NO874550L - Fremgangsmaate for fremstilling av estere av hexahydro-8-hydroxy-2,6-methano-2h-kinolizin-3(4h)-on og beslektede forbindelser. - Google Patents

Fremgangsmaate for fremstilling av estere av hexahydro-8-hydroxy-2,6-methano-2h-kinolizin-3(4h)-on og beslektede forbindelser.

Info

Publication number
NO874550L
NO874550L NO874550A NO874550A NO874550L NO 874550 L NO874550 L NO 874550L NO 874550 A NO874550 A NO 874550A NO 874550 A NO874550 A NO 874550A NO 874550 L NO874550 L NO 874550L
Authority
NO
Norway
Prior art keywords
quinolizin
methano
hexahydro
hydroxy
procedure
Prior art date
Application number
NO874550A
Other languages
English (en)
Other versions
NO165922C (no
NO874550D0 (no
NO165922B (no
Inventor
Maurice Ward Gittos
Original Assignee
Merrell Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Pharma Inc filed Critical Merrell Pharma Inc
Publication of NO874550D0 publication Critical patent/NO874550D0/no
Publication of NO874550L publication Critical patent/NO874550L/no
Publication of NO165922B publication Critical patent/NO165922B/no
Publication of NO165922C publication Critical patent/NO165922C/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
NO874550A 1986-11-03 1987-11-02 Analogifremgangsmaate for fremstilling av terapeutisk aktive estere av hexahydro-8-hydroxy-2,6-methano-2h-kinolizin-3-(4h)-on og beslektede forbindelser. NO165922C (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US92661986A 1986-11-03 1986-11-03

Publications (4)

Publication Number Publication Date
NO874550D0 NO874550D0 (no) 1987-11-02
NO874550L true NO874550L (no) 1988-05-04
NO165922B NO165922B (no) 1991-01-21
NO165922C NO165922C (no) 1991-05-02

Family

ID=25453460

Family Applications (2)

Application Number Title Priority Date Filing Date
NO874550A NO165922C (no) 1986-11-03 1987-11-02 Analogifremgangsmaate for fremstilling av terapeutisk aktive estere av hexahydro-8-hydroxy-2,6-methano-2h-kinolizin-3-(4h)-on og beslektede forbindelser.
NO1999020C NO1999020I1 (no) 1986-11-03 1999-08-26 Dolasetron

Family Applications After (1)

Application Number Title Priority Date Filing Date
NO1999020C NO1999020I1 (no) 1986-11-03 1999-08-26 Dolasetron

Country Status (21)

