DK170248B1 - Sulfoneret 4-demethyl-13-dioxolanyl-daunomycinon, 4-demethoxy-4-(beskyttet amino)-13-dioxolanyl-daunomycinon, og fremgangsmåde til fremstilling af 4-demethoxy-daunomycinon, aglyconet af 4-demethoxy-daunorubicin - Google Patents

Sulfoneret 4-demethyl-13-dioxolanyl-daunomycinon, 4-demethoxy-4-(beskyttet amino)-13-dioxolanyl-daunomycinon, og fremgangsmåde til fremstilling af 4-demethoxy-daunomycinon, aglyconet af 4-demethoxy-daunorubicin Download PDF

Info

Publication number
DK170248B1
DK170248B1 DK063889A DK63889A DK170248B1 DK 170248 B1 DK170248 B1 DK 170248B1 DK 063889 A DK063889 A DK 063889A DK 63889 A DK63889 A DK 63889A DK 170248 B1 DK170248 B1 DK 170248B1
Authority
DK
Denmark
Prior art keywords
formula
daunomycinone
demethoxy
dioxolanyl
process according
Prior art date
Application number
DK063889A
Other languages
Danish (da)
English (en)
Other versions
DK63889A (da
DK63889D0 (da
Inventor
Silvia De Bernadinis
Walter Cabri
Tiziano Martinengo
Franco Francalanci
Original Assignee
Erba Carlo Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Erba Carlo Spa filed Critical Erba Carlo Spa
Publication of DK63889D0 publication Critical patent/DK63889D0/da
Publication of DK63889A publication Critical patent/DK63889A/da
Application granted granted Critical
Publication of DK170248B1 publication Critical patent/DK170248B1/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C50/00—Quinones
    • C07C50/38—Quinones containing —CHO or non—quinoid keto groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C46/00—Preparation of quinones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/40—Ortho- or ortho- and peri-condensed systems containing four condensed rings
    • C07C2603/42—Ortho- or ortho- and peri-condensed systems containing four condensed rings containing only six-membered rings
    • C07C2603/44—Naphthacenes; Hydrogenated naphthacenes
    • C07C2603/46—1,4,4a,5,5a,6,11,12a- Octahydronaphthacenes, e.g. tetracyclines
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Cephalosporin Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
DK063889A 1988-02-12 1989-02-10 Sulfoneret 4-demethyl-13-dioxolanyl-daunomycinon, 4-demethoxy-4-(beskyttet amino)-13-dioxolanyl-daunomycinon, og fremgangsmåde til fremstilling af 4-demethoxy-daunomycinon, aglyconet af 4-demethoxy-daunorubicin DK170248B1 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB888803301A GB8803301D0 (en) 1988-02-12 1988-02-12 Process for preparation of 4-demethoxy-daunomycinone aglycone of 4-demethoxy-daunorubicin
GB8803301 1988-02-12

Publications (3)

Publication Number Publication Date
DK63889D0 DK63889D0 (da) 1989-02-10
DK63889A DK63889A (da) 1989-08-13
DK170248B1 true DK170248B1 (da) 1995-07-17

Family

ID=10631620

Family Applications (1)

Application Number Title Priority Date Filing Date
DK063889A DK170248B1 (da) 1988-02-12 1989-02-10 Sulfoneret 4-demethyl-13-dioxolanyl-daunomycinon, 4-demethoxy-4-(beskyttet amino)-13-dioxolanyl-daunomycinon, og fremgangsmåde til fremstilling af 4-demethoxy-daunomycinon, aglyconet af 4-demethoxy-daunorubicin

Country Status (26)

