DE60044957D1 - Bereitstellung von Peptiden mit Kleeblattstruktur - Google Patents

Bereitstellung von Peptiden mit Kleeblattstruktur

Info

Publication number
DE60044957D1
DE60044957D1 DE60044957T DE60044957T DE60044957D1 DE 60044957 D1 DE60044957 D1 DE 60044957D1 DE 60044957 T DE60044957 T DE 60044957T DE 60044957 T DE60044957 T DE 60044957T DE 60044957 D1 DE60044957 D1 DE 60044957D1
Authority
DE
Germany
Prior art keywords
trefoil peptide
gastro
strain
present
delivering
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60044957T
Other languages
English (en)
Inventor
Wolfgang Christian Hans
Lothar Steidler
Erik Rene Remaut
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Intrexon Actobiotics NV
Original Assignee
Actogenix NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Actogenix NV filed Critical Actogenix NV
Application granted granted Critical
Publication of DE60044957D1 publication Critical patent/DE60044957D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • C12N15/746—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for lactic acid bacteria (Streptococcus; Lactococcus; Lactobacillus; Pediococcus; Enterococcus; Leuconostoc; Propionibacterium; Bifidobacterium; Sporolactobacillus)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Toxicology (AREA)
  • Endocrinology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
DE60044957T 1999-07-05 2000-07-05 Bereitstellung von Peptiden mit Kleeblattstruktur Expired - Lifetime DE60044957D1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP99870143 1999-07-05

Publications (1)

Publication Number Publication Date
DE60044957D1 true DE60044957D1 (de) 2010-10-21

Family

ID=8243867

Family Applications (2)

Application Number Title Priority Date Filing Date
DE60031405T Expired - Lifetime DE60031405T2 (de) 1999-07-05 2000-07-05 Bereitstellung von peptiden mit kleeblattstruktur
DE60044957T Expired - Lifetime DE60044957D1 (de) 1999-07-05 2000-07-05 Bereitstellung von Peptiden mit Kleeblattstruktur

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE60031405T Expired - Lifetime DE60031405T2 (de) 1999-07-05 2000-07-05 Bereitstellung von peptiden mit kleeblattstruktur

Country Status (11)

Country Link
US (3) US7220418B1 (de)
EP (2) EP1739178B1 (de)
JP (1) JP4644401B2 (de)
AT (2) ATE342983T1 (de)
AU (1) AU781679B2 (de)
CA (1) CA2377107C (de)
DE (2) DE60031405T2 (de)
DK (2) DK1194554T3 (de)
ES (2) ES2351349T3 (de)
PT (2) PT1739178E (de)
WO (1) WO2001002570A1 (de)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6525018B1 (en) 1999-05-17 2003-02-25 The General Hospital Corp. Treating eye disorders using intestinal trefoil proteins
CA2377107C (en) * 1999-07-05 2013-04-23 Wolfgang Christian Hans Delivery of trefoil peptides
EP1842858A3 (de) 2001-04-24 2008-04-02 The General Hospital Corporation Verfahren und Zusammensetzungen zur Behandlung von Verletzungen des Mundes und der Speiseröhre
US7538082B2 (en) 2001-04-24 2009-05-26 The General Hospital Corporation Methods and compositions for treating oral and esophageal lesions
WO2003068817A1 (en) * 2002-02-11 2003-08-21 Novo Nordisk A/S Management of mucosal viscosity by tff monomer peptides
CN1655675A (zh) * 2002-03-26 2005-08-17 综合医院公司 利用三叶肽的联合治疗
WO2003082306A1 (en) * 2002-03-28 2003-10-09 Gregor Reid Lactobacillus iners for the enhancement of urogenital health
WO2004039961A2 (en) * 2002-10-31 2004-05-13 The Gi Company, Inc. Trefoil domain-containing polypeptides and uses thereof
EP1789529B1 (de) 2004-08-20 2013-10-02 Actogenix N.V. Verfahren zur verbesserung der aufbewahrung von lactococcus
RU2420569C2 (ru) 2005-11-29 2011-06-10 Актогеникс Нв Индукция толерантности к антигенам через слизистую
US8734823B2 (en) * 2005-12-14 2014-05-27 The Invention Science Fund I, Llc Device including altered microorganisms, and methods and systems of use
US8278094B2 (en) 2005-12-14 2012-10-02 The Invention Science Fund I, Llc Bone semi-permeable device
US20110172826A1 (en) * 2005-12-14 2011-07-14 Amodei Dario G Device including altered microorganisms, and methods and systems of use
US20110182859A1 (en) * 2010-01-22 2011-07-28 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Compositions and methods for therapeutic delivery with microorganisms
US8682619B2 (en) * 2005-12-14 2014-03-25 The Invention Science Fund I, Llc Device including altered microorganisms, and methods and systems of use
BRPI0711119A2 (pt) * 2006-05-02 2011-08-30 Actogenix Nv administração microbiana de peptìdeos intestinais associados à obesidade
EP2115146B1 (de) * 2007-01-12 2016-07-06 Intrexon Actobiotics NV Lactococcus-promotoren und verwendungen davon
BRPI0807857A2 (pt) 2007-01-25 2014-05-27 Actogenix Nv Tratamento de doença imune por meio de distribuição através da mucosa de antígenos.
EP2164512A2 (de) * 2007-06-20 2010-03-24 Actogenix N.V. Verfahren und zusammensetzungen zur behandlung von mucositis
EP3181682B1 (de) 2008-09-29 2021-04-21 Intrexon Actobiotics NV Reduzierte mikrobenkolonisierung an der schleimhaut
WO2010124855A1 (en) 2009-04-30 2010-11-04 Actogenix Nv Cryoprotectants for freeze drying of lactic acid bacteria
WO2010139195A1 (en) * 2009-06-04 2010-12-09 The Chinese University Of Hong Kong Anti-inflammatory bacteria
EP2275527A1 (de) 2009-07-17 2011-01-19 ActoGeniX NV Kulturmedium zur Fermentation von Bakterien welches frei von tierischen Bestandteilen ist
US20120183503A1 (en) 2009-09-29 2012-07-19 Actogenix N.V. Lactobacillus and streptococcus promoters and uses thereof
RU2644346C2 (ru) 2011-06-01 2018-02-08 Интрексон Актобиотикс Н.В. Система полицистронной экспрессии для бактерий
DK2758512T3 (en) 2011-09-23 2018-07-23 Intrexon Actobiotics Nv MODIFIED GRAM POSITIVE BACTERIES AND APPLICATIONS THEREOF
KR102028771B1 (ko) 2011-09-23 2019-10-04 인트랙슨 액토바이오틱스 엔.브이. 변형된 그람 양성 박테리아 및 그 사용 방법
WO2014047625A1 (en) * 2012-09-24 2014-03-27 Montana State University Recombinant lactococcus lactis expressing escherichia coli colonization factor antigen i (cfa/i) fimbriae and their methods of use
JP6581208B2 (ja) 2014-12-23 2019-09-25 イリヤ ファーマ エービー 創傷治癒の方法
CA3011331A1 (en) 2016-01-14 2017-07-20 Intrexon Actobiotics N.V. Compositions and methods for the treatment of type 1 diabetes
KR102348734B1 (ko) 2016-09-13 2022-01-07 인트랙슨 액토바이오틱스 엔.브이. 점막부착성 미생물
KR102251294B1 (ko) * 2018-11-06 2021-05-12 주식회사 메디뉴트롤 락토바실러스 살리바리우스 v133 균주의 사균체를 유효성분으로 함유하는 알코올성 위염의 예방, 개선 또는 치료용 조성물

