FI874768A - Estrar av hexahydro-8-hydroxy-2,6 -metano-2h-kinolizin-3(4h)- och beslaektade foereningar. - Google Patents

Estrar av hexahydro-8-hydroxy-2,6 -metano-2h-kinolizin-3(4h)- och beslaektade foereningar. Download PDF

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Publication number
FI874768A
FI874768A FI874768A FI874768A FI874768A FI 874768 A FI874768 A FI 874768A FI 874768 A FI874768 A FI 874768A FI 874768 A FI874768 A FI 874768A FI 874768 A FI874768 A FI 874768A
Authority
FI
Finland
Prior art keywords
beslaektade
estrar
foereningar
quinolizin
methano
Prior art date
Application number
FI874768A
Other languages
English (en)
Other versions
FI87786C (fi
FI87786B (fi
FI874768A0 (fi
Inventor
Maurice Ward Gittos
Original Assignee
Merrell Dow Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma
Publication of FI874768A0 publication Critical patent/FI874768A0/fi
Publication of FI874768A publication Critical patent/FI874768A/fi
Application granted granted Critical
Publication of FI87786B publication Critical patent/FI87786B/fi
Publication of FI87786C publication Critical patent/FI87786C/fi

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
FI874768A 1986-11-03 1987-10-29 Analogifoerfarande foer framstaellning av terapeutiskt anvaendbara estrar av hexahydro-8-hydroxi-2,6-metano-2h-kinolizin-3(4h)-on och beslaektade foereningar samt en mellanprodukt i foerfarandet FI87786C (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US92661986A 1986-11-03 1986-11-03
US92661986 1986-11-03

Publications (4)

Publication Number Publication Date
FI874768A0 FI874768A0 (fi) 1987-10-29
FI874768A true FI874768A (fi) 1988-05-04
FI87786B FI87786B (fi) 1992-11-13
FI87786C FI87786C (fi) 1993-02-25

Family

ID=25453460

Family Applications (1)

Application Number Title Priority Date Filing Date
FI874768A FI87786C (fi) 1986-11-03 1987-10-29 Analogifoerfarande foer framstaellning av terapeutiskt anvaendbara estrar av hexahydro-8-hydroxi-2,6-metano-2h-kinolizin-3(4h)-on och beslaektade foereningar samt en mellanprodukt i foerfarandet

Country Status (21)

Country Link
EP (1) EP0266730B1 (fi)
JP (2) JP2542225B2 (fi)
KR (1) KR950011737B1 (fi)
CN (1) CN1021654C (fi)
AR (1) AR246264A1 (fi)
AT (1) ATE109779T1 (fi)
AU (1) AU600318B2 (fi)
CA (1) CA1329203C (fi)
DE (2) DE3750359T2 (fi)
DK (1) DK171116B1 (fi)
ES (1) ES2061469T3 (fi)
FI (1) FI87786C (fi)
HU (1) HU197008B (fi)
IE (1) IE63670B1 (fi)
IL (1) IL84309A (fi)
NL (1) NL970043I2 (fi)
NO (2) NO165922C (fi)
NZ (1) NZ222349A (fi)
PH (2) PH24664A (fi)
PT (1) PT86060B (fi)
ZA (1) ZA878096B (fi)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0329902A1 (en) * 1988-02-23 1989-08-30 Merrell Dow Pharmaceuticals Inc. Use of quinolizinone and quinolizine derivatives in the manufacture of medicaments for the treatment of psychosis
EP0329932B1 (en) * 1988-02-23 1995-10-18 Merrell Pharmaceuticals Inc. Use of quinolizine and quinolizinone derivatives in the manufacture of medicaments
EP0329904A1 (en) * 1988-02-23 1989-08-30 Merrell Dow Pharmaceuticals Inc. Use of quinolizine and quinolizinone derivatives in the manufacture of medicaments for the treatment of anxiety
EP0329903A1 (en) * 1988-02-23 1989-08-30 Merrell Dow Pharmaceuticals Inc. Use of quinolizinone and quinolizine derivatives in the manufacture of medicaments for the treatment of glaucoma
US5011846A (en) * 1988-02-23 1991-04-30 Merrell Dow Pharmaceuticals Inc. Medicament compositions derived from quinolizine and quinolizinone and methods of use thereof
EP0329905A1 (en) * 1988-02-23 1989-08-30 Merrell Dow Pharmaceuticals Inc. Use of quinolizine and quinolizinone derivatives in the manufacture of medicaments for increasing gastric motility
EP0330788A1 (en) * 1988-03-01 1989-09-06 Merrell Dow Pharmaceuticals Inc. Use of quinolizine and quinolizinone derivatives in the manufacture of medicaments for the treatment of cardiac arrhythmia
ZA893008B (en) * 1988-04-29 1989-12-27 Merrell Dow Pharma Process for preparing indole-3-carboxylic acid esters of transhexahydro-8-hydroxy-2,6-methano-2h-quinolizin-3(4h)-one
GB8928837D0 (en) * 1989-12-21 1990-02-28 Beecham Group Plc Pharmaceuticals
EP0492020A1 (en) * 1990-12-21 1992-07-01 Merrell Dow Pharmaceuticals Inc. Use of certain esters of hexahydro-8-hydroxy-2,6-methano-2H-quinolizin-3(4H)-one and related compounds for treating cognitive disorders
BR9813480A (pt) * 1997-12-17 2000-10-10 Biocryst Pharm Inc Compostos inibidores de neuraminidase de ciclopentano substituìdo, composição e métodos de inibição da neuraminidase do vìrus da influenza- e de tratamento de infecção por vìrus da influenza-
CN100390172C (zh) * 2004-09-10 2008-05-28 成都欣捷高新技术开发有限公司 一种甲磺酸多拉司琼晶型及其制备方法
EP1819705A1 (de) * 2004-11-25 2007-08-22 Cilag Ltd. Verfahren zur herstellung von estern von hexahydro-8-hydroxy-2,6-methano-2h-chinolizin-3(4h)-on
EP1904492B1 (en) * 2005-07-06 2008-10-15 Inke, S.A. Method for obtaining the pharmaceutically active compound dolasetron, synthesis intermediates thereof and methods for obtaining them
ES2264901B1 (es) 2005-07-06 2007-12-01 Inke, S.A. Procedimiento para la obtencion de un compuesto farmaceuticamente activo, sus intermedios de sintesis y procedimiento para la obtencion de los mismos.
US20070203176A1 (en) * 2006-01-05 2007-08-30 Janos Hajko Crystalline forms of dolasetron base and processes for preparation thereof
EP2060557B1 (en) 2007-11-13 2012-06-06 Inke, S.A. Intermediate compounds useful to prepare dolasetron
ES2432618T3 (es) 2009-05-20 2013-12-04 Inserm (Institut National De La Santé Et De La Recherche Medicale) Antagonistas del receptor 5-HT3 de serotonina para usar en el tratamiento o prevención de una patología del oído interno con déficit vestibular
JP5955767B2 (ja) 2009-05-20 2016-07-20 インセルム（インスティチュート ナショナル デ ラ サンテ エ デ ラ リシェルシェ メディカル） 損傷性前庭障害の処置における使用のためのセロトニン５−ｈｔ３受容体拮抗薬
US20180250270A1 (en) 2015-09-11 2018-09-06 Chase Pharmaceuticals Corporation Muscarinic combination and its use for combating hypocholinergic disorders of the central nervous system
CN108976230A (zh) * 2018-06-18 2018-12-11 东莞市联洲知识产权运营管理有限公司 一种基于石墨烯活化制备甲磺酸多拉司琼关键中间体的方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2531083B1 (fr) * 1982-06-29 1986-11-28 Sandoz Sa Nouveaux derives de la piperidine, leur preparation et leur utilisation comme medicaments
DE3429830A1 (de) * 1983-08-26 1985-03-07 Sandoz-Patent-GmbH, 7850 Lörrach Automatische carbonsaeure- und sulfonsaeureester oder -amide
DE3587151T2 (de) * 1984-12-20 1993-07-15 Sandoz Ag Behandlung von gastrointestinalkrankheiten durch anwendung von 5-ht3-antagonisten.

