DK1751105T3 - Piperazinderivater af alkyloxindoler - Google Patents

Piperazinderivater af alkyloxindoler

Info

Publication number
DK1751105T3
DK1751105T3 DK05745440T DK05745440T DK1751105T3 DK 1751105 T3 DK1751105 T3 DK 1751105T3 DK 05745440 T DK05745440 T DK 05745440T DK 05745440 T DK05745440 T DK 05745440T DK 1751105 T3 DK1751105 T3 DK 1751105T3
Authority
DK
Denmark
Prior art keywords
alkyloxindoles
piperazine derivatives
derivatives
cadiovascular
prophylaxis
Prior art date
Application number
DK05745440T
Other languages
Danish (da)
English (en)
Inventor
Balazs Volk
Jozsef Barkeczy
Gyula Simig
Tibor Mezei
Dezsofi Rita Kapillerne
Istvan Gacsalyi
Katalin Pallagi
Gabor Gigler
Gyoergy Levay
Krisztina Mericz
Csilla Leveleki
Nora Sziray
Gabor Szenasi
Andras Egyed
Laszlo Gabor Harsing Laszlo Gabor Harsing
Original Assignee
Egis Gyogyszergyar Nyrt
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Egis Gyogyszergyar Nyrt filed Critical Egis Gyogyszergyar Nyrt
Application granted granted Critical
Publication of DK1751105T3 publication Critical patent/DK1751105T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/34—Oxygen atoms in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychiatry (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Hospice & Palliative Care (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
DK05745440T 2004-05-11 2005-05-11 Piperazinderivater af alkyloxindoler DK1751105T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HU0400953A HUP0400953A3 (en) 2004-05-11 2004-05-11 Piperazine derivatives of alkyl-oxindoles, pharmaceutical compositions containing them, process for producing them and their use
PCT/HU2005/000050 WO2005108364A1 (fr) 2004-05-11 2005-05-11 Derives de piperazine d'alkyl oxindoles

Publications (1)

Publication Number Publication Date
DK1751105T3 true DK1751105T3 (da) 2009-03-09

Family

ID=89982207

Family Applications (1)

Application Number Title Priority Date Filing Date
DK05745440T DK1751105T3 (da) 2004-05-11 2005-05-11 Piperazinderivater af alkyloxindoler

Country Status (27)

Country Link
US (1) US7910591B2 (fr)
EP (1) EP1751105B1 (fr)
JP (1) JP2007537227A (fr)
CN (1) CN101010296B (fr)
AT (1) ATE412633T1 (fr)
AU (1) AU2005240843B2 (fr)
BG (1) BG109769A (fr)
CA (1) CA2566096A1 (fr)
CZ (1) CZ2006779A3 (fr)
DE (1) DE602005010693D1 (fr)
DK (1) DK1751105T3 (fr)
EA (1) EA010789B1 (fr)
ES (1) ES2319795T3 (fr)
HR (1) HRP20060420A2 (fr)
HU (1) HUP0400953A3 (fr)
IL (1) IL179028A (fr)
MX (1) MXPA06013068A (fr)
NO (1) NO20065609L (fr)
NZ (1) NZ551545A (fr)
PL (2) PL381615A1 (fr)
PT (1) PT1751105E (fr)
RS (1) RS20060621A (fr)
SI (1) SI1751105T1 (fr)
SK (1) SK51102006A3 (fr)
UA (1) UA84927C2 (fr)
WO (1) WO2005108364A1 (fr)
ZA (1) ZA200610345B (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUP0400953A3 (en) * 2004-05-11 2008-02-28 Egis Gyogyszergyar Nyilvanosan Piperazine derivatives of alkyl-oxindoles, pharmaceutical compositions containing them, process for producing them and their use
CN104163813B (zh) * 2013-05-16 2017-02-01 广东东阳光药业有限公司 取代的吲哚化合物及其使用方法和用途
US10316025B2 (en) 2015-06-03 2019-06-11 Sunshine Lake Pharma Co., Ltd. Substituted piperazine compounds and methods of use and use thereof

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4452808A (en) * 1982-12-07 1984-06-05 Smithkline Beckman Corporation 4-Aminoalkyl-2(3H)-indolones
MX173362B (es) * 1987-03-02 1994-02-23 Pfizer Compuestos de piperazinil heterociclicos y procedimiento para su preparacion
FR2635104B1 (fr) 1988-08-03 1992-04-30 Synthelabo Derives d'indolone, leur preparation et leur application en therapeutique
GB8830312D0 (en) * 1988-12-28 1989-02-22 Lundbeck & Co As H Heterocyclic compounds
WO1998008816A1 (fr) * 1996-08-26 1998-03-05 Meiji Seika Kaisha, Ltd. Derives d'indoxyle et psychotropes
HUP0400953A3 (en) * 2004-05-11 2008-02-28 Egis Gyogyszergyar Nyilvanosan Piperazine derivatives of alkyl-oxindoles, pharmaceutical compositions containing them, process for producing them and their use

