DK2091938T3 - Piperidinylaminopyridaziner og anvendelse deraf som hurtigt opløsende antagonister af dopamin-2-receptorer - Google Patents
Piperidinylaminopyridaziner og anvendelse deraf som hurtigt opløsende antagonister af dopamin-2-receptorerInfo
- Publication number
- DK2091938T3 DK2091938T3 DK07847833.6T DK07847833T DK2091938T3 DK 2091938 T3 DK2091938 T3 DK 2091938T3 DK 07847833 T DK07847833 T DK 07847833T DK 2091938 T3 DK2091938 T3 DK 2091938T3
- Authority
- DK
- Denmark
- Prior art keywords
- piperidinylaminopyridazines
- dopamine
- antagonists
- receptors
- dissolving
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Dermatology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP06125685 | 2006-12-08 | ||
| PCT/EP2007/063338 WO2008068277A1 (en) | 2006-12-08 | 2007-12-05 | Piperidinylamino-pyridazines and their use as fast dissociating dopamine 2 receptor antagonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2091938T3 true DK2091938T3 (da) | 2011-02-07 |
Family
ID=37964744
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK07847833.6T DK2091938T3 (da) | 2006-12-08 | 2007-12-05 | Piperidinylaminopyridaziner og anvendelse deraf som hurtigt opløsende antagonister af dopamin-2-receptorer |
Country Status (29)
| Country | Link |
|---|---|
| US (1) | US8466153B2 (da) |
| EP (1) | EP2091938B1 (da) |
| JP (1) | JP5255568B2 (da) |
| KR (1) | KR101468384B1 (da) |
| CN (1) | CN101547915B (da) |
| AR (1) | AR064198A1 (da) |
| AT (1) | ATE486070T1 (da) |
| AU (1) | AU2007328897B2 (da) |
| BR (1) | BRPI0720247A2 (da) |
| CA (1) | CA2665924C (da) |
| CL (1) | CL2007003556A1 (da) |
| CY (1) | CY1112227T1 (da) |
| DE (1) | DE602007010179D1 (da) |
| DK (1) | DK2091938T3 (da) |
| EA (1) | EA016654B1 (da) |
| ES (1) | ES2354756T3 (da) |
| HK (1) | HK1137434A1 (da) |
| IL (1) | IL199076A (da) |
| JO (1) | JO2642B1 (da) |
| MX (1) | MX2009005983A (da) |
| MY (1) | MY148772A (da) |
| NO (1) | NO20092574L (da) |
| NZ (1) | NZ576484A (da) |
| PL (1) | PL2091938T3 (da) |
| PT (1) | PT2091938E (da) |
| SI (1) | SI2091938T1 (da) |
| TW (1) | TWI433676B (da) |
| UA (1) | UA98940C2 (da) |
| WO (1) | WO2008068277A1 (da) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JO2769B1 (en) | 2005-10-26 | 2014-03-15 | جانسين فارماسوتيكا ان. في | Rapid decomposition of physiologically antagonistic agents of the 2-dopamine receptor |
| JO2849B1 (en) | 2007-02-13 | 2015-03-15 | جانسين فارماسوتيكا ان. في | Dopamine 2 receptor antagonists are rapidly hydrolyzed |
| EP2148872A1 (en) * | 2007-04-23 | 2010-02-03 | Janssen Pharmaceutica, N.V. | Pyridine derivatives as fast dissociating dopamine 2 receptor antagonists |
| KR101506156B1 (ko) * | 2007-04-23 | 2015-03-26 | 얀센 파마슈티카 엔.브이. | 속해리성 도파민 2 수용체 길항제로서의 티아(디아)졸 |
| CN101663292A (zh) * | 2007-04-23 | 2010-03-03 | 詹森药业有限公司 | 作为快速解离的多巴胺2受体拮抗剂的4-烷氧基哒嗪衍生物 |
| CA2729313C (en) * | 2008-07-03 | 2016-08-30 | Janssen Pharmaceutica Nv | Substituted 6-(1-piperazinyl)-pyridazines as 5-ht6 receptor antagonists |
| EA019048B1 (ru) * | 2008-07-31 | 2013-12-30 | Янссен Фармацевтика Нв | Пиперазин-1-илтрифторметилзамещенные пиридины в качестве быстро диссоциирующихся антагонистов d-рецепторов дофамина |
Family Cites Families (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2341965C3 (de) | 1973-08-20 | 1979-01-25 | C.H. Boehringer Sohn, 6507 Ingelheim | 4- [N- (o-PyridyD- N-acyl] -aminolphenäthylpiperidine, Verfahren zu deren Herstellung sowie deren Verwendung bei der Bekämpfung von Schmerzzuständen |
