DK3456340T3 - Glp-1-receptorantagonist til brug ved behandling af medfødt hyperinsulisme - Google Patents

Glp-1-receptorantagonist til brug ved behandling af medfødt hyperinsulisme Download PDF

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Publication number
DK3456340T3
DK3456340T3 DK18201976.0T DK18201976T DK3456340T3 DK 3456340 T3 DK3456340 T3 DK 3456340T3 DK 18201976 T DK18201976 T DK 18201976T DK 3456340 T3 DK3456340 T3 DK 3456340T3
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DK
Denmark
Prior art keywords
hyperinsulism
glp
congenital
treatment
receptor antagonist
Prior art date
Application number
DK18201976.0T
Other languages
English (en)
Inventor
Doris Stoffers
Leon Diva D De
Charles Stanley
Original Assignee
Univ Pennsylvania
Childrens Hospital Of Philadelphia
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Pennsylvania, Childrens Hospital Of Philadelphia filed Critical Univ Pennsylvania
Application granted granted Critical
Publication of DK3456340T3 publication Critical patent/DK3456340T3/da

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22Hormones
    • A61K38/26Glucagons
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Endocrinology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
DK18201976.0T 2007-01-08 2008-01-08 Glp-1-receptorantagonist til brug ved behandling af medfødt hyperinsulisme DK3456340T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US87903307P 2007-01-08 2007-01-08
EP14171762.9A EP2818181B1 (en) 2007-01-08 2008-01-08 Compositions and medical uses thereof

Publications (1)

Publication Number Publication Date
DK3456340T3 true DK3456340T3 (da) 2022-03-21

Family

ID=39609282

Family Applications (1)

Application Number Title Priority Date Filing Date
DK18201976.0T DK3456340T3 (da) 2007-01-08 2008-01-08 Glp-1-receptorantagonist til brug ved behandling af medfødt hyperinsulisme

Country Status (13)

Country Link
US (6) US9821031B2 (da)
EP (4) EP2120994B1 (da)
CY (1) CY1125273T1 (da)
DK (1) DK3456340T3 (da)
ES (3) ES2908838T3 (da)
HR (1) HRP20220346T3 (da)
HU (1) HUE058307T2 (da)
LT (1) LT3456340T (da)
PL (1) PL3456340T3 (da)
PT (1) PT3456340T (da)
SI (1) SI3456340T1 (da)
TR (1) TR201900959T4 (da)
WO (1) WO2008085982A2 (da)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HRP20220346T3 (hr) 2007-01-08 2022-09-02 The Trustees Of The University Of Pennsylvania Antagonist glp-1 receptora za upotrebu u liječenju kongenitalnog hiperinzulinizma
CA2875983A1 (en) * 2012-02-08 2013-08-15 Seneb Biosciences, Inc. Treatment of hypoglycemia
CN106232627A (zh) * 2014-02-21 2016-12-14 免疫医疗有限责任公司 抗pcsk9~glp‑1融合体及其使用方法
EP3265491A1 (en) 2015-03-03 2018-01-10 Xoma (Us) Llc Treatment of post-prandial hyperinsulinemia and hypoglycemia after bariatric surgery
ES2887723T3 (es) * 2015-05-22 2021-12-27 Univ Leland Stanford Junior Tratamiento de hipoglucemia posbariátrica con exendina(9-39)
US10653753B2 (en) 2016-03-04 2020-05-19 Eiger Biopharmaceuticals, Inc. Treatment of hyperinsulinemic hypoglycemia with exendin-4 derivatives
BR112019010236A2 (pt) * 2016-11-21 2019-08-20 Eiger Biopharmaceuticals Inc formulações tamponadas de exendina (9-39)
CN116606367A (zh) * 2022-05-31 2023-08-18 南京盛德瑞尔医药科技有限公司 长效Exendin-9-39及其在低血糖治疗中的应用和作为治疗低血糖的药物

