DK1729753T3 - Anvendelse af en NMDA-receptor-antagonist til behandling af tinnitus induceret ved kokleær excitotoksicitet - Google Patents
Anvendelse af en NMDA-receptor-antagonist til behandling af tinnitus induceret ved kokleær excitotoksicitetInfo
- Publication number
- DK1729753T3 DK1729753T3 DK05736619T DK05736619T DK1729753T3 DK 1729753 T3 DK1729753 T3 DK 1729753T3 DK 05736619 T DK05736619 T DK 05736619T DK 05736619 T DK05736619 T DK 05736619T DK 1729753 T3 DK1729753 T3 DK 1729753T3
- Authority
- DK
- Denmark
- Prior art keywords
- receptor antagonist
- nmda receptor
- treat tinnitus
- cochlear excitotoxicity
- tinnitus induced
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/01—Hydrocarbons
- A61K31/015—Hydrocarbons carbocyclic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/02—Halogenated hydrocarbons
- A61K31/025—Halogenated hydrocarbons carbocyclic
- A61K31/03—Halogenated hydrocarbons carbocyclic aromatic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4535—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom, e.g. pizotifen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/812,298 US8268866B2 (en) | 2004-03-29 | 2004-03-29 | Methods for the treatment of tinnitus induced by cochlear excitotoxicity |
PCT/EP2005/003254 WO2005094799A2 (en) | 2004-03-29 | 2005-03-29 | Use of an nmda receptor antagonist for the treatment of tinnitus induced by cochlear excitotoxicity |
Publications (1)
Publication Number | Publication Date |
---|---|
DK1729753T3 true DK1729753T3 (da) | 2009-11-23 |
Family
ID=34966520
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK05736619T DK1729753T3 (da) | 2004-03-29 | 2005-03-29 | Anvendelse af en NMDA-receptor-antagonist til behandling af tinnitus induceret ved kokleær excitotoksicitet |
Country Status (21)
Country | Link |
---|---|
US (1) | US8268866B2 (es) |
EP (2) | EP1729753B1 (es) |
JP (2) | JP4927706B2 (es) |
KR (2) | KR101429735B1 (es) |
CN (2) | CN1972677B (es) |
AU (1) | AU2005229543B2 (es) |
BR (1) | BRPI0508251A (es) |
CA (1) | CA2558896C (es) |
CY (1) | CY1110495T1 (es) |
DE (1) | DE602005015562D1 (es) |
DK (1) | DK1729753T3 (es) |
ES (1) | ES2330350T3 (es) |
IL (1) | IL177490A (es) |
MX (1) | MXPA06011078A (es) |
NZ (1) | NZ549399A (es) |
PL (1) | PL1729753T3 (es) |
PT (1) | PT1729753E (es) |
RU (1) | RU2380094C2 (es) |
SI (1) | SI1729753T1 (es) |
WO (1) | WO2005094799A2 (es) |
ZA (1) | ZA200607161B (es) |
Families Citing this family (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8268866B2 (en) | 2004-03-29 | 2012-09-18 | Matthieu Guitton | Methods for the treatment of tinnitus induced by cochlear excitotoxicity |
US9072662B2 (en) | 2004-03-29 | 2015-07-07 | Auris Medical Ag | Methods for the treatment of tinnitus induced by cochlear excitotoxicity |
US20060063802A1 (en) * | 2004-03-29 | 2006-03-23 | Matthieu Guitton | Methods for the treatment of tinnitus induced by cochlear excitotoxicity |
WO2006096518A2 (en) * | 2005-03-04 | 2006-09-14 | Neurosystec Corporation | Improved gacyclidine formulations |
NZ566062A (en) * | 2005-09-28 | 2009-08-28 | Auris Medical Ag | Pharmaceutical compositions for the treatment of inner ear disorders comprising an arylcycloalkylamine such as ketamine and a biocompatible polymer |
US7803148B2 (en) | 2006-06-09 | 2010-09-28 | Neurosystec Corporation | Flow-induced delivery from a drug mass |
US8175712B2 (en) * | 2006-09-05 | 2012-05-08 | The Penn State Research Foundation | Homotopic conditioning of the brain stem baroreflex of a subject |
US11969501B2 (en) | 2008-04-21 | 2024-04-30 | Dompé Farmaceutici S.P.A. | Auris formulations for treating otic diseases and conditions |
CA2721927C (en) | 2008-04-21 | 2014-01-28 | Otonomy, Inc. | Auris formulations for treating otic diseases and conditions |
CA2723458C (en) | 2008-05-14 | 2014-01-28 | Otonomy, Inc. | Controlled release corticosteroid compositions and methods for the treatment of otic disorders |
US8648119B2 (en) * | 2008-05-23 | 2014-02-11 | Otonomy, Inc. | Controlled release immunomodulator compositions and methods for the treatment of otic disorders |
US8846770B2 (en) * | 2008-06-18 | 2014-09-30 | Otonomy, Inc. | Controlled release aural pressure modulator compositions and methods for the treatment of OTIC disorders |
US8349353B2 (en) * | 2008-06-27 | 2013-01-08 | Otonomy, Inc. | Controlled release cytotoxic agent compositions and methods for the treatment of otic disorders |
WO2010011466A2 (en) * | 2008-06-27 | 2010-01-28 | Otonomy, Inc. | Controlled-release cns modulating compositions and methods for the treatment of otic disorders |
MX2011000545A (es) * | 2008-07-14 | 2011-02-24 | Otonomy Inc | Composiciones de liberacion controlada para la modulacion de apoptosis y metodos para el tratamiento de trastornos oticos. |
US8318817B2 (en) | 2008-07-21 | 2012-11-27 | Otonomy, Inc. | Controlled release antimicrobial compositions and methods for the treatment of otic disorders |
US10092580B2 (en) * | 2008-07-21 | 2018-10-09 | Otonomy, Inc. | Controlled-release otic structure modulating and innate immune system modulating compositions and methods for the treatment of otic disorders |
US8784870B2 (en) * | 2008-07-21 | 2014-07-22 | Otonomy, Inc. | Controlled release compositions for modulating free-radical induced damage and methods of use thereof |
US8399018B2 (en) * | 2008-07-21 | 2013-03-19 | Otonomy, Inc. | Controlled release ion channel modulator compositions and methods for the treatment of otic disorders |
US20100016450A1 (en) * | 2008-07-21 | 2010-01-21 | Otonomy, Inc. | Controlled release delivery devices for the treatment of otic disorders |
US8496957B2 (en) | 2008-07-21 | 2013-07-30 | Otonomy, Inc | Controlled release auris sensory cell modulator compositions and methods for the treatment of otic disorders |
CA2751761A1 (en) | 2008-10-22 | 2010-04-29 | House Ear Institute | Treatment and/or prevention of inner ear conditions by modulation of a metabotropic glutamate receptor |
JP6013736B2 (ja) * | 2008-12-22 | 2016-10-25 | オトノミ—,インク. | 耳の障害の処置のための耳感覚細胞モジュレータ組成物の制御放出及びその方法 |
EP2665474A1 (en) * | 2011-01-20 | 2013-11-27 | Merz Pharma GmbH & Co. KGaA | Neramexane for the treatment or prevention of tinnitus related with stress or acute hearing loss |
ES2862673T3 (es) | 2011-12-12 | 2021-10-07 | Zilentin AG | Tratamiento del tinnitus mediante la modulación del cotransportador de cloruro NKCC1 en el sistema auditivo |
US8920855B1 (en) | 2012-10-30 | 2014-12-30 | Setem Hemth, Inc | Methods of topically treating tinnitus and related disorders |
WO2015031393A1 (en) | 2013-08-27 | 2015-03-05 | Otonomy, Inc. | Treatment of pediatric otic disorders |
