DK174627B1 - Forbindelse, farmaceutisk præparat, lægemiddel og anvendelse af 3'-deoxythymidin-2'-en til fremstilling af et farmaceutisk præparat til behandling af retrovirusinfektioner - Google Patents

Forbindelse, farmaceutisk præparat, lægemiddel og anvendelse af 3'-deoxythymidin-2'-en til fremstilling af et farmaceutisk præparat til behandling af retrovirusinfektioner Download PDF

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Publication number
DK174627B1
DK174627B1 DK198705570A DK557087A DK174627B1 DK 174627 B1 DK174627 B1 DK 174627B1 DK 198705570 A DK198705570 A DK 198705570A DK 557087 A DK557087 A DK 557087A DK 174627 B1 DK174627 B1 DK 174627B1
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DK
Denmark
Prior art keywords
pharmaceutical composition
deoxythymidin
compound
treatment
retrovirus
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Application number
DK198705570A
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Danish (da)
English (en)
Other versions
DK557087A (da
DK557087D0 (da
Inventor
Tai-Shun Lin
William H Prunsoff
Original Assignee
Univ Yale
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Application filed by Univ Yale filed Critical Univ Yale
Publication of DK557087D0 publication Critical patent/DK557087D0/da
Publication of DK557087A publication Critical patent/DK557087A/da
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Publication of DK174627B1 publication Critical patent/DK174627B1/da

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Virology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DK198705570A 1986-12-17 1987-10-23 Forbindelse, farmaceutisk præparat, lægemiddel og anvendelse af 3'-deoxythymidin-2'-en til fremstilling af et farmaceutisk præparat til behandling af retrovirusinfektioner DK174627B1 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US94266686 1986-12-17
US06/942,666 US4978655A (en) 1986-12-17 1986-12-17 Use of 3'-deoxythymidin-2'-ene (3'deoxy-2',3'-didehydrothymidine) in treating patients infected with retroviruses

Publications (3)

Publication Number Publication Date
DK557087D0 DK557087D0 (da) 1987-10-23
DK557087A DK557087A (da) 1988-06-18
DK174627B1 true DK174627B1 (da) 2003-07-28

Family

ID=25478432

Family Applications (1)

Application Number Title Priority Date Filing Date
DK198705570A DK174627B1 (da) 1986-12-17 1987-10-23 Forbindelse, farmaceutisk præparat, lægemiddel og anvendelse af 3'-deoxythymidin-2'-en til fremstilling af et farmaceutisk præparat til behandling af retrovirusinfektioner

Country Status (22)

Country Link
US (1) US4978655A (xx)
EP (1) EP0273277B1 (xx)
JP (1) JPH07116041B2 (xx)
KR (1) KR960000433B1 (xx)
AT (1) ATE77554T1 (xx)
AU (1) AU593405B2 (xx)
CA (1) CA1293447C (xx)
DE (1) DE3780016T2 (xx)
DK (1) DK174627B1 (xx)
EG (1) EG19157A (xx)
ES (1) ES2038650T3 (xx)
FI (1) FI875544A (xx)
GR (1) GR3005691T3 (xx)
HK (1) HK55896A (xx)
IE (1) IE60866B1 (xx)
IL (1) IL84790A (xx)
LU (1) LU88822I2 (xx)
NL (1) NL960024I2 (xx)
NZ (1) NZ222935A (xx)
PH (1) PH26380A (xx)
PT (1) PT86346B (xx)
ZA (1) ZA877171B (xx)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5631370A (en) * 1988-01-20 1997-05-20 Regents Of The University Of Minnesota Optically-active isomers of dideoxycarbocyclic nucleosides
US5175292A (en) * 1988-01-20 1992-12-29 Regents Of The University Of Minnesota Intermediates for the preparation of dideoxycarbocyclic nucleosides
FI95269C (fi) * 1989-05-15 1996-01-10 Squibb Bristol Myers Co 2',3'-dideoksi-inosiinimonohydraatin, 2',3'-dideoksi-2',3'-didehydrot ymidiinimonohydraatin ja 2',3'-dideoksi-2'-fluori-inosiinihemihydraatin antiviraalisia, hyvin vesiliukoisia, stabiileja, kiteisiä suoloja
US6207650B1 (en) 1989-05-15 2001-03-27 Bristol-Myers Squibb Company Antiviral, highly water soluble, stable, crystalline salts of 2′, 3′-dideoxyinosine, 2′, 3′-dideoxy-2′, 3′-didehydrothymidine and 2′, 3′-dideoxy-2′-fluoroinosine
US5608048A (en) * 1995-06-05 1997-03-04 Bristol-Myers Squibb Company d4 T polymorphic Form 1 process
US5840711A (en) * 1995-06-21 1998-11-24 University Of Kentucky Research Foundation Compositions containing lithium inorganic salts and anti-viral drugs and method of treating viral infections such as acquired immunodeficiency syndrome
CA2189097A1 (en) 1995-11-15 1997-05-16 Pin-Fang Lin Composition and method of treating retroviral infection
US5719132A (en) * 1996-06-27 1998-02-17 Bristol-Myers Squibb Company Compositions and methods of treating HIV with d4T, 5-fluorouracil/tegafur, and uracil
WO2000016625A1 (en) * 1998-09-23 2000-03-30 University Of Kentucky Research Foundation Antiviral drug compositions containing lithium inorganic salts
AU2001249591A1 (en) 2000-03-30 2001-10-15 Bristol-Myers Squibb Company Sustained release beadlets containing stavudine
KR20040088519A (ko) 2002-02-22 2004-10-16 뉴 리버 파마슈티칼스, 인크. 활성 제제 전달 시스템 및 활성 제제의 보호 및 투여 방법
MXPA05008736A (es) * 2003-02-19 2005-10-05 Univ Yale Analogos de nucleosido antivirales y metodos para tratar infecciones virales, especialmente infecciones por vih.
US20040200730A1 (en) * 2003-04-14 2004-10-14 Kyo Jibiki Hydrometallurgical copper recovery process
ES2363160T3 (es) 2004-07-27 2011-07-22 Gilead Sciences, Inc. Conjugados de fosfonato nucelosidico como agentes anti-vih.
US20080241265A1 (en) * 2005-08-31 2008-10-02 Amar Lulla Pharmaceutical Combinations Containing Lamivudine, Stavudine and Nevirapine
CN103497192B (zh) 2008-12-09 2015-09-23 吉里德科学公司 Toll样受体调节剂
US20110223131A1 (en) 2010-02-24 2011-09-15 Gilead Sciences, Inc. Antiviral compounds
WO2016001907A1 (en) 2014-07-02 2016-01-07 Prendergast Patrick T Mogroside iv and mogroside v as agonist/stimulator/un-blocking agent for toll-like receptor 4 and adjuvant for use in human/animal vaccine and to stimulate immunity against disease agents.
WO2016007765A1 (en) 2014-07-11 2016-01-14 Gilead Sciences, Inc. Modulators of toll-like receptors for the treatment of hiv
JP2018527366A (ja) 2015-09-15 2018-09-20 ギリアード サイエンシーズ， インコーポレイテッド ＨＩＶを処置するためのｔｏｌｌ様レセプターのモジュレーター

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3322747A (en) * 1965-04-01 1967-05-30 Merck & Co Inc Thionocarbonate nucleosides
US3817982A (en) * 1971-12-29 1974-06-18 Syntex Inc 2{40 ,3{40 -unsaturated nucleosides and method of making
GB1523865A (en) * 1974-09-02 1978-09-06 Wellcome Found Purine compunds and salts thereof
JPS5943550B2 (ja) * 1975-08-29 1984-10-23 田辺製薬株式会社 不飽和ヌクレオシドの製法
DE3515870A1 (de) * 1985-05-03 1986-11-06 Bayer Ag, 5090 Leverkusen Verfahren zur herstellung von 5-fluortoluol-2,4-disulfochlorid
US4710492A (en) * 1986-06-23 1987-12-01 Yale University 3'-azido-2',3'-dideoxy-5-halouridine and its use in treating patients infected with retroviruses
NL8700089A (nl) * 1987-01-15 1988-08-01 Stichting Rega V Z W Therapeutische toepassing van dideoxythymidine en dideoxythymidineen.
DE3806633A1 (de) * 1987-09-01 1989-03-09 Bayer Ag Antivirales mittel
JP2648329B2 (ja) * 1987-09-18 1997-08-27 エフ・ホフマン−ラ ロシュ アーゲー エイズの予防または治療用医薬組成物
SE8704298D0 (sv) * 1987-11-03 1987-11-03 Astra Ab Compounds for use in therapy
JPH0227782A (ja) * 1988-07-15 1990-01-30 Hikari Gijutsu Kenkyu Kaihatsu Kk 半導体発光素子
JPH0438727A (ja) * 1990-06-04 1992-02-07 Sharp Corp 光学式ピックアップ装置の対物レンズ塵埃付着防止機構

Also Published As

Publication number Publication date
NL960024I2 (nl) 1997-06-02
LU88822I2 (fr) 1997-01-06
PT86346B (pt) 1990-11-07
ATE77554T1 (de) 1992-07-15
IL84790A0 (en) 1988-05-31
GR3005691T3 (xx) 1993-06-07
DK557087A (da) 1988-06-18
IE60866B1 (en) 1994-08-24
JPS63215632A (ja) 1988-09-08
EG19157A (en) 1994-09-29
IL84790A (en) 1993-03-15
AU8090087A (en) 1988-06-23
AU593405B2 (en) 1990-02-08
CA1293447C (en) 1991-12-24
KR880007079A (ko) 1988-08-26
DE3780016T2 (de) 1992-12-24
ZA877171B (en) 1988-03-24
PT86346A (en) 1988-01-01
EP0273277B1 (en) 1992-06-24
DK557087D0 (da) 1987-10-23
JPH07116041B2 (ja) 1995-12-13
NZ222935A (en) 1990-09-26
KR960000433B1 (ko) 1996-01-06
HK55896A (en) 1996-04-03
ES2038650T3 (es) 1993-08-01
US4978655A (en) 1990-12-18
IE873245L (en) 1988-06-17
DE3780016D1 (de) 1992-07-30
PH26380A (en) 1992-06-01
FI875544A (fi) 1988-06-18
EP0273277A3 (en) 1989-09-13
NL960024I1 (nl) 1996-12-02
FI875544A0 (fi) 1987-12-16
EP0273277A2 (en) 1988-07-06

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