
amino acid
positions
type
wild
Prior art date
Application number
DK199100369A
Other languages
Danish (da)
English (en)
Other versions
DK36991A (da
DK36991D0 (da
Inventor
Stephen Anderson
William F Bennett
David Botstein
Deborah L Higgins
Nicholas A Paoni
Mark Zoller
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of DK36991D0 publication Critical patent/DK36991D0/da
Publication of DK36991A publication Critical patent/DK36991A/da
Application granted granted Critical
Publication of DK175958B1 publication Critical patent/DK175958B1/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DK199100369A 1988-09-02 1991-03-01 Vævsplasminoaktivator-(t-PA)-variant med zymogene eller fibrinspecifikke eller plasmakoagel-specifikke egenskaber, fremgangsmåde til fremstilling deraf, DNA-sekvens, som koder for varianten, replicerbar udtrykkelsesvektor for denne og værtsceller tran DK175958B1 (da)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US24085688A 1988-09-02 1988-09-02
US24085688 1988-09-02
US38460889 1989-07-24
US07/384,608 US5108901A (en) 1988-09-02 1989-07-24 Tissue plasminogen activator having zymogenic or fibrin specific properties
US8903755 1989-08-29
PCT/US1989/003755 WO1990002798A1 (en) 1988-09-02 1989-08-29 Tissue plasminogen activator having zymogenic or fibrin specific properties

Publications (3)

Publication Number Publication Date
DK36991D0 DK36991D0 (da) 1991-03-01
DK36991A DK36991A (da) 1991-05-02
DK175958B1 true DK175958B1 (da) 2005-08-29

Family

ID=26933781

Family Applications (1)

Application Number Title Priority Date Filing Date
DK199100369A DK175958B1 (da) 1988-09-02 1991-03-01 Vævsplasminoaktivator-(t-PA)-variant med zymogene eller fibrinspecifikke eller plasmakoagel-specifikke egenskaber, fremgangsmåde til fremstilling deraf, DNA-sekvens, som koder for varianten, replicerbar udtrykkelsesvektor for denne og værtsceller tran

Country Status (18)

