DK170071B1 - Mitomycinderivater samt fremgangsmåde til femstilling deraf - Google Patents

Mitomycinderivater samt fremgangsmåde til femstilling deraf Download PDF

Info

Publication number
DK170071B1
DK170071B1 DK183984A DK183984A DK170071B1 DK 170071 B1 DK170071 B1 DK 170071B1 DK 183984 A DK183984 A DK 183984A DK 183984 A DK183984 A DK 183984A DK 170071 B1 DK170071 B1 DK 170071B1
Authority
DK
Denmark
Prior art keywords
ethylamino
compound according
methoxymitosan
phenyl
carbon atoms
Prior art date
Application number
DK183984A
Other languages
Danish (da)
English (en)
Other versions
DK183984A (da
DK183984D0 (da
Inventor
Dolatrai Mohanlal Vyas
Terrence William Doyle
Yulin Chiang
Original Assignee
Squibb Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Squibb Bristol Myers Co filed Critical Squibb Bristol Myers Co
Publication of DK183984D0 publication Critical patent/DK183984D0/da
Publication of DK183984A publication Critical patent/DK183984A/da
Application granted granted Critical
Publication of DK170071B1 publication Critical patent/DK170071B1/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DK183984A 1983-04-11 1984-04-09 Mitomycinderivater samt fremgangsmåde til femstilling deraf DK170071B1 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US48401683A 1983-04-11 1983-04-11
US48401683 1983-04-11
US58129184 1984-02-24
US06/581,291 US4803212A (en) 1983-04-11 1984-02-24 Amino disulfides

Publications (3)

Publication Number Publication Date
DK183984D0 DK183984D0 (da) 1984-04-09
DK183984A DK183984A (da) 1984-10-12
DK170071B1 true DK170071B1 (da) 1995-05-15

Family

ID=27047825

Family Applications (1)

Application Number Title Priority Date Filing Date
DK183984A DK170071B1 (da) 1983-04-11 1984-04-09 Mitomycinderivater samt fremgangsmåde til femstilling deraf

Country Status (23)

Country Link
US (1) US4803212A (nl)
KR (1) KR890001488B1 (nl)
AT (1) AT387019B (nl)
AU (1) AU577523B2 (nl)
CA (1) CA1285567C (nl)
CH (1) CH661273A5 (nl)
CY (1) CY1533A (nl)
DE (1) DE3413489A1 (nl)
DK (1) DK170071B1 (nl)
ES (1) ES8602798A1 (nl)
FI (1) FI78701C (nl)
FR (1) FR2543953B1 (nl)
GB (1) GB2140799B (nl)
GR (1) GR79579B (nl)
HK (1) HK82690A (nl)
IE (1) IE57348B1 (nl)
IT (1) IT1176003B (nl)
LU (1) LU85295A1 (nl)
MX (1) MX9202850A (nl)
MY (1) MY102071A (nl)
NL (1) NL8401104A (nl)
PT (1) PT78399B (nl)
SE (1) SE461735B (nl)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4487769A (en) * 1982-06-04 1984-12-11 Bristol-Myers Company Amidines
US4866180A (en) * 1984-02-24 1989-09-12 Bristol-Myers Company Amino disulfide thiol exchange products
JPS60255789A (ja) * 1984-06-01 1985-12-17 Kyowa Hakko Kogyo Co Ltd マイトマイシン誘導体，その製造法および抗腫瘍剤
US4888341A (en) * 1984-09-04 1989-12-19 University Patents, Inc. 6-substituted mitomycin analogs
US4927943A (en) * 1984-09-04 1990-05-22 Bristol-Myers Company Substituted 7-oxomitosanes
AU581673B2 (en) * 1984-09-04 1989-03-02 Bristol-Myers Company Substituted 7-oxomitosanes
EP0197799B1 (en) * 1985-04-10 1990-09-12 Kyowa Hakko Kogyo Kabushiki Kaisha Pharmacologically active mitomycin derivatives
JPS6354380A (ja) * 1986-08-26 1988-03-08 Kyowa Hakko Kogyo Co Ltd マイトマイシン誘導体
JPS63150282A (ja) * 1986-12-13 1988-06-22 Kyowa Hakko Kogyo Co Ltd マイトマイシン誘導体
ZA886812B (en) * 1987-11-23 1989-07-26 Bristol Myers Co Anti-tumor prodrugs
US5075454A (en) * 1990-03-08 1991-12-24 Bristol-Myers Squibb Company 7-(diphenylmethyl)oxy-9a-methoxymitosane
US5175303A (en) * 1990-03-08 1992-12-29 Bristol-Myers Squibb Company Preparation of 7-(diphenylmethyl)oxy-9A-methoxymitosane

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3660578A (en) * 1957-04-06 1972-05-02 Kyowa Hakko Kogyo Kk Mitomycin c
NL129868C (nl) * 1963-06-07
DE1570029A1 (de) * 1964-07-09 1970-04-09 Kyowa Hakko Kogyo Kk Verfahren zur Herstellung von Mitosanverbindungen
NL130086C (nl) * 1964-07-14 1970-06-15
US3332944A (en) * 1964-11-02 1967-07-25 American Cyanamid Co Antibiotic derivatives of mitomycins a, b, c and porfiromycin
JPS5439098A (en) * 1977-08-31 1979-03-24 Kyowa Hakko Kogyo Co Ltd Mitomycin c derivatives
US4268676A (en) * 1979-12-05 1981-05-19 University Patents, Inc. Mitomycin analogs
GB2093643A (en) * 1981-02-17 1982-09-02 Standard Telephones Cables Ltd DC-to-DC converter
NZ199617A (en) * 1981-05-15 1985-08-30 University Patents Inc Azirino(2',3',:3,4)pyrrolo(1,2-a)indole-4,7-dione derivatives and pharmaceutical compositions
US4487769A (en) * 1982-06-04 1984-12-11 Bristol-Myers Company Amidines
EP0116208B1 (en) * 1982-12-07 1988-03-30 Kyowa Hakko Kogyo Co., Ltd. Mitomycin analogues
US4642352A (en) * 1983-12-23 1987-02-10 Bristol-Myers Company Acylamino mitosanes
AU581673B2 (en) * 1984-09-04 1989-03-02 Bristol-Myers Company Substituted 7-oxomitosanes

