DK171116B1 - Estere af hexahydro-8-hydroxy-2,6-methano-2H-quinolizin-3(4H)-oner og hexahydro-8-hydroxy-2,6-methano-2H-quinoliziner og farmaceutisk acceptable syreadditionssalte og kvaternære ammoniumsalte deraf, fremgangsmåde til deres fremstilling samt et mellemprodukt - Google Patents

Estere af hexahydro-8-hydroxy-2,6-methano-2H-quinolizin-3(4H)-oner og hexahydro-8-hydroxy-2,6-methano-2H-quinoliziner og farmaceutisk acceptable syreadditionssalte og kvaternære ammoniumsalte deraf, fremgangsmåde til deres fremstilling samt et mellemprodukt Download PDF

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Publication number
DK171116B1
DK171116B1 DK572887A DK572887A DK171116B1 DK 171116 B1 DK171116 B1 DK 171116B1 DK 572887 A DK572887 A DK 572887A DK 572887 A DK572887 A DK 572887A DK 171116 B1 DK171116 B1 DK 171116B1
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Prior art keywords
hydrogen
compound
alkyl
methano
formula
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DK572887A
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Danish (da)
English (en)
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DK572887D0 (da
DK572887A (da
Inventor
Maurice Ward Gittos
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Merrell Dow Pharma
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Publication of DK572887D0 publication Critical patent/DK572887D0/da
Publication of DK572887A publication Critical patent/DK572887A/da
Application granted granted Critical
Publication of DK171116B1 publication Critical patent/DK171116B1/da

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DK572887A 1986-11-03 1987-11-02 Estere af hexahydro-8-hydroxy-2,6-methano-2H-quinolizin-3(4H)-oner og hexahydro-8-hydroxy-2,6-methano-2H-quinoliziner og farmaceutisk acceptable syreadditionssalte og kvaternære ammoniumsalte deraf, fremgangsmåde til deres fremstilling samt et mellemprodukt DK171116B1 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US92661986A 1986-11-03 1986-11-03
US92661986 1986-11-03

Publications (3)

Publication Number Publication Date
DK572887D0 DK572887D0 (da) 1987-11-02
DK572887A DK572887A (da) 1988-05-04
DK171116B1 true DK171116B1 (da) 1996-06-17

Family

ID=25453460

Family Applications (1)

Application Number Title Priority Date Filing Date
DK572887A DK171116B1 (da) 1986-11-03 1987-11-02 Estere af hexahydro-8-hydroxy-2,6-methano-2H-quinolizin-3(4H)-oner og hexahydro-8-hydroxy-2,6-methano-2H-quinoliziner og farmaceutisk acceptable syreadditionssalte og kvaternære ammoniumsalte deraf, fremgangsmåde til deres fremstilling samt et mellemprodukt

Country Status (21)

