DK175316B1 - System til transmucosal indgivelse af den aktive bestanddel af et lægemiddel - Google Patents

System til transmucosal indgivelse af den aktive bestanddel af et lægemiddel Download PDF

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Publication number
DK175316B1
DK175316B1 DK198905837A DK583789A DK175316B1 DK 175316 B1 DK175316 B1 DK 175316B1 DK 198905837 A DK198905837 A DK 198905837A DK 583789 A DK583789 A DK 583789A DK 175316 B1 DK175316 B1 DK 175316B1
Authority
DK
Denmark
Prior art keywords
insulin
microspheres
administration
drug
nasal
Prior art date
Application number
DK198905837A
Other languages
Danish (da)
English (en)
Other versions
DK583789D0 (da
DK583789A (da
Inventor
Lisbeth Illum
Original Assignee
West Pharm Serv Drug Res Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by West Pharm Serv Drug Res Ltd filed Critical West Pharm Serv Drug Res Ltd
Publication of DK583789D0 publication Critical patent/DK583789D0/da
Publication of DK583789A publication Critical patent/DK583789A/da
Application granted granted Critical
Publication of DK175316B1 publication Critical patent/DK175316B1/da

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0043—Nose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1658—Proteins, e.g. albumin, gelatin

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Otolaryngology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
DK198905837A 1987-05-22 1989-11-21 System til transmucosal indgivelse af den aktive bestanddel af et lægemiddel DK175316B1 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB878712176A GB8712176D0 (en) 1987-05-22 1987-05-22 Drug delivery system
GB8712176 1987-05-22
PCT/GB1988/000396 WO1988009163A1 (fr) 1987-05-22 1988-05-20 Systeme d'administration d'un medicament facilitant sa fixattion
GB8800396 1988-05-20

Publications (3)

Publication Number Publication Date
DK583789D0 DK583789D0 (da) 1989-11-21
DK583789A DK583789A (da) 1990-01-18
DK175316B1 true DK175316B1 (da) 2004-08-16

Family

ID=10617794

Family Applications (1)

Application Number Title Priority Date Filing Date
DK198905837A DK175316B1 (da) 1987-05-22 1989-11-21 System til transmucosal indgivelse af den aktive bestanddel af et lægemiddel

Country Status (10)

Country Link
EP (1) EP0391896B1 (fr)
JP (1) JP2914670B2 (fr)
AU (1) AU614290B2 (fr)
CA (1) CA1324079C (fr)
DE (1) DE3888201T2 (fr)
DK (1) DK175316B1 (fr)
FI (1) FI97444C (fr)
GB (2) GB8712176D0 (fr)
NO (1) NO178564C (fr)
WO (1) WO1988009163A1 (fr)