Also Published As

Publication number Publication date
US20080161323A1 (en) 2008-07-03
RS20060621A (en) 2008-09-29
EP1751105B1 (fr) 2008-10-29
CN101010296B (zh) 2011-08-17
HRP20060420A2 (en) 2007-04-30
ES2319795T3 (es) 2009-05-12
PT1751105E (pt) 2009-02-10
US7910591B2 (en) 2011-03-22
EP1751105A1 (fr) 2007-02-14
CA2566096A1 (fr) 2005-11-17
MXPA06013068A (es) 2007-05-04
HU0400953D0 (en) 2004-07-28
NZ551545A (en) 2010-07-30
SK51102006A3 (sk) 2007-05-03
BG109769A (bg) 2008-03-31
AU2005240843A1 (en) 2005-11-17
IL179028A0 (en) 2007-03-08
CZ2006779A3 (cs) 2007-03-07
AU2005240843B2 (en) 2012-02-02
JP2007537227A (ja) 2007-12-20
ZA200610345B (en) 2008-05-28
EA200602084A1 (ru) 2007-04-27
NO20065609L (no) 2007-02-05
CN101010296A (zh) 2007-08-01
HUP0400953A2 (en) 2007-09-28
EA010789B1 (ru) 2008-10-30
HUP0400953A3 (en) 2008-02-28
PL1751105T3 (pl) 2009-07-31
UA84927C2 (en) 2008-12-10
PL381615A1 (pl) 2007-06-11
WO2005108364A1 (fr) 2005-11-17
SI1751105T1 (sl) 2009-06-30
DE602005010693D1 (de) 2008-12-11
IL179028A (en) 2011-08-31
ATE412633T1 (de) 2008-11-15

Similar Documents

Publication Publication Date Title
ATE406351T1 (de) Kondensierte heteroyralderivate zur verwendung als p38-kinase-inhibitoren
GEP20084550B (en) Substituted morpholine compounds for the treatment of central nervous system disorders
TW200736233A (en) Cyclohexyl piperazinyl methanone derivatives
ATE450530T1 (de) Zusammensetzungen zur verwendung als protein- kinase-inhibitoren
EA201190158A1 (ru) Производные бензофуранила для применения в качестве ингибиторов глюкокиназы
NO20082026L (no) Deazapuriner som er nyttige som inhibitorer for Janus-kinaser
ATE553093T1 (de) Indazolderivate zur hemmung von trpv1 und verwendungen davon
CY1111733T1 (el) Παραγωγα 2-(1η-ινδολυλοσουλφανυλ)-βενζυλαμινης ως ssri
ATE413392T1 (de) Kondensierte heteroyralderivate und deren verwendung als p38-kinase-inhibitoren
DE602006017574D1 (de) Als protein-kinase-inhibitoren nutzbare benzimidazole
NI200700032A (es) Derivados arilsulfonilestilbeno para tratamiento de insomnio y afecciones relacionadas
MX2010005047A (es) Inhibidores de aldh-2 en el tratamiento de enfermedades psiquiatricas.
DK1853581T3 (da) 2-Sulfinyl- og 2-sulfonyl-substituerede imidazolderivater og deres anvendelse som cytokininhibitorer
DK1751105T3 (da) Piperazinderivater af alkyloxindoler
UA94054C2 (en) Nitrocatechol derivatives as comt inhibitors
EA200801240A1 (ru) Новые способы получения производных циклопропиламида
ATE532514T1 (de) Piperidin- und piperazinderivate
EA200602081A1 (ru) Пиридиновые производные алкилоксиндолов в качестве агентов, активных в отношении рецептора 5-нт7
ATE534638T1 (de) Piperazin-derivate
ATE412634T1 (de) Piperazinderivate von alkyloxindolen
ATE423772T1 (de) Morpholinderivate als inhibitoren der wiederaufnahme von norepinephrin
DE602004005863D1 (de) 4-arylsulphonylpiperidin-derivate als 5-ht2a -rezeptor antagonisten
DOP2005000168A (es) Derivados arilsulfonilestilbeno para tratamiento de insomnio y afecciones relacionadas
UA110108C2 (xx) Азетидинові похідні піперидин-4-ілу як інгібітори jak1
UA106617C2 (uk) N-(ГЕТЕРО)АРИЛПІРОЛІДИНОВІ ПОХІДНІ ПІРАЗОЛ-4-ІЛПІРОЛО[2,3-d]ПІРИМІДИНІВ І ПІРОЛ-3-ІЛПІРОЛО[2,3-d]ПІРИМІДИНІВ ЯК ІНГІБІТОРИ ЯНУС-КІНАЗИ