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5424286A (en) * 1993-05-24 1995-06-13 Eng; John Exendin-3 and exendin-4 polypeptides, and pharmaceutical compositions comprising same
US20040092443A1 (en) * 1996-08-06 2004-05-13 Yeda Research And Development Co., Ltd Long-acting exendins and exendin agonists
US6469021B1 (en) * 1998-12-10 2002-10-22 Agouron Pharmaceuticals, Inc. Non-peptide antagonists of GLP-1 receptor and methods of use
US6903074B1 (en) 1999-06-04 2005-06-07 Societe De Conseils De Recherches Et D'applications Scientifiques, S.A.S. Neuromedin b and somatostatin receptor agonists
SE0004462D0 (sv) * 2000-12-04 2000-12-04 Pharmacia Ab Novel method and use
WO2002066062A2 (en) * 2001-02-01 2002-08-29 Drucker Daniel J Enhancement of glp-2 activity
JP4398644B2 (ja) 2001-04-06 2010-01-13 ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルベニア ErbB界面ペプチド擬態およびその使用方法
CN1162446C (zh) * 2001-05-10 2004-08-18 上海华谊生物技术有限公司 促胰岛素分泌肽衍生物
US7378385B2 (en) 2002-08-08 2008-05-27 University Of Cincinnati Role for GLP-1 to mediate responses to disparate stressors
DE102004043153B4 (de) 2004-09-03 2013-11-21 Philipps-Universität Marburg Erfindung betreffend GLP-1 und Exendin
EA200870575A1 (ru) 2006-05-26 2009-08-28 Амилин Фармасьютикалз, Инк. Композиции и способы лечения застойной сердечной недостаточности
HRP20220346T3 (hr) 2007-01-08 2022-09-02 The Trustees Of The University Of Pennsylvania Antagonist glp-1 receptora za upotrebu u liječenju kongenitalnog hiperinzulinizma
EP2310042B1 (en) 2008-07-08 2012-12-05 Novartis AG Use of pasireotide for the treatment of endogenous hyperinsulinemic hypoglycemia
AU2010258898B8 (en) 2009-06-08 2015-02-05 Amunix Operating Inc. Glucose-regulating polypeptides and methods of making and using same
US9932381B2 (en) 2014-06-18 2018-04-03 Sanofi Exendin-4 derivatives as selective glucagon receptor agonists
ES2887723T3 (es) 2015-05-22 2021-12-27 Univ Leland Stanford Junior Tratamiento de hipoglucemia posbariátrica con exendina(9-39)
BR112019010236A2 (pt) 2016-11-21 2019-08-20 Eiger Biopharmaceuticals Inc formulações tamponadas de exendina (9-39)

Also Published As

Publication number Publication date
US9616108B2 (en) 2017-04-11
TR201900959T4 (tr) 2019-02-21
SI3456340T1 (sl) 2022-08-31
US20100190700A1 (en) 2010-07-29
EP2818181B1 (en) 2018-10-24
PT3456340T (pt) 2022-05-25
ES2499390T3 (es) 2014-09-29
US20080269130A1 (en) 2008-10-30
US10188702B2 (en) 2019-01-29
US20210252110A1 (en) 2021-08-19
HRP20220346T3 (hr) 2022-09-02
US20240082361A1 (en) 2024-03-14
CY1125273T1 (el) 2023-06-09
US20190336584A1 (en) 2019-11-07
ES2710948T3 (es) 2019-04-29
EP4049673A1 (en) 2022-08-31
ES2908838T3 (es) 2022-05-04
EP3456340B1 (en) 2022-02-16
EP2818181A1 (en) 2014-12-31
EP3456340A1 (en) 2019-03-20
US10987407B2 (en) 2021-04-27
PL3456340T3 (pl) 2022-08-22
EP2120994B1 (en) 2014-06-11
WO2008085982A3 (en) 2008-11-20
US9821031B2 (en) 2017-11-21
EP2120994A2 (en) 2009-11-25
LT3456340T (lt) 2022-05-10
WO2008085982A2 (en) 2008-07-17
HUE058307T2 (hu) 2022-07-28
US20180050095A1 (en) 2018-02-22
EP2120994A4 (en) 2011-09-28

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