ATE342983T1 - Bereitstellung von peptiden mit kleeblattstruktur - Google Patents

Bereitstellung von peptiden mit kleeblattstruktur

Info

Publication number
ATE342983T1
ATE342983T1 AT00954434T AT00954434T ATE342983T1 AT E342983 T1 ATE342983 T1 AT E342983T1 AT 00954434 T AT00954434 T AT 00954434T AT 00954434 T AT00954434 T AT 00954434T AT E342983 T1 ATE342983 T1 AT E342983T1
Authority
AT
Austria
Prior art keywords
trefoil peptide
gastro
strain
present
delivering
Prior art date
Application number
AT00954434T
Other languages
English (en)
Inventor
Wolfgang Christian Hans
Lothar Steidler
Erik Rene Remaut
Original Assignee
Vlaams Interuniv Inst Biotech
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vlaams Interuniv Inst Biotech filed Critical Vlaams Interuniv Inst Biotech
Application granted granted Critical
Publication of ATE342983T1 publication Critical patent/ATE342983T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • C12N15/746—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for lactic acid bacteria (Streptococcus; Lactococcus; Lactobacillus; Pediococcus; Enterococcus; Leuconostoc; Propionibacterium; Bifidobacterium; Sporolactobacillus)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Physics & Mathematics (AREA)
  • Toxicology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Endocrinology (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
AT00954434T 1999-07-05 2000-07-05 Bereitstellung von peptiden mit kleeblattstruktur ATE342983T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP99870143 1999-07-05

Publications (1)

Publication Number Publication Date
ATE342983T1 true ATE342983T1 (de) 2006-11-15

Family

ID=8243867

Family Applications (2)

Application Number Title Priority Date Filing Date
AT00954434T ATE342983T1 (de) 1999-07-05 2000-07-05 Bereitstellung von peptiden mit kleeblattstruktur
AT06021747T ATE480623T1 (de) 1999-07-05 2000-07-05 Bereitstellung von peptiden mit kleeblattstruktur

Family Applications After (1)

Application Number Title Priority Date Filing Date
AT06021747T ATE480623T1 (de) 1999-07-05 2000-07-05 Bereitstellung von peptiden mit kleeblattstruktur

Country Status (11)

Country Link
US (3) US7220418B1 (de)
EP (2) EP1739178B1 (de)
JP (1) JP4644401B2 (de)
AT (2) ATE342983T1 (de)
AU (1) AU781679B2 (de)
CA (1) CA2377107C (de)
DE (2) DE60031405T2 (de)
DK (2) DK1739178T3 (de)
ES (2) ES2351349T3 (de)
PT (2) PT1194554E (de)
WO (1) WO2001002570A1 (de)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6525018B1 (en) 1999-05-17 2003-02-25 The General Hospital Corp. Treating eye disorders using intestinal trefoil proteins
DK1739178T3 (da) * 1999-07-05 2010-11-22 Actogenix Nv Levering af trekløverpeptider
US7538082B2 (en) 2001-04-24 2009-05-26 The General Hospital Corporation Methods and compositions for treating oral and esophageal lesions
EP1842858A3 (de) 2001-04-24 2008-04-02 The General Hospital Corporation Verfahren und Zusammensetzungen zur Behandlung von Verletzungen des Mundes und der Speiseröhre
WO2003068817A1 (en) * 2002-02-11 2003-08-21 Novo Nordisk A/S Management of mucosal viscosity by tff monomer peptides
WO2003082196A2 (en) * 2002-03-26 2003-10-09 The General Hospital Corporation Combination therapy using trefoil peptides
WO2003082306A1 (en) * 2002-03-28 2003-10-09 Gregor Reid Lactobacillus iners for the enhancement of urogenital health
WO2004039961A2 (en) * 2002-10-31 2004-05-13 The Gi Company, Inc. Trefoil domain-containing polypeptides and uses thereof
ES2439698T3 (es) 2004-08-20 2014-01-24 Actogenix N.V. Procedimiento para mejorar la conservación de lactococos
EP1957100B1 (de) 2005-11-29 2016-07-13 Intrexon Actobiotics NV Induktion von schleimhauttoleranz gegen antigene
US8682619B2 (en) * 2005-12-14 2014-03-25 The Invention Science Fund I, Llc Device including altered microorganisms, and methods and systems of use
US8852916B2 (en) 2010-01-22 2014-10-07 The Invention Science Fund I, Llc Compositions and methods for therapeutic delivery with microorganisms
US8734823B2 (en) * 2005-12-14 2014-05-27 The Invention Science Fund I, Llc Device including altered microorganisms, and methods and systems of use
US8278094B2 (en) 2005-12-14 2012-10-02 The Invention Science Fund I, Llc Bone semi-permeable device
US20110172826A1 (en) * 2005-12-14 2011-07-14 Amodei Dario G Device including altered microorganisms, and methods and systems of use
BRPI0711119A2 (pt) * 2006-05-02 2011-08-30 Actogenix Nv administração microbiana de peptìdeos intestinais associados à obesidade
AU2008204442B2 (en) * 2007-01-12 2013-03-14 Intrexon Actobiotics Nv Lactococcus promoters and uses thereof
EP2125010B1 (de) 2007-01-25 2014-06-04 Actogenix N.V. Behandlung von immunkrankheiten durch mukosale abgabe von antigenen mit genetisch modifiziertem lactobacillus
CA2689658A1 (en) * 2007-06-20 2008-12-24 Actogenix Nv Methods and compositions for treating mucositis
JP2012504116A (ja) * 2008-09-29 2012-02-16 アクトジェニックス・エヌブイ 粘膜での微生物のコロニー形成の低減
DK2424972T3 (da) 2009-04-30 2013-10-14 Actogenix Nv Kryobeskyttende midler til frysetørring af mælkesyrebakterier
CN102459571B (zh) * 2009-06-04 2014-01-08 香港中文大学 抗炎细菌
EP2275527A1 (de) 2009-07-17 2011-01-19 ActoGeniX NV Kulturmedium zur Fermentation von Bakterien welches frei von tierischen Bestandteilen ist
EP3192873A1 (de) 2009-09-29 2017-07-19 Intrexon Actobiotics NV Promotoren von lactobacillus und streptococcus und ihre verwendung
JP6175428B2 (ja) 2011-06-01 2017-08-02 イントレクソン・アクトバイオテイクス・エヌブイＩｎｔｒｅｘｏｎ Ａｃｔｏｂｉｏｔｉｃｓ ＮＶ 細菌のポリシストロン性発現系
HUE038336T2 (hu) 2011-09-23 2018-10-29 Intrexon Actobiotics Nv Módosított gram-pozitív baktériumok és alkalmazásaik
ES2676707T3 (es) 2011-09-23 2018-07-24 Intrexon Actobiotics Nv Bacterias gram positivas modificadas y usos de las mismas
WO2014047625A1 (en) * 2012-09-24 2014-03-27 Montana State University Recombinant lactococcus lactis expressing escherichia coli colonization factor antigen i (cfa/i) fimbriae and their methods of use
EP3237622B1 (de) 2014-12-23 2021-02-24 Ilya Pharma AB Verfahren zur wundheilung
DK3402499T3 (da) 2016-01-14 2021-09-27 Intrexon Actobiotics Nv Sammensætninger og fremgangsmåder til behandlingen af type 1 diabetes
IL265177B1 (en) 2016-09-13 2024-09-01 Intrexon Actobiotics N V A microorganism that adheres to the mucosa
KR102251294B1 (ko) * 2018-11-06 2021-05-12 주식회사 메디뉴트롤 락토바실러스 살리바리우스 v133 균주의 사균체를 유효성분으로 함유하는 알코올성 위염의 예방, 개선 또는 치료용 조성물

