DK171097B1 - Metalkomplekser af di- og tri(carboxymethyl)-tri- og -tetra(azabicykloalkan)-derivater og salte deraf, farmaceutiske midler, der indeholder disse forbindelser, anvendelse af forbindelserne til fremstilling af midler til NMR-røntgen- eller radiodiagnostik eller til radio- eller stråleterapi samt fremmgangsmåde til fremstilling af forbindelserne - Google Patents

Metalkomplekser af di- og tri(carboxymethyl)-tri- og -tetra(azabicykloalkan)-derivater og salte deraf, farmaceutiske midler, der indeholder disse forbindelser, anvendelse af forbindelserne til fremstilling af midler til NMR-røntgen- eller radiodiagnostik eller til radio- eller stråleterapi samt fremmgangsmåde til fremstilling af forbindelserne Download PDF

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Publication number
DK171097B1
DK171097B1 DK358889A DK358889A DK171097B1 DK 171097 B1 DK171097 B1 DK 171097B1 DK 358889 A DK358889 A DK 358889A DK 358889 A DK358889 A DK 358889A DK 171097 B1 DK171097 B1 DK 171097B1
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DK
Denmark
Prior art keywords
mmol
group
triene
compounds
tri
Prior art date
Application number
DK358889A
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Danish (da)
English (en)
Other versions
DK358889D0 (da
DK358889A (da
Inventor
Johannes Platzek
Bernd Raduechel
Heinz Gries
Hans-Joachim Weinmann
Ulrich Speck
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
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Publication of DK358889D0 publication Critical patent/DK358889D0/da
Publication of DK358889A publication Critical patent/DK358889A/da
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Publication of DK171097B1 publication Critical patent/DK171097B1/da

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D255/00—Heterocyclic compounds containing rings having three nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D249/00 - C07D253/00
    • C07D255/04—Heterocyclic compounds containing rings having three nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D249/00 - C07D253/00 condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/08—Bridged systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Radiology & Medical Imaging (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Medicinal Preparation (AREA)
DK358889A 1988-07-20 1989-07-19 Metalkomplekser af di- og tri(carboxymethyl)-tri- og -tetra(azabicykloalkan)-derivater og salte deraf, farmaceutiske midler, der indeholder disse forbindelser, anvendelse af forbindelserne til fremstilling af midler til NMR-røntgen- eller radiodiagnostik eller til radio- eller stråleterapi samt fremmgangsmåde til fremstilling af forbindelserne DK171097B1 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3825040A DE3825040A1 (de) 1988-07-20 1988-07-20 5- oder 6-ring- enthaltende makrocyclische polyaza-verbindungen, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel
DE3825040 1988-07-20

Publications (3)

Publication Number Publication Date
DK358889D0 DK358889D0 (da) 1989-07-19
DK358889A DK358889A (da) 1990-01-21
DK171097B1 true DK171097B1 (da) 1996-06-03

Family

ID=6359368

Family Applications (1)

Application Number Title Priority Date Filing Date
DK358889A DK171097B1 (da) 1988-07-20 1989-07-19 Metalkomplekser af di- og tri(carboxymethyl)-tri- og -tetra(azabicykloalkan)-derivater og salte deraf, farmaceutiske midler, der indeholder disse forbindelser, anvendelse af forbindelserne til fremstilling af midler til NMR-røntgen- eller radiodiagnostik eller til radio- eller stråleterapi samt fremmgangsmåde til fremstilling af forbindelserne

Country Status (15)

Country Link
EP (1) EP0352218B1 (no)
JP (1) JP2877844B2 (no)
AT (1) ATE118775T1 (no)
CA (1) CA1341035C (no)
DE (2) DE3825040A1 (no)
DK (1) DK171097B1 (no)
ES (1) ES2068908T3 (no)
FI (1) FI893509A (no)
GR (1) GR3015162T3 (no)
IE (1) IE66693B1 (no)
IL (1) IL91046A (no)
NO (1) NO179104C (no)
NZ (1) NZ229996A (no)
PT (1) PT91211B (no)
ZA (1) ZA895543B (no)

