DK175938B1 - Plasminogenaktivator-varianter, DNA-sekvenser, vektorer, celler og cellekulturer, der omfatter DNA-sekvenser, der koder for sådanne varianter, samt sammensætninger til behandling af karsygdom eller -tilstand, der omfatter en sådan variant - Google Patents

Plasminogenaktivator-varianter, DNA-sekvenser, vektorer, celler og cellekulturer, der omfatter DNA-sekvenser, der koder for sådanne varianter, samt sammensætninger til behandling af karsygdom eller -tilstand, der omfatter en sådan variant Download PDF

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Publication number
DK175938B1
DK175938B1 DK199002749A DK274990A DK175938B1 DK 175938 B1 DK175938 B1 DK 175938B1 DK 199002749 A DK199002749 A DK 199002749A DK 274990 A DK274990 A DK 274990A DK 175938 B1 DK175938 B1 DK 175938B1
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DK
Denmark
Prior art keywords
variant
native
amino acid
site
dec
Prior art date
Application number
DK199002749A
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Danish (da)
English (en)
Other versions
DK274990A (da
DK274990D0 (da
Inventor
Stephen Anderson
Bruce Keyt
Original Assignee
Genentech Inc
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Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of DK274990D0 publication Critical patent/DK274990D0/da
Publication of DK274990A publication Critical patent/DK274990A/da
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Publication of DK175938B1 publication Critical patent/DK175938B1/da

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21069—Protein C activated (3.4.21.69)

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biotechnology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
DK199002749A 1988-05-20 1990-11-19 Plasminogenaktivator-varianter, DNA-sekvenser, vektorer, celler og cellekulturer, der omfatter DNA-sekvenser, der koder for sådanne varianter, samt sammensætninger til behandling af karsygdom eller -tilstand, der omfatter en sådan variant DK175938B1 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US19690988A 1988-05-20 1988-05-20
US19690988 1988-05-20
US8901947 1989-05-04
PCT/US1989/001947 WO1989011531A1 (en) 1988-05-20 1989-05-04 Variants of plasminogen activators and processes for their production

Publications (3)

Publication Number Publication Date
DK274990D0 DK274990D0 (da) 1990-11-19
DK274990A DK274990A (da) 1991-01-18
DK175938B1 true DK175938B1 (da) 2005-07-25

Family

ID=22727245

Family Applications (1)

Application Number Title Priority Date Filing Date
DK199002749A DK175938B1 (da) 1988-05-20 1990-11-19 Plasminogenaktivator-varianter, DNA-sekvenser, vektorer, celler og cellekulturer, der omfatter DNA-sekvenser, der koder for sådanne varianter, samt sammensætninger til behandling af karsygdom eller -tilstand, der omfatter en sådan variant

Country Status (12)

Country Link
EP (1) EP0424405B1 (ja)
JP (1) JP2928798B2 (ja)
AT (1) ATE111525T1 (ja)
AU (1) AU624158B2 (ja)
CA (1) CA1341432C (ja)
DE (1) DE68918279T2 (ja)
DK (1) DK175938B1 (ja)
ES (1) ES2013500A6 (ja)
HK (1) HK1007333A1 (ja)
IL (1) IL90146A (ja)
NZ (1) NZ229081A (ja)
WO (1) WO1989011531A1 (ja)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5098840A (en) * 1986-07-03 1992-03-24 The Green Cross Corporation Human prourokinase mutants
US5218092A (en) * 1988-09-29 1993-06-08 Kyowa Hakko Kogyo Co., Ltd. Modified granulocyte-colony stimulating factor polypeptide with added carbohydrate chains
NO894967L (no) * 1988-12-12 1990-06-13 Yamanouchi Pharma Co Ltd Fremgangsmaate for fremstilling av nye thrombolytiske proteiner.
JPH0387180A (ja) * 1989-05-18 1991-04-11 Green Cross Corp:The 変異ヒトプロウロキナーゼ、その製法、ｄｎａ配列、プラスミド、宿主
JP3126381B2 (ja) * 1990-07-31 2001-01-22 ジェネンテク，インコーポレイテッド 減少されたクリアランスを有する組織プラスミノーゲンアクチベーター変異体
US5246850A (en) * 1990-07-31 1993-09-21 Genentech, Inc. DNA molecules encoding human tissue plasminogen activator variants with decreased clearance, vectors, and host cells
US5242688A (en) * 1990-12-24 1993-09-07 Eli Lilly And Company Method of treating thromboembolic disorders by administration of diglycosylated t-pa variants
US5595736A (en) * 1991-04-22 1997-01-21 Eli Lilly And Company Compounds and methods for treatment of thromboembolic disorders
US5223408A (en) * 1991-07-11 1993-06-29 Genentech, Inc. Method for making variant secreted proteins with altered properties
ATE155816T1 (de) * 1992-06-03 1997-08-15 Genentech Inc Varianten des gewebeplasminogenaktivators mit verbesserter therapeutischer wirkung
US5945432A (en) * 1995-12-22 1999-08-31 The University Of Vermont And State Agricultural College Thrombolytic agents and thienopyridine derivatives in acute stroke
US7553930B2 (en) 2003-01-06 2009-06-30 Xencor, Inc. BAFF variants and methods thereof
CA2553257A1 (en) * 2004-01-14 2005-08-04 Ohio University Methods of producing peptides/proteins in plants and peptides/proteins produced thereby

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8528321D0 (en) * 1985-11-18 1985-12-24 Ciba Geigy Ag Modified fibrinolytic agents
ZA869626B (en) * 1985-12-23 1987-10-28 Chiron Corp Peptide plasminogen activators
DK43387A (da) * 1986-01-29 1987-07-30 Beecham Group Plc Fibrinolytisk enzym
AU7090787A (en) * 1986-02-19 1987-10-08 Beecham Group Plc Tissue plasminogen activator
IE81073B1 (en) * 1986-03-18 2000-01-12 Genentech Inc Modified human tissue-type plasminogen activator and its preparation

Also Published As

Publication number Publication date
WO1989011531A1 (en) 1989-11-30
DK274990A (da) 1991-01-18
ES2013500A6 (es) 1990-05-01
ATE111525T1 (de) 1994-09-15
JPH03504327A (ja) 1991-09-26
IL90146A0 (en) 1989-12-15
CA1341432C (en) 2003-06-17
JP2928798B2 (ja) 1999-08-03
EP0424405A1 (en) 1991-05-02
HK1007333A1 (en) 1999-04-09
EP0424405B1 (en) 1994-09-14
NZ229081A (en) 1991-03-26
AU624158B2 (en) 1992-06-04
DE68918279T2 (de) 1995-03-23
IL90146A (en) 1994-10-07
AU3744889A (en) 1989-12-12
DK274990D0 (da) 1990-11-19
DE68918279D1 (de) 1994-10-20

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