| NO147672C (no) | 1975-09-23 | 1983-05-25 | Janssen Pharmaceutica Nv | Analogifremgangsmaate for fremstilling av n-aryl-n-(1-l1-4-piperidinyl)-arylacetamider |
| US4197304A (en) | 1975-09-23 | 1980-04-08 | Janssen Pharmaceutica N.V. | N-Aryl-N-(1-L-4-piperidinyl)-arylacetamides |
| EG12406A (en) | 1976-08-12 | 1979-03-31 | Janssen Pharmaceutica Nv | Process for preparing of novel n-aryl-n-(1-l-4-piperidinyl)-arylacetamides |
| DE3218482A1 (de) | 1982-05-15 | 1983-11-17 | Bayer Ag, 5090 Leverkusen | Substituierte 5-trifluormethyl-1,3,4-thiadiazol-2-yloxyessigsaeureamide, verfahren zu ihrer herstellung und ihre verwendung als herbizide |
| MX173362B (es) | 1987-03-02 | 1994-02-23 | Pfizer | Compuestos de piperazinil heterociclicos y procedimiento para su preparacion |
| GB9216298D0 (en) | 1991-08-15 | 1992-09-16 | Ici Plc | Piperidine derivatives |
| TW406075B (en) | 1994-12-13 | 2000-09-21 | Upjohn Co | Alkyl substituted piperidinyl and piperazinyl anti-AIDS compounds |
| US5753679A (en) | 1995-05-10 | 1998-05-19 | Hoffmann-La Roche Inc. | Benzyl-piperidine derivatives |
| MY116093A (en) | 1996-02-26 | 2003-11-28 | Upjohn Co | Azolyl piperazinyl phenyl oxazolidinone antimicrobials |
| TW504510B (en) * | 1996-05-10 | 2002-10-01 | Janssen Pharmaceutica Nv | 2,4-diaminopyrimidine derivatives |
| JP2002536291A (ja) * | 1997-08-15 | 2002-10-29 | ファイザー・プロダクツ・インク | ２−（４−アリール又はヘテロアリール−ピペラジン−１−イルメチル）−１ｈ−インドール誘導体 |
| KR100261139B1 (ko) | 1998-01-16 | 2000-08-01 | 황준수 | 신규한 알릴티오피리다진 유도체 및 그의 제조방법 |
| US7494999B2 (en) | 2004-10-29 | 2009-02-24 | Kalypsys, Inc | Sulfonyl-substituted bicyclic compounds as modulators of PPAR |
| AR028948A1 (es) | 2000-06-20 | 2003-05-28 | Astrazeneca Ab | Compuestos novedosos |
| SI1379520T1 (sl) | 2001-02-23 | 2006-08-31 | Merck & Co Inc | N-substituirani nonaril-heterociklicni NMDA/NR2B antagonisti |
| ES2319879T3 (es) | 2001-10-09 | 2009-05-14 | Kyorin Pharmaceutical Co., Ltd. | 4-(2-furoil)aminopiperidinas novedosas, productos intermedios en la sintesis de las mismas, procedimiento para producir las mismas y uso medico de las mismas. |
| AU2002360561A1 (en) | 2001-12-11 | 2003-06-23 | Sepracor, Inc. | 4-substituted piperidines, and methods of use thereof |
| CA2474322A1 (en) | 2002-01-25 | 2003-07-31 | Kylix Pharmaceuticals B.V. | 4(hetero-) aryl substituted (thia-/oxa-/pyra) zoles for inhibition of tie-2 |
| MXPA04007612A (es) | 2002-02-05 | 2004-11-10 | Novo Nordisk As | Aril- y heteroarilpiperazinas novedosas. |
| US7183276B2 (en) | 2002-02-28 | 2007-02-27 | Takeda Pharmaceutical Company Limited | Azole compounds |
| SE0201544D0 (sv) | 2002-05-17 | 2002-05-17 | Biovitrum Ab | Novel compounds and thier use |
| AU2003272892A1 (en) | 2002-09-26 | 2004-04-19 | Mandom Corporation | Antiseptic bactericides and cosmetics, drugs and foods containing the antiseptic bactericides |
| EP2325183A1 (en) | 2003-05-08 | 2011-05-25 | Kyorin Pharmaceutical Co., Ltd. | 4-(2-Furoyl) Aminopiperidine compound useful as therapeutic agent for itching |
| WO2005005779A2 (en) | 2003-07-14 | 2005-01-20 | Genesis Mining Technologies (Pty) Ltd | Dual retention cutting arrangement |
| CN100584831C (zh) | 2003-07-29 | 2010-01-27 | 高点制药有限责任公司 | 哒嗪基-哌嗪类及其作为组胺h3受体配体的应用 |
| EP1653969A4 (en) | 2003-08-07 | 2006-12-20 | Japan Tobacco Inc | PYRROLO 1,2-B PYRIDAZINE DERIVATIVES |