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US6024983A (en) * 1986-10-24 2000-02-15 Southern Research Institute Composition for delivering bioactive agents for immune response and its preparation
US5075109A (en) * 1986-10-24 1991-12-24 Southern Research Institute Method of potentiating an immune response
US5298243A (en) * 1988-10-20 1994-03-29 Denki Kagaku Kogyo Kabushiki Kaisha Colony stimulating factor-gelatin conjugate
ATE138071T1 (de) * 1989-02-17 1996-06-15 Liposome Co Inc Lipidhilfstoffe für verabreichung durch die nase und örtliche anwendung
US5554388A (en) * 1989-02-25 1996-09-10 Danbiosyst Uk Limited Systemic drug delivery compositions comprising a polycationi substance
CA2013225A1 (fr) * 1989-03-29 1990-09-29 Tai-Lee Ke Utilisation de monoacyl phosphoglycerides pour favoriser la penetration de medicaments ophtalmiques dans la cornee
US5725871A (en) * 1989-08-18 1998-03-10 Danbiosyst Uk Limited Drug delivery compositions comprising lysophosphoglycerolipid
GB8918879D0 (en) * 1989-08-18 1989-09-27 Danbiosyst Uk Pharmaceutical compositions
GB2237510B (en) * 1989-11-04 1993-09-15 Danbiosyst Uk Small particle drug compositions for nasal administration
US5707644A (en) * 1989-11-04 1998-01-13 Danbiosyst Uk Limited Small particle compositions for intranasal drug delivery
GB9001635D0 (en) * 1990-01-24 1990-03-21 Ganderton David Aerosol carriers
GB9012663D0 (en) * 1990-06-07 1990-08-01 Erba Carlo Spa Galenic formulations containing cyclodextrins
DK49791D0 (da) * 1991-03-20 1991-03-20 Novo Nordisk As Nasalt pulverpraeparat
IT1247472B (it) * 1991-05-31 1994-12-17 Fidia Spa Processo per la preparazione di microsfere contenenti componenti biologicamente attivi.
CA2094217A1 (fr) * 1992-04-17 1993-10-18 Yasutaka Igari Composition therapeutique transmucosale
WO1994012158A1 (fr) * 1992-12-02 1994-06-09 Alkermes Controlled Therapeutics, Inc. Microspheres contenant une hormone de croissance a liberation regulee
US5549908A (en) * 1993-05-20 1996-08-27 The University Of Akron Hydrolytically labile microspheres of polysaccharide crosslinked with cyanogen halide and their application in wound dressings
IS1796B (is) * 1993-06-24 2001-12-31 Ab Astra Fjölpeptíð lyfjablanda til innöndunar sem einnig inniheldur eykjaefnasamband
US6632456B1 (en) 1993-06-24 2003-10-14 Astrazeneca Ab Compositions for inhalation
TW402506B (en) * 1993-06-24 2000-08-21 Astra Ab Therapeutic preparation for inhalation
US5506203C1 (en) * 1993-06-24 2001-02-06 Astra Ab Systemic administration of a therapeutic preparation
US5830853A (en) * 1994-06-23 1998-11-03 Astra Aktiebolag Systemic administration of a therapeutic preparation
US5747445A (en) * 1993-06-24 1998-05-05 Astra Aktiebolag Therapeutic preparation for inhalation
SE9303574D0 (sv) * 1993-11-01 1993-11-01 Kabi Pharmacia Ab Composition for drug delivery and method the manufacturing thereof
US6165976A (en) 1994-06-23 2000-12-26 Astra Aktiebolag Therapeutic preparation for inhalation
US6524557B1 (en) 1994-12-22 2003-02-25 Astrazeneca Ab Aerosol formulations of peptides and proteins
CN1170527C (zh) 1994-12-22 2004-10-13 阿斯特拉公司 含有甲状旁腺激素(pth)的吸入用治疗剂
GB9522351D0 (en) * 1995-11-01 1996-01-03 Medeva Holdings Bv Vaccine compositions
US6652837B1 (en) 1996-05-24 2003-11-25 Massachusetts Institute Of Technology Preparation of novel particles for inhalation
US5985309A (en) * 1996-05-24 1999-11-16 Massachusetts Institute Of Technology Preparation of particles for inhalation
US5874064A (en) 1996-05-24 1999-02-23 Massachusetts Institute Of Technology Aerodynamically light particles for pulmonary drug delivery
GB9700624D0 (en) 1997-01-14 1997-03-05 Danbiosyst Uk Drug delivery composition
US6391452B1 (en) 1997-07-18 2002-05-21 Bayer Corporation Compositions for nasal drug delivery, methods of making same, and methods of removing residual solvent from pharmaceutical preparations
US6309623B1 (en) 1997-09-29 2001-10-30 Inhale Therapeutic Systems, Inc. Stabilized preparations for use in metered dose inhalers
US6433040B1 (en) 1997-09-29 2002-08-13 Inhale Therapeutic Systems, Inc. Stabilized bioactive preparations and methods of use
US6565885B1 (en) 1997-09-29 2003-05-20 Inhale Therapeutic Systems, Inc. Methods of spray drying pharmaceutical compositions
US20060165606A1 (en) 1997-09-29 2006-07-27 Nektar Therapeutics Pulmonary delivery particles comprising water insoluble or crystalline active agents
JP2000290184A (ja) * 1999-04-01 2000-10-17 Kyowa Hakko Kogyo Co Ltd 経鼻投与製剤
AU2001231000A1 (en) * 2000-01-19 2001-07-31 Pharmaceutical Discovery Corporation Dry powder formulations of antihistamine for nasal administration
ES2525087T5 (es) 2000-05-10 2018-06-28 Novartis Ag Polvos basados en fosfolípidos para administración de fármacos
US7871598B1 (en) 2000-05-10 2011-01-18 Novartis Ag Stable metal ion-lipid powdered pharmaceutical compositions for drug delivery and methods of use
US8404217B2 (en) 2000-05-10 2013-03-26 Novartis Ag Formulation for pulmonary administration of antifungal agents, and associated methods of manufacture and use
GB0027357D0 (en) 2000-11-09 2000-12-27 Bradford Particle Design Plc Particle formation methods and their products
WO2003026699A1 (fr) * 2001-09-26 2003-04-03 Tanabe Seiyaku Co., Ltd. Compositions medicinales favorisant l'absorption de medicaments
US7368102B2 (en) 2001-12-19 2008-05-06 Nektar Therapeutics Pulmonary delivery of aminoglycosides
US9339459B2 (en) 2003-04-24 2016-05-17 Nektar Therapeutics Particulate materials
NL1022442C2 (nl) * 2003-01-20 2004-07-22 Tno Toepassing van lipide ter verbetring van de opname van nutrienten en (farmaceutisch) actieve stoffen.
JP4493594B2 (ja) * 2003-03-04 2010-06-30 田辺三菱製薬株式会社 粉末経鼻投与製剤
EP1643970A2 (fr) * 2003-06-09 2006-04-12 Nastech Pharmaceutical Company Inc. Compositions et procedes d'une meilleure administration d'hormone de croissance par voie muqueuse
US9808030B2 (en) 2011-02-11 2017-11-07 Grain Processing Corporation Salt composition
AU2015208699B2 (en) 2014-01-27 2019-06-13 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd Nanoencapsulation of hydrophilic active compounds

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3681500A (en) * 1969-12-12 1972-08-01 Boehringer Sohn Ingelheim Spray compositions for treatment of obstructive disorders of the respiratory tract and methods therefor
JPS59163313A (ja) * 1983-03-09 1984-09-14 Teijin Ltd 経鼻投与用ペプチドホルモン類組成物
GB8514090D0 (en) * 1985-06-04 1985-07-10 Sandoz Ltd Organic compounds
JP2765700B2 (ja) * 1986-08-11 1998-06-18 イノベータ・バイオメド・リミテツド マイクロカプセルを含有する医薬調合物

Also Published As

Publication number Publication date
EP0391896B1 (fr) 1994-03-02
FI97444C (fi) 1996-12-27
GB2231495B (en) 1991-08-28
AU1793188A (en) 1988-12-21
GB8712176D0 (en) 1987-06-24
WO1988009163A1 (fr) 1988-12-01
NO178564C (no) 1996-04-24
NO890283D0 (no) 1989-01-23
DE3888201T2 (de) 1994-07-14
EP0391896A1 (fr) 1990-10-17
GB2231495A (en) 1990-11-21
NO890283L (no) 1989-01-23
NO178564B (no) 1996-01-15
FI895555A0 (fi) 1989-11-21
AU614290B2 (en) 1991-08-29
JP2914670B2 (ja) 1999-07-05
DK583789D0 (da) 1989-11-21
JPH02503915A (ja) 1990-11-15
DK583789A (da) 1990-01-18
FI97444B (fi) 1996-09-13
CA1324079C (fr) 1993-11-09
DE3888201D1 (de) 1994-04-07
GB8924696D0 (en) 1990-09-05

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