Country Link
US (1) US5108901A (de)
EP (1) EP0457758B1 (de)
JP (1) JP2794028B2 (de)
KR (1) KR0148575B1 (de)
AT (1) ATE124452T1 (de)
AU (1) AU626323B2 (de)
CA (1) CA1341484C (de)
DE (1) DE68923298T2 (de)
DK (1) DK175958B1 (de)
ES (1) ES2018729A6 (de)
FI (1) FI109359B (de)
HK (1) HK1007334A1 (de)
HU (1) HU213922B (de)
IE (1) IE67508B1 (de)
IL (1) IL91306A (de)
NO (1) NO310778B1 (de)
NZ (1) NZ230509A (de)
WO (1) WO1990002798A1 (de)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5756093A (en) * 1985-04-22 1998-05-26 Genentech, Inc. Tissue plasminogen activator variants
US5736134A (en) * 1985-04-22 1998-04-07 Genentech, In.C Tissue plasminogen activator variants
GB8815135D0 (en) * 1988-06-24 1988-08-03 British Bio Technology Proteins & nucleic acids
DK395288D0 (da) * 1988-07-15 1988-07-15 Novo Industri As Proteiner
US5262170A (en) * 1988-09-02 1993-11-16 Genentech, Inc. Tissue plasminogen activator having zymogenic or fibrin specific properties and substituted at amino acid positions 296-299, DNA molecules encoding them, vectors, and host cells
US5156969A (en) * 1988-09-02 1992-10-20 Genentech Inc. Tissue plasminogen activator variant with deletion of amino acids 466-470 having fibrin specific properties
US5714145A (en) * 1988-09-02 1998-02-03 Genentech, Inc. Tissue plasminogen activator having zymogenic or fibrin specific properties
US5866413A (en) * 1989-03-06 1999-02-02 Board Of Regents Of The University Of Texas System Pai-1 mutants
EP1029921B1 (de) * 1989-03-06 2002-10-23 The Board of Regents of The University of Texas System Serpin-resistenter T-PA; Mutanten; Gene
US5550042A (en) * 1989-03-06 1996-08-27 The Board Of Regents Of The University Of Texas System Serine protease mutants of the chymotrypsin superfamily resistant to inhibition by their cognate inhibitors and genes encoding the same and serine protease inhibitor mutants and genes encoding the same
US5304482A (en) * 1989-03-06 1994-04-19 The Board Of Regents Of The University Of Texas System Serine protease mutants of the chymotrypsin superfamily resistant to inhibition by their cognate inhibitors
JP3559559B2 (ja) * 1992-06-03 2004-09-02 ジェネンテク，インコーポレイテッド 向上した治療特性を有する組織プラスミノーゲン活性化因子グリコシル化変異体
US5472692A (en) * 1993-07-02 1995-12-05 New England Deaconess Hospital Corporation Pro-urokinase mutants
US5877016A (en) 1994-03-18 1999-03-02 Genentech, Inc. Human trk receptors and neurotrophic factor inhibitors
US5656427A (en) * 1994-08-29 1997-08-12 Gen-Probe Incorporated Nucleic acid hybridization assay probes, helper probes and amplification oligonucleotides targeted to Mycoplasma pneumoniae nucleic acid
US5798448A (en) * 1994-10-27 1998-08-25 Genentech, Inc. AL-1 neurotrophic factor antibodies
ZA966663B (en) 1995-08-17 1998-02-06 Genentech Inc Traf Inhibitors.
US6610296B2 (en) 1995-10-26 2003-08-26 Genentech, Inc. Methods of enhancing cognitive function using an AL-1 neurotrophic factor immunoadhesin
JP2001505765A (ja) * 1996-11-12 2001-05-08 ザ スクリプス リサーチ インスティテュート 組織型プラスミノーゲンアクチベーター（ｔ―ＰＡ）の変異体：組成物およびその使用方法
US6706504B1 (en) 1996-11-12 2004-03-16 The Scripps Research Institute Tissue type plasminogen activator (t-PA) variants: compositions and methods of use
US20030113271A1 (en) * 1997-01-29 2003-06-19 University Technology Corporation Formulations for pulmonary delivery
DE69737457T2 (de) 1997-01-31 2007-11-29 Genentech, Inc., South San Francisco O-fukosyltransferase
US20040241645A1 (en) * 1997-01-31 2004-12-02 Genentech, Inc. O-fucosyltransferase
WO1999009185A1 (de) * 1997-08-13 1999-02-25 Roche Diagnostics Gmbh Plasminogenaktivator mit verbesserter zymogenität
WO1999009184A1 (de) * 1997-08-13 1999-02-25 Roche Diagnostics Gmbh Plasminogenaktivator mit verbesserter zymogenität und verminderter fibrinbindung
KR100408844B1 (ko) * 2000-07-29 2003-12-06 한국산업기술평가원 동물세포 발현벡터
US20060104969A1 (en) * 2004-08-16 2006-05-18 Massachusetts Institute Of Technology Compositions and methods for enhancing structural and functional nervous system reorganization and recovery
EP2012815A4 (de) * 2006-04-14 2009-12-09 Massachusetts Inst Technology Identifikation und modulierung molekularer pfade zur vermittlung neuronaler plastizität
WO2008014054A2 (en) * 2006-07-27 2008-01-31 Centocor, Inc. Bmp-7 variant compositions, methods and uses
WO2015023830A1 (en) 2013-08-14 2015-02-19 Stc.Unm Treatment and prevention of stroke and other neurological disorders
DK3215221T3 (da) 2014-11-03 2020-05-11 Thrombolytic Science Llc Fremgangsmåder og sammensætninger til sikker og effektiv trombolyse
US11154596B2 (en) 2017-06-16 2021-10-26 Thrombolytic Science, Llc Methods for thrombolysis

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1984001960A1 (en) * 1982-11-11 1984-05-24 Beecham Group Plc Pharmaceutically active compounds
DE3382389D1 (de) * 1982-12-14 1991-10-02 South African Inventions Plasminogenaktivator.
US4753879A (en) * 1984-08-27 1988-06-28 Biogen N.V. Modified tissue plasminogen activators
EP0201153A3 (de) * 1985-02-09 1987-10-07 Beecham Group Plc Modifiziertes Enzym und Verfahren zu dessen Herstellung
DE3682104D1 (de) * 1985-04-22 1991-11-28 Genentech Inc Plasminogenaktivator-mutante des menschlichen gewebes, verfahren und zwischenprodukte dafuer und diese mutante verwendende zusammensetzungen.
GB8528321D0 (en) * 1985-11-18 1985-12-24 Ciba Geigy Ag Modified fibrinolytic agents
ATE74379T1 (de) * 1985-12-23 1992-04-15 Chiron Corp Peptidplasminogenaktivatoren.
DK43387A (da) * 1986-01-29 1987-07-30 Beecham Group Plc Fibrinolytisk enzym
EP0293394B2 (de) * 1986-01-31 2003-10-29 Genetics Institute, LLC Neue thrombolytische proteine
IE81073B1 (en) * 1986-03-18 2000-01-12 Genentech Inc Modified human tissue-type plasminogen activator and its preparation
PT84589B (en) * 1986-04-02 1989-05-09 Beecham Group Plc Process for preparing a fibrinolytic enzyme
DK345087A (da) * 1986-07-11 1988-01-12 Novo Industri As Modificeret vaevsplasminogenaktivator
WO1988005081A2 (en) * 1986-12-30 1988-07-14 Cetus Corporation Novel plasminogen activator
GB8705377D0 (en) * 1987-03-07 1987-04-08 Beecham Group Plc Compounds
FI882407A (fi) * 1987-05-22 1988-11-23 Zymogenetics Inc Fibrinolytiska proteiner.
ATE118815T1 (de) * 1987-06-04 1995-03-15 Zymogenetics Inc Gewebs-plasminogen-aktivator-analoge mit modifizierten wachstumsfaktordomänen.
EP0293934B1 (de) * 1987-06-04 1994-08-31 Zymogenetics, Inc. Mutierter t-PA mit Kringle-Ersatz
SE8702562L (sv) * 1987-06-18 1988-12-19 Kabigen Ab Nya fibrinolytiska enzymer
WO1988010119A1 (en) * 1987-06-22 1988-12-29 Genetics Institute, Inc. Novel thrombolytic proteins
AU2081788A (en) * 1987-07-06 1989-01-30 Genetics Institute Inc. Novel thrombolytic proteins
AU1893988A (en) * 1987-07-13 1989-01-19 Collaborative Research Inc. Nonglycosylated plasminogen activator and method of preparation
DK395288D0 (da) * 1988-07-15 1988-07-15 Novo Industri As Proteiner