WO2015164580A1 (en) * | 2014-04-23 | 2015-10-29 | Auris Medical Ag | Methods and compositions for treating and preventing tinnitus |
US11207316B2 (en) | 2014-05-30 | 2021-12-28 | West Virginia University | Ketamine or dextromethorphan formulations and methods of use |
JP7033789B2 (ja) | 2016-06-29 | 2022-03-11 | オトノミー,インク. | トリグリセリド耳用製剤とその使用 |
EP3512513A4 (en) | 2016-09-16 | 2020-04-15 | Otonomy, Inc. | GEL FORMULA FOR THE EAR FOR TREATING OTITIS EXTERNA |
US10561736B1 (en) | 2019-01-09 | 2020-02-18 | Spiral Therapeutics, Inc. | Apoptosis inhibitor formulations for prevention of hearing loss |
Family Cites Families (39)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3254124A (en) * | 1962-06-29 | 1966-05-31 | Parke Davis & Co | Aminoketones and methods for their production |
CH535201A (de) | 1969-12-19 | 1973-03-31 | Bristol Myers Co | Verfahren zur Spaltung von racemischen 2-(o-Chlorphenyl)-2-methylaminocyclohexanon in die optisch-aktiven Isomeren |
AU5171293A (en) | 1992-10-14 | 1994-05-09 | Regents Of The University Of Colorado, The | Ion-pairing of drugs for improved efficacy and delivery |
US5421818A (en) * | 1993-10-18 | 1995-06-06 | Inner Ear Medical Delivery Systems, Inc. | Multi-functional inner ear treatment and diagnostic system |
AU8071894A (en) * | 1994-09-22 | 1996-04-09 | Jonathan M Licht | Compositions useful for the preparation of medicines for treating a variety of intractable disorders |
US5945409A (en) * | 1995-03-10 | 1999-08-31 | Wilson T. Crandall | Topical moisturizing composition and method |
US5654337A (en) * | 1995-03-24 | 1997-08-05 | II William Scott Snyder | Topical formulation for local delivery of a pharmaceutically active agent |
DE19528388A1 (de) * | 1995-08-02 | 1997-02-06 | Hans Peter Prof Dr Med Zenner | Verwendung von Adamantan-Derivaten zur Behandlung von Erkrankungen des Innenohrs |
TW450807B (en) | 1995-09-15 | 2001-08-21 | Pfizer | Pharmaceutical compositions for treating tinnitus comprising neuroprotective agents |
US5746961A (en) * | 1995-12-04 | 1998-05-05 | Michael J. Stevenson | Method for enhancement of the surfaces of molded plastic products |
WO1997038698A1 (en) | 1996-04-18 | 1997-10-23 | University Technology Corporation | Methods for treating middle and inner ear disorders |
AU4424697A (en) | 1996-09-11 | 1998-04-02 | Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The | The use of functional n-methyl-d-aspartate antagonists to ameliorate or prevent aminoglycoside-induced ototoxicity |
US6045528A (en) * | 1997-06-13 | 2000-04-04 | Intraear, Inc. | Inner ear fluid transfer and diagnostic system |
US6309410B1 (en) * | 1998-08-26 | 2001-10-30 | Advanced Bionics Corporation | Cochlear electrode with drug delivery channel and method of making same |
DE19853299C2 (de) * | 1998-11-19 | 2003-04-03 | Thomas Lenarz | Katheter zur Applikation von Medikamenten in Flüssigkeitsräumen des menschlichen Innenohrs |
US6120484A (en) * | 1999-02-17 | 2000-09-19 | Silverstein; Herbert | Otological implant for delivery of medicament and method of using same |
US6017961A (en) * | 1999-07-08 | 2000-01-25 | Flores; John Anthony | Ketamine and n-butyl-p-aminobezoate in PLO |
DE19936719A1 (de) * | 1999-08-06 | 2001-02-15 | Gruenenthal Gmbh | Substituierte 1,5-Dihydropyrrol-2-on-Derivate |
US6265379B1 (en) * | 1999-10-13 | 2001-07-24 | Allergan Sales, Inc. | Method for treating otic disorders |
