DK175787B1 - Anvendelse af visse naphthoquinoner til fremstilling af et lægemiddel mod Pneumocystis carinii infektioner samt farmaceutiske præparater med indhold af sådanne forbindelser - Google Patents

Anvendelse af visse naphthoquinoner til fremstilling af et lægemiddel mod Pneumocystis carinii infektioner samt farmaceutiske præparater med indhold af sådanne forbindelser Download PDF

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Publication number
DK175787B1
DK175787B1 DK198903999A DK399989A DK175787B1 DK 175787 B1 DK175787 B1 DK 175787B1 DK 198903999 A DK198903999 A DK 198903999A DK 399989 A DK399989 A DK 399989A DK 175787 B1 DK175787 B1 DK 175787B1
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DK
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Prior art keywords
group
hydroxy
naphthoquinone
phenyl
compound
Prior art date
Application number
DK198903999A
Other languages
Danish (da)
English (en)
Other versions
DK399989D0 (da
DK399989A (da
Inventor
Alan Thomas Hudson
Victoria Susan Latter
Winston Edward Gutteridge
Original Assignee
Wellcome Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB888819480A external-priority patent/GB8819480D0/en
Priority claimed from GB888819478A external-priority patent/GB8819478D0/en
Priority claimed from GB888819479A external-priority patent/GB8819479D0/en
Priority claimed from GB888819477A external-priority patent/GB8819477D0/en
Application filed by Wellcome Found filed Critical Wellcome Found
Publication of DK399989D0 publication Critical patent/DK399989D0/da
Publication of DK399989A publication Critical patent/DK399989A/da
Priority to DK200401402A priority Critical patent/DK175868B1/da
Application granted granted Critical
Publication of DK175787B1 publication Critical patent/DK175787B1/da

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/52—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
    • C07C229/54—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton with amino and carboxyl groups bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • C07C229/60—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton with amino and carboxyl groups bound to carbon atoms of the same non-condensed six-membered aromatic ring with amino and carboxyl groups bound in meta- or para- positions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C217/04—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C217/06—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted
    • C07C217/12—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C225/00—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones
    • C07C225/24—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones the carbon skeleton containing carbon atoms of quinone rings
    • C07C225/26—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones the carbon skeleton containing carbon atoms of quinone rings having amino groups bound to carbon atoms of quinone rings or of condensed ring systems containing quinone rings
    • C07C225/30—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones the carbon skeleton containing carbon atoms of quinone rings having amino groups bound to carbon atoms of quinone rings or of condensed ring systems containing quinone rings of condensed quinone ring systems formed by two rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C46/00—Preparation of quinones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C50/00—Quinones
    • C07C50/24—Quinones containing halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C50/00—Quinones
    • C07C50/26—Quinones containing groups having oxygen atoms singly bound to carbon atoms
    • C07C50/32—Quinones containing groups having oxygen atoms singly bound to carbon atoms the quinoid structure being part of a condensed ring system having two rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/013—Esters of alcohols having the esterified hydroxy group bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/017—Esters of hydroxy compounds having the esterified hydroxy group bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/96—Esters of carbonic or haloformic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/14—All rings being cycloaliphatic
    • C07C2602/26—All rings being cycloaliphatic the ring system containing ten carbon atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
DK198903999A 1988-08-16 1989-08-15 Anvendelse af visse naphthoquinoner til fremstilling af et lægemiddel mod Pneumocystis carinii infektioner samt farmaceutiske præparater med indhold af sådanne forbindelser DK175787B1 (da)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DK200401402A DK175868B1 (da) 1988-08-16 2004-09-15 2- (4-chlorphenyl) cyclohexylnaphthoquinonderivater, fremgangsmåde til fremstilling af sådanne forbindelser, forbindelserne til anvendelse i terapi samt anvendelse af forbindelserne til fremstilling af et lægemiddel mod Pneumocystis carinii.........

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
GB8819478 1988-08-16
GB888819480A GB8819480D0 (en) 1988-08-16 1988-08-16 Medicaments
GB8819479 1988-08-16
GB888819478A GB8819478D0 (en) 1988-08-16 1988-08-16 Medicaments
GB888819479A GB8819479D0 (en) 1988-08-16 1988-08-16 Medicaments
GB888819477A GB8819477D0 (en) 1988-08-16 1988-08-16 Medicaments
GB8819480 1988-08-16
GB8819477 1988-08-16

Publications (3)

Publication Number Publication Date
DK399989D0 DK399989D0 (da) 1989-08-15
DK399989A DK399989A (da) 1990-02-17
DK175787B1 true DK175787B1 (da) 2005-02-21

Family

ID=27450160

Family Applications (1)

Application Number Title Priority Date Filing Date
DK198903999A DK175787B1 (da) 1988-08-16 1989-08-15 Anvendelse af visse naphthoquinoner til fremstilling af et lægemiddel mod Pneumocystis carinii infektioner samt farmaceutiske præparater med indhold af sådanne forbindelser

Country Status (20)