Country Link
EP (1) EP0266730B1 (fr)
JP (2) JP2542225B2 (fr)
KR (1) KR950011737B1 (fr)
CN (1) CN1021654C (fr)
AR (1) AR246264A1 (fr)
AT (1) ATE109779T1 (fr)
AU (1) AU600318B2 (fr)
CA (1) CA1329203C (fr)
DE (2) DE19775092I2 (fr)
DK (1) DK171116B1 (fr)
ES (1) ES2061469T3 (fr)
FI (1) FI87786C (fr)
HU (1) HU197008B (fr)
IE (1) IE63670B1 (fr)
IL (1) IL84309A (fr)
NL (1) NL970043I2 (fr)
NO (2) NO165922C (fr)
NZ (1) NZ222349A (fr)
PH (2) PH24664A (fr)
PT (1) PT86060B (fr)
ZA (1) ZA878096B (fr)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5011846A (en) * 1988-02-23 1991-04-30 Merrell Dow Pharmaceuticals Inc. Medicament compositions derived from quinolizine and quinolizinone and methods of use thereof
EP0329903A1 (fr) * 1988-02-23 1989-08-30 Merrell Dow Pharmaceuticals Inc. Utilisation des dérivés de quinolizinone et de la quinolizine pour la manufacture des médicaments pour le traitement du glaucome
EP0329932B1 (fr) * 1988-02-23 1995-10-18 Merrell Pharmaceuticals Inc. Utilisation des dérivés de la quinolizine et de la quinolizinone pour la manufacture des médicaments
EP0329904A1 (fr) * 1988-02-23 1989-08-30 Merrell Dow Pharmaceuticals Inc. Utilisation des dérivés de la quinolizine et de la quinolizinone dans la manufacture des médicaments pour le traitement de l'anxiété
EP0329905A1 (fr) * 1988-02-23 1989-08-30 Merrell Dow Pharmaceuticals Inc. Utilisation des dérivés de la quinolizine et de la quinolizinone pour la manufacture des médicaments pour l'augmentation de la motilité gastrique
EP0329902A1 (fr) * 1988-02-23 1989-08-30 Merrell Dow Pharmaceuticals Inc. Utilisation des dérivés de la quinolizinone et de la quinolizine pour la manufacture des médicaments pour le traitement de la psychose
EP0330788A1 (fr) * 1988-03-01 1989-09-06 Merrell Dow Pharmaceuticals Inc. Utilisation des dérivés de la quinolizine et de la quinolizinone pour la manufacture des médicaments pour le traitement de l'arythmie cardiaque
ZA893008B (en) * 1988-04-29 1989-12-27 Merrell Dow Pharma Process for preparing indole-3-carboxylic acid esters of transhexahydro-8-hydroxy-2,6-methano-2h-quinolizin-3(4h)-one
GB8928837D0 (en) * 1989-12-21 1990-02-28 Beecham Group Plc Pharmaceuticals
EP0492020A1 (fr) * 1990-12-21 1992-07-01 Merrell Dow Pharmaceuticals Inc. Utilisation de certains esters de la hexahydro-8-hydroxy-2,6-méthano-2H-quinolizine-3(4H)-one et des composés apparentés pour le traitement des maladies cognitives
SK8712000A3 (en) * 1997-12-17 2000-11-07 Biocryst Pharm Inc Substituted cyclopentane and cyclopentene compounds useful as neuraminidase inhibitors
CN100390172C (zh) * 2004-09-10 2008-05-28 成都欣捷高新技术开发有限公司 一种甲磺酸多拉司琼晶型及其制备方法
EP1819705A1 (fr) * 2004-11-25 2007-08-22 Cilag Ltd. Procede pour preparer des esters d'hexahydro-8-hydroxy-2,6-methano-2h-chinolizin-3(4h)-one
ES2264901B1 (es) 2005-07-06 2007-12-01 Inke, S.A. Procedimiento para la obtencion de un compuesto farmaceuticamente activo, sus intermedios de sintesis y procedimiento para la obtencion de los mismos.
EP1904492B1 (fr) * 2005-07-06 2008-10-15 Inke, S.A. Procédé servant à obtenir le composé actif du point de vue pharmaceutique dolasetron, intermédiaires de synthèse de celui-ci et procédés servant à obtenir ceux-ci
US20070203175A1 (en) 2006-01-05 2007-08-30 Janos Hajko Productioin of dolasetron
ES2389261T3 (es) 2007-11-13 2012-10-24 Inke, S.A. Compuestos intermedios útiles para preparar dolasetrón
ES2664599T3 (es) 2009-05-20 2018-04-20 INSERM (Institut National de la Santé et de la Recherche Médicale) Antagonistas del receptor 5-HT3 de serotonina para uso en el tratamiento de trastornos vestibulares lesionales
EP2253316B1 (fr) 2009-05-20 2013-08-14 INSERM (Institut National de la Santé et de la Recherche Médicale) Antagonistes du récepteur 5-HT3 de la sérotonine pour une utilisation dans le traitement ou la prévention d'une pathologie de l'oreille interne avec déficits vestibulaires
EP4019018A1 (fr) 2015-09-11 2022-06-29 Chase Pharmaceuticals Corporation Combinaisons muscariniques et leur utilisation pour lutter contre des troubles hypocholinergiques du système nerveux central
CN108976230A (zh) * 2018-06-18 2018-12-11 东莞市联洲知识产权运营管理有限公司 一种基于石墨烯活化制备甲磺酸多拉司琼关键中间体的方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2531083B1 (fr) * 1982-06-29 1986-11-28 Sandoz Sa Nouveaux derives de la piperidine, leur preparation et leur utilisation comme medicaments
DE3429830A1 (de) * 1983-08-26 1985-03-07 Sandoz-Patent-GmbH, 7850 Lörrach Automatische carbonsaeure- und sulfonsaeureester oder -amide
ATE86110T1 (de) * 1984-12-20 1993-03-15 Sandoz Ag Behandlung von gastrointestinalkrankheiten durch anwendung von 5-ht3-antagonisten.

Also Published As

Publication number Publication date
NO165922B (no) 1991-01-21
CN87107629A (zh) 1988-06-15
FI87786C (fi) 1993-02-25
NO165922C (no) 1991-05-02
ATE109779T1 (de) 1994-08-15
EP0266730A1 (fr) 1988-05-11
IL84309A (en) 1991-09-16
NO874550D0 (no) 1987-11-02
DE19775092I2 (de) 2001-11-22
PH24664A (en) 1990-09-07
AU600318B2 (en) 1990-08-09
NL970043I2 (nl) 1998-10-01
EP0266730B1 (fr) 1994-08-10
ES2061469T3 (es) 1994-12-16
DE3750359D1 (de) 1994-09-15
ZA878096B (en) 1988-04-26
NL970043I1 (nl) 1998-03-02
KR880006240A (ko) 1988-07-22
CA1329203C (fr) 1994-05-03
JPS63258476A (ja) 1988-10-25
HU197008B (en) 1989-02-28
DE3750359T2 (de) 1994-12-08
JP2542225B2 (ja) 1996-10-09
PH26261A (en) 1992-04-01
NO874550L (no) 1988-05-04
IE63670B1 (en) 1995-05-31
JP2657267B2 (ja) 1997-09-24
PT86060A (en) 1987-12-01
NZ222349A (en) 1990-05-28
AR246264A1 (es) 1994-07-29
NO1999020I1 (no) 1999-08-26
PT86060B (pt) 1990-07-31
CN1021654C (zh) 1993-07-21
FI874768A (fi) 1988-05-04
FI87786B (fi) 1992-11-13
DK572887D0 (da) 1987-11-02
IE872955L (en) 1988-05-03
AU8059687A (en) 1988-05-05
HUT45055A (en) 1988-05-30
KR950011737B1 (ko) 1995-10-09
JPH0977769A (ja) 1997-03-25
DK572887A (da) 1988-05-04
FI874768A0 (fi) 1987-10-29

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Legal Events

Date Code Title Description
B1 Patent granted (law 1993)
CTFF Application for supplementary protection certificate (spc) filed

Spc suppl protection certif: CA 1998 00008

Filing date: 19980218

Extension date: 20110926

CTFG Supplementary protection certificate (spc) issued

Free format text: PRODUCT NAME: DOLASETRONMESILAT

Spc suppl protection certif: CA 1998 00008

PUP Patent expired