ATE480623T1 - Bereitstellung von peptiden mit kleeblattstruktur - Google Patents

Bereitstellung von peptiden mit kleeblattstruktur

Info

Publication number
ATE480623T1
ATE480623T1 AT06021747T AT06021747T ATE480623T1 AT E480623 T1 ATE480623 T1 AT E480623T1 AT 06021747 T AT06021747 T AT 06021747T AT 06021747 T AT06021747 T AT 06021747T AT E480623 T1 ATE480623 T1 AT E480623T1
Authority
AT
Austria
Prior art keywords
trefoil peptide
gastro
strain
present
delivering
Prior art date
Application number
AT06021747T
Other languages
English (en)
Inventor
Wolfgang Christian Hans
Lothar Steidler
Erik Rene Remaut
Original Assignee
Actogenix Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Actogenix Nv filed Critical Actogenix Nv
Application granted granted Critical
Publication of ATE480623T1 publication Critical patent/ATE480623T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • C12N15/746—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for lactic acid bacteria (Streptococcus; Lactococcus; Lactobacillus; Pediococcus; Enterococcus; Leuconostoc; Propionibacterium; Bifidobacterium; Sporolactobacillus)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Endocrinology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
AT06021747T 1999-07-05 2000-07-05 Bereitstellung von peptiden mit kleeblattstruktur ATE480623T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP99870143 1999-07-05

Publications (1)

Publication Number Publication Date
ATE480623T1 true ATE480623T1 (de) 2010-09-15

Family

ID=8243867

Family Applications (2)

Application Number Title Priority Date Filing Date
AT00954434T ATE342983T1 (de) 1999-07-05 2000-07-05 Bereitstellung von peptiden mit kleeblattstruktur
AT06021747T ATE480623T1 (de) 1999-07-05 2000-07-05 Bereitstellung von peptiden mit kleeblattstruktur

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AT00954434T ATE342983T1 (de) 1999-07-05 2000-07-05 Bereitstellung von peptiden mit kleeblattstruktur

Country Status (11)

Country Link
US (3) US7220418B1 (de)
EP (2) EP1739178B1 (de)
JP (1) JP4644401B2 (de)
AT (2) ATE342983T1 (de)
AU (1) AU781679B2 (de)
CA (1) CA2377107C (de)
DE (2) DE60031405T2 (de)
DK (2) DK1194554T3 (de)
ES (2) ES2272311T3 (de)
PT (2) PT1194554E (de)
WO (1) WO2001002570A1 (de)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6525018B1 (en) 1999-05-17 2003-02-25 The General Hospital Corp. Treating eye disorders using intestinal trefoil proteins
DK1194554T3 (da) * 1999-07-05 2007-01-29 Vlaams Interuniv Inst Biotech Administration af treklöverpeptider
EP1842858A3 (de) 2001-04-24 2008-04-02 The General Hospital Corporation Verfahren und Zusammensetzungen zur Behandlung von Verletzungen des Mundes und der Speiseröhre
US7538082B2 (en) 2001-04-24 2009-05-26 The General Hospital Corporation Methods and compositions for treating oral and esophageal lesions
WO2003068817A1 (en) * 2002-02-11 2003-08-21 Novo Nordisk A/S Management of mucosal viscosity by tff monomer peptides
MXPA04009363A (es) * 2002-03-26 2005-01-25 Gen Hospital Corp Terapia de combinacion usando peptidos trifolios.
WO2003082306A1 (en) * 2002-03-28 2003-10-09 Gregor Reid Lactobacillus iners for the enhancement of urogenital health
WO2004039961A2 (en) * 2002-10-31 2004-05-13 The Gi Company, Inc. Trefoil domain-containing polypeptides and uses thereof
US9200249B2 (en) 2004-08-20 2015-12-01 Actogenix N.V. Method to improve Lactococcus preservation
RU2420569C2 (ru) 2005-11-29 2011-06-10 Актогеникс Нв Индукция толерантности к антигенам через слизистую
US8682619B2 (en) * 2005-12-14 2014-03-25 The Invention Science Fund I, Llc Device including altered microorganisms, and methods and systems of use
US8278094B2 (en) 2005-12-14 2012-10-02 The Invention Science Fund I, Llc Bone semi-permeable device
US8734823B2 (en) * 2005-12-14 2014-05-27 The Invention Science Fund I, Llc Device including altered microorganisms, and methods and systems of use
US20110183351A1 (en) * 2010-01-22 2011-07-28 Hyde Roderick A Compositions and methods for therapeutic delivery with microorganisms
US20110172826A1 (en) * 2005-12-14 2011-07-14 Amodei Dario G Device including altered microorganisms, and methods and systems of use
JP2009535380A (ja) * 2006-05-02 2009-10-01 アクトジェニックス・エヌブイ 肥満関連ペプチドの微生物性腸送達
US8759088B2 (en) 2007-01-12 2014-06-24 Actogenix N.V. Lactococcus promoters and uses thereof
ES2666658T3 (es) 2007-01-25 2018-05-07 Intrexon Actobiotics Nv Tratamiento de enfermedad inmune mediante suministro a la mucosa de antígenos
US20100178273A1 (en) * 2007-06-20 2010-07-15 Actogenix Nv Corporation Methods and compositions for treating mucositis
EP3933029A3 (de) 2008-09-29 2022-03-23 Intrexon Actobiotics NV Reduzierte mikrobenkolonisierung an der schleimhaut
DK2424972T3 (da) 2009-04-30 2013-10-14 Actogenix Nv Kryobeskyttende midler til frysetørring af mælkesyrebakterier
WO2010139195A1 (en) * 2009-06-04 2010-12-09 The Chinese University Of Hong Kong Anti-inflammatory bacteria
EP2275527A1 (de) 2009-07-17 2011-01-19 ActoGeniX NV Kulturmedium zur Fermentation von Bakterien welches frei von tierischen Bestandteilen ist
US20120183503A1 (en) 2009-09-29 2012-07-19 Actogenix N.V. Lactobacillus and streptococcus promoters and uses thereof
DK2714912T3 (en) 2011-06-01 2018-08-13 Intrexon Actobiotics Nv POLYCISTRONIC EXPRESSION SYSTEM FOR BACTERIA
JP6117212B2 (ja) 2011-09-23 2017-04-19 イントレクソン・アクトバイオテイクス・エヌブイＩｎｔｒｅｘｏｎ Ａｃｔｏｂｉｏｔｉｃｓ ＮＶ 改変されたグラム陽性菌及びその使用
JP6329903B2 (ja) 2011-09-23 2018-05-23 イントレクソン・アクトバイオテイクス・エヌブイＩｎｔｒｅｘｏｎ Ａｃｔｏｂｉｏｔｉｃｓ ＮＶ 改変されたグラム陽性菌及びその使用
EP2897638A1 (de) 2012-09-24 2015-07-29 Montana State University-Bozeman Rekombinanter lactococcus lactis zur expression des escherichia coli-kolonisationsfaktor-antigens i (cfa/i) fimbriae und verfahren zu deren verwendung
KR102297619B1 (ko) 2014-12-23 2021-09-02 일리야 팔마 에이비 상처 치유 방법
CA3011331C (en) 2016-01-14 2025-05-13 Intrexon Actobiotics N.V. COMPOSITIONS AND TREATMENT METHODS FOR TYPE 1 DIABETES
KR102348734B1 (ko) 2016-09-13 2022-01-07 인트랙슨 액토바이오틱스 엔.브이. 점막부착성 미생물
KR102251294B1 (ko) * 2018-11-06 2021-05-12 주식회사 메디뉴트롤 락토바실러스 살리바리우스 v133 균주의 사균체를 유효성분으로 함유하는 알코올성 위염의 예방, 개선 또는 치료용 조성물
EP4331597A3 (de) * 2019-02-07 2024-05-15 The General Hospital Corporation Carotinoide zur behandlung oder vorbeugung von übelkeit