Also Published As

Publication number Publication date
NZ230509A (en) 1991-06-25
JPH04500157A (ja) 1992-01-16
FI911049A0 (fi) 1991-03-01
HU213922B (en) 1997-11-28
IE892650L (en) 1990-03-02
IL91306A0 (en) 1990-03-19
KR900702019A (ko) 1990-12-05
WO1990002798A1 (en) 1990-03-22
NO910811L (no) 1991-02-28
AU4194689A (en) 1990-04-02
IL91306A (en) 1997-08-14
US5108901A (en) 1992-04-28
AU626323B2 (en) 1992-07-30
EP0457758A1 (de) 1991-11-27
CA1341484C (en) 2005-05-24
ES2018729A6 (es) 1991-05-01
ATE124452T1 (de) 1995-07-15
DK36991A (da) 1991-05-02
EP0457758B1 (de) 1995-06-28
KR0148575B1 (ko) 1998-10-15
IE67508B1 (en) 1996-04-03
FI109359B (fi) 2002-07-15
HUT58812A (en) 1992-03-30
DE68923298D1 (de) 1995-08-03
DE68923298T2 (de) 1996-01-11
DK36991D0 (da) 1991-03-01
NO310778B1 (no) 2001-08-27
JP2794028B2 (ja) 1998-09-03
NO910811D0 (no) 1991-02-28
HK1007334A1 (en) 1999-04-09
HU896005D0 (en) 1991-07-29

Similar Documents

Publication Publication Date Title
DK175958B1 (da) Vævsplasminoaktivator-(t-PA)-variant med zymogene eller fibrinspecifikke eller plasmakoagel-specifikke egenskaber, fremgangsmåde til fremstilling deraf, DNA-sekvens, som koder for varianten, replicerbar udtrykkelsesvektor for denne og værtsceller tran
DK174236B1 (da) Fremgangsmåde til fremstilling af et protein som har human vævsplasminogenaktivatorfunktion, fremgangsmåde til fremstilling af et farmaceutisk præparat indeholdende proteinet, DNA-isolat, som koder for proteinet, rekombinante klonings- og ......
US5614190A (en) Tissue plasminogen activator having zymogenic or fibrin specific properties
US5246850A (en) DNA molecules encoding human tissue plasminogen activator variants with decreased clearance, vectors, and host cells
US5258180A (en) Tissue plasminogen activator having fibrin specific properties and deletion of amino acids 466-970, compositions and methods of treatment
US5714145A (en) Tissue plasminogen activator having zymogenic or fibrin specific properties
AU642984B2 (en) Tissue plaminogen activator having fibrin specific properties
EP0542869B1 (de) Varianten des gewebeplasminogenaktivators mit vermindertem abbau
AU665979B2 (en) t-PA substitution variants with improved fibrin-specificity
EP0563280B1 (de) Substitutionsvariante des gewebeplasminogenaktivators
HU210541A9 (hu) Zimogén- vagy fibrin-specifikus tulajdonságú, a 296-299 aminosav-tartományban helyettesített szöveti plazminogén aktivátor, ezt kódoló DNS-molekulák, vektorok és gazdasejtek
HU210529A9 (hu) Zimogén vagy fibrinspecifikus tulajdonságokkal rendelkező szöveti plazminogén aktivátor Az átmeneti oltalom az 1-7. igénypontra vonatkozik.

Legal Events

Date Code Title Description
PUP Patent expired