ATE342983T1 - Bereitstellung von peptiden mit kleeblattstruktur - Google Patents

Bereitstellung von peptiden mit kleeblattstruktur

Info

Publication number
ATE342983T1
ATE342983T1 AT00954434T AT00954434T ATE342983T1 AT E342983 T1 ATE342983 T1 AT E342983T1 AT 00954434 T AT00954434 T AT 00954434T AT 00954434 T AT00954434 T AT 00954434T AT E342983 T1 ATE342983 T1 AT E342983T1
Authority
AT
Austria
Prior art keywords
trefoil peptide
gastro
strain
present
delivering
Prior art date
Application number
AT00954434T
Other languages
English (en)
Inventor
Wolfgang Christian Hans
Lothar Steidler
Erik Rene Remaut
Original Assignee
Vlaams Interuniv Inst Biotech
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vlaams Interuniv Inst Biotech filed Critical Vlaams Interuniv Inst Biotech
Application granted granted Critical
Publication of ATE342983T1 publication Critical patent/ATE342983T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • C12N15/746—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for lactic acid bacteria (Streptococcus; Lactococcus; Lactobacillus; Pediococcus; Enterococcus; Leuconostoc; Propionibacterium; Bifidobacterium; Sporolactobacillus)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Physics & Mathematics (AREA)
  • Toxicology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Endocrinology (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
AT00954434T 1999-07-05 2000-07-05 Bereitstellung von peptiden mit kleeblattstruktur ATE342983T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP99870143 1999-07-05

Publications (1)

Publication Number Publication Date
ATE342983T1 true ATE342983T1 (de) 2006-11-15

Family

ID=8243867

Family Applications (2)

Application Number Title Priority Date Filing Date
AT00954434T ATE342983T1 (de) 1999-07-05 2000-07-05 Bereitstellung von peptiden mit kleeblattstruktur
AT06021747T ATE480623T1 (de) 1999-07-05 2000-07-05 Bereitstellung von peptiden mit kleeblattstruktur

Family Applications After (1)

Application Number Title Priority Date Filing Date
AT06021747T ATE480623T1 (de) 1999-07-05 2000-07-05 Bereitstellung von peptiden mit kleeblattstruktur

Country Status (11)

Country Link
US (3) US7220418B1 (de)
EP (2) EP1739178B1 (de)
JP (1) JP4644401B2 (de)
AT (2) ATE342983T1 (de)
AU (1) AU781679B2 (de)
CA (1) CA2377107C (de)
DE (2) DE60044957D1 (de)
DK (2) DK1194554T3 (de)
ES (2) ES2351349T3 (de)
PT (2) PT1739178E (de)
WO (1) WO2001002570A1 (de)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6525018B1 (en) 1999-05-17 2003-02-25 The General Hospital Corp. Treating eye disorders using intestinal trefoil proteins
CA2377107C (en) * 1999-07-05 2013-04-23 Wolfgang Christian Hans Delivery of trefoil peptides
EP1842858A3 (de) 2001-04-24 2008-04-02 The General Hospital Corporation Verfahren und Zusammensetzungen zur Behandlung von Verletzungen des Mundes und der Speiseröhre
US7538082B2 (en) 2001-04-24 2009-05-26 The General Hospital Corporation Methods and compositions for treating oral and esophageal lesions
EP1476466A1 (de) * 2002-02-11 2004-11-17 Novo Nordisk A/S Verwendung von viskositätmukosale für tff monomere peptide
CA2480372A1 (en) * 2002-03-26 2003-10-09 The General Hospital Corporation Combination therapy using trefoil peptides
US7829079B2 (en) * 2002-03-28 2010-11-09 Christian Hansen A/S Lactobacillus iners for the enhancement of urogenital health
JP2006516964A (ja) * 2002-10-31 2006-07-13 ザ ジーアイ カンパニー インコーポレーティッド 三つ葉型ドメイン含有ポリペプチドおよびその使用
US9200249B2 (en) 2004-08-20 2015-12-01 Actogenix N.V. Method to improve Lactococcus preservation
PT2119450E (pt) 2005-11-29 2013-04-26 Actogenix Nv Indução de tolerância da mucosa a autoantigénios de células beta de ilhéus pancreáticos
US8734823B2 (en) * 2005-12-14 2014-05-27 The Invention Science Fund I, Llc Device including altered microorganisms, and methods and systems of use
US20110172826A1 (en) * 2005-12-14 2011-07-14 Amodei Dario G Device including altered microorganisms, and methods and systems of use
US20110183348A1 (en) * 2010-01-22 2011-07-28 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Compositions and methods for therapeutic delivery with microorganisms
US8682619B2 (en) * 2005-12-14 2014-03-25 The Invention Science Fund I, Llc Device including altered microorganisms, and methods and systems of use
US8278094B2 (en) 2005-12-14 2012-10-02 The Invention Science Fund I, Llc Bone semi-permeable device
CN101437945A (zh) 2006-05-02 2009-05-20 阿克托杰尼斯有限公司 肥胖相关肽的微生物肠内递送
CA2675115C (en) * 2007-01-12 2014-12-09 Actogenix N.V. Lactococcus promoters and uses thereof
ES2666658T3 (es) 2007-01-25 2018-05-07 Intrexon Actobiotics Nv Tratamiento de enfermedad inmune mediante suministro a la mucosa de antígenos
CA2689658A1 (en) * 2007-06-20 2008-12-24 Actogenix Nv Methods and compositions for treating mucositis
DK3181682T3 (da) 2008-09-29 2021-07-05 Intrexon Actobiotics Nv Reduceret kolonisering af mikrober på slimhinden
KR101821417B1 (ko) 2009-04-30 2018-01-23 인트랙슨 액토바이오틱스 엔.브이. 유산균의 냉동건조에 사용하기 위한 냉동보호제
US20100310514A1 (en) * 2009-06-04 2010-12-09 Chi Hin Cho Anti-Inflammatory Bacteria
EP2275527A1 (de) 2009-07-17 2011-01-19 ActoGeniX NV Kulturmedium zur Fermentation von Bakterien welches frei von tierischen Bestandteilen ist
US20120183503A1 (en) 2009-09-29 2012-07-19 Actogenix N.V. Lactobacillus and streptococcus promoters and uses thereof
CN107267546B (zh) 2011-06-01 2021-08-17 英特瑞克斯顿阿克图比奥帝克斯有限公司 用于细菌的多顺反子表达系统
CA2848471C (en) 2011-09-23 2021-11-16 Actogenix Nv Modified gram positive bacteria and uses thereof
HUE038830T2 (hu) 2011-09-23 2018-11-28 Intrexon Actobiotics Nv Módosított gram-pozitív baktériumok és alkalmazásaik
WO2014047625A1 (en) 2012-09-24 2014-03-27 Montana State University Recombinant lactococcus lactis expressing escherichia coli colonization factor antigen i (cfa/i) fimbriae and their methods of use
ES2864373T3 (es) 2014-12-23 2021-10-13 Ilya Pharma Ab Métodos para la cicatrización
CN108883140A (zh) 2016-01-14 2018-11-23 英特瑞克斯顿阿克图比奥帝克斯有限公司 治疗1型糖尿病的组合物和方法
WO2018051223A1 (en) 2016-09-13 2018-03-22 Intrexon Actobiotics N.V. Mucoadhesive microorganism
KR102251294B1 (ko) * 2018-11-06 2021-05-12 주식회사 메디뉴트롤 락토바실러스 살리바리우스 v133 균주의 사균체를 유효성분으로 함유하는 알코올성 위염의 예방, 개선 또는 치료용 조성물
US11001870B2 (en) * 2019-02-07 2021-05-11 The General Hospital Corporation Carotenoids for treating or preventing nausea

