ES8201596A1 - Procedimiento de obtencion de mucopolisacaridos - Google Patents
Procedimiento de obtencion de mucopolisacaridosInfo
- Publication number
- ES8201596A1 ES8201596A1 ES501130A ES501130A ES8201596A1 ES 8201596 A1 ES8201596 A1 ES 8201596A1 ES 501130 A ES501130 A ES 501130A ES 501130 A ES501130 A ES 501130A ES 8201596 A1 ES8201596 A1 ES 8201596A1
- Authority
- ES
- Spain
- Prior art keywords
- heparin
- mucopolysaccharides
- preparation
- titre
- conditions
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
- C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Biochemistry (AREA)
- Materials Engineering (AREA)
- Polymers & Plastics (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Abstract
PROCEDIMIENTO PARA LA OBTENCION DE MUCOPOLISACARIDOS, CON ACTIVIDAD ANTIXA, QUE TIENE APLICACIONES FARMACOLOGICAS COMO AGENTE ANTITROMBOTICO. CONSISTE EN EL TRATAMIENTO CONTROLADO DE HEPARINA CON AGENTE QUIMICO, TAL COMO EL ACIDO NITROSO, CAPAZ DE DESPOLIMERIZAR O FRAGMENTAR LAS CADENAS HEPARINICAS, DE MODO QUE SE FORMA UNA MEZCLA CONSTITUIDA FUNDAMENTALMENTE POR PRODUCTOS QUE TIENE UNOS TITULOS YIN-WESLER Y USP EN RELACION SUPERIOR A 2 Y QUE CONTIENEN GRUPOS REDUCTORES TERMINALES DE ESTRUCTURA 2,5-ANIHIDRO-D-MANOSA. EL ACIDO NITROSO DE SE GENERA IN SITU POR MEDIO DE NITRITO SODICO Y UN ACIDO Y LA DESPOLIMERIZACION SE REALIZA A TEMPERATURAS ENTRE 0C Y 10C. LOS PRODUCTOS SE RECUPERAN PRECIPITANDOLOS MEDIANTE UN DISOLVENTE ALCOHILICO.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR8006282A FR2478646A2 (fr) | 1980-03-20 | 1980-03-20 | Composition mucopolysaccharidique ayant une activite regulatrice de la coagulation, medicament la contenant et procede pour l'obtenir |
Publications (2)
Publication Number | Publication Date |
---|---|
ES8201596A1 true ES8201596A1 (es) | 1982-01-16 |
ES501130A0 ES501130A0 (es) | 1982-01-16 |
Family
ID=9239907
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES501130A Granted ES501130A0 (es) | 1980-03-20 | 1981-03-20 | Procedimiento de obtencion de mucopolisacaridos |
Country Status (20)
Country | Link |
---|---|
US (1) | US4686288A (es) |
EP (1) | EP0037319B2 (es) |
JP (1) | JPH0231081B2 (es) |
AR (1) | AR227417A1 (es) |
AT (1) | ATE26450T1 (es) |
CA (1) | CA1207759A (es) |
CS (1) | CS222245B2 (es) |
DD (1) | DD157561A5 (es) |
DE (1) | DE3176086D1 (es) |
DK (1) | DK172877B1 (es) |
ES (1) | ES501130A0 (es) |
FR (1) | FR2478646A2 (es) |
HU (1) | HU188657B (es) |
IE (1) | IE52951B1 (es) |
IL (1) | IL62424A (es) |
PL (1) | PL135948B1 (es) |
SU (1) | SU1658820A3 (es) |
UA (1) | UA5934A1 (es) |
WO (1) | WO1981002737A1 (es) |
YU (1) | YU43008B (es) |
Families Citing this family (42)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2503714B1 (fr) * | 1981-04-10 | 1986-11-21 | Choay Sa | Procede d'obtention de mucopolysaccharides biologiquement actifs, de purete elevee, par depolymerisation de l'heparine |
FR2553287B1 (fr) * | 1983-10-18 | 1986-09-12 | Choay Sa | Compositions a base de mucopolysaccharides ou d'oligosaccharides, notamment a base de fractions ou fragments d'heparine, appropriees au traitement de desordres de la proliferation cellulaire |
FR2572080B1 (fr) * | 1984-10-18 | 1987-06-26 | Dropic | Procede de preparation de compositions de mucopolysaccharides dotees d'une activite antithrombotique elevee, les compositions obtenues et leur application en tant que medicaments |
CA1260461A (fr) * | 1984-10-18 | 1989-09-26 | Jean-Claude Lormeau | Procede de preparation de compositions de mucopolysaccharides dotes d'une activite antithrombotique elevee |
FR2584606A1 (fr) * | 1985-07-12 | 1987-01-16 | Dropic | Utilisation de poly- et oligosaccharides pour l'obtention de medicaments actifs dans les pathologies du tissu conjonctif |
US4788307A (en) * | 1986-04-30 | 1988-11-29 | Choay S.A. | Oligosaccharidic fractions devoid or practically devoid of antithrombotic activity |
US4879282A (en) * | 1987-03-17 | 1989-11-07 | Saliba Jr Michael J | Medical application for heparin and related molecules |
IT1230582B (it) | 1988-10-21 | 1991-10-28 | Opocrin S P A Lab Farmabiologi | Oliogosaccaridi di dermatan solfato ed eparina aventi attivita' antiaterosclerotica |
JP2871822B2 (ja) * | 1989-08-29 | 1999-03-17 | 玉造株式会社 | 末端に2,5―アンヒドロマンニトール基または2,5―アンヒドロマンノース基を有するキチン・キトサンオリゴマーおよびその製造方法 |
WO1991015216A1 (en) * | 1990-04-05 | 1991-10-17 | Kennedy Thomas P | Method and medicament for prevention or medication of human leucocyte elastase-mediated pulmonary diseases |
CA2061703C (en) * | 1992-02-20 | 2002-07-02 | Rudolf E. Falk | Formulations containing hyaluronic acid |
US5910489A (en) * | 1990-09-18 | 1999-06-08 | Hyal Pharmaceutical Corporation | Topical composition containing hyaluronic acid and NSAIDS |
US5824658A (en) * | 1990-09-18 | 1998-10-20 | Hyal Pharmaceutical Corporation | Topical composition containing hyaluronic acid and NSAIDS |
US5990096A (en) * | 1990-09-18 | 1999-11-23 | Hyal Pharmaceutical Corporation | Formulations containing hyaluronic acid |
US5707973A (en) * | 1991-04-23 | 1998-01-13 | Rhone-Poulenc Rorer S.A. | Sulfated polysaccharids for treatment or prevention of thromboses |
US5977088A (en) * | 1991-07-03 | 1999-11-02 | Hyal Pharmaceutical Corporation | Formulations containing hyaluronic acid |
US5792753A (en) * | 1991-07-03 | 1998-08-11 | Hyal Pharmaceutical Corporation | Compositions comprising hyaluronic acid and prostaglandin-synthesis-inhibiting drugs |
US6103704A (en) * | 1991-07-03 | 2000-08-15 | Hyal Pharmaceutical Corporation | Therapeutic methods using hyaluronic acid |
US6218373B1 (en) | 1992-02-20 | 2001-04-17 | Hyal Pharmaceutical Corporation | Formulations containing hyaluronic acid |
US5767106A (en) * | 1992-02-21 | 1998-06-16 | Hyal Pharmaceutical Corporation | Treatment of disease and conditions associated with macrophage infiltration |
FR2691066B1 (fr) * | 1992-05-15 | 1995-06-09 | Sanofi Elf | Utilisation de glycosaminoglycanes exogenes, de leurs analogues ainsi que de leurs fragments, fractions et derives, pour la preparation de medicaments destines au traitement de thrombopenies. |
DE4217917A1 (de) * | 1992-05-30 | 1993-12-02 | Job Prof Dr Med Harenberg | Immobilisation von chemisch kovalent gebundenem Heparin an Polymere mit Arylresten im Polymer |
JP3390477B2 (ja) * | 1993-01-25 | 2003-03-24 | 生化学工業株式会社 | 薬剤組成物及びその製造法 |
FR2704861B1 (fr) * | 1993-05-07 | 1995-07-28 | Sanofi Elf | Fractions d'héparine purifiées, procédé d'obtention et compositions pharmaceutiques les contenant. |
US5646130A (en) * | 1995-06-30 | 1997-07-08 | Ocean University Of Oingdao | Low molecular weight sulfated polysaccharides and uses thereof |
AP1390A (en) * | 1996-11-27 | 2005-04-15 | Aventis Pharmaceuticals Products Inc | Pharmaceutical composition comprising a compound having anti-Xa activity and a platelet aggregation antagonist compound. |
US5945457A (en) * | 1997-10-01 | 1999-08-31 | A.V. Topchiev Institute Of Petrochemical Synthesis, Russian Academy Of Science | Process for preparing biologically compatible polymers and their use in medical devices |
DE29900874U1 (de) | 1999-01-20 | 1999-07-22 | Knoll AG, 67061 Ludwigshafen | Organprotektive Lösungen |
JP4585072B2 (ja) * | 2000-02-29 | 2010-11-24 | 扶桑薬品工業株式会社 | ヘパリン解重合法、解重合ヘパリン、その誘導体および医薬組成物 |
US6969705B2 (en) | 2000-07-21 | 2005-11-29 | Aventis Pharma S.A. | Compositions of polysaccharides derived from heparin, their preparation and pharmaceutical compositions containing them |
FR2811992B1 (fr) * | 2000-07-21 | 2003-07-04 | Aventis Pharma Sa | Melanges de polysaccharides derives d'heparine, leur preparation et les compositions pharmaceutiques les contenant |
EP2284535A1 (en) * | 2002-03-11 | 2011-02-16 | Momenta Pharmaceuticals, Inc. | Low molecular weight heparins |
US20040171819A1 (en) | 2002-10-10 | 2004-09-02 | Aventis Pharma S.A. | Mixtures of polysaccharides derived from heparin, their preparation and pharmaceutical compositions containing them |
US7956046B2 (en) | 2003-07-24 | 2011-06-07 | Aventis Pharma S.A. | Oligosaccharide mixtures derived from heparin, preparation thereof and pharmaceutical compositions containing them |
EP1582531A1 (en) | 2004-03-24 | 2005-10-05 | Aventis Pharma S.A. | Process for oxidizing unfractionated heparins and detecting presence or absence of glycoserine in heparin and heparin products |
EP1792621B1 (en) | 2005-11-30 | 2012-04-04 | Istituto di Ricerche Chimiche e Biochimiche "G. Ronzoni" | Orally administrable heparin derivatives |
US9139876B1 (en) | 2007-05-03 | 2015-09-22 | Momenta Pharmacueticals, Inc. | Method of analyzing a preparation of a low molecular weight heparin |
CN102046781A (zh) | 2008-05-30 | 2011-05-04 | 动量制药公司 | 糖结构以及制造和使用此类结构的方法 |
CN102791742B (zh) * | 2010-01-19 | 2014-12-24 | 动量制药公司 | 评价肝素制剂 |
WO2012115952A1 (en) | 2011-02-21 | 2012-08-30 | Momenta Pharmaceuticals, Inc. | Evaluating heparin preparations |
BR112022000255A8 (pt) | 2019-07-09 | 2022-03-22 | Optimvia Llc | Métodos para sintetizar polissacarídeos anticoagulantes |
EP4182452A4 (en) | 2020-07-14 | 2024-07-31 | Optimvia Llc | METHOD FOR THE SYNTHESIS OF NON-ANTICOAGULATING HEPARAN SULFATE |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3766167A (en) * | 1971-03-26 | 1973-10-16 | Research Corp | Orally active anticoagulant |
IT1083903B (it) * | 1977-08-09 | 1985-05-25 | Lobo Srl | Oligo-eteropolisaccaridi con attivita' eparinosimili,procedimento per il loro ottenimento e relative composizioni terapeutiche |
US4175182A (en) * | 1978-07-03 | 1979-11-20 | Research Corporation | Separation of high-activity heparin by affinity chromatography on supported protamine |
FR2440376A1 (fr) * | 1978-11-06 | 1980-05-30 | Choay Sa | Composition mucopolysaccharidique ayant une activite regulatrice de la coagulation, medicament la contenant et procede pour l'obtenir |
US4500519A (en) * | 1978-11-06 | 1985-02-19 | Choay S.A. | Mucopolysaccharides having biological properties, preparation and method of use |
SE449753B (sv) * | 1978-11-06 | 1987-05-18 | Choay Sa | Mukopolysackaridkomposition med reglerande verkan pa koagulation, lekemedel innehallande densamma samt forfarande for framstellning derav |
CA1136620A (en) * | 1979-01-08 | 1982-11-30 | Ulf P.F. Lindahl | Heparin fragments having selective anticoagulation activity |
IL61201A (en) * | 1979-10-05 | 1984-09-30 | Choay Sa | Oligosaccharides having no more than 8 saccharide moieties,their obtention from heparin and pharmaceutical compositions containing them |
US4281108A (en) * | 1980-01-28 | 1981-07-28 | Hepar Industries, Inc. | Process for obtaining low molecular weight heparins endowed with elevated pharmacological properties, and product so obtained |
GB2071127B (en) * | 1980-02-29 | 1984-07-25 | Italfarmaco Spa | Process for the purification of glucosaninoglucans |
CA1171375A (en) * | 1980-09-15 | 1984-07-24 | Ulf P.F. Lindahl | Oligosaccharides having selective anticoagulation activity |
-
1980
- 1980-03-20 FR FR8006282A patent/FR2478646A2/fr active Granted
-
1981
- 1981-03-18 IL IL62424A patent/IL62424A/xx not_active IP Right Cessation
- 1981-03-20 IE IE632/81A patent/IE52951B1/en not_active IP Right Cessation
- 1981-03-20 AT AT81400449T patent/ATE26450T1/de not_active IP Right Cessation
- 1981-03-20 CS CS812064A patent/CS222245B2/cs unknown
- 1981-03-20 YU YU736/81A patent/YU43008B/xx unknown
- 1981-03-20 HU HU81718A patent/HU188657B/hu unknown
- 1981-03-20 UA UA3360355A patent/UA5934A1/uk unknown
- 1981-03-20 DD DD81228490A patent/DD157561A5/de not_active IP Right Cessation
- 1981-03-20 AR AR284697A patent/AR227417A1/es active
- 1981-03-20 PL PL1981230237A patent/PL135948B1/pl unknown
- 1981-03-20 DE DE8181400449T patent/DE3176086D1/de not_active Expired
- 1981-03-20 EP EP81400449A patent/EP0037319B2/fr not_active Expired - Lifetime
- 1981-03-20 JP JP56500903A patent/JPH0231081B2/ja not_active Expired - Lifetime
- 1981-03-20 ES ES501130A patent/ES501130A0/es active Granted
- 1981-03-20 WO PCT/FR1981/000041 patent/WO1981002737A1/fr unknown
- 1981-03-20 CA CA000373478A patent/CA1207759A/en not_active Expired
- 1981-11-18 DK DK198105113A patent/DK172877B1/da active
- 1981-11-20 SU SU813360355A patent/SU1658820A3/ru active
-
1984
- 1984-12-13 US US06/681,017 patent/US4686288A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
YU43008B (en) | 1989-02-28 |
JPS57500335A (es) | 1982-02-25 |
EP0037319A1 (fr) | 1981-10-07 |
IE810632L (en) | 1981-09-20 |
DD157561A5 (de) | 1982-11-17 |
SU1658820A3 (ru) | 1991-06-23 |
ATE26450T1 (de) | 1987-04-15 |
CA1207759A (en) | 1986-07-15 |
CS222245B2 (en) | 1983-05-27 |
WO1981002737A1 (fr) | 1981-10-01 |
US4686288A (en) | 1987-08-11 |
ES501130A0 (es) | 1982-01-16 |
PL230237A1 (en) | 1981-11-13 |
JPH0231081B2 (es) | 1990-07-11 |
FR2478646B2 (es) | 1983-06-24 |
IE52951B1 (en) | 1988-04-27 |
EP0037319B1 (fr) | 1987-04-08 |
HU188657B (en) | 1986-05-28 |
EP0037319B2 (fr) | 1995-06-28 |
YU73681A (en) | 1983-10-31 |
DK511381A (da) | 1981-11-18 |
DK172877B1 (da) | 1999-09-06 |
IL62424A0 (en) | 1981-05-20 |
IL62424A (en) | 1984-12-31 |
AR227417A1 (es) | 1982-10-29 |
DE3176086D1 (en) | 1987-05-14 |
PL135948B1 (en) | 1986-01-31 |
UA5934A1 (uk) | 1994-12-29 |
FR2478646A2 (fr) | 1981-09-25 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PC1A | Transfer granted |