DK171648B1 - Polypeptid, der er et interleukin-1beta-derivat, gen, der koder for polypeptidet, vektor indeholdende genet, mikroorganisme indeholdende vektoren, og lægemidel indeholdende polypeptidet - Google Patents

Polypeptid, der er et interleukin-1beta-derivat, gen, der koder for polypeptidet, vektor indeholdende genet, mikroorganisme indeholdende vektoren, og lægemidel indeholdende polypeptidet Download PDF

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Publication number
DK171648B1
DK171648B1 DK127887A DK127887A DK171648B1 DK 171648 B1 DK171648 B1 DK 171648B1 DK 127887 A DK127887 A DK 127887A DK 127887 A DK127887 A DK 127887A DK 171648 B1 DK171648 B1 DK 171648B1
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DK
Denmark
Prior art keywords
polypeptide
ser
leu
lys
asp
Prior art date
Application number
DK127887A
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Danish (da)
English (en)
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DK127887D0 (da
DK127887A (da
Inventor
Kiyoshi Ishii
Yasuo Yanagihara
Yoshikatsu Hirai
Satoru Nakai
Mayumi Kaneta
Kazuyoshi Kawai
Yoshikazu Kikumoto
Yeong-Man Hong
Setsuko Takegata
Original Assignee
Otsuka Pharma Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Otsuka Pharma Co Ltd filed Critical Otsuka Pharma Co Ltd
Publication of DK127887D0 publication Critical patent/DK127887D0/da
Publication of DK127887A publication Critical patent/DK127887A/da
Application granted granted Critical
Publication of DK171648B1 publication Critical patent/DK171648B1/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/545—IL-1
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Pain & Pain Management (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
DK127887A 1986-03-14 1987-03-12 Polypeptid, der er et interleukin-1beta-derivat, gen, der koder for polypeptidet, vektor indeholdende genet, mikroorganisme indeholdende vektoren, og lægemidel indeholdende polypeptidet DK171648B1 (da)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
JP5788586 1986-03-14
JP5788586 1986-03-14
JP14583086 1986-06-20
JP14583086 1986-06-20
JP16118486 1986-07-09
JP16118486 1986-07-09
JP20032486 1986-08-27
JP20032486 1986-08-27

Publications (3)

Publication Number Publication Date
DK127887D0 DK127887D0 (da) 1987-03-12
DK127887A DK127887A (da) 1987-09-15
DK171648B1 true DK171648B1 (da) 1997-03-03

Family

ID=27463573

Family Applications (1)

Application Number Title Priority Date Filing Date
DK127887A DK171648B1 (da) 1986-03-14 1987-03-12 Polypeptid, der er et interleukin-1beta-derivat, gen, der koder for polypeptidet, vektor indeholdende genet, mikroorganisme indeholdende vektoren, og lægemidel indeholdende polypeptidet

Country Status (5)

Country Link
EP (2) EP0237967B1 (de)
JP (1) JP2591615B2 (de)
DE (1) DE3751593T2 (de)
DK (1) DK171648B1 (de)
ES (1) ES2009215A6 (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5047505A (en) * 1987-01-27 1991-09-10 Du Pont Merck Pharmaceutical Company High level expression in E. coli of soluble mature HIL-1beta and derivatives with altered biological activity
US4904584A (en) * 1987-12-23 1990-02-27 Genetics Institute, Inc. Site-specific homogeneous modification of polypeptides
JP2698976B2 (ja) * 1988-02-03 1998-01-19 大日本製薬株式会社 新規ポリペプチド及びそれをコードするｄｎａ
US5120534A (en) * 1988-07-29 1992-06-09 Otsuka Pharmaceutical Co., Ltd. IL-1α derivatives and medicament for treating thrombocytopenia
JP2554528B2 (ja) * 1988-09-19 1996-11-13 大塚製薬株式会社 副腎皮質刺激ホルモン分泌能検査薬
WO1990006127A1 (en) * 1988-12-06 1990-06-14 Otsuka Pharmaceutical Co., Ltd. STABILIZED COMPOSITION OF INTERLEUKIN-1$g(b)
US5039790A (en) * 1989-01-11 1991-08-13 Monsanto Company Bioactive fragment of interleukin-1-B that has antagonistic activity
EP0460052B1 (de) * 1989-02-27 1998-04-15 New England Medical Center Il-1, dessen biologische aktivität inhibiert ist
US5723117A (en) * 1990-08-10 1998-03-03 Otsuka Pharmaceutical Co., Ltd. Use of interleukin-1 (IL-1) to inhibit development of hepatitis
DE69126116T2 (de) * 1990-08-10 1997-08-28 Otsuka Pharma Co Ltd Wirkstoff zur hepatitisverhütung und -behandlung
JP2678689B2 (ja) * 1990-08-10 1997-11-17 大塚製薬株式会社 肝炎予防・治療剤
FR2667601A1 (fr) * 1990-10-05 1992-04-10 Rhone Poulenc Sante Polypeptides derives de l'interleukine-1 beta, procede de preparation et utilisation, notamment dans le cadre des pathologies osteoarticulaires.
AU1270592A (en) * 1991-02-05 1992-09-07 University Of Maryland Modified interleukin-1beta
SE9201966D0 (sv) * 1992-06-25 1992-06-25 Trion Forskning & Utveckling Interleukin-1beta deletion mutant
GB9916630D0 (en) * 1999-07-16 1999-09-15 Univ Manchester Molecules derived from interleukins
DE60040740D1 (de) * 1999-12-03 2008-12-18 Celltech Chiroscience Ltd VERWENDUNG OF INTERLEUkIN-1 MUTEIN ALS IMPFSTOFFADJUVANS
WO2002017958A1 (de) * 2000-08-29 2002-03-07 Max-Delbrück-Centrum für Molekulare Medizin Mittel zur beeinflussung der angiogenese
WO2005084198A2 (en) * 2004-02-27 2005-09-15 Vaxconsulting Peptides of il1 beta and tnf alpha and method of treatment using same
EA023680B1 (ru) * 2009-03-17 2016-06-30 Общество С Ограниченной Ответственностью "Сенгара" Интерлейкин-1 бета в косметических композициях и способы его использования

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4816436A (en) * 1986-10-29 1989-03-28 Immunex Corporation Anti-arthritic use of interleukin-1 proteins

Also Published As

Publication number Publication date
DK127887D0 (da) 1987-03-12
EP0237967A2 (de) 1987-09-23
EP0569042A1 (de) 1993-11-10
EP0237967B1 (de) 1995-11-15
JPS63152398A (ja) 1988-06-24
JP2591615B2 (ja) 1997-03-19
EP0237967A3 (en) 1990-03-28
ES2009215A6 (es) 1989-09-16
DE3751593D1 (de) 1995-12-21
DE3751593T2 (de) 1996-03-28
DK127887A (da) 1987-09-15

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Date Code Title Description
B1 Patent granted (law 1993)
PBP Patent lapsed