JP2001187737A (ja) | 1999-10-18 | 2001-07-10 | Toyama Chem Co Ltd | 聴力改善剤 |
DE10025238A1 (de) | 2000-05-22 | 2001-11-29 | Gruenenthal Gmbh | Verwendung substituierter 1-Amino-5-phenylpentan-3-ol- und/oder 1-Amino-6-phenylhexan-3-ol- Verbindungen als Arzneimittel |
BRPI0002693B8 (pt) | 2000-06-19 | 2021-05-25 | Cristalia Produtos Quim Farmaceuticos Ltda | processo de obtenção dos enantiômeros da cetamina e seus sais farmaceuticamente aceitáveis |
DE10048969A1 (de) | 2000-08-23 | 2002-03-14 | Mueller Schwefe Gerhard | Verwendung von Flupirtin zur Tinnitusbehandlung |
DE10044649A1 (de) | 2000-09-08 | 2002-07-04 | Gruenenthal Gmbh | Substituierte 4-Phenyl-1-(1-phenyl-cyclohexyl)-1,2,3,6-tetrahydropyridine |
US6924273B2 (en) * | 2000-10-03 | 2005-08-02 | Scott W. Pierce | Chondroprotective/restorative compositions and methods of use thereof |
DE10124953A1 (de) | 2001-05-21 | 2002-12-12 | Marlies Knipper | Substanz für die therapeutische Behandlung von Tinnitus |
US6638981B2 (en) * | 2001-08-17 | 2003-10-28 | Epicept Corporation | Topical compositions and methods for treating pain |
US20030143195A1 (en) * | 2002-01-30 | 2003-07-31 | Pinsker Judy Senior | Use of histamine as a drug delivery enhancing compound for use in transmucosal or transdermal delivery |
US6638081B2 (en) * | 2002-03-22 | 2003-10-28 | Hon Hai Precision Ind. Co., Ltd. | Electrical connector |
EP1545551A4 (en) | 2002-09-06 | 2008-10-22 | Durect Corp | DISTRIBUTION OF MODULATORS OF THE GLUTAMAT-MEDIATED NEUROTRANSMISSION TO THE INNER EAR |
US6969383B2 (en) * | 2002-09-27 | 2005-11-29 | Medtronic, Inc. | Method for treating severe tinnitus |
US6656172B1 (en) * | 2002-09-27 | 2003-12-02 | Medtronic, Inc. | Method for treating severe tinnitus |
WO2004043902A1 (de) | 2002-11-12 | 2004-05-27 | Grünenthal GmbH | 4-hydroxymethyl-1-aryl-cyclohexylamin-derivative |
US7220431B2 (en) * | 2002-11-27 | 2007-05-22 | Regents Of The University Of Minnesota | Methods and compositions for applying pharmacologic agents to the ear |
EP1438942A1 (en) | 2003-01-17 | 2004-07-21 | Schering Oy | An otorhinological drug delivery device |
EP1624936B1 (en) | 2003-05-16 | 2009-10-28 | Universite Laval | Cns chloride modulation and uses thereof |
ES2552936T3 (es) | 2003-12-12 | 2015-12-03 | Otic Pharma Ltd. | Composiciones para el tratamiento del desordenes en el oído y métodos para el uso de los mismos |
GB0402118D0 (en) | 2004-01-30 | 2004-03-03 | Merck Sharp & Dohme | Polymorphic forms of a GABAA agonist |
US8268866B2 (en) * | 2004-03-29 | 2012-09-18 | Matthieu Guitton | Methods for the treatment of tinnitus induced by cochlear excitotoxicity |
-
2004
- 2004-03-29 US US10/812,298 patent/US8268866B2/en not_active Expired - Fee Related
-
2005
- 2005-03-29 EP EP05736619A patent/EP1729753B1/en active Active
- 2005-03-29 CN CN200580009886.5A patent/CN1972677B/zh not_active Expired - Fee Related
- 2005-03-29 MX MXPA06011078A patent/MXPA06011078A/es active IP Right Grant
- 2005-03-29 JP JP2007505480A patent/JP4927706B2/ja not_active Expired - Fee Related
- 2005-03-29 DK DK05736619T patent/DK1729753T3/da active
- 2005-03-29 PT PT05736619T patent/PT1729753E/pt unknown
- 2005-03-29 CN CN201510076933.3A patent/CN104906079B/zh not_active Expired - Fee Related
- 2005-03-29 RU RU2006138153/14A patent/RU2380094C2/ru active