Also Published As

Publication number Publication date
EP0266730B1 (en) 1994-08-10
PH26261A (en) 1992-04-01
DE3750359T2 (de) 1994-12-08
JP2542225B2 (ja) 1996-10-09
IE872955L (en) 1988-05-03
DE3750359D1 (de) 1994-09-15
NO874550L (no) 1988-05-04
FI87786C (fi) 1993-02-25
PT86060B (pt) 1990-07-31
JP2657267B2 (ja) 1997-09-24
KR880006240A (ko) 1988-07-22
NO165922C (no) 1991-05-02
AR246264A1 (es) 1994-07-29
FI87786B (fi) 1992-11-13
ATE109779T1 (de) 1994-08-15
DK572887D0 (da) 1987-11-02
ES2061469T3 (es) 1994-12-16
AU8059687A (en) 1988-05-05
NO874550D0 (no) 1987-11-02
NL970043I1 (nl) 1998-03-02
CA1329203C (en) 1994-05-03
NZ222349A (en) 1990-05-28
CN87107629A (zh) 1988-06-15
NO1999020I1 (no) 1999-08-26
NL970043I2 (nl) 1998-10-01
AU600318B2 (en) 1990-08-09
IE63670B1 (en) 1995-05-31
IL84309A (en) 1991-09-16
JPS63258476A (ja) 1988-10-25
JPH0977769A (ja) 1997-03-25
FI874768A0 (fi) 1987-10-29
DK572887A (da) 1988-05-04
KR950011737B1 (ko) 1995-10-09
PT86060A (en) 1987-12-01
EP0266730A1 (en) 1988-05-11
DK171116B1 (da) 1996-06-17
HU197008B (en) 1989-02-28
ZA878096B (en) 1988-04-26
PH24664A (en) 1990-09-07
NO165922B (no) 1991-01-21
HUT45055A (en) 1988-05-30
DE19775092I2 (de) 2001-11-22
CN1021654C (zh) 1993-07-21

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Legal Events

Date Code Title Description
TC Name/ company changed in patent

Owner name: MERRELL PHARMACEUTICALS INC.

SPCG Supplementary protection certificate granted

Spc suppl protection certif: L121

Extension date: 20110925

FG Patent granted

Owner name: MERRELL PHARMACEUTICALS, INC.

PC Transfer of assignment of patent

Owner name: AVENTIS INC.

Free format text: AVENTIS INC.

MA Patent expired