Country Link
US (1) US5015745A (ru)
EP (1) EP0328399B1 (ru)
JP (1) JP2784202B2 (ru)
KR (1) KR970000484B1 (ru)
CN (1) CN1020592C (ru)
AT (1) ATE92457T1 (ru)
AU (1) AU605960B2 (ru)
CA (1) CA1339634C (ru)
CS (1) CS273198B2 (ru)
DE (1) DE68907934T2 (ru)
DK (1) DK170248B1 (ru)
ES (1) ES2059718T3 (ru)
FI (1) FI92186C (ru)
GB (1) GB8803301D0 (ru)
HU (1) HU200979B (ru)
IE (1) IE62954B1 (ru)
IL (1) IL89198A (ru)
MY (1) MY104941A (ru)
NO (1) NO169483C (ru)
NZ (1) NZ227873A (ru)
PH (1) PH27328A (ru)
PT (1) PT89663B (ru)
RU (1) RU1819256C (ru)
UA (1) UA19151A (ru)
YU (1) YU47206B (ru)
ZA (1) ZA891018B (ru)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ224252A (en) * 1987-04-21 1991-09-25 Erba Carlo Spa An anthracycline glycoside and its preparation
GB8808475D0 (en) * 1988-04-11 1988-05-11 Erba Carlo Spa Process for preparing 4-demethoxydauno-mycinone
IT1275953B1 (it) * 1995-03-22 1997-10-24 Sicor Spa Procedimento per la preparazione di antibiotici della classe delle antracicline
AUPQ319799A0 (en) * 1999-10-01 1999-10-28 Institute Of Drug Technology Australia Limited Chemical methods
US7053191B2 (en) 2003-05-21 2006-05-30 Solux Corporation Method of preparing 4-R-substituted 4-demethoxydaunorubicin
TW200621698A (en) * 2004-08-23 2006-07-01 Sicor Inc Synthesis of idarubicin aglycone
RU2450013C2 (ru) 2005-12-13 2012-05-10 Солюкс Корпорейшен Способ получения 4-деметилдаунорубицина
US8802830B2 (en) 2005-12-20 2014-08-12 Solux Corporation Synthesis of epirubicin from 13-dihydrodaunorubicine
US8357785B2 (en) 2008-01-08 2013-01-22 Solux Corporation Method of aralkylation of 4′-hydroxyl group of anthracylins
US8846882B2 (en) * 2011-04-29 2014-09-30 Synbias Pharma Ag Method of producing 4-demethoxydaunorubicin

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3862225A (en) * 1961-08-18 1975-01-21 Pfizer D-ring substituted tetracyclines
US4020270A (en) * 1974-05-02 1977-04-26 Societa' Farmaceutici Italia S.P.A. L-lyxohex-1-enopyranose derivative
GB1467383A (en) * 1974-06-12 1977-03-16 Farmaceutici Italia Daunomycin analogues
GB1500421A (en) * 1975-01-22 1978-02-08 Farmaceutici Italia Optically active anthracyclinones
GB1509875A (en) * 1976-06-14 1978-05-04 Farmaceutici Italia Optically active anthracyclinones and anthracycline glycosides
GB1527050A (en) * 1976-06-19 1978-10-04 Farmaceutici Italia Optically active anthracyclinones
GB8317037D0 (en) * 1983-06-23 1983-07-27 Erba Farmitalia 6-deoxyanthracyclines
US4495103A (en) * 1982-07-30 1985-01-22 Sumitomo Chemical Company, Ltd. Preparation of optically active 4-demethoxydaunomycinone
WO1985001726A1 (en) * 1983-10-19 1985-04-25 The University Of Melbourne Carminomycinone precursors and analogues and derivatives thereof
NZ224252A (en) * 1987-04-21 1991-09-25 Erba Carlo Spa An anthracycline glycoside and its preparation
GB8808475D0 (en) * 1988-04-11 1988-05-11 Erba Carlo Spa Process for preparing 4-demethoxydauno-mycinone
GB8824947D0 (en) * 1988-10-25 1988-11-30 Erba Carlo Spa New 4-substituted anthracyclinones & process for preparing them

Also Published As

Publication number Publication date
KR970000484B1 (ko) 1997-01-13
ZA891018B (en) 1989-10-25
CA1339634C (en) 1998-01-20
IE890383L (en) 1989-08-12
US5015745A (en) 1991-05-14
IE62954B1 (en) 1995-02-20
UA19151A (ru) 1997-12-25
MY104941A (en) 1994-07-30
ES2059718T3 (es) 1994-11-16
DK63889A (da) 1989-08-13
FI92186C (fi) 1994-10-10
NO169483C (no) 1992-07-01
NO169483B (no) 1992-03-23
CN1020592C (zh) 1993-05-12
AU2974589A (en) 1989-08-17
JPH021423A (ja) 1990-01-05
KR890012931A (ko) 1989-09-20
YU47206B (sh) 1995-01-31
HUT49319A (en) 1989-09-28
AU605960B2 (en) 1991-01-24
CS80789A2 (en) 1990-06-13
EP0328399B1 (en) 1993-08-04
YU31089A (en) 1990-08-31
RU1819256C (en) 1993-05-30
EP0328399A2 (en) 1989-08-16
FI92186B (fi) 1994-06-30
IL89198A0 (en) 1989-09-10
FI890612A0 (fi) 1989-02-09
IL89198A (en) 1994-10-07
NZ227873A (en) 1990-09-26
PT89663B (pt) 1994-02-28
ATE92457T1 (de) 1993-08-15
PT89663A (pt) 1989-10-04
NO890566L (no) 1989-08-11
GB8803301D0 (en) 1988-03-09
NO890566D0 (no) 1989-02-09
CS273198B2 (en) 1991-03-12
HU200979B (en) 1990-09-28
DK63889D0 (da) 1989-02-10
JP2784202B2 (ja) 1998-08-06
PH27328A (en) 1993-06-08
CN1037152A (zh) 1989-11-15
DE68907934D1 (de) 1993-09-09
EP0328399A3 (en) 1990-03-07
FI890612A (fi) 1989-08-13
DE68907934T2 (de) 1994-04-28

Similar Documents

Publication Publication Date Title
SU1729294A3 (ru) Способ получени 4-деметокси-7-деокси-дауномицинона или 4-деметокси-дауномицинона
DK170248B1 (da) Sulfoneret 4-demethyl-13-dioxolanyl-daunomycinon, 4-demethoxy-4-(beskyttet amino)-13-dioxolanyl-daunomycinon, og fremgangsmåde til fremstilling af 4-demethoxy-daunomycinon, aglyconet af 4-demethoxy-daunorubicin
JP3554560B2 (ja) 相間移動触媒を用いたインドロカルバゾールのグリコシド化
PL177140B1 (pl) Izoindole i sposób wytwarzania izoindoli
DK170157B1 (da) Fremgangsmåde til fremstilling af 4-demethoxydaunomycinon
JP3153552B2 (ja) モノ及びビスアルキルアミノ−アントラサイクリン類
NZ230051A (en) 4-demethoxy-4-carboxy-daunomycinone ester derivatives, pharmaceutical compositions and preparatory processes
DK168597B1 (da) 4-substituerede demethoxy-daunomydinoner og anthracyclinglycosider deraf samt fremgangsmåde til fremstilling af glycosiderne
RU2404188C2 (ru) Производные антрациклинов, способ получения 13-бензенидсульфонилгидразоновых производных антрациклинов, способ получения 13-деоксиантрациклинов, способ получения 5-имино-13-деоксиантрациклинов
EP0475071B1 (en) 2-acyloxy-4-morpholinyl anthracycline
EP0381989B1 (en) New 4'-epi-4'-amino anthracyclines
EP1627881B1 (en) Process for the preparation of topiramate
FR2590260A1 (fr) Nitro-anthracycline, aglycone correspondante, procedes pour les preparer, composition pharmaceutique correspondante
SI8910310A (sl) Postopek za pripravo 4-demetoksidavnomicinona, aglikona 4-demetoksi-davnorubicina
WO2005044832A1 (en) Process for the preparation of 1-chloro-3,5-di-o-acyl-2-deoxy-l-ribofuranoside derivatives
JPH05140168A (ja) インドロカルバゾール誘導体及び該化合物を有効成分とする抗腫瘍剤
KR0157612B1 (ko) 신규 안트라사이클린 글리코사이드 유도체
JP5478612B2 (ja) コルヒチンおよびチオコルヒチンのグリコシド化の方法
ES2215922T3 (es) Procedimiento para la preparacion de 9,10 dihidropirrolo(2,1-b)(1,3)benzotiacepinas aminosustituidas en la posicion 9'.
GB2411399A (en) Purification of N4-acylcytidine derviatives via their alkali metal or alkaline earth metal salts
NZ513025A (en) Process for the preparation of an azamacrolide with 4" (R) -NH2
GB2159518A (en) New anthracyclines and process for manufacture
CS158992A3 (en) Process for preparing 6-0-acylelasmycin a derivatives

Legal Events

Date Code Title Description
B1 Patent granted (law 1993)
PBP Patent lapsed

Country of ref document: DK