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1982003329A1 (en) * 1981-03-31 1982-10-14 David B A Silk Glucose polymers and method of producing same
US6221840B1 (en) * 1991-02-14 2001-04-24 The General Hospital Corporation Intestinal trefoil proteins
WO1992014837A1 (en) 1991-02-14 1992-09-03 The General Hospital Corporation Intestinal trefoil proteins
HK1005465A1 (en) * 1992-02-27 1999-01-08 Microbial Technics Limited Heterologous gene expression in lactococcus, and the expression products therefrom
US7226761B2 (en) 1992-11-05 2007-06-05 Danisco Sweeteners Oy Manufacture of five-carbon sugars and sugar alcohols
IT1270123B (it) * 1994-10-05 1997-04-28 Dompe Spa Composizioni farmaceutiche contenenti microorganismi ingegnerizzati e loro uso per terapia
GB9518323D0 (en) * 1995-09-07 1995-11-08 Steidler Lothar Materials and methods relating to the attachment and display of substances on cell surfaces
GB9521568D0 (en) * 1995-10-20 1995-12-20 Lynxvale Ltd Delivery of biologically active polypeptides
AU770726B2 (en) * 1998-10-20 2004-02-26 Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw Use of a cytokine-producing lactococcus strain to treat colitis
DK1194554T3 (da) * 1999-07-05 2007-01-29 Vlaams Interuniv Inst Biotech Administration af treklöverpeptider
EP1084709A1 (de) * 1999-09-17 2001-03-21 Nederlandse Organisatie Voor Toegepast-Natuurwetenschappelijk Onderzoek Tno Oraler Impfstoff enthaltend rekombinanten Lactobacilli

Also Published As

Publication number Publication date
PT1194554E (pt) 2007-01-31
DK1194554T3 (da) 2007-01-29
EP1739178B1 (de) 2010-09-08
AU781679B2 (en) 2005-06-09
WO2001002570A1 (en) 2001-01-11
CA2377107A1 (en) 2001-01-11
DE60044957D1 (de) 2010-10-21
PT1739178E (pt) 2010-11-17
US7220418B1 (en) 2007-05-22
ATE342983T1 (de) 2006-11-15
DK1739178T3 (da) 2010-11-22
US20070122427A1 (en) 2007-05-31
JP4644401B2 (ja) 2011-03-02
CA2377107C (en) 2013-04-23
EP1194554A1 (de) 2002-04-10
EP1739178A3 (de) 2008-12-31
US7592013B2 (en) 2009-09-22
DE60031405D1 (de) 2006-11-30
US20070110723A1 (en) 2007-05-17
JP2003504025A (ja) 2003-02-04
EP1739178A2 (de) 2007-01-03
DE60031405T2 (de) 2007-08-16
ES2272311T3 (es) 2007-05-01
EP1194554B1 (de) 2006-10-18
AU6689200A (en) 2001-01-22
ES2351349T3 (es) 2011-02-03

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