FI875544A - Anvaendning av 3'-deoxitymidin-2'-en (3'-deoxi-2',3'-didehydrotymidin) foer behandling av patienter infekterade med retrovirus. - Google Patents

Anvaendning av 3'-deoxitymidin-2'-en (3'-deoxi-2',3'-didehydrotymidin) foer behandling av patienter infekterade med retrovirus. Download PDF

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Publication number
FI875544A
FI875544A FI875544A FI875544A FI875544A FI 875544 A FI875544 A FI 875544A FI 875544 A FI875544 A FI 875544A FI 875544 A FI875544 A FI 875544A FI 875544 A FI875544 A FI 875544A
Authority
FI
Finland
Prior art keywords
retrovirus
deoxy
patienter
infekterade
didehydrotymidine
Prior art date
Application number
FI875544A
Other languages
English (en)
Other versions
FI875544A0 (fi
Inventor
Tai-Shun Lin
William H Prusoff
Original Assignee
Univ Yale
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
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Application filed by Univ Yale filed Critical Univ Yale
Publication of FI875544A0 publication Critical patent/FI875544A0/fi
Publication of FI875544A publication Critical patent/FI875544A/fi

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
FI875544A 1986-12-17 1987-12-16 Anvaendning av 3'-deoxitymidin-2'-en (3'-deoxi-2',3'-didehydrotymidin) foer behandling av patienter infekterade med retrovirus. FI875544A (fi)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/942,666 US4978655A (en) 1986-12-17 1986-12-17 Use of 3'-deoxythymidin-2'-ene (3'deoxy-2',3'-didehydrothymidine) in treating patients infected with retroviruses

Publications (2)

Publication Number Publication Date
FI875544A0 FI875544A0 (fi) 1987-12-16
FI875544A true FI875544A (fi) 1988-06-18

Family

ID=25478432

Family Applications (1)

Application Number Title Priority Date Filing Date
FI875544A FI875544A (fi) 1986-12-17 1987-12-16 Anvaendning av 3'-deoxitymidin-2'-en (3'-deoxi-2',3'-didehydrotymidin) foer behandling av patienter infekterade med retrovirus.

Country Status (22)

Country Link
US (1) US4978655A (fi)
EP (1) EP0273277B1 (fi)
JP (1) JPH07116041B2 (fi)
KR (1) KR960000433B1 (fi)
AT (1) ATE77554T1 (fi)
AU (1) AU593405B2 (fi)
CA (1) CA1293447C (fi)
DE (1) DE3780016T2 (fi)
DK (1) DK174627B1 (fi)
EG (1) EG19157A (fi)
ES (1) ES2038650T3 (fi)
FI (1) FI875544A (fi)
GR (1) GR3005691T3 (fi)
HK (1) HK55896A (fi)
IE (1) IE60866B1 (fi)
IL (1) IL84790A (fi)
LU (1) LU88822I2 (fi)
NL (1) NL960024I2 (fi)
NZ (1) NZ222935A (fi)
PH (1) PH26380A (fi)
PT (1) PT86346B (fi)
ZA (1) ZA877171B (fi)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5175292A (en) * 1988-01-20 1992-12-29 Regents Of The University Of Minnesota Intermediates for the preparation of dideoxycarbocyclic nucleosides
US5631370A (en) * 1988-01-20 1997-05-20 Regents Of The University Of Minnesota Optically-active isomers of dideoxycarbocyclic nucleosides
FI95269C (fi) * 1989-05-15 1996-01-10 Squibb Bristol Myers Co 2',3'-dideoksi-inosiinimonohydraatin, 2',3'-dideoksi-2',3'-didehydrot ymidiinimonohydraatin ja 2',3'-dideoksi-2'-fluori-inosiinihemihydraatin antiviraalisia, hyvin vesiliukoisia, stabiileja, kiteisiä suoloja
US6207650B1 (en) 1989-05-15 2001-03-27 Bristol-Myers Squibb Company Antiviral, highly water soluble, stable, crystalline salts of 2′, 3′-dideoxyinosine, 2′, 3′-dideoxy-2′, 3′-didehydrothymidine and 2′, 3′-dideoxy-2′-fluoroinosine
US5608048A (en) * 1995-06-05 1997-03-04 Bristol-Myers Squibb Company d4 T polymorphic Form 1 process
US5840711A (en) * 1995-06-21 1998-11-24 University Of Kentucky Research Foundation Compositions containing lithium inorganic salts and anti-viral drugs and method of treating viral infections such as acquired immunodeficiency syndrome
CA2189097A1 (en) 1995-11-15 1997-05-16 Pin-Fang Lin Composition and method of treating retroviral infection
US5719132A (en) * 1996-06-27 1998-02-17 Bristol-Myers Squibb Company Compositions and methods of treating HIV with d4T, 5-fluorouracil/tegafur, and uracil
WO2000016625A1 (en) * 1998-09-23 2000-03-30 University Of Kentucky Research Foundation Antiviral drug compositions containing lithium inorganic salts
US7135465B2 (en) 2000-03-30 2006-11-14 Bristol-Myers Squibb Company Sustained release beadlets containing stavudine
JP4625637B2 (ja) 2002-02-22 2011-02-02 シャイア エルエルシー 活性物質送達系及び活性物質を保護し投与する方法
CN102174038A (zh) 2003-02-19 2011-09-07 耶鲁大学 用于治疗病毒感染的抗病毒核苷
US20040200730A1 (en) * 2003-04-14 2004-10-14 Kyo Jibiki Hydrometallurgical copper recovery process
SI2258376T1 (sl) 2004-07-27 2019-04-30 Gilead Sciences, Inc. Analogi fosfonata spojin inhibitorjev HIV
US20080241265A1 (en) * 2005-08-31 2008-10-02 Amar Lulla Pharmaceutical Combinations Containing Lamivudine, Stavudine and Nevirapine
JP5600116B2 (ja) 2008-12-09 2014-10-01 ギリアード サイエンシーズ， インコーポレイテッド Ｔｏｌｌ様受容体のモジュレーター
US20110223131A1 (en) 2010-02-24 2011-09-15 Gilead Sciences, Inc. Antiviral compounds
WO2016001907A1 (en) 2014-07-02 2016-01-07 Prendergast Patrick T Mogroside iv and mogroside v as agonist/stimulator/un-blocking agent for toll-like receptor 4 and adjuvant for use in human/animal vaccine and to stimulate immunity against disease agents.
CN113577081A (zh) 2014-07-11 2021-11-02 吉利德科学公司 用于治疗hiv的toll样受体调节剂
CA2997955A1 (en) 2015-09-15 2017-03-23 Gilead Sciences, Inc. Modulators of toll-like receptors for the treatment of hiv