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0075594A1 (de) * 1981-03-31 1983-04-06 SILK, David B. A. Glukosepolymere, sowie verfahren zur herstellung derselben
US6221840B1 (en) 1991-02-14 2001-04-24 The General Hospital Corporation Intestinal trefoil proteins
WO1992014837A1 (en) * 1991-02-14 1992-09-03 The General Hospital Corporation Intestinal trefoil proteins
CA2130453A1 (en) * 1992-02-27 1993-09-02 Richard W. F. Le Page Heterologous gene expression in lactococcus, and the expression products threrefrom
US7226761B2 (en) 1992-11-05 2007-06-05 Danisco Sweeteners Oy Manufacture of five-carbon sugars and sugar alcohols
IT1270123B (it) * 1994-10-05 1997-04-28 Dompe Spa Composizioni farmaceutiche contenenti microorganismi ingegnerizzati e loro uso per terapia
GB9518323D0 (en) 1995-09-07 1995-11-08 Steidler Lothar Materials and methods relating to the attachment and display of substances on cell surfaces
GB9521568D0 (en) * 1995-10-20 1995-12-20 Lynxvale Ltd Delivery of biologically active polypeptides
WO2000023471A2 (en) * 1998-10-20 2000-04-27 Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw Use of a cytokine-producing lactococcus strain to treat colitis
CA2377107C (en) * 1999-07-05 2013-04-23 Wolfgang Christian Hans Delivery of trefoil peptides
EP1084709A1 (de) * 1999-09-17 2001-03-21 Nederlandse Organisatie Voor Toegepast-Natuurwetenschappelijk Onderzoek Tno Oraler Impfstoff enthaltend rekombinanten Lactobacilli

Also Published As

Publication number Publication date
EP1194554B1 (de) 2006-10-18
EP1739178A2 (de) 2007-01-03
PT1739178E (pt) 2010-11-17
JP4644401B2 (ja) 2011-03-02
US20070110723A1 (en) 2007-05-17
CA2377107C (en) 2013-04-23
CA2377107A1 (en) 2001-01-11
EP1194554A1 (de) 2002-04-10
DE60031405D1 (de) 2006-11-30
EP1739178A3 (de) 2008-12-31
AU6689200A (en) 2001-01-22
US7592013B2 (en) 2009-09-22
ATE342983T1 (de) 2006-11-15
US7220418B1 (en) 2007-05-22
AU781679B2 (en) 2005-06-09
DE60031405T2 (de) 2007-08-16
WO2001002570A1 (en) 2001-01-11
US20070122427A1 (en) 2007-05-31
PT1194554E (pt) 2007-01-31
ES2272311T3 (es) 2007-05-01
DK1739178T3 (da) 2010-11-22
ES2351349T3 (es) 2011-02-03
ATE480623T1 (de) 2010-09-15
DK1194554T3 (da) 2007-01-29
EP1739178B1 (de) 2010-09-08
JP2003504025A (ja) 2003-02-04

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