KR890009868A - 1-메틸-β-옥소-α-(페닐카바모일)-2- 피롤프로피오니트릴의 트로메트아민염 - Google Patents
1-메틸-β-옥소-α-(페닐카바모일)-2- 피롤프로피오니트릴의 트로메트아민염 Download PDFInfo
- Publication number
- KR890009868A KR890009868A KR1019880016763A KR880016763A KR890009868A KR 890009868 A KR890009868 A KR 890009868A KR 1019880016763 A KR1019880016763 A KR 1019880016763A KR 880016763 A KR880016763 A KR 880016763A KR 890009868 A KR890009868 A KR 890009868A
- Authority
- KR
- South Korea
- Prior art keywords
- pharmaceutical composition
- treatment
- arthritis
- inflammatory
- preparing
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/337—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pain & Pain Management (AREA)
- Pharmacology & Pharmacy (AREA)
- Rheumatology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrrole Compounds (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (10)
1-메틸-β-옥소-α-(페닐카바모임)-2-피롤프로피오니트릴의 트로메트아민 염.
유효량의 제1항의 화합물과 하나 또는 그 이상의 약제학적으로 허용되는 담체를 함께 함유함을 특징으로하는 소염성 또는 관절염 치료용 약제학적 조성물.
소염제 또는 관절염 치료제로서의 또는 소염 및 관절염 치료 활성을 갖는 약제학적 조성물의 제조를 위한 제1항에 따른 화합물의 용도.
제3항에 있어서, 류마티스성 관절염의 치료를 위한 용도.
제3항에 있어서, 골 관절염의 치료를 위한 용도.
호중구 주화성을 억제하거나, 또는 호중구 주화성억제용 약제학적 조성물을 제조하기 위한 제1항에 따른 화합물의 용도.
세포 매개된 면역을 강화하거나, 세포 매개된 면역 강화용 약제학적 조성물의 제조를 위한 제1항에 따른 화합물의 용도.
제1항에 따른 화합물을 류마티스성 관절염 치료용으로 적합한 제제로 제형화시킴을 특징으로하여, 염증 또는 관절염 질환을 치료하기 위한 약제학적 조성물을 제조하는 방법.
제1항에 따른 화합물을 골 관절염 치료용으로 적합한 제제로 제형화시킴을 특징으로하여, 염증 또는 관절염 질환을 치료하기 위한 약제학적 조성물을 제조하는 방법.
제1항에 따른 화합물을 면역학적으로 매개된 질환치료용으로 적합한 제제로 제형화시킴을 특징으로하여, 면역촉진 효과를 갖는 약제학적 조성물을 제조하는 방법.
※참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| USPUS87/03413 | 1987-12-18 | ||
| PCT/US1987/003413 WO1989005798A1 (en) | 1987-12-18 | 1987-12-18 | TROMETHAMINE SALT OF 1-METHYL-beta-OXO-alpha-(PHENYLCARBAMOYL)-2-PYRROLEPROPIONITRILE |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR890009868A true KR890009868A (ko) | 1989-08-04 |
Family
ID=22202723
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019880016763A KR890009868A (ko) | 1987-12-18 | 1988-12-16 | 1-메틸-β-옥소-α-(페닐카바모일)-2- 피롤프로피오니트릴의 트로메트아민염 |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US4977181A (ko) |
| JP (1) | JPH02502534A (ko) |
| KR (1) | KR890009868A (ko) |
| AT (1) | AT390437B (ko) |
| AU (1) | AU3596889A (ko) |
| DD (1) | DD283375A5 (ko) |
| DE (1) | DE3842250A1 (ko) |
| DK (1) | DK704188A (ko) |
| ES (1) | ES2012578A6 (ko) |
| FI (1) | FI885828A (ko) |
| FR (1) | FR2624856A1 (ko) |
| GB (1) | GB2211187A (ko) |
| HU (1) | HU199788B (ko) |
| IL (1) | IL88654A0 (ko) |
| IT (1) | IT1235336B (ko) |
| LU (1) | LU87406A1 (ko) |
| NL (1) | NL8803092A (ko) |
| NO (1) | NO885576L (ko) |
| PT (1) | PT88104A (ko) |
| WO (1) | WO1989005798A1 (ko) |
| YU (1) | YU227788A (ko) |
| ZA (1) | ZA889355B (ko) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4977181A (en) * | 1987-12-18 | 1990-12-11 | Ciba-Geigy Corporation | Tromethamine salt of 1-methyl-beta-oxo-alpha-(phenylcarbamoyl)-2-pyrrolepropionitrile |
| ES2058024B1 (es) * | 1992-11-10 | 1995-05-01 | Menarini Lab | Nuevo derivado arilpropionico, procedimiento de fabricacion del mismo y su utilizacion como analgesico. |
| US5431717A (en) * | 1993-12-03 | 1995-07-11 | Geobiotics, Inc. | Method for rendering refractory sulfide ores more susceptible to biooxidation |
| US7008979B2 (en) | 2002-04-30 | 2006-03-07 | Hydromer, Inc. | Coating composition for multiple hydrophilic applications |
| KR100576332B1 (ko) | 2004-07-16 | 2006-05-03 | 강승우 | 신규한 글라이세리드 유도체 및 이를 포함하는 통증완화용조성물 |
| EP2854768B1 (en) | 2012-05-30 | 2017-03-22 | Fresenius Kabi Oncology Limited | Pharmaceutical compositions of pemetrexed |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU4028772A (en) * | 1971-04-02 | 1973-09-27 | Merck & Co., Inc | Chemical processes |
| GB1398072A (en) * | 1971-06-14 | 1975-06-18 | May & Baker Ltd | Cyclopentane derivatives |
| US4089969A (en) * | 1976-07-14 | 1978-05-16 | Syntex (U.S.A.) Inc. | 5-Aroyl-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid derivatives and process for the production thereof |
| FI71129C (fi) * | 1979-06-11 | 1986-11-24 | Ciba Geigy Ag | Foerfarande foer framstaellning av farmaceutiskt aktiva alfakarbamoylpyrrolpropionitriler |
| US4256759A (en) * | 1979-06-11 | 1981-03-17 | Ciba-Geigy Corporation | Alphacarbamoyl-pyrrolpropionitriles |
| HU185926B (en) * | 1979-09-27 | 1985-04-28 | Agostne Kahan | Process for preparing water soluble derivatives of non-steroid antiinflammatory compositions and pharmaceutical compositins containing such derivatives |
| US4644010A (en) * | 1982-09-28 | 1987-02-17 | Ciba-Geigy Corporation | Certain β-oxo-α-carbamoylpyrrolepropionitriles |
| US4977181A (en) * | 1987-12-18 | 1990-12-11 | Ciba-Geigy Corporation | Tromethamine salt of 1-methyl-beta-oxo-alpha-(phenylcarbamoyl)-2-pyrrolepropionitrile |
-
1987
- 1987-12-18 US US07/424,297 patent/US4977181A/en not_active Expired - Fee Related
- 1987-12-18 JP JP63500815A patent/JPH02502534A/ja active Pending
- 1987-12-18 WO PCT/US1987/003413 patent/WO1989005798A1/en active Application Filing
-
1988
- 1988-07-26 PT PT88104A patent/PT88104A/pt not_active Application Discontinuation
- 1988-12-11 IL IL88654A patent/IL88654A0/xx unknown
- 1988-12-14 ZA ZA889355A patent/ZA889355B/xx unknown
- 1988-12-14 LU LU87406A patent/LU87406A1/de unknown
- 1988-12-14 GB GB8829136A patent/GB2211187A/en not_active Withdrawn
- 1988-12-15 NO NO88885576A patent/NO885576L/no unknown
- 1988-12-15 IT IT8848657A patent/IT1235336B/it active
- 1988-12-15 DE DE3842250A patent/DE3842250A1/de not_active Withdrawn
- 1988-12-16 NL NL8803092A patent/NL8803092A/nl not_active Application Discontinuation
- 1988-12-16 FI FI885828A patent/FI885828A/fi not_active Application Discontinuation
- 1988-12-16 HU HU886477A patent/HU199788B/hu not_active IP Right Cessation
- 1988-12-16 AT AT0307488A patent/AT390437B/de not_active IP Right Cessation
- 1988-12-16 FR FR8816638A patent/FR2624856A1/fr not_active Withdrawn
- 1988-12-16 ES ES888803830A patent/ES2012578A6/es not_active Expired - Lifetime
- 1988-12-16 DD DD88323311A patent/DD283375A5/de not_active IP Right Cessation
- 1988-12-16 YU YU02277/88A patent/YU227788A/xx unknown
- 1988-12-16 KR KR1019880016763A patent/KR890009868A/ko not_active Application Discontinuation
- 1988-12-16 DK DK704188A patent/DK704188A/da not_active Application Discontinuation
-
1989
- 1989-03-21 AU AU35968/89A patent/AU3596889A/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| DK704188A (da) | 1989-06-19 |
| DD283375A5 (de) | 1990-10-10 |
| DE3842250A1 (de) | 1989-06-29 |
| IL88654A0 (en) | 1989-07-31 |
| JPH02502534A (ja) | 1990-08-16 |
| ATA307488A (de) | 1989-10-15 |
| AT390437B (de) | 1990-05-10 |
| NL8803092A (nl) | 1989-07-17 |
| PT88104A (pt) | 1989-09-14 |
| DK704188D0 (da) | 1988-12-16 |
| FI885828A (fi) | 1989-06-19 |
| NO885576D0 (no) | 1988-12-15 |
| HUT48582A (en) | 1989-06-28 |
| GB8829136D0 (en) | 1989-01-25 |
| ES2012578A6 (es) | 1990-04-01 |
| US4977181A (en) | 1990-12-11 |
| FR2624856A1 (en) | 1989-06-23 |
| NO885576L (no) | 1989-06-19 |
| LU87406A1 (de) | 1990-02-28 |
| IT8848657A0 (it) | 1988-12-15 |
| YU227788A (en) | 1990-08-31 |
| ZA889355B (en) | 1989-10-25 |
| WO1989005798A1 (en) | 1989-06-29 |
| HU199788B (en) | 1990-03-28 |
| GB2211187A (en) | 1989-06-28 |
| IT1235336B (it) | 1992-06-30 |
| FI885828A0 (fi) | 1988-12-16 |
| AU3596889A (en) | 1990-01-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| WITN | Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid |