ATE66614T1 - Insulinzubereitung fuer nicht-parenterale verabreichung. - Google Patents

Insulinzubereitung fuer nicht-parenterale verabreichung.

Info

Publication number
ATE66614T1
ATE66614T1 AT87902450T AT87902450T ATE66614T1 AT E66614 T1 ATE66614 T1 AT E66614T1 AT 87902450 T AT87902450 T AT 87902450T AT 87902450 T AT87902450 T AT 87902450T AT E66614 T1 ATE66614 T1 AT E66614T1
Authority
AT
Austria
Prior art keywords
parenteral administration
pct
insulin
insulin preparation
sec
Prior art date
Application number
AT87902450T
Other languages
English (en)
Inventor
Per Balschmidt
Finn Benned Hansen
Bente Rose Johansen
Original Assignee
Novo Nordisk As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk As filed Critical Novo Nordisk As
Application granted granted Critical
Publication of ATE66614T1 publication Critical patent/ATE66614T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0043—Nose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Endocrinology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Otolaryngology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
AT87902450T 1986-04-18 1987-04-14 Insulinzubereitung fuer nicht-parenterale verabreichung. ATE66614T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DK179286A DK179286D0 (da) 1986-04-18 1986-04-18 Insulinpraeparat
PCT/DK1987/000038 WO1987006137A1 (en) 1986-04-18 1987-04-14 An insulin preparation for non-parenteral administration
EP87902450A EP0267208B1 (de) 1986-04-18 1987-04-14 Insulinzubereitung für nicht-parenterale verabreichung

Publications (1)

Publication Number Publication Date
ATE66614T1 true ATE66614T1 (de) 1991-09-15

Family

ID=8108089

Family Applications (1)

Application Number Title Priority Date Filing Date
AT87902450T ATE66614T1 (de) 1986-04-18 1987-04-14 Insulinzubereitung fuer nicht-parenterale verabreichung.

Country Status (13)

Country Link
US (1) US5053389A (de)
EP (1) EP0267208B1 (de)
JP (1) JPH01500116A (de)
AT (1) ATE66614T1 (de)
AU (1) AU598543B2 (de)
CA (1) CA1283358C (de)
DE (1) DE3772521D1 (de)
DK (2) DK179286D0 (de)
ES (1) ES2007607A6 (de)
FI (1) FI87529C (de)
IL (1) IL82209A0 (de)
NO (1) NO875299D0 (de)
WO (1) WO1987006137A1 (de)

Families Citing this family (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2062227T3 (es) * 1989-08-21 1994-12-16 Hoffmann La Roche Composiciones farmaceuticas no parenterales para la insulina.
IL99699A (en) * 1990-10-10 2002-04-21 Autoimmune Inc Drug with the option of oral, intra-intestinal, or inhaled dosing for suppression of autoimmune response associated with type I diabetes
FR2686899B1 (fr) * 1992-01-31 1995-09-01 Rhone Poulenc Rorer Sa Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant.
EP1607086A1 (de) * 1993-01-29 2005-12-21 Aradigm Corporation Verfahren zur Verwendung monomeren Insulins als Mittel zur Verbesserung der Reproduzierbarkeit inhalierten Insulins
US6131567A (en) * 1993-01-29 2000-10-17 Aradigm Corporation Method of use of monomeric insulin as a means for improving the reproducibility of inhaled insulin
TW404844B (en) * 1993-04-08 2000-09-11 Oxford Biosciences Ltd Needleless syringe
US6893664B1 (en) 1996-06-17 2005-05-17 Powderject Research Limited Particle delivery techniques
US5948751A (en) * 1996-06-20 1999-09-07 Novo Nordisk A/S X14-mannitol
UA65549C2 (uk) * 1996-11-05 2004-04-15 Елі Ліллі Енд Компані Спосіб регулювання ожиріння шляхом периферійного введення аналогів та похідних glp-1 (варіанти) та фармацевтична композиція
CO4750643A1 (es) * 1997-06-13 1999-03-31 Lilly Co Eli Formulacion estable de la insulina que contiene l-arginina y protamina
EP1283051B1 (de) * 1997-06-13 2006-06-14 Eli Lilly And Company Stabile Insulinformulierungen
US20010007853A1 (en) * 1998-01-08 2001-07-12 Dimarchi Richard Dennis Method for administering monomeric insulin analogs
US6350458B1 (en) 1998-02-10 2002-02-26 Generex Pharmaceuticals Incorporated Mixed micellar drug deliver system and method of preparation
US7070799B1 (en) * 1998-02-10 2006-07-04 Generex Pharmaceuticals, Inc. Method for administering insulin to the buccal region
US6221378B1 (en) 1998-02-10 2001-04-24 Generex Pharmaceuticals Incorporated Mixed micellar delivery system and method of preparation
US6294153B1 (en) 1998-12-21 2001-09-25 Generex Pharmaceuticals, Inc. Aerosol pharmaceutical formulation for pulmonary and nasal delivery
US6375975B1 (en) 1998-12-21 2002-04-23 Generex Pharmaceuticals Incorporated Pharmaceutical compositions for buccal and pulmonary application
US6451286B1 (en) 1998-12-21 2002-09-17 Generex Pharmaceuticals Incorporated Pharmaceutical compositions for buccal and pulmonary administration comprising an alkali metal alkyl sulfate and at least three micelle-forming compounds
US7087215B2 (en) * 1998-12-21 2006-08-08 Generex Pharmaceuticals Incorporated Methods of administering and enhancing absorption of pharmaceutical agents
US6849263B2 (en) * 1998-12-21 2005-02-01 Generex Pharmaceutical Incorporated Pharmaceutical compositions for buccal delivery of pain relief medications
US6350432B1 (en) 1999-03-19 2002-02-26 Generex Pharmaceuticals Incorporated Pressurized container having an aerosolized pharmaceutical composition
CA2375914A1 (en) 1999-06-04 2000-12-14 Delrx Pharmaceutical Corporation Formulations comprising dehydrated particles of pharmaceutical agents and process for preparing the same
GB2355009A (en) * 1999-07-30 2001-04-11 Univ Glasgow Peptides conjugated to bile acids/salts
AU2001261024A1 (en) 2000-04-12 2001-10-30 Delta Biotechnology Limited Albumin fusion proteins
US8061006B2 (en) * 2001-07-26 2011-11-22 Powderject Research Limited Particle cassette, method and kit therefor
EP2277910A1 (de) 2001-12-21 2011-01-26 Human Genome Sciences, Inc. Albumin Fusionsproteine
EP1594530A4 (de) 2003-01-22 2006-10-11 Human Genome Sciences Inc Albuminfusionsproteine
US8147426B2 (en) * 2003-12-31 2012-04-03 Nipro Diagnostics, Inc. Integrated diagnostic test system
CA2652989A1 (en) * 2006-06-08 2007-12-13 Diabecore Medical Inc. Derivatized insulin oligomers
EP2134351B1 (de) 2007-03-13 2016-04-27 Nutrition 21, Inc. Verfahren und zusammensetzungen zur verzögerten freisetzung von chrom
WO2008132224A2 (en) 2007-04-30 2008-11-06 Novo Nordisk A/S Method for drying a protein composition, a dried protein composition and a pharmaceutical composition comprising the dried protein
WO2009002867A2 (en) 2007-06-26 2008-12-31 Nutrition 21, Inc. Multiple unit dosage form having a therapeutic agents in combination with a nutritional supplement
EP2077132A1 (de) 2008-01-02 2009-07-08 Boehringer Ingelheim Pharma GmbH & Co. KG Abgabevorrichtung, Aufbewahrungsvorrichtung und Verfahren zur Abgabe einer Formulierung
US10011906B2 (en) 2009-03-31 2018-07-03 Beohringer Ingelheim International Gmbh Method for coating a surface of a component
JP5763053B2 (ja) 2009-05-18 2015-08-12 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング アダプタ、吸入器具及びアトマイザ
US10016568B2 (en) 2009-11-25 2018-07-10 Boehringer Ingelheim International Gmbh Nebulizer
EP2504051B1 (de) 2009-11-25 2019-09-04 Boehringer Ingelheim International GmbH Zerstäuber
AP3141A (en) 2009-11-25 2015-02-28 Boehringer Ingelheim Int Nebulizer
JP5874724B2 (ja) 2010-06-24 2016-03-02 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング ネブライザ
CN105749253A (zh) 2011-03-01 2016-07-13 Jds治疗有限公司 用于预防和治疗糖尿病、低血糖症及相关病症的胰岛素和铬组合物
WO2012130757A1 (de) 2011-04-01 2012-10-04 Boehringer Ingelheim International Gmbh Medizinisches gerät mit behälter
US9827384B2 (en) 2011-05-23 2017-11-28 Boehringer Ingelheim International Gmbh Nebulizer
WO2013152894A1 (de) 2012-04-13 2013-10-17 Boehringer Ingelheim International Gmbh Zerstäuber mit kodiermitteln
ES2836977T3 (es) 2013-08-09 2021-06-28 Boehringer Ingelheim Int Nebulizador
US9744313B2 (en) 2013-08-09 2017-08-29 Boehringer Ingelheim International Gmbh Nebulizer
CN106255554B (zh) 2014-05-07 2021-05-04 勃林格殷格翰国际有限公司 容器、喷雾器及用途
ES2874029T3 (es) 2014-05-07 2021-11-04 Boehringer Ingelheim Int Nebulizador
PE20210959A1 (es) 2014-05-07 2021-05-25 Boehringer Ingelheim Int Nebulizador, dispositivo indicador y recipiente
CN109069532A (zh) 2016-02-11 2018-12-21 营养21有限责任公司 含铬组合物用于改善健康和健身

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1381274A (en) * 1971-01-28 1975-01-22 Nat Res Dev Insulin derivatives
IE36225B1 (en) * 1971-01-28 1976-09-15 Nat Res Dev Improvements relating to insulin derivatives
GB1381273A (en) * 1971-01-28 1975-01-22 Nat Res Dev Insulin derivatives
DK135268A (de) * 1973-02-09
US4153689A (en) * 1975-06-13 1979-05-08 Takeda Chemical Industries, Ltd. Stable insulin preparation for nasal administration
US4164573A (en) * 1975-06-13 1979-08-14 Galinsky Alvin M Composition and method for making a suppository for introducing a hypoglycemic agent into a mammal
GB1554157A (en) * 1975-06-13 1979-10-17 Takeda Chemical Industries Ltd Stable insulin preparation for intra nasal administration
GB1527605A (en) * 1975-08-20 1978-10-04 Takeda Chemical Industries Ltd Insulin preparation for intranasal administration
US4442090A (en) * 1980-11-09 1984-04-10 Kyoto Yakuhin Kogyo Kabushiki Kaisha Absorption-promoting compounds, compositions thereof with pharmaceuticals and/or bases for rectal administration and method of use
DE3382112D1 (de) * 1982-04-30 1991-02-21 Ajinomoto Kk Pharmazeutische zusammensetzung.
JPS58189118A (ja) * 1982-04-30 1983-11-04 Takeda Chem Ind Ltd 経鼻投与製剤
US4534894A (en) * 1982-11-17 1985-08-13 The Rockefeller University Process for sulphation and phosphorylation of proteins and peptides
JPS59163313A (ja) * 1983-03-09 1984-09-14 Teijin Ltd 経鼻投与用ペプチドホルモン類組成物
IL68769A (en) * 1983-05-23 1986-02-28 Hadassah Med Org Pharmaceutical compositions containing insulin for oral administration
US4746508A (en) * 1983-06-06 1988-05-24 Beth Israel Hospital Assn. Drug administration
JPS60224616A (ja) * 1984-04-24 1985-11-09 Teijin Ltd 経鼻投与用組成物

Also Published As

Publication number Publication date
JPH01500116A (ja) 1989-01-19
NO875299L (no) 1987-12-17
EP0267208A1 (de) 1988-05-18
DK179286D0 (da) 1986-04-18
IL82209A0 (en) 1987-10-30
DK642587D0 (da) 1987-12-08
AU7356187A (en) 1987-11-09
FI875533L (fi) 1987-12-16
DK160460B (da) 1991-03-18
EP0267208B1 (de) 1991-08-28
FI875533A0 (fi) 1987-12-16
DE3772521D1 (de) 1991-10-02
ES2007607A6 (es) 1989-07-01
DK642587A (da) 1987-12-08
NO875299D0 (no) 1987-12-17
CA1283358C (en) 1991-04-23
DK160460C (da) 1991-08-26
AU598543B2 (en) 1990-06-28
WO1987006137A1 (en) 1987-10-22
FI87529C (fi) 1993-01-25
US5053389A (en) 1991-10-01
FI87529B (fi) 1992-10-15

Similar Documents

Publication Publication Date Title
ATE66614T1 (de) Insulinzubereitung fuer nicht-parenterale verabreichung.
AU1923088A (en) Piperazinyl derivatives of purines and isosteres thereof as hypoglycemic agents
HUP0002373A2 (hu) Glükagon antagonisták/inverz agonisták és ezeket tartalmazó gyógyászati készítmények
NO904378D0 (no) Fremgangsmaate for fremstilling av et modifisert protein for terapeutisk anvendelse.
PH23014A (en) Novel insulin derivatives,their use and pharmaceutical agents for the treatment of diabetes mellitus
SE8504945L (sv) Farmaceutiska kompositioner innehallande antracyklinglykosider
SE8402560D0 (sv) Farmaceutisk komposition
DE3575076D1 (de) Katheter fuer rueckinfusion von pharmazeutischen agenten.
SE8802569D0 (sv) Improvements in or relation to somatostatins
FI881061A7 (fi) Hitaasti vapauttavia valmisteita ruoansulatuskanavan ulkopuolisesti annettaviksi ja niiden käyttö.
DE68909409D1 (de) Heilmitteldosierung zur verabreichung an fische.
NO871295D0 (no) Fremgangsmaate for fremstilling av terapeutisk aktive aminosyrederivater.
NZ223043A (en) Sialic acid derivatives; use as stabilisers for physiologically active substances and as binders in chromatography
EP0177342A3 (de) Orale Formulierungen therapeutischer Proteine
ATE54824T1 (de) System zur arzneistoffabgabe mit erhoehter bioakzeptanz.
AU3024389A (en) Therapeutic agent for the prevention of intraventricular hemorrhage in premature infants
EP0289572A4 (de) Verwendung von interleukin-1-proteinen gegen arthritis.
FI884240A0 (fi) Menetelmä paikalliseen käyttöön tarkoitetun farmaseuttisen valmisteen valmistamiseksi
DE3874610D1 (de)
ATE116849T1 (de) Pharmazeutische verwendung von fettsäuren.
BG44709A3 (bg) Метод за получаване на 9-хлор-1,5-бензотиазепинови производни
ATE126437T1 (de) Verwendung von depogen zur behandlung von eingeschränktem blutkreislauf.
FI843695A7 (fi) Insuliini-johdannaisia, joissa B 30-asema on modifioitu, menetelmiä niiden valmistamiseksi ja niiden käyttö sekä sokeritaudin hoitoon tarkoitettuja lääkeaineita.
AU609435B2 (en) Prevention of bovine respiratory disease complex in cattle by administration of interferon
ATE67674T1 (de) Pharmazeutische zubereitungen mit heilender aktivitaet.