- 2005-03-29 KR KR1020127007363A patent/KR101429735B1/ko active IP Right Grant
- 2005-03-29 AU AU2005229543A patent/AU2005229543B2/en not_active Ceased
- 2005-03-29 WO PCT/EP2005/003254 patent/WO2005094799A2/en active Application Filing
- 2005-03-29 BR BRPI0508251-0A patent/BRPI0508251A/pt not_active Application Discontinuation
- 2005-03-29 KR KR1020137020276A patent/KR101451414B1/ko active IP Right Grant
- 2005-03-29 SI SI200530751T patent/SI1729753T1/sl unknown
- 2005-03-29 EP EP09005167A patent/EP2077108A1/en not_active Withdrawn
- 2005-03-29 NZ NZ549399A patent/NZ549399A/en not_active IP Right Cessation
- 2005-03-29 ZA ZA200607161A patent/ZA200607161B/en unknown
- 2005-03-29 DE DE602005015562T patent/DE602005015562D1/de active Active
- 2005-03-29 PL PL05736619T patent/PL1729753T3/pl unknown
- 2005-03-29 ES ES05736619T patent/ES2330350T3/es active Active
- 2005-03-29 CA CA2558896A patent/CA2558896C/en active Active
-
2006
- 2006-08-15 IL IL177490A patent/IL177490A/en active IP Right Grant
-
2009
- 2009-09-10 CY CY20091100944T patent/CY1110495T1/el unknown
-
2011
- 2011-01-25 JP JP2011013018A patent/JP2011105740A/ja active Pending
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DK1729753T3 (da) | Anvendelse af en NMDA-receptor-antagonist til behandling af tinnitus induceret ved kokleær excitotoksicitet | |
DK1828164T3 (da) | Fremgangsmåde til fremstilling af N-phenylpyrazol-1-carboxamider | |
DK1778668T3 (da) | Fremgangsmåde til fremstilling af dihydropteridion | |
DK1720866T3 (da) | Fremgangsmåde | |
DK2086944T3 (da) | Fremgangsmåde til fremstilling af difluormethylpyrazolylcarboxylater | |
DK1706112T3 (da) | Fremgangsmåder til at behandle en inflammatorisk-beslægtet sygdom | |
DK2068874T3 (da) | Fremgangsmåder til behandling af multiple myelom med anvendelse af kombinationsterapier baseret på anti-cs1 antistoffer | |
DK1893586T3 (da) | Fremgangsmåde til fremstilling af 1-alkyl-3-phenyluraciler | |
DK2019825T3 (da) | Inhibitorer af human immundefektvirus-replikation | |
DK2094676T3 (da) | Ny fremgangsmåde til fremstillingen af 2-iminothiazolidin-4-on-derivater | |
DK1813678T3 (da) | Fremgangsmåde til fremstilling af glycogen | |
DE602007006040D1 (de) | Hemmstoffe des progesteron-rezeptors | |
DK1943242T3 (da) | Piperidin-4-yl-pyridazin-3-ylamin-derivater som hurtigt opløsende antagonister af dopamin-2-receptorer | |
ATE481405T1 (de) | Thiazolpyrazolopyrimidine als antagonisten des crf1-rezeptors | |
DK1763520T3 (da) | Anvendelse af trisubstituerede benzopyranoner | |
CR8618A (es) | Nuevos derivados de bencil (dieno)-lactamas | |
DK1841433T3 (da) | Præparat til behandling af lidelser i centralnervesystemet | |
DK1831223T3 (da) | Fremgangsmåde til fremstilling af L-biopterin | |
DK1814555T3 (da) | S-mirtazapin til behandling af hedeture | |
NO20043305D0 (no) | Preparation of lodixanol | |
DK3456340T3 (da) | Glp-1-receptorantagonist til brug ved behandling af medfødt hyperinsulisme | |
DK1856035T3 (da) | Fremgangsmåde til fremstilling af beskyttelse amidiner | |
DK1833821T3 (da) | Sulfamider som endotelreceptorantagonister til behandlingen af kardiovaskulære sygdomme | |
DK2091938T3 (da) | Piperidinylaminopyridaziner og anvendelse deraf som hurtigt opløsende antagonister af dopamin-2-receptorer | |
DK1912961T3 (da) | Fremgangsmåde til fremstilling af bepromolin |