Country Link
EP (2) EP0362996B1 (ar)
JP (1) JP2804302B2 (ar)
AT (1) ATE178311T1 (ar)
AU (1) AU633836B2 (ar)
CA (1) CA1329621C (ar)
CY (1) CY1863A (ar)
DE (2) DE68914930T2 (ar)
DK (1) DK175787B1 (ar)
ES (2) ES2130199T3 (ar)
FI (1) FI893835A (ar)
HK (1) HK103395A (ar)
HU (1) HU208624B (ar)
IE (1) IE65715B1 (ar)
IL (1) IL91308A (ar)
LV (1) LV11273B (ar)
MX (1) MX9202995A (ar)
NZ (1) NZ230313A (ar)
PT (2) PT91456B (ar)
SA (1) SA95160138B1 (ar)
SG (1) SG23618G (ar)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8921516D0 (en) * 1989-09-22 1989-11-08 Wellcome Found Medicaments
EP0567162A1 (en) * 1989-09-22 1993-10-27 The Wellcome Foundation Limited Medicaments for the treatment of toxoplasmosis
GB9103075D0 (en) * 1991-02-13 1991-03-27 Washington Odur Ayuko Trinitrobenzene derivatives and their therapeutic use
GB9121316D0 (en) * 1991-10-09 1991-11-20 Wellcome Found Heterocyclic compounds
GB9126874D0 (en) * 1991-12-18 1992-02-19 Wellcome Found Medicaments
GB9207517D0 (en) * 1992-04-06 1992-05-20 Wellcome Found Heterocyclic compounds
GB9216859D0 (en) * 1992-08-07 1992-09-23 Wellcome Found Medicaments
GB9224739D0 (en) * 1992-11-26 1993-01-13 Wellcome Found Medicaments
GB9226905D0 (en) * 1992-12-24 1993-02-17 Wellcome Found Pharmaceutical preparation
AU3705695A (en) * 1994-10-26 1996-05-23 Wellcome Foundation Limited, The Pharmaceutical composition comprising atovaquone
GB9613309D0 (en) * 1996-06-25 1996-08-28 Univ Sheffield Quinone bacterial inhibitors
BRPI0513951A (pt) * 2004-07-30 2008-05-20 Japan Health Science Found agente antiprotozoário
WO2009007991A2 (en) 2007-04-19 2009-01-15 Ipca Laboratories Limited A new process for preparation of atovaquone and novel intermediates thereof
ITMI20070941A1 (it) * 2007-05-09 2008-11-10 Chimico Internazi0Nale S P A L Procedimento per la preparazione di naftochinoni trans2,3-disostituiti
US9169232B2 (en) * 2011-09-16 2015-10-27 Alkem Laboratories Limited 3-(5-methyl-2-oxo-l, 3-dioxol-4-yl) methyloxy-2-trans-[(4-chloro phenyl) cyclohexyl][1,4]naphthaquinone-atovaquone prodrug
KR20190020774A (ko) * 2016-06-20 2019-03-04 더 스크립스 리서치 인스티튜트 항말라리아 조성물 및 이의 용도
WO2022144920A1 (en) * 2020-12-30 2022-07-07 Ipca Laboratories Limited Atovaquone prodrugs

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1553424A (en) * 1976-02-10 1979-09-26 Wellcome Found Method of treating protozal diseases
US4485117A (en) * 1981-10-16 1984-11-27 Hudson Alan T Antiprotozoal compounds
GB8310141D0 (en) * 1983-04-14 1983-05-18 Wellcome Found Naphthoquinone derivatives
GB8310140D0 (en) * 1983-04-14 1983-05-18 Wellcome Found Antiprotozoal agents
GB8500292D0 (en) * 1985-01-07 1985-02-13 Wellcome Found Treatment of babesiosis
DE3801743A1 (de) * 1987-07-03 1989-01-19 Bayer Ag Schaedlingsbekaempfungsmittel auf basis von substituierten 1,4-naphthochinonen und neue substituierte 1,4-naphthochinone

Also Published As

Publication number Publication date
AU3994889A (en) 1990-02-22
LV11273A (lv) 1996-06-20
HU208624B (en) 1993-12-28
LV11273B (en) 1996-10-20
PT91456B (pt) 1996-06-28
HUT57041A (en) 1991-11-28
CA1329621C (en) 1994-05-17
DE68914930D1 (de) 1994-06-01
IE65715B1 (en) 1995-11-15
PT101734B (pt) 1997-08-29
DE68914930T2 (de) 1994-08-18
CY1863A (en) 1996-04-05
DE68928964D1 (de) 1999-05-06
PT101734A (pt) 1996-01-31
IL91308A (en) 1994-07-31
FI893835A (fi) 1990-02-17
DK399989D0 (da) 1989-08-15
ES2052012T3 (es) 1994-07-01
PT91456A (pt) 1990-03-08
EP0362996B1 (en) 1994-04-27
ES2130199T3 (es) 1999-07-01
MX9202995A (es) 1992-07-01
IL91308A0 (en) 1990-03-19
EP0362996A3 (en) 1992-04-15
EP0580185A1 (en) 1994-01-26
DK399989A (da) 1990-02-17
NZ230313A (en) 1992-07-28
EP0580185B1 (en) 1999-03-31
IE892616L (en) 1990-02-16
EP0362996A2 (en) 1990-04-11
JPH0291037A (ja) 1990-03-30
SG23618G (en) 1995-09-18
SA95160138B1 (ar) 2006-03-15
AU633836B2 (en) 1993-02-11
DE68928964T2 (de) 1999-07-29
FI893835A0 (fi) 1989-08-15
HU911004D0 (en) 1991-10-28
JP2804302B2 (ja) 1998-09-24
ATE178311T1 (de) 1999-04-15
HK103395A (en) 1995-07-07

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