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0075594A1 (de) * 1981-03-31 1983-04-06 SILK, David B. A. Glukosepolymere, sowie verfahren zur herstellung derselben
US6221840B1 (en) 1991-02-14 2001-04-24 The General Hospital Corporation Intestinal trefoil proteins
AU1415892A (en) 1991-02-14 1992-09-15 General Hospital Corporation, The Intestinal trefoil proteins
GB2278358B (en) * 1992-02-27 1995-07-26 Lynxvale Ltd Heterologous gene expression in Lactococcus,and the expression products therefrom
US7226761B2 (en) 1992-11-05 2007-06-05 Danisco Sweeteners Oy Manufacture of five-carbon sugars and sugar alcohols
IT1270123B (it) * 1994-10-05 1997-04-28 Dompe Spa Composizioni farmaceutiche contenenti microorganismi ingegnerizzati e loro uso per terapia
GB9518323D0 (en) 1995-09-07 1995-11-08 Steidler Lothar Materials and methods relating to the attachment and display of substances on cell surfaces
GB9521568D0 (en) * 1995-10-20 1995-12-20 Lynxvale Ltd Delivery of biologically active polypeptides
ATE259829T1 (de) 1998-10-20 2004-03-15 Vlaams Interuniv Inst Biotech Verwendung eines zytokine-produzierenden lactococcus stammes zur behandlung von kolitis
CA2377107C (en) * 1999-07-05 2013-04-23 Wolfgang Christian Hans Delivery of trefoil peptides
EP1084709A1 (de) * 1999-09-17 2001-03-21 Nederlandse Organisatie Voor Toegepast-Natuurwetenschappelijk Onderzoek Tno Oraler Impfstoff enthaltend rekombinanten Lactobacilli

Also Published As

Publication number Publication date
AU781679B2 (en) 2005-06-09
DK1194554T3 (da) 2007-01-29
EP1194554A1 (de) 2002-04-10
EP1739178A3 (de) 2008-12-31
US20070110723A1 (en) 2007-05-17
ATE480623T1 (de) 2010-09-15
CA2377107A1 (en) 2001-01-11
EP1739178A2 (de) 2007-01-03
EP1739178B1 (de) 2010-09-08
JP2003504025A (ja) 2003-02-04
CA2377107C (en) 2013-04-23
DK1739178T3 (da) 2010-11-22
US7220418B1 (en) 2007-05-22
US20070122427A1 (en) 2007-05-31
AU6689200A (en) 2001-01-22
DE60031405D1 (de) 2006-11-30
WO2001002570A1 (en) 2001-01-11
ES2272311T3 (es) 2007-05-01
DE60031405T2 (de) 2007-08-16
DE60044957D1 (de) 2010-10-21
PT1194554E (pt) 2007-01-31
EP1194554B1 (de) 2006-10-18
PT1739178E (pt) 2010-11-17
US7592013B2 (en) 2009-09-22
JP4644401B2 (ja) 2011-03-02
ES2351349T3 (es) 2011-02-03

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