DK169306B1 - Middel til fjernelse eller inaktivering af uønskede komponenter i blod eller andre ekstracellulære legemsvæsker samt fremgangsmåde til fremstilling af dextran-O-carbonyl-benzo-18-crown-6 og af dextran-hydroxyethylbenzo-18-crown-6 - Google Patents

Middel til fjernelse eller inaktivering af uønskede komponenter i blod eller andre ekstracellulære legemsvæsker samt fremgangsmåde til fremstilling af dextran-O-carbonyl-benzo-18-crown-6 og af dextran-hydroxyethylbenzo-18-crown-6 Download PDF

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Publication number
DK169306B1
DK169306B1 DK291389A DK291389A DK169306B1 DK 169306 B1 DK169306 B1 DK 169306B1 DK 291389 A DK291389 A DK 291389A DK 291389 A DK291389 A DK 291389A DK 169306 B1 DK169306 B1 DK 169306B1
Authority
DK
Denmark
Prior art keywords
crown
dextran
crown ether
substituted
agent according
Prior art date
Application number
DK291389A
Other languages
Danish (da)
English (en)
Other versions
DK291389A (da
DK291389D0 (da
Inventor
Henry Marinus Christensen
Hans Berg Andreasen
Original Assignee
Af 18 Juni 1990 As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Af 18 Juni 1990 As filed Critical Af 18 Juni 1990 As
Publication of DK291389D0 publication Critical patent/DK291389D0/da
Priority to DK291389A priority Critical patent/DK169306B1/da
Priority to ZA904546A priority patent/ZA904546B/xx
Priority to NZ234034A priority patent/NZ234034A/xx
Priority to IE213190A priority patent/IE62998B1/en
Priority to IL9471290A priority patent/IL94712A/en
Priority to HU906647A priority patent/HU208083B/hu
Priority to DE69012818T priority patent/DE69012818T2/de
Priority to PCT/DK1990/000151 priority patent/WO1990015610A1/en
Priority to ES90917756T priority patent/ES2062571T3/es
Priority to KR1019910701848A priority patent/KR920702624A/ko
Priority to EP90917756A priority patent/EP0481013B1/en
Priority to MD95-0010A priority patent/MD950010A/ro
Priority to AT90917756T priority patent/ATE111739T1/de
Priority to CA002058442A priority patent/CA2058442A1/en
Priority to DK90917756.0T priority patent/DK0481013T3/da
Priority to AU59401/90A priority patent/AU635464B2/en
Priority to JP2509373A priority patent/JPH04506211A/ja
Publication of DK291389A publication Critical patent/DK291389A/da
Priority to NO914854A priority patent/NO914854D0/no
Priority to BG095622A priority patent/BG60089B2/bg
Priority to OA60112A priority patent/OA09646A/en
Priority to US07/806,206 priority patent/US5314878A/en
Priority to FI915888A priority patent/FI95139C/sv
Priority to US08/205,629 priority patent/US5514668A/en
Application granted granted Critical
Publication of DK169306B1 publication Critical patent/DK169306B1/da

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0009—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Glucans, e.g. polydextrose, alternan, glycogen; (alpha-1,4)(alpha-1,6)-D-Glucans; (alpha-1,3)(alpha-1,4)-D-Glucans, e.g. isolichenan or nigeran; (alpha-1,4)-D-Glucans; (alpha-1,3)-D-Glucans, e.g. pseudonigeran; Derivatives thereof
    • C08B37/0021—Dextran, i.e. (alpha-1,4)-D-glucan; Derivatives thereof, e.g. Sephadex, i.e. crosslinked dextran
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
    • A61L2/0082—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using chemical substances
    • A61L2/0088—Liquid substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3202—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the carrier, support or substrate used for impregnation or coating
    • B01J20/3206—Organic carriers, supports or substrates
    • B01J20/3208—Polymeric carriers, supports or substrates
    • B01J20/3212—Polymeric carriers, supports or substrates consisting of a polymer obtained by reactions otherwise than involving only carbon to carbon unsaturated bonds
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3214—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the method for obtaining this coating or impregnating
    • B01J20/3217—Resulting in a chemical bond between the coating or impregnating layer and the carrier, support or substrate, e.g. a covalent bond
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3214—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the method for obtaining this coating or impregnating
    • B01J20/3217—Resulting in a chemical bond between the coating or impregnating layer and the carrier, support or substrate, e.g. a covalent bond
    • B01J20/3219—Resulting in a chemical bond between the coating or impregnating layer and the carrier, support or substrate, e.g. a covalent bond involving a particular spacer or linking group, e.g. for attaching an active group
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3231—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the coating or impregnating layer
    • B01J20/3242—Layers with a functional group, e.g. an affinity material, a ligand, a reactant or a complexing group
    • B01J20/3244—Non-macromolecular compounds
    • B01J20/3246—Non-macromolecular compounds having a well defined chemical structure
    • B01J20/3248—Non-macromolecular compounds having a well defined chemical structure the functional group or the linking, spacer or anchoring group as a whole comprising at least one type of heteroatom selected from a nitrogen, oxygen or sulfur, these atoms not being part of the carrier as such
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3231—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the coating or impregnating layer
    • B01J20/3242—Layers with a functional group, e.g. an affinity material, a ligand, a reactant or a complexing group
    • B01J20/3244—Non-macromolecular compounds
    • B01J20/3246—Non-macromolecular compounds having a well defined chemical structure
    • B01J20/3248—Non-macromolecular compounds having a well defined chemical structure the functional group or the linking, spacer or anchoring group as a whole comprising at least one type of heteroatom selected from a nitrogen, oxygen or sulfur, these atoms not being part of the carrier as such
    • B01J20/3253—Non-macromolecular compounds having a well defined chemical structure the functional group or the linking, spacer or anchoring group as a whole comprising at least one type of heteroatom selected from a nitrogen, oxygen or sulfur, these atoms not being part of the carrier as such comprising a cyclic structure not containing any of the heteroatoms nitrogen, oxygen or sulfur, e.g. aromatic structures
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3231—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the coating or impregnating layer
    • B01J20/3242—Layers with a functional group, e.g. an affinity material, a ligand, a reactant or a complexing group
    • B01J20/3244—Non-macromolecular compounds
    • B01J20/3246—Non-macromolecular compounds having a well defined chemical structure
    • B01J20/3248—Non-macromolecular compounds having a well defined chemical structure the functional group or the linking, spacer or anchoring group as a whole comprising at least one type of heteroatom selected from a nitrogen, oxygen or sulfur, these atoms not being part of the carrier as such
    • B01J20/3255—Non-macromolecular compounds having a well defined chemical structure the functional group or the linking, spacer or anchoring group as a whole comprising at least one type of heteroatom selected from a nitrogen, oxygen or sulfur, these atoms not being part of the carrier as such comprising a cyclic structure containing at least one of the heteroatoms nitrogen, oxygen or sulfur, e.g. heterocyclic or heteroaromatic structures
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2220/00—Aspects relating to sorbent materials
    • B01J2220/40—Aspects relating to the composition of sorbent or filter aid materials
    • B01J2220/48—Sorbents characterised by the starting material used for their preparation
    • B01J2220/4812—Sorbents characterised by the starting material used for their preparation the starting material being of organic character
    • B01J2220/4825—Polysaccharides or cellulose materials, e.g. starch, chitin, sawdust, wood, straw, cotton