| JP2007534740A (ja) | 2004-04-28 | 2007-11-29 | ファイザー・インク | バソプレッシンＶ１ａ受容体の阻害剤としての３−ヘテロシクリル−４−フェニル−トリアゾール誘導体 |
| RU2006146985A (ru) | 2004-05-28 | 2008-07-10 | Вертекс Фармасьютикалз Инкорпорейтед (Us) | Модуляторы мускариновых рецепторов |
| AR051092A1 (es) | 2004-09-20 | 2006-12-20 | Xenon Pharmaceuticals Inc | Derivados heterociclicos y su uso como inhibidores de la estearoil-coa |
| KR20080021082A (ko) | 2005-06-20 | 2008-03-06 | 쉐링 코포레이션 | 히스타민 ｈ3 길항제로서 유용한 피페리딘 유도체 |
| JO2769B1 (en) * | 2005-10-26 | 2014-03-15 | جانسين فارماسوتيكا ان. في | Rapid decomposition of physiologically antagonistic agents of the 2-dopamine receptor |
| WO2007130383A2 (en) | 2006-04-28 | 2007-11-15 | Northwestern University | Compositions and treatments using pyridazine compounds and secretases |
| WO2008019967A2 (en) | 2006-08-15 | 2008-02-21 | F. Hoffmann-La Roche Ag | Phenyl, pyridine and quinoline derivatives |
| US8058243B2 (en) | 2006-10-13 | 2011-11-15 | Hsc Research And Development Limited Partnership | Method for treating a brain cancer with ifenprodil |
| JO2849B1 (en) | 2007-02-13 | 2015-03-15 | جانسين فارماسوتيكا ان. في | Dopamine 2 receptor antagonists are rapidly hydrolyzed |
| EA019048B1 (ru) | 2008-07-31 | 2013-12-30 | Янссен Фармацевтика Нв | Пиперазин-1-илтрифторметилзамещенные пиридины в качестве быстро диссоциирующихся антагонистов d-рецепторов дофамина |
-
2007
- 2007-11-19 JO JO2007479A patent/JO2642B1/en active
- 2007-12-05 EA EA200970553A patent/EA016654B1/ru not_active IP Right Cessation
- 2007-12-05 AU AU2007328897A patent/AU2007328897B2/en not_active Ceased
- 2007-12-05 MY MYPI20092235A patent/MY148772A/en unknown
- 2007-12-05 PT PT07847833T patent/PT2091938E/pt unknown
- 2007-12-05 DE DE602007010179T patent/DE602007010179D1/de active Active
- 2007-12-05 NZ NZ576484A patent/NZ576484A/en not_active IP Right Cessation
- 2007-12-05 CA CA2665924A patent/CA2665924C/en active Active
- 2007-12-05 PL PL07847833T patent/PL2091938T3/pl unknown
- 2007-12-05 US US12/516,645 patent/US8466153B2/en active Active
- 2007-12-05 AT AT07847833T patent/ATE486070T1/de active
- 2007-12-05 BR BRPI0720247-4A patent/BRPI0720247A2/pt active Search and Examination
- 2007-12-05 MX MX2009005983A patent/MX2009005983A/es active IP Right Grant
- 2007-12-05 EP EP07847833A patent/EP2091938B1/en active Active
- 2007-12-05 UA UAA200903503A patent/UA98940C2/ru unknown
- 2007-12-05 SI SI200730472T patent/SI2091938T1/sl unknown
- 2007-12-05 KR KR1020097010872A patent/KR101468384B1/ko active IP Right Grant
- 2007-12-05 JP JP2009539743A patent/JP5255568B2/ja active Active
- 2007-12-05 WO PCT/EP2007/063338 patent/WO2008068277A1/en active Application Filing
- 2007-12-05 CN CN2007800446538A patent/CN101547915B/zh active Active
- 2007-12-05 ES ES07847833T patent/ES2354756T3/es active Active
- 2007-12-05 DK DK07847833.6T patent/DK2091938T3/da active
- 2007-12-07 CL CL200703556A patent/CL2007003556A1/es unknown
- 2007-12-07 TW TW096146645A patent/TWI433676B/zh not_active IP Right Cessation
- 2007-12-07 AR ARP070105498A patent/AR064198A1/es unknown
-
2009
- 2009-06-02 IL IL199076A patent/IL199076A/en active IP Right Grant
- 2009-07-07 NO NO20092574A patent/NO20092574L/no not_active Application Discontinuation
-
2010
- 2010-02-02 HK HK10101123.6A patent/HK1137434A1/xx not_active IP Right Cessation
-
2011
- 2011-01-27 CY CY20111100088T patent/CY1112227T1/el unknown
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