DK1739178T3 - Levering af trekløverpeptider - Google Patents

Levering af trekløverpeptider

Info

Publication number
DK1739178T3
DK1739178T3 DK06021747.8T DK06021747T DK1739178T3 DK 1739178 T3 DK1739178 T3 DK 1739178T3 DK 06021747 T DK06021747 T DK 06021747T DK 1739178 T3 DK1739178 T3 DK 1739178T3
Authority
DK
Denmark
Prior art keywords
trefoil peptide
gastro
strain
present
delivering
Prior art date
Application number
DK06021747.8T
Other languages
English (en)
Inventor
Wolfgang Christian Hans
Lothar Steidler
Erik Rene Remaut
Original Assignee
Actogenix Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Actogenix Nv filed Critical Actogenix Nv
Application granted granted Critical
Publication of DK1739178T3 publication Critical patent/DK1739178T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • C12N15/746—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for lactic acid bacteria (Streptococcus; Lactococcus; Lactobacillus; Pediococcus; Enterococcus; Leuconostoc; Propionibacterium; Bifidobacterium; Sporolactobacillus)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Endocrinology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
DK06021747.8T 1999-07-05 2000-07-05 Levering af trekløverpeptider DK1739178T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP99870143 1999-07-05
EP00954434A EP1194554B1 (en) 1999-07-05 2000-07-05 Delivery of trefoil peptides

Publications (1)

Publication Number Publication Date
DK1739178T3 true DK1739178T3 (da) 2010-11-22

Family

ID=8243867

Family Applications (2)

Application Number Title Priority Date Filing Date
DK00954434T DK1194554T3 (da) 1999-07-05 2000-07-05 Administration af treklöverpeptider
DK06021747.8T DK1739178T3 (da) 1999-07-05 2000-07-05 Levering af trekløverpeptider

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DK00954434T DK1194554T3 (da) 1999-07-05 2000-07-05 Administration af treklöverpeptider

Country Status (11)

Country Link
US (3) US7220418B1 (da)
EP (2) EP1194554B1 (da)
JP (1) JP4644401B2 (da)
AT (2) ATE480623T1 (da)
AU (1) AU781679B2 (da)
CA (1) CA2377107C (da)
DE (2) DE60031405T2 (da)
DK (2) DK1194554T3 (da)
ES (2) ES2272311T3 (da)
PT (2) PT1194554E (da)
WO (1) WO2001002570A1 (da)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6525018B1 (en) 1999-05-17 2003-02-25 The General Hospital Corp. Treating eye disorders using intestinal trefoil proteins
EP1194554B1 (en) * 1999-07-05 2006-10-18 Vlaams Interuniversitair Instituut voor Biotechnologie Delivery of trefoil peptides
US7538082B2 (en) 2001-04-24 2009-05-26 The General Hospital Corporation Methods and compositions for treating oral and esophageal lesions
EP1842858A3 (en) 2001-04-24 2008-04-02 The General Hospital Corporation Methods and compositions for treating oral and esophageal lesions
JP2005524641A (ja) * 2002-02-11 2005-08-18 ノボ　ノルディスク　アクティーゼルスカブ Ｔｆｆモノマーペプチドによる粘膜の粘性の管理
EP1494530A4 (en) * 2002-03-26 2009-06-24 Gen Hospital Corp COMBINATION THERAPY WITH CLEEPEPTIDES
US7829079B2 (en) * 2002-03-28 2010-11-09 Christian Hansen A/S Lactobacillus iners for the enhancement of urogenital health
JP2006516964A (ja) * 2002-10-31 2006-07-13 ザ ジーアイ カンパニー インコーポレーティッド 三つ葉型ドメイン含有ポリペプチドおよびその使用
EP1789529B1 (en) 2004-08-20 2013-10-02 Actogenix N.V. Method to improve lactococcus preservation
RU2420569C2 (ru) 2005-11-29 2011-06-10 Актогеникс Нв Индукция толерантности к антигенам через слизистую
US8278094B2 (en) 2005-12-14 2012-10-02 The Invention Science Fund I, Llc Bone semi-permeable device
US20110183319A1 (en) * 2010-01-22 2011-07-28 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Compositions and methods for therapeutic delivery with microorganisms
US8682619B2 (en) * 2005-12-14 2014-03-25 The Invention Science Fund I, Llc Device including altered microorganisms, and methods and systems of use
US8734823B2 (en) * 2005-12-14 2014-05-27 The Invention Science Fund I, Llc Device including altered microorganisms, and methods and systems of use
US20110172826A1 (en) * 2005-12-14 2011-07-14 Amodei Dario G Device including altered microorganisms, and methods and systems of use
AU2007247137A1 (en) 2006-05-02 2007-11-15 Actogenix N.V. Microbial intestinal delivery of obesity related peptides
KR101557509B1 (ko) * 2007-01-12 2015-10-06 액토제닉스 엔.브이. 락토코커스 프로모터 및 그것의 용도
EP2774621B1 (en) 2007-01-25 2018-01-24 Intrexon Actobiotics NV Treatment of immune disease by mucosal delivery of antigens
EP2164512A2 (en) * 2007-06-20 2010-03-24 Actogenix N.V. Methods and compositions for treating mucositis
DK3181682T3 (da) 2008-09-29 2021-07-05 Intrexon Actobiotics Nv Reduceret kolonisering af mikrober på slimhinden
DK2424972T3 (da) 2009-04-30 2013-10-14 Actogenix Nv Kryobeskyttende midler til frysetørring af mælkesyrebakterier
US20100310514A1 (en) * 2009-06-04 2010-12-09 Chi Hin Cho Anti-Inflammatory Bacteria
EP2275527A1 (en) 2009-07-17 2011-01-19 ActoGeniX NV Animal component-free culture medium for bacterial fermentation
EP2483409B1 (en) 2009-09-29 2017-03-22 Intrexon Actobiotics NV LACTOBACILLUS glyceraldehyde-3-phosphate dehydrogenase PROMOTERS AND USES THEREOF
RU2766157C2 (ru) 2011-06-01 2022-02-08 Интрексон Актобиотикс Н.В. Система полицистронной экспрессии для бактерий
DK2758513T3 (da) 2011-09-23 2018-07-23 Intrexon Actobiotics Nv Modifiecerede grampositive bakterier og anvendelser deraf
ES2676707T3 (es) 2011-09-23 2018-07-24 Intrexon Actobiotics Nv Bacterias gram positivas modificadas y usos de las mismas
US9452205B2 (en) * 2012-09-24 2016-09-27 Montana State University Recombinant Lactococcus lactis expressing Escherichia coli colonization factor antigen I (CFA/I) fimbriae and their methods of use
JP6581208B2 (ja) 2014-12-23 2019-09-25 イリヤ ファーマ エービー 創傷治癒の方法
CN108883140A (zh) 2016-01-14 2018-11-23 英特瑞克斯顿阿克图比奥帝克斯有限公司 治疗1型糖尿病的组合物和方法
CN109983028B (zh) 2016-09-13 2023-10-20 英特瑞克斯顿阿克图比奥帝克斯有限公司 黏膜黏附性微生物
KR102251294B1 (ko) * 2018-11-06 2021-05-12 주식회사 메디뉴트롤 락토바실러스 살리바리우스 v133 균주의 사균체를 유효성분으로 함유하는 알코올성 위염의 예방, 개선 또는 치료용 조성물

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0075594A1 (en) * 1981-03-31 1983-04-06 SILK, David B. A. Glucose polymers and method of producing same
CA2104104A1 (en) * 1991-02-14 1992-09-03 Daniel K. Podolsky Intestinal trefoil proteins
US6221840B1 (en) * 1991-02-14 2001-04-24 The General Hospital Corporation Intestinal trefoil proteins
GB2278358B (en) * 1992-02-27 1995-07-26 Lynxvale Ltd Heterologous gene expression in Lactococcus,and the expression products therefrom
US7226761B2 (en) * 1992-11-05 2007-06-05 Danisco Sweeteners Oy Manufacture of five-carbon sugars and sugar alcohols
IT1270123B (it) * 1994-10-05 1997-04-28 Dompe Spa Composizioni farmaceutiche contenenti microorganismi ingegnerizzati e loro uso per terapia
GB9518323D0 (en) * 1995-09-07 1995-11-08 Steidler Lothar Materials and methods relating to the attachment and display of substances on cell surfaces
GB9521568D0 (en) * 1995-10-20 1995-12-20 Lynxvale Ltd Delivery of biologically active polypeptides
AU770726B2 (en) * 1998-10-20 2004-02-26 Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw Use of a cytokine-producing lactococcus strain to treat colitis
EP1194554B1 (en) * 1999-07-05 2006-10-18 Vlaams Interuniversitair Instituut voor Biotechnologie Delivery of trefoil peptides
EP1084709A1 (en) * 1999-09-17 2001-03-21 Nederlandse Organisatie Voor Toegepast-Natuurwetenschappelijk Onderzoek Tno Oral recombinant lactobacilli vaccines

Also Published As

Publication number Publication date
PT1194554E (pt) 2007-01-31
JP4644401B2 (ja) 2011-03-02
PT1739178E (pt) 2010-11-17
US7592013B2 (en) 2009-09-22
DK1194554T3 (da) 2007-01-29
DE60044957D1 (de) 2010-10-21
US20070110723A1 (en) 2007-05-17
EP1739178A2 (en) 2007-01-03
CA2377107C (en) 2013-04-23
JP2003504025A (ja) 2003-02-04
AU6689200A (en) 2001-01-22
EP1194554A1 (en) 2002-04-10
CA2377107A1 (en) 2001-01-11
ES2351349T3 (es) 2011-02-03
WO2001002570A1 (en) 2001-01-11
EP1739178B1 (en) 2010-09-08
US20070122427A1 (en) 2007-05-31
AU781679B2 (en) 2005-06-09
US7220418B1 (en) 2007-05-22
DE60031405D1 (de) 2006-11-30
DE60031405T2 (de) 2007-08-16
ATE342983T1 (de) 2006-11-15
EP1739178A3 (en) 2008-12-31
ES2272311T3 (es) 2007-05-01
ATE480623T1 (de) 2010-09-15
EP1194554B1 (en) 2006-10-18

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