Also Published As

Publication number Publication date
CH661273A5 (de) 1987-07-15
FI78701B (fi) 1989-05-31
GB2140799A (en) 1984-12-05
FI78701C (fi) 1989-09-11
NL8401104A (nl) 1984-11-01
AU2595184A (en) 1984-10-18
DE3413489C2 (nl) 1991-07-25
IT1176003B (it) 1987-08-12
KR890001488B1 (ko) 1989-05-04
AU577523B2 (en) 1988-09-29
US4803212A (en) 1989-02-07
GB8409242D0 (en) 1984-05-23
MX9202850A (es) 1992-06-30
SE461735B (sv) 1990-03-19
GR79579B (nl) 1984-10-30
FR2543953B1 (fr) 1988-08-26
IE57348B1 (en) 1992-08-12
DK183984A (da) 1984-10-12
FI841380A0 (fi) 1984-04-06
ES531338A0 (es) 1985-12-01
GB2140799B (en) 1987-04-08
DK183984D0 (da) 1984-04-09
FR2543953A1 (fr) 1984-10-12
CY1533A (en) 1990-11-16
IT8420478A0 (it) 1984-04-10
ES8602798A1 (es) 1985-12-01
CA1285567C (en) 1991-07-02
MY102071A (en) 1992-03-31
PT78399A (en) 1984-05-01
FI841380A (fi) 1984-10-12
HK82690A (en) 1990-10-19
ATA122384A (de) 1988-04-15
PT78399B (en) 1986-07-17
AT387019B (de) 1988-11-25
SE8401999L (sv) 1984-10-12
IE840878L (en) 1984-10-11
DE3413489A1 (de) 1984-10-11
SE8401999D0 (sv) 1984-04-10
LU85295A1 (fr) 1984-11-28

Similar Documents

Publication Publication Date Title
DK170071B1 (da) Mitomycinderivater samt fremgangsmåde til femstilling deraf
KR100366727B1 (ko) 포스포네이트뉴클레오티드화합물
WO2020245664A1 (en) N-(5-(6-ethoxypyrazin-2-yl)pyridin-2-yl)-4-(2-(methylsulfonamido)pyrimidin-4-yl) tetrahydro-2h-pyran-4-carboxamide derivatives and related compounds as human ctps1 inhibitors for the treatment of proliferative diseases
KR20090031787A (ko) Ｊａｋ 키나제 억제제로서의 ２,４-디(아릴아미노)-피리미딘-５-카르복스아미드 화합물
CA2970546A1 (en) Antimicrobial polymyxins for treatment of bacterial infections
WO2018170200A1 (en) Heteroaryl compounds useful as mk2 inhibitors
NZ204352A (en) Mitomycin analogs carrying one or more guanidino substituents in the 7- and/or 10-positions
Zhang et al. Antitumor Agents. 148. Synthesis and Biological Evaluation of Novel 4. beta.-Amino Derivatives of Etoposide with Better Pharmacological Profiles
EP3044225A1 (en) Tricyclic gyrase inhibitors
UA74834C2 (en) Non-nucleoside inhibitors of reverse transcriptase and a pharmaceutical composition based thereon
CZ286394A3 (en) Salts of clavulanic acid with diamines, process of their preparation, and pharmaceutical compositions based thereon, use of such salts for preparing clavulanic acid or their pharmaceutically acceptable salts or esters and purification method of the latter compounds
IE57835B1 (en) 7-acylamino mitosanes
SE452619B (sv) Nytt forfarande for framstellning av cefalosporiner
EP0160546A2 (en) Cephalosporin compounds, and their production, and medicaments containing them
IE56782B1 (en) Substituted anthra(1,9-cd)pyrazol-6(2h)-ones
Jursic et al. Preparation of 5-diaminomethylenebarbiturates by barbituric acid addition to carbodiimides
CA1291293C (en) Substituted 7-oxomitosanes
Christlieb et al. Isolation and Crystal Structure of Novel by-products Observed During the Formation of bis (thiosemicarbazones)
FI89497C (fi) Foerfarande foer framstaellning av 2'-deoxi-5-fluoruridins derivat
US4927943A (en) Substituted 7-oxomitosanes
Reddy et al. Synthesis and pharmacological activity of some novel bis-heterocycles encompassing pyrrole
Kudzin et al. Long Chain 1-Aminothiaalkane-Phosphonates, Their Sulphinyl and Sulphonyl Derivatives. A New Type of Complexane Type Surfactants
Przychodzeń et al. Medium-sized cyclic bis (anisylphosphonothioyl) disulfanes and their corresponding cyclic sulfane-structures and most characteristic reactions
Hirayama et al. Structural studies of mitomycins. II. Structure of mitomycin A hemihydrate
Slivka et al. Preparation of Bioactive Fused Pyrimidines via Environmental Technologies

Legal Events

Date Code Title Description
B1 Patent granted (law 1993)
PBP Patent lapsed