DK172877B1 - Analogifremgangsmåde til fremstilling af fra heparin afledede mucopolysaccharider med biologiske egenskaber - Google Patents

Analogifremgangsmåde til fremstilling af fra heparin afledede mucopolysaccharider med biologiske egenskaber Download PDF

Info

Publication number
DK172877B1
DK172877B1 DK198105113A DK511381A DK172877B1 DK 172877 B1 DK172877 B1 DK 172877B1 DK 198105113 A DK198105113 A DK 198105113A DK 511381 A DK511381 A DK 511381A DK 172877 B1 DK172877 B1 DK 172877B1
Authority
DK
Denmark
Prior art keywords
heparin
groups
process according
acid
nitric acid
Prior art date
Application number
DK198105113A
Other languages
Danish (da)
English (en)
Other versions
DK511381A (da
Inventor
Maurice Petitou
Jean-Claude Lormeau
Jean Choay
Original Assignee
Sanofi Synthelabo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=9239907&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK172877(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Sanofi Synthelabo filed Critical Sanofi Synthelabo
Publication of DK511381A publication Critical patent/DK511381A/da
Application granted granted Critical
Publication of DK172877B1 publication Critical patent/DK172877B1/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biochemistry (AREA)
  • Materials Engineering (AREA)
  • Polymers & Plastics (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
DK198105113A 1980-03-20 1981-11-18 Analogifremgangsmåde til fremstilling af fra heparin afledede mucopolysaccharider med biologiske egenskaber DK172877B1 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
FR8006282 1980-03-20
FR8006282A FR2478646A2 (fr) 1980-03-20 1980-03-20 Composition mucopolysaccharidique ayant une activite regulatrice de la coagulation, medicament la contenant et procede pour l'obtenir
PCT/FR1981/000041 WO1981002737A1 (fr) 1980-03-20 1981-03-20 Mucopolysaccharides possedant des proprietes biologiques, leur preparation et leur application en tant que medicaments
FR8100041 1981-03-20

Publications (2)

Publication Number Publication Date
DK511381A DK511381A (da) 1981-11-18
DK172877B1 true DK172877B1 (da) 1999-09-06

Family

ID=9239907

Family Applications (1)

Application Number Title Priority Date Filing Date
DK198105113A DK172877B1 (da) 1980-03-20 1981-11-18 Analogifremgangsmåde til fremstilling af fra heparin afledede mucopolysaccharider med biologiske egenskaber

Country Status (20)

Country Link
US (1) US4686288A (de)
EP (1) EP0037319B2 (de)
JP (1) JPH0231081B2 (de)
AR (1) AR227417A1 (de)
AT (1) ATE26450T1 (de)
CA (1) CA1207759A (de)
CS (1) CS222245B2 (de)
DD (1) DD157561A5 (de)
DE (1) DE3176086D1 (de)
DK (1) DK172877B1 (de)
ES (1) ES501130A0 (de)
FR (1) FR2478646A2 (de)
HU (1) HU188657B (de)
IE (1) IE52951B1 (de)
IL (1) IL62424A (de)
PL (1) PL135948B1 (de)
SU (1) SU1658820A3 (de)
UA (1) UA5934A1 (de)
WO (1) WO1981002737A1 (de)
YU (1) YU43008B (de)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2503714B1 (fr) * 1981-04-10 1986-11-21 Choay Sa Procede d'obtention de mucopolysaccharides biologiquement actifs, de purete elevee, par depolymerisation de l'heparine
FR2553287B1 (fr) * 1983-10-18 1986-09-12 Choay Sa Compositions a base de mucopolysaccharides ou d'oligosaccharides, notamment a base de fractions ou fragments d'heparine, appropriees au traitement de desordres de la proliferation cellulaire
CA1260461A (fr) * 1984-10-18 1989-09-26 Jean-Claude Lormeau Procede de preparation de compositions de mucopolysaccharides dotes d'une activite antithrombotique elevee
FR2572080B1 (fr) * 1984-10-18 1987-06-26 Dropic Procede de preparation de compositions de mucopolysaccharides dotees d'une activite antithrombotique elevee, les compositions obtenues et leur application en tant que medicaments
FR2584606A1 (fr) * 1985-07-12 1987-01-16 Dropic Utilisation de poly- et oligosaccharides pour l'obtention de medicaments actifs dans les pathologies du tissu conjonctif
US4788307A (en) * 1986-04-30 1988-11-29 Choay S.A. Oligosaccharidic fractions devoid or practically devoid of antithrombotic activity
US4879282A (en) * 1987-03-17 1989-11-07 Saliba Jr Michael J Medical application for heparin and related molecules
IT1230582B (it) 1988-10-21 1991-10-28 Opocrin S P A Lab Farmabiologi Oliogosaccaridi di dermatan solfato ed eparina aventi attivita' antiaterosclerotica
JP2871822B2 (ja) * 1989-08-29 1999-03-17 玉造株式会社 末端に２，５―アンヒドロマンニトール基または２，５―アンヒドロマンノース基を有するキチン・キトサンオリゴマーおよびその製造方法
WO1991015216A1 (en) * 1990-04-05 1991-10-17 Kennedy Thomas P Method and medicament for prevention or medication of human leucocyte elastase-mediated pulmonary diseases
US5824658A (en) * 1990-09-18 1998-10-20 Hyal Pharmaceutical Corporation Topical composition containing hyaluronic acid and NSAIDS
CA2061703C (en) * 1992-02-20 2002-07-02 Rudolf E. Falk Formulations containing hyaluronic acid
US5910489A (en) * 1990-09-18 1999-06-08 Hyal Pharmaceutical Corporation Topical composition containing hyaluronic acid and NSAIDS
US5990096A (en) * 1990-09-18 1999-11-23 Hyal Pharmaceutical Corporation Formulations containing hyaluronic acid
US5707973A (en) * 1991-04-23 1998-01-13 Rhone-Poulenc Rorer S.A. Sulfated polysaccharids for treatment or prevention of thromboses
US5792753A (en) * 1991-07-03 1998-08-11 Hyal Pharmaceutical Corporation Compositions comprising hyaluronic acid and prostaglandin-synthesis-inhibiting drugs
US6103704A (en) * 1991-07-03 2000-08-15 Hyal Pharmaceutical Corporation Therapeutic methods using hyaluronic acid
US5977088A (en) * 1991-07-03 1999-11-02 Hyal Pharmaceutical Corporation Formulations containing hyaluronic acid
US6218373B1 (en) 1992-02-20 2001-04-17 Hyal Pharmaceutical Corporation Formulations containing hyaluronic acid
US5767106A (en) * 1992-02-21 1998-06-16 Hyal Pharmaceutical Corporation Treatment of disease and conditions associated with macrophage infiltration
FR2691066B1 (fr) * 1992-05-15 1995-06-09 Sanofi Elf Utilisation de glycosaminoglycanes exogenes, de leurs analogues ainsi que de leurs fragments, fractions et derives, pour la preparation de medicaments destines au traitement de thrombopenies.
DE4217917A1 (de) * 1992-05-30 1993-12-02 Job Prof Dr Med Harenberg Immobilisation von chemisch kovalent gebundenem Heparin an Polymere mit Arylresten im Polymer
JP3390477B2 (ja) * 1993-01-25 2003-03-24 生化学工業株式会社 薬剤組成物及びその製造法
FR2704861B1 (fr) * 1993-05-07 1995-07-28 Sanofi Elf Fractions d'héparine purifiées, procédé d'obtention et compositions pharmaceutiques les contenant.
US5646130A (en) * 1995-06-30 1997-07-08 Ocean University Of Oingdao Low molecular weight sulfated polysaccharides and uses thereof
AU754936B2 (en) * 1996-11-27 2002-11-28 Aventis Pharmaceuticals Inc. Pharmaceutical composition comprising a compound having anti-Xa activity and a platelet aggregation antagonist compound
US5945457A (en) * 1997-10-01 1999-08-31 A.V. Topchiev Institute Of Petrochemical Synthesis, Russian Academy Of Science Process for preparing biologically compatible polymers and their use in medical devices
DE29900874U1 (de) 1999-01-20 1999-07-22 Knoll Ag Organprotektive Lösungen
JP4585072B2 (ja) * 2000-02-29 2010-11-24 扶桑薬品工業株式会社 ヘパリン解重合法、解重合ヘパリン、その誘導体および医薬組成物
US6969705B2 (en) 2000-07-21 2005-11-29 Aventis Pharma S.A. Compositions of polysaccharides derived from heparin, their preparation and pharmaceutical compositions containing them
FR2811992B1 (fr) * 2000-07-21 2003-07-04 Aventis Pharma Sa Melanges de polysaccharides derives d'heparine, leur preparation et les compositions pharmaceutiques les contenant
US7575886B2 (en) * 2002-03-11 2009-08-18 Momenta Pharmaceuticals, Inc. Analysis of sulfated polysaccharides
US20040171819A1 (en) 2002-10-10 2004-09-02 Aventis Pharma S.A. Mixtures of polysaccharides derived from heparin, their preparation and pharmaceutical compositions containing them
US7956046B2 (en) 2003-07-24 2011-06-07 Aventis Pharma S.A. Oligosaccharide mixtures derived from heparin, preparation thereof and pharmaceutical compositions containing them
EP1582531A1 (de) 2004-03-24 2005-10-05 Aventis Pharma S.A. Verfahren zur Oxydierung nicht-fraktionierten Heparins und die Detektion der Anwesenheit oder Abwesenheit von Glykoserin in Heparin und in von Heparin abgeleiteten Produkten
ATE552004T1 (de) 2005-11-30 2012-04-15 Istituto G Ronzoni Oral verabreichbare heparinderivate
US9139876B1 (en) 2007-05-03 2015-09-22 Momenta Pharmacueticals, Inc. Method of analyzing a preparation of a low molecular weight heparin
KR101529061B1 (ko) 2008-05-30 2015-06-16 모멘타 파머슈티컬스 인코포레이티드 당류 구조물, 그리고 이러한 구조물의 제조 및 사용 방법
WO2011090948A1 (en) * 2010-01-19 2011-07-28 Momenta Pharmaceuticals, Inc. Evaluating heparin preparations
WO2012115952A1 (en) 2011-02-21 2012-08-30 Momenta Pharmaceuticals, Inc. Evaluating heparin preparations
WO2022015794A1 (en) 2020-07-14 2022-01-20 Optimvia, Llc Methods for synthesizing non-anticoagulant heparan sulfate
EP3997238A1 (de) 2019-07-09 2022-05-18 Optimvia, LLC Verfahren zur synthese von antikoagulierenden polysacchariden

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3766167A (en) * 1971-03-26 1973-10-16 Research Corp Orally active anticoagulant
IT1083903B (it) * 1977-08-09 1985-05-25 Lobo Srl Oligo-eteropolisaccaridi con attivita' eparinosimili,procedimento per il loro ottenimento e relative composizioni terapeutiche
US4175182A (en) * 1978-07-03 1979-11-20 Research Corporation Separation of high-activity heparin by affinity chromatography on supported protamine
FR2440376A1 (fr) * 1978-11-06 1980-05-30 Choay Sa Composition mucopolysaccharidique ayant une activite regulatrice de la coagulation, medicament la contenant et procede pour l'obtenir
US4500519A (en) * 1978-11-06 1985-02-19 Choay S.A. Mucopolysaccharides having biological properties, preparation and method of use
SE449753B (sv) * 1978-11-06 1987-05-18 Choay Sa Mukopolysackaridkomposition med reglerande verkan pa koagulation, lekemedel innehallande densamma samt forfarande for framstellning derav
CA1136620A (en) * 1979-01-08 1982-11-30 Ulf P.F. Lindahl Heparin fragments having selective anticoagulation activity
IL61201A (en) * 1979-10-05 1984-09-30 Choay Sa Oligosaccharides having no more than 8 saccharide moieties,their obtention from heparin and pharmaceutical compositions containing them
US4281108A (en) * 1980-01-28 1981-07-28 Hepar Industries, Inc. Process for obtaining low molecular weight heparins endowed with elevated pharmacological properties, and product so obtained
GB2071127B (en) * 1980-02-29 1984-07-25 Italfarmaco Spa Process for the purification of glucosaninoglucans
CA1171375A (en) * 1980-09-15 1984-07-24 Ulf P.F. Lindahl Oligosaccharides having selective anticoagulation activity

Also Published As

Publication number Publication date
DD157561A5 (de) 1982-11-17
ATE26450T1 (de) 1987-04-15
EP0037319A1 (de) 1981-10-07
JPS57500335A (de) 1982-02-25
IL62424A0 (en) 1981-05-20
HU188657B (en) 1986-05-28
JPH0231081B2 (de) 1990-07-11
CA1207759A (en) 1986-07-15
ES8201596A1 (es) 1982-01-16
DE3176086D1 (en) 1987-05-14
IL62424A (en) 1984-12-31
DK511381A (da) 1981-11-18
PL135948B1 (en) 1986-01-31
UA5934A1 (uk) 1994-12-29
YU43008B (en) 1989-02-28
IE52951B1 (en) 1988-04-27
EP0037319B2 (de) 1995-06-28
PL230237A1 (en) 1981-11-13
YU73681A (en) 1983-10-31
AR227417A1 (es) 1982-10-29
IE810632L (en) 1981-09-20
EP0037319B1 (de) 1987-04-08
US4686288A (en) 1987-08-11
FR2478646B2 (de) 1983-06-24
SU1658820A3 (ru) 1991-06-23
ES501130A0 (es) 1982-01-16
WO1981002737A1 (fr) 1981-10-01
CS222245B2 (en) 1983-05-27
FR2478646A2 (fr) 1981-09-25

Similar Documents

Publication Publication Date Title
DK172877B1 (da) Analogifremgangsmåde til fremstilling af fra heparin afledede mucopolysaccharider med biologiske egenskaber
US4500519A (en) Mucopolysaccharides having biological properties, preparation and method of use
US4804652A (en) Mucopolysaccharides having biological properties, preparation and application thereof as drugs
EP0125152B1 (de) Xylansulphate, Verfahren zu deren Herstellung und ihre antithrombotische und hypolipemische Wirkung
KR940004062B1 (ko) 화학적으로 명명되고 재생이 가능한 폴리디옥시리보뉴클레오티드의 제조방법
CA1327968C (fr) Heparines de bas poids moleculaire, a structure reguliere leur preparation et leurs applications biologiques
EP0027089B1 (de) Oligosaccharidfraktionen und Oligosaccharide mit biologischen Eigenschaften, Verfahren zu ihrer Herstellung und ihre Verwendungen als Arzneimittel
US4533549A (en) Antithrombotic agent
JP2581722B2 (ja) 化学的に定義された再現性のあるポリデオキシリボヌクレオチドを得る方法
US2508433A (en) Alginic acid sulfate anticoagulant
EP0116801A1 (de) Depolymerisiertes und supersulfatiertes Heparin, Verfahren zu dessen Herstellung und dieses enthaltende pharmazeutische Zusammensetzungen
EP0238994B1 (de) Verfahren zur Herstellung von sehr reinem Dermatansulfat und pharmazeutische Zusammensetzungen, welche dieses enthalten
CN110776578B (zh) 低分子海参糖胺聚糖及其应用
JP2006291028A (ja) 低分子ヘパリンまたはその塩、ならびにその製造方法
DK172798B1 (da) Fremgangsmåde til fremstilling af lavmolekylære hepariner ved depolymerisation af normal heparin
JP3023485B2 (ja) ヘパリノイド活性を有する多糖類組成物或いは多糖類、それらの製造方法及びそれらを有効成分とする抗血液凝固剤
USRE35770E (en) Oligosaccharides having anti-Xa activity and pharmaceutical compositions containing them
CN108285498B (zh) 一种抑制内源性凝血因子x酶复合物的寡糖化合物及其制备方法与用途
JPH10182703A (ja) 低分子量のフカン類とその医薬組成物
CN1183149C (zh) 含有低聚糖的药物组合物及其制备方法
HU211988A9 (en) New sulfated polysaccharide, pharmaceutically acceptable salts thereof, process for preparation thereof, and drug containing the same
JP2521083B2 (ja) ヘパリノイド活性を有する多糖体及びその製造方法並びにそれを含有する抗血液凝固剤
CN112851833B (zh) 一种降低玻璃酸钠及其衍生物中蛋白质含量的纯化方法
FR2495935A1 (fr) Fractions mucopolysaccharidiques possedant des proprietes biologiques, leur procede de preparation et leur application en tant que medicaments
JP2004002355A (ja) 新規な抗血液凝固剤