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Materials Engineering (AREA)
  • Biomedical Technology (AREA)
  • Polymers & Plastics (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Toxicology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • External Artificial Organs (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Detergent Compositions (AREA)
DK291389A 1989-06-14 1989-06-14 Middel til fjernelse eller inaktivering af uønskede komponenter i blod eller andre ekstracellulære legemsvæsker samt fremgangsmåde til fremstilling af dextran-O-carbonyl-benzo-18-crown-6 og af dextran-hydroxyethylbenzo-18-crown-6 DK169306B1 (da)

Priority Applications (23)

Application Number Priority Date Filing Date Title
DK291389A DK169306B1 (da) 1989-06-14 1989-06-14 Middel til fjernelse eller inaktivering af uønskede komponenter i blod eller andre ekstracellulære legemsvæsker samt fremgangsmåde til fremstilling af dextran-O-carbonyl-benzo-18-crown-6 og af dextran-hydroxyethylbenzo-18-crown-6
ZA904546A ZA904546B (en) 1989-06-14 1990-06-12 A composition for removing or inactivating harmful components in blood or other extracellular body fluids
NZ234034A NZ234034A (en) 1989-06-14 1990-06-12 Compositions containing a crownether bound to a polysaccharide
IE213190A IE62998B1 (en) 1989-06-14 1990-06-13 Composition for removing or inactivating harmful components in blood or other body fluids
IL9471290A IL94712A (en) 1989-06-14 1990-06-13 Crown sites are associated with polysaccharides and preparations containing them for the removal or inactivation of harmful components in the blood or other extracellular body fluids
AT90917756T ATE111739T1 (de) 1989-06-14 1990-06-14 Zusammensetzung zur beseitigung und inaktivierung von schadstoffen im blut oder sonstigen extrazellularen körperflüssigkeiten.
JP2509373A JPH04506211A (ja) 1989-06-14 1990-06-14 血液または他の細胞外体液中の有害成分を除去または不活性化する組成物
PCT/DK1990/000151 WO1990015610A1 (en) 1989-06-14 1990-06-14 A composition for removing or inactivating harmful components in blood or other extracellular body fluids
ES90917756T ES2062571T3 (es) 1989-06-14 1990-06-14 Composicion para eliminar o inactivar componentes dañinos en sangre u otros fluidos corporales extracelulares.
KR1019910701848A KR920702624A (ko) 1989-06-14 1990-06-14 혈액 또는 기타 세포외 체액중의 유해 성분을 제거하거나 이를 비활성화시키기 위한 조성물
EP90917756A EP0481013B1 (en) 1989-06-14 1990-06-14 A composition for removing or inactivating harmful components in blood or other extracellular body fluids
MD95-0010A MD950010A (ro) 1989-06-14 1990-06-14 Compoziţie pentru înlăturarea sau dezactivarea componentelor dăunătoare în sînge sau alte lichide extracelulare ale organismului şi procedeu de obţinere
HU906647A HU208083B (en) 1989-06-14 1990-06-14 Process for producing composition suitable for inactivating or removing deleterious materials from blood or other extracellular liquid
CA002058442A CA2058442A1 (en) 1989-06-14 1990-06-14 Composition for removing or inactivating harmful components in blood or other extracellular body fluids
DK90917756.0T DK0481013T3 (da) 1989-06-14 1990-06-14 Middel til fjernelse eller inaktivering af skadelige komponenter i blod eller andre ekstracellulære legemsvæsker
AU59401/90A AU635464B2 (en) 1989-06-14 1990-06-14 Composition for removing or inactivating harmful components in blood or other extracellular body fluids
DE69012818T DE69012818T2 (de) 1989-06-14 1990-06-14 Zusammensetzung zur beseitigung und inaktivierung von schadstoffen im blut oder sonstigen extrazellularen körperflüssigkeiten.
NO914854A NO914854D0 (no) 1989-06-14 1991-12-10 Blanding for aa fjerne eller inaktivere skadelige komponenter i blