ES2009215A6 - Procedimiento de preparar un derivado de interleucina-1beta. - Google Patents

Procedimiento de preparar un derivado de interleucina-1beta.

Info

Publication number
ES2009215A6
ES2009215A6 ES8701021A ES8701021A ES2009215A6 ES 2009215 A6 ES2009215 A6 ES 2009215A6 ES 8701021 A ES8701021 A ES 8701021A ES 8701021 A ES8701021 A ES 8701021A ES 2009215 A6 ES2009215 A6 ES 2009215A6
Authority
ES
Spain
Prior art keywords
beta
derivative
drugs
derivatives
interleukin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES8701021A
Other languages
English (en)
Inventor
Satoru Nakai
Mayumi Kaneta
Yoshikazu Kikumoto
Yeong-Man Hong
Kazuyoshi Kawai
Setsuko Takegata
Kiyoshi Ishii
Yasuo Yanagihara
Yoshikatsu Hirai
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Otsuka Pharmaceutical Co Ltd
Original Assignee
Otsuka Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Otsuka Pharmaceutical Co Ltd filed Critical Otsuka Pharmaceutical Co Ltd
Publication of ES2009215A6 publication Critical patent/ES2009215A6/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/545—IL-1
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Pain & Pain Management (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

PROCEDIMIENTO DE PREPARAR UN DERIVADO DE INTERLEUCINA-1BETA (IL-1BETA), QUE TIENE UNA SECUENCIA MODIFICADA DE AMINOACIDOS. EL PROCEDIMIENTO CONSISTE EN INCUBAR UNA CELULA TRANSFORMANTE QUE TIENE UN VECTOR DE EXPRESION (TAL COMO UN VIRUS O UN ORGANULO CELULAR ADECUADO) QUE INCLUYE UN GEN QUE CODIFICA PARA EL DERIVADO DE IL-1BETA PARA PRODUCIR EL DERIVADO Y RECOGER EL DERIVADO ASI PRODUCIDO, SIENDO DICHO DERIVADO DE IL-1BETA UN POLIPEPTIDO QUE TIENE UNA SECUENCIA MODIFICADA DE AMINOACIDOS QUE CUMPLE DETERMINADOS REQUISITOS. ALGUNOS DE LOS PRODUCTOS OBTENIDOS TIENEN APLICACIONES FARMACEUTICAS.
ES8701021A 1986-03-14 1987-03-13 Procedimiento de preparar un derivado de interleucina-1beta. Expired ES2009215A6 (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP5788586 1986-03-14
JP14583086 1986-06-20
JP16118486 1986-07-09
JP20032486 1986-08-27

Publications (1)

Publication Number Publication Date
ES2009215A6 true ES2009215A6 (es) 1989-09-16

Family

ID=27463573

Family Applications (1)

Application Number Title Priority Date Filing Date
ES8701021A Expired ES2009215A6 (es) 1986-03-14 1987-03-13 Procedimiento de preparar un derivado de interleucina-1beta.

Country Status (5)

Country Link
EP (2) EP0569042A1 (es)
JP (1) JP2591615B2 (es)
DE (1) DE3751593T2 (es)
DK (1) DK171648B1 (es)
ES (1) ES2009215A6 (es)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5047505A (en) * 1987-01-27 1991-09-10 Du Pont Merck Pharmaceutical Company High level expression in E. coli of soluble mature HIL-1beta and derivatives with altered biological activity
US4904584A (en) * 1987-12-23 1990-02-27 Genetics Institute, Inc. Site-specific homogeneous modification of polypeptides
JP2698976B2 (ja) * 1988-02-03 1998-01-19 大日本製薬株式会社 新規ポリペプチド及びそれをコードするｄｎａ
EP0644203A1 (en) * 1988-07-29 1995-03-22 Otsuka Pharmaceutical Co., Ltd. IL-1alpha derivatives and medicament for treating thrombocytopenia
JP2554528B2 (ja) * 1988-09-19 1996-11-13 大塚製薬株式会社 副腎皮質刺激ホルモン分泌能検査薬
KR910700061A (ko) * 1988-12-06 1991-03-13 오스카 아끼히꼬 인터로이킨-1β의 안정화 조성물
US5039790A (en) * 1989-01-11 1991-08-13 Monsanto Company Bioactive fragment of interleukin-1-B that has antagonistic activity
JPH0824595B2 (ja) * 1989-02-27 1996-03-13 ニューイングランド メディカルセンター ホスピタルズ インコーポレイテッド Ｉｌ―１生物活性の抑制剤
JP2678689B2 (ja) * 1990-08-10 1997-11-17 大塚製薬株式会社 肝炎予防・治療剤
US5723117A (en) * 1990-08-10 1998-03-03 Otsuka Pharmaceutical Co., Ltd. Use of interleukin-1 (IL-1) to inhibit development of hepatitis
AU642764B2 (en) * 1990-08-10 1993-10-28 Otsuka Pharmaceutical Co., Ltd. Agent for preventing and treating hepatitis
FR2667601A1 (fr) * 1990-10-05 1992-04-10 Rhone Poulenc Sante Polypeptides derives de l'interleukine-1 beta, procede de preparation et utilisation, notamment dans le cadre des pathologies osteoarticulaires.
WO1992013885A1 (en) * 1991-02-05 1992-08-20 University Of Maryland MODIFIED INTERLEUKIN-1$g(b)
SE9201966D0 (sv) * 1992-06-25 1992-06-25 Trion Forskning & Utveckling Interleukin-1beta deletion mutant
GB9916630D0 (en) * 1999-07-16 1999-09-15 Univ Manchester Molecules derived from interleukins
US6656462B2 (en) * 1999-12-03 2003-12-02 Richard S. Dondero Interleukin-1 muteins useful as vaccine adjuvants
DE10141749A1 (de) * 2000-08-29 2002-03-14 Max Delbrueck Centrum Mittel zur Beeinflussung der Angiogenese
CN1960744A (zh) * 2004-02-27 2007-05-09 瓦克斯咨询公司 肽IL1β和TNFα以及应用其治疗的方法
EA023680B1 (ru) * 2009-03-17 2016-06-30 Общество С Ограниченной Ответственностью "Сенгара" Интерлейкин-1 бета в косметических композициях и способы его использования

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4816436A (en) * 1986-10-29 1989-03-28 Immunex Corporation Anti-arthritic use of interleukin-1 proteins

Also Published As

Publication number Publication date
EP0237967A3 (en) 1990-03-28
JP2591615B2 (ja) 1997-03-19
DK127887D0 (da) 1987-03-12
DK127887A (da) 1987-09-15
JPS63152398A (ja) 1988-06-24
DK171648B1 (da) 1997-03-03
DE3751593D1 (de) 1995-12-21
DE3751593T2 (de) 1996-03-28
EP0569042A1 (en) 1993-11-10
EP0237967A2 (en) 1987-09-23
EP0237967B1 (en) 1995-11-15

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20000314