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3322747A (en) * 1965-04-01 1967-05-30 Merck & Co Inc Thionocarbonate nucleosides
US3817982A (en) * 1971-12-29 1974-06-18 Syntex Inc 2{40 ,3{40 -unsaturated nucleosides and method of making
GB1523865A (en) * 1974-09-02 1978-09-06 Wellcome Found Purine compunds and salts thereof
JPS5943550B2 (ja) * 1975-08-29 1984-10-23 田辺製薬株式会社 不飽和ヌクレオシドの製法
DE3515870A1 (de) * 1985-05-03 1986-11-06 Bayer Ag, 5090 Leverkusen Verfahren zur herstellung von 5-fluortoluol-2,4-disulfochlorid
US4710492A (en) * 1986-06-23 1987-12-01 Yale University 3'-azido-2',3'-dideoxy-5-halouridine and its use in treating patients infected with retroviruses
NL8700089A (nl) * 1987-01-15 1988-08-01 Stichting Rega V Z W Therapeutische toepassing van dideoxythymidine en dideoxythymidineen.
DE3806633A1 (de) * 1987-09-01 1989-03-09 Bayer Ag Antivirales mittel
JP2648329B2 (ja) * 1987-09-18 1997-08-27 エフ・ホフマン−ラ ロシュ アーゲー エイズの予防または治療用医薬組成物
SE8704298D0 (sv) * 1987-11-03 1987-11-03 Astra Ab Compounds for use in therapy
JPH0227782A (ja) * 1988-07-15 1990-01-30 Hikari Gijutsu Kenkyu Kaihatsu Kk 半導体発光素子
JPH0438727A (ja) * 1990-06-04 1992-02-07 Sharp Corp 光学式ピックアップ装置の対物レンズ塵埃付着防止機構

Also Published As

Publication number Publication date
EG19157A (en) 1994-09-29
ES2038650T3 (es) 1993-08-01
EP0273277A3 (en) 1989-09-13
AU8090087A (en) 1988-06-23
JPS63215632A (ja) 1988-09-08
KR880007079A (ko) 1988-08-26
PH26380A (en) 1992-06-01
HK55896A (en) 1996-04-03
GR3005691T3 (fi) 1993-06-07
EP0273277A2 (en) 1988-07-06
EP0273277B1 (en) 1992-06-24
DK174627B1 (da) 2003-07-28
PT86346A (en) 1988-01-01
IE873245L (en) 1988-06-17
IE60866B1 (en) 1994-08-24
FI875544A0 (fi) 1987-12-16
DE3780016T2 (de) 1992-12-24
ZA877171B (en) 1988-03-24
NZ222935A (en) 1990-09-26
ATE77554T1 (de) 1992-07-15
IL84790A0 (en) 1988-05-31
LU88822I2 (fr) 1997-01-06
DK557087D0 (da) 1987-10-23
IL84790A (en) 1993-03-15
DK557087A (da) 1988-06-18
NL960024I1 (nl) 1996-12-02
DE3780016D1 (de) 1992-07-30
KR960000433B1 (ko) 1996-01-06
US4978655A (en) 1990-12-18
AU593405B2 (en) 1990-02-08
JPH07116041B2 (ja) 1995-12-13
CA1293447C (en) 1991-12-24
NL960024I2 (nl) 1997-06-02
PT86346B (pt) 1990-11-07

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BB Publication of examined application
FD Application lapsed

Owner name: YALE UNIVERSITY