DK1733735T3 - Fremgangsmåder og produkter til induktion af mukosal immunitet - Google Patents

Fremgangsmåder og produkter til induktion af mukosal immunitet Download PDF

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Publication number
DK1733735T3
DK1733735T3 DK06118586.4T DK06118586T DK1733735T3 DK 1733735 T3 DK1733735 T3 DK 1733735T3 DK 06118586 T DK06118586 T DK 06118586T DK 1733735 T3 DK1733735 T3 DK 1733735T3
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virus
cpg
mucosal
antigen
dna
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DK06118586.4T
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Heather Davis
Michael J Mccluskie
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Ottawa Hospital Res Inst
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53—DNA (RNA) vaccination
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A61K2039/541—Mucosal route
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55522—Cytokines; Lymphokines; Interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55544—Bacterial toxins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/5555—Muramyl dipeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55561—CpG containing adjuvants; Oligonucleotide containing adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55577—Saponins; Quil A; QS21; ISCOMS

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Claims (7)

1. Immunstimulatorisk CpG-oligonukleotid, til anvendelse som mukosal adjuvans til at inducere immunrespons mod et antigen administreret til mukosa-væv.
2. Immunstimulatorisk CpG-oligonukleotid til anvendelse ifølge krav 1, hvor immun responset er mukosalt.
3. Immunstimulatorisk CpG-oligonukleotid til anvendelse ifølge krav 2, hvor immunresponset også er systemisk.
4. Immunstimulatorisk CpG-oligonukleotid til anvendelse ifølge krav 2 eller 3, hvor det mukosale immunrespons er både lokalt og fjernt fra administrationsstedet for oligonukleotidet.
5. Immunstimulatorisk CpG-oligonukleotid til anvendelse ifølge et hvilket som helst af de foregående krav, hvor antigenet er et protein.
6. Immunstimulatorisk CpG-oligonukleotid til anvendelse ifølge et hvilket som helst af de foregående krav, hvor oligonukleotidet skal administreres med en anden mukosal adjuvans.
7. Immunstimulatorisk CpG-oligonukleotid til anvendelse ifølge et hvilket som helst af de foregående krav hvor oligonukleoidet er DNA.
DK06118586.4T 1998-05-22 1999-05-21 Fremgangsmåder og produkter til induktion af mukosal immunitet DK1733735T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US8639398P 1998-05-22 1998-05-22
EP99925754A EP1077722B1 (en) 1998-05-22 1999-05-21 Methods and products for inducing mucosal immunity

Publications (1)

Publication Number Publication Date
DK1733735T3 true DK1733735T3 (da) 2017-06-19

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DK99925754T DK1077722T3 (da) 1998-05-22 1999-05-21 Fremgangsmåder og produkter til induktion af mukosaimmunitet
DK06118586.4T DK1733735T3 (da) 1998-05-22 1999-05-21 Fremgangsmåder og produkter til induktion af mukosal immunitet

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DK99925754T DK1077722T3 (da) 1998-05-22 1999-05-21 Fremgangsmåder og produkter til induktion af mukosaimmunitet

Country Status (18)

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US (2) US8574599B1 (da)
EP (2) EP1077722B1 (da)
JP (1) JP2002516294A (da)
AT (1) ATE335510T1 (da)
AU (1) AU761899B2 (da)
BR (1) BR9910643A (da)
CA (1) CA2328894A1 (da)
CY (1) CY1107337T1 (da)
DE (1) DE69932717T2 (da)
DK (2) DK1077722T3 (da)
ES (2) ES2272069T3 (da)
HK (1) HK1037125A1 (da)
IL (2) IL139813A0 (da)
NZ (1) NZ508927A (da)
PT (2) PT1077722E (da)
SI (1) SI1077722T1 (da)
WO (1) WO1999061056A2 (da)
ZA (1) ZA200006765B (da)

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EP1733735A3 (en) 2008-08-27
US20040266719A1 (en) 2004-12-30
EP1077722B1 (en) 2006-08-09
US8574599B1 (en) 2013-11-05
CY1107337T1 (el) 2012-12-19
AU4197799A (en) 1999-12-13
EP1077722A2 (en) 2001-02-28
CA2328894A1 (en) 1999-12-02
HK1037125A1 (en) 2002-02-01
NZ508927A (en) 2003-12-19
AU761899B2 (en) 2003-06-12
IL139813A (en) 2007-06-03
ES2272069T3 (es) 2007-04-16
WO1999061056A9 (en) 2000-06-15
BR9910643A (pt) 2001-10-30
DE69932717D1 (de) 2006-09-21
ES2628744T3 (es) 2017-08-03
DE69932717T2 (de) 2007-08-09
PT1077722E (pt) 2006-12-29
ZA200006765B (en) 2002-08-22
PT1733735T (pt) 2017-06-16
WO1999061056A2 (en) 1999-12-02
EP1733735A2 (en) 2006-12-20
EP1733735B1 (en) 2017-03-22
SI1077722T1 (sl) 2007-02-28
ATE335510T1 (de) 2006-09-15
DK1077722T3 (da) 2006-11-27

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