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1982003329A1 (en) * 1981-03-31 1982-10-14 David B A Silk Glucose polymers and method of producing same
WO1992014837A1 (en) 1991-02-14 1992-09-03 The General Hospital Corporation Intestinal trefoil proteins
US6221840B1 (en) * 1991-02-14 2001-04-24 The General Hospital Corporation Intestinal trefoil proteins
WO1993017117A1 (en) * 1992-02-27 1993-09-02 Lynxvale Limited Heterologous gene expression in lactococcus, and the expression products therefrom
US7226761B2 (en) 1992-11-05 2007-06-05 Danisco Sweeteners Oy Manufacture of five-carbon sugars and sugar alcohols
IT1270123B (it) * 1994-10-05 1997-04-28 Dompe Spa Composizioni farmaceutiche contenenti microorganismi ingegnerizzati e loro uso per terapia
GB9518323D0 (en) * 1995-09-07 1995-11-08 Steidler Lothar Materials and methods relating to the attachment and display of substances on cell surfaces
GB9521568D0 (en) * 1995-10-20 1995-12-20 Lynxvale Ltd Delivery of biologically active polypeptides
DE69914932T2 (de) * 1998-10-20 2004-12-09 Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw. Verwendung eines zytokine-produzierenden lactococcus stammes zur behandlung von kolitis
DK1739178T3 (da) * 1999-07-05 2010-11-22 Actogenix Nv Levering af trekløverpeptider
EP1084709A1 (de) * 1999-09-17 2001-03-21 Nederlandse Organisatie Voor Toegepast-Natuurwetenschappelijk Onderzoek Tno Oraler Impfstoff enthaltend rekombinanten Lactobacilli

Also Published As

Publication number Publication date
US20070122427A1 (en) 2007-05-31
EP1739178B1 (de) 2010-09-08
DK1739178T3 (da) 2010-11-22
AU6689200A (en) 2001-01-22
US7592013B2 (en) 2009-09-22
CA2377107C (en) 2013-04-23
PT1739178E (pt) 2010-11-17
JP4644401B2 (ja) 2011-03-02
JP2003504025A (ja) 2003-02-04
EP1194554A1 (de) 2002-04-10
DK1194554T3 (da) 2007-01-29
PT1194554E (pt) 2007-01-31
DE60031405D1 (de) 2006-11-30
EP1739178A3 (de) 2008-12-31
US7220418B1 (en) 2007-05-22
DE60044957D1 (de) 2010-10-21
DE60031405T2 (de) 2007-08-16
WO2001002570A1 (en) 2001-01-11
US20070110723A1 (en) 2007-05-17
EP1739178A2 (de) 2007-01-03
ATE480623T1 (de) 2010-09-15
AU781679B2 (en) 2005-06-09
ES2351349T3 (es) 2011-02-03
CA2377107A1 (en) 2001-01-11
ES2272311T3 (es) 2007-05-01
EP1194554B1 (de) 2006-10-18

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