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US5334371A (en) * 1988-07-20 1994-08-02 Schering Aktiengesellschaft Marcocyclic polyaza bicyclo compounds containing 5 or 6 membered rings, and method for MRI
DE4001655A1 (de) * 1990-01-18 1991-07-25 Schering Ag 6-ring enthaltende makrocyclische tetraaza-verbindungen, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel
DK0454702T3 (da) * 1989-01-17 1996-05-06 Xyrofin Oy Fremgangsmåde til fremstilling af xylitol ud fra xylose-holdige blandinger
FR2652589B1 (fr) * 1989-10-04 1995-02-17 Roquette Freres Procede de fabrication de xylitol et de produits riches en xylitol.
JP3131219B2 (ja) * 1990-01-19 2001-01-31 ニユコメド・イメージング・アクシエセルカペト キレート化合物
GB9001245D0 (en) * 1990-01-19 1990-03-21 Salutar Inc Compounds
US5330737A (en) * 1991-12-06 1994-07-19 Mallinckrodt Medical, Inc. Nitrogen-sulfur ligands as opiate receptor drug mimics
US5480990A (en) * 1991-12-10 1996-01-02 The Dow Chemical Company Bicyclopolyazamacrocyclocarboxylic acid complexes for use as contrast agents
WO1994026313A1 (en) * 1993-05-06 1994-11-24 The Dow Chemical Company Bicyclopolyazamacrocyclocarboxylic acid complexes, their conjugates, processes for their preparation, and use as contrast agents
IL104059A0 (en) * 1991-12-10 1993-05-13 Dow Chemical Co Bicyclopolyazamacrocyclocarboxylic acid complexes,their conjugates,processes for their preparation,and use as contrast agents
HU9302308D0 (en) * 1991-12-10 1993-12-28 Dow Chemical Co Process for production lof biciclo-polyaza-macrocyclyc-carbonic acid-complexes and their conjugates and of medical preparatives containing them
US5739294A (en) * 1991-12-10 1998-04-14 The Dow Chemical Company Bicyclopol yazamacrocyclophosphonic acid complexes for use as contrast agents
US5428139A (en) * 1991-12-10 1995-06-27 The Dow Chemical Company Bicyclopolyazamacrocyclophosphonic acid complexes for use as radiopharmaceuticals
MX9207166A (es) * 1991-12-10 1993-07-01 Dow Chemical Co Acidos biciclopoliazamacrociclofosfonicos, sus complejos y conjugados, para uso como agentes de contraste, y procedimientos para su preparacion.
US5385893A (en) * 1993-05-06 1995-01-31 The Dow Chemical Company Tricyclopolyazamacrocyclophosphonic acids, complexes and derivatives thereof, for use as contrast agents
AU4237493A (en) * 1993-05-06 1994-12-12 Dow Chemical Company, The Bicyclopolyazamacrocyclocarboxylic acid complexes, their conjugates, processes for their preparation, and use as radiopharmaceuticals
US5480970A (en) * 1993-12-22 1996-01-02 Resolution Pharmaceuticals Metal chelators
US5569745A (en) * 1994-02-25 1996-10-29 Resolution Pharmaceuticals Inc. Peptide-Chelator conjugates
US5928627A (en) * 1996-04-19 1999-07-27 The Dow Chemical Company Fluorescent chelates as visual tissue specific imaging agents
FR2794744B1 (fr) * 1999-06-09 2001-09-21 Guerbet Sa Complexes metalliques de polyaminoacides bicycliques, leur procede de preparation et leur application en imagerie medicale
CA2419629A1 (en) * 2000-09-25 2002-04-04 The Procter & Gamble Company Mri image enhancement compositions
FR2891830B1 (fr) * 2005-10-07 2011-06-24 Guerbet Sa Composes a chaines aminoalcools courtes et complexes metalliques pour l'imagerie medicale
US8986650B2 (en) 2005-10-07 2015-03-24 Guerbet Complex folate-NOTA-Ga68
JP5368099B2 (ja) * 2005-10-07 2013-12-18 ゲルベ ガリウムと錯体形成することが可能なシグナル部分にカップリングされた、生物学的標的の認識のための部分を含んでなる化合物
GB201610738D0 (en) 2016-06-20 2016-08-03 Ge Healthcare As Chelate compounds
US11110186B2 (en) * 2017-12-20 2021-09-07 General Electric Company Anionic chelate compounds

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2478456A (en) 1946-03-15 1949-08-09 Socony Vaeuum Oil Company Inc Solvent dewaxing
US3194818A (en) 1963-08-14 1965-07-13 Sterling Drug Inc Alpha-aryl or aralkyl furfurylamines
DE3129906C3 (de) * 1981-07-24 1996-12-19 Schering Ag Paramagnetische Komplexsalze, deren Herstellung und Mittel zur Verwendung bei der NMR-Diagnostik
DE3150917A1 (de) 1981-12-18 1983-06-30 Schering Ag, 1000 Berlin Und 4619 Bergkamen "2-amino-1-(1,3-dioxolan-4-yl)-ethanol-verbindungen, deren herstellung und verwendung zur weiterverarbeitung"
NL194579C (nl) * 1983-01-21 2002-08-05 Schering Ag Diagnostisch middel.
DE3324235A1 (de) * 1983-07-01 1985-01-10 Schering AG, 1000 Berlin und 4709 Bergkamen Neue komplexbildner, komplexe und komplexsalze
SE8502573D0 (sv) * 1985-05-23 1985-05-23 Jouko Kanakre Fluorescent lanthanide chelates useful as labels of physiologically active materials
DE3772785D1 (de) 1986-01-23 1991-10-17 Squibb & Sons Inc 1-substituiertes-4,7,10-triscarboxymethyl-1,4,7,10-tetraazacyclododecan und analoga.

Also Published As

Publication number Publication date
GR3015162T3 (en) 1995-05-31
IE66693B1 (en) 1996-01-24
NO179104B (no) 1996-04-29
IL91046A0 (en) 1990-02-09
PT91211B (pt) 1995-03-01
DE3825040A1 (de) 1990-01-25
JP2877844B2 (ja) 1999-04-05
NO892959L (no) 1990-01-22
NO179104C (no) 1996-08-07
IE892335L (en) 1990-01-20
DK358889D0 (da) 1989-07-19
EP0352218A3 (de) 1991-01-16
DE58909022D1 (de) 1995-04-06
FI893509A (fi) 1990-01-21
CA1341035C (en) 2000-06-20
JPH02104588A (ja) 1990-04-17
AU637052B2 (en) 1993-05-20
ZA895543B (en) 1990-05-30
ES2068908T3 (es) 1995-05-01
ATE118775T1 (de) 1995-03-15
DK358889A (da) 1990-01-21
FI893509A0 (fi) 1989-07-20
AU3827589A (en) 1990-02-01
NO892959D0 (no) 1989-07-19
EP0352218A2 (de) 1990-01-24
EP0352218B1 (de) 1995-02-22
NZ229996A (en) 1992-05-26
PT91211A (pt) 1990-02-08
IL91046A (en) 1995-10-31

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Legal Events

Date Code Title Description
B1 Patent granted (law 1993)
PBP Patent lapsed