Country Link
EP (1) EP0266730B1 (no)
JP (2) JP2542225B2 (no)
KR (1) KR950011737B1 (no)
CN (1) CN1021654C (no)
AR (1) AR246264A1 (no)
AT (1) ATE109779T1 (no)
AU (1) AU600318B2 (no)
CA (1) CA1329203C (no)
DE (2) DE19775092I2 (no)
DK (1) DK171116B1 (no)
ES (1) ES2061469T3 (no)
FI (1) FI87786C (no)
HU (1) HU197008B (no)
IE (1) IE63670B1 (no)
IL (1) IL84309A (no)
NL (1) NL970043I2 (no)
NO (2) NO165922C (no)
NZ (1) NZ222349A (no)
PH (2) PH24664A (no)
PT (1) PT86060B (no)
ZA (1) ZA878096B (no)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0329902A1 (en) * 1988-02-23 1989-08-30 Merrell Dow Pharmaceuticals Inc. Use of quinolizinone and quinolizine derivatives in the manufacture of medicaments for the treatment of psychosis
US5011846A (en) * 1988-02-23 1991-04-30 Merrell Dow Pharmaceuticals Inc. Medicament compositions derived from quinolizine and quinolizinone and methods of use thereof
EP0329904A1 (en) * 1988-02-23 1989-08-30 Merrell Dow Pharmaceuticals Inc. Use of quinolizine and quinolizinone derivatives in the manufacture of medicaments for the treatment of anxiety
EP0329903A1 (en) * 1988-02-23 1989-08-30 Merrell Dow Pharmaceuticals Inc. Use of quinolizinone and quinolizine derivatives in the manufacture of medicaments for the treatment of glaucoma
ES2080727T3 (es) * 1988-02-23 1996-02-16 Merrell Pharma Inc Uso de quinolizina y derivados de quinolizinona en la fabricacion de medicamentos.
EP0329905A1 (en) * 1988-02-23 1989-08-30 Merrell Dow Pharmaceuticals Inc. Use of quinolizine and quinolizinone derivatives in the manufacture of medicaments for increasing gastric motility
EP0330788A1 (en) * 1988-03-01 1989-09-06 Merrell Dow Pharmaceuticals Inc. Use of quinolizine and quinolizinone derivatives in the manufacture of medicaments for the treatment of cardiac arrhythmia
ZA893008B (en) * 1988-04-29 1989-12-27 Merrell Dow Pharma Process for preparing indole-3-carboxylic acid esters of transhexahydro-8-hydroxy-2,6-methano-2h-quinolizin-3(4h)-one
GB8928837D0 (en) * 1989-12-21 1990-02-28 Beecham Group Plc Pharmaceuticals
EP0492020A1 (en) * 1990-12-21 1992-07-01 Merrell Dow Pharmaceuticals Inc. Use of certain esters of hexahydro-8-hydroxy-2,6-methano-2H-quinolizin-3(4H)-one and related compounds for treating cognitive disorders
DE69840674D1 (de) * 1997-12-17 2009-04-30 Biocryst Pharm Inc Substituierte cyclopentan- und cyclopenten-verbindungen als neuraminidase-blocker
CN100390172C (zh) * 2004-09-10 2008-05-28 成都欣捷高新技术开发有限公司 一种甲磺酸多拉司琼晶型及其制备方法
US20070299260A1 (en) * 2004-11-25 2007-12-27 Cilag Ltd. Method for Preparing Hexahydro-8-Hydroxy-2, 6-Methano-2H-Chinolizin-3 (4H) -One Esters
WO2007003522A1 (en) * 2005-07-06 2007-01-11 Inke, S.A. Method for obtaining a pharmaceutically active compound, synthesis intermediates thereof and methods for obtaining them
ES2264901B1 (es) 2005-07-06 2007-12-01 Inke, S.A. Procedimiento para la obtencion de un compuesto farmaceuticamente activo, sus intermedios de sintesis y procedimiento para la obtencion de los mismos.
TW200734339A (en) * 2006-01-05 2007-09-16 Teva Gyogyszergyar Zartkoruen Mukodo Reszvenytarsasag Forms of dolasetron mesylate and processes for their preparation
EP2060557B1 (en) 2007-11-13 2012-06-06 Inke, S.A. Intermediate compounds useful to prepare dolasetron
EP2253316B1 (en) 2009-05-20 2013-08-14 INSERM (Institut National de la Santé et de la Recherche Médicale) Serotonin 5-HT3 receptor antagonists for use in the treatment or prevention of an inner ear pathology with vestibular deficits
JP5955767B2 (ja) 2009-05-20 2016-07-20 インセルム（インスティチュート ナショナル デ ラ サンテ エ デ ラ リシェルシェ メディカル） 損傷性前庭障害の処置における使用のためのセロトニン５−ｈｔ３受容体拮抗薬
EP3347011A4 (en) 2015-09-11 2019-06-19 Chase Pharmaceuticals Corporation MUSCARIN COMBINATION AND ITS USE FOR COMBATING HYPOCHOLINERGEN DISORDERS OF THE CENTRAL NERVOUS SYSTEM
CN108976230A (zh) * 2018-06-18 2018-12-11 东莞市联洲知识产权运营管理有限公司 一种基于石墨烯活化制备甲磺酸多拉司琼关键中间体的方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI74707C (fi) * 1982-06-29 1988-03-10 Sandoz Ag Foerfarande foer framstaellning av terapeutiskt anvaendbara alkylenoeverbryggade piperidylestrar eller -amider av bicykliska karboxylsyror.
CH664567A5 (de) * 1983-08-26 1988-03-15 Sandoz Ag Aromatische carbonsaeure- und sulfonsaeureester oder -amide.
ATE86110T1 (de) * 1984-12-20 1993-03-15 Sandoz Ag Behandlung von gastrointestinalkrankheiten durch anwendung von 5-ht3-antagonisten.

Also Published As

Publication number Publication date
KR880006240A (ko) 1988-07-22
FI874768A (fi) 1988-05-04
NZ222349A (en) 1990-05-28
HU197008B (en) 1989-02-28
DK171116B1 (da) 1996-06-17
AU8059687A (en) 1988-05-05
AR246264A1 (es) 1994-07-29
FI87786C (fi) 1993-02-25
ATE109779T1 (de) 1994-08-15
CA1329203C (en) 1994-05-03
NO1999020I1 (no) 1999-08-26
PH26261A (en) 1992-04-01
PT86060B (pt) 1990-07-31
DK572887D0 (da) 1987-11-02
KR950011737B1 (ko) 1995-10-09
CN1021654C (zh) 1993-07-21
EP0266730B1 (en) 1994-08-10
IE63670B1 (en) 1995-05-31
EP0266730A1 (en) 1988-05-11
JP2542225B2 (ja) 1996-10-09
DE19775092I2 (de) 2001-11-22
JP2657267B2 (ja) 1997-09-24
ZA878096B (en) 1988-04-26
PT86060A (en) 1987-12-01
NL970043I2 (nl) 1998-10-01
NO165922C (no) 1991-05-02
DE3750359D1 (de) 1994-09-15
DK572887A (da) 1988-05-04
DE3750359T2 (de) 1994-12-08
JPS63258476A (ja) 1988-10-25
AU600318B2 (en) 1990-08-09
PH24664A (en) 1990-09-07
HUT45055A (en) 1988-05-30
FI874768A0 (fi) 1987-10-29
CN87107629A (zh) 1988-06-15
JPH0977769A (ja) 1997-03-25
IL84309A (en) 1991-09-16
ES2061469T3 (es) 1994-12-16
NL970043I1 (nl) 1998-03-02
FI87786B (fi) 1992-11-13
IE872955L (en) 1988-05-03
NO874550D0 (no) 1987-11-02
NO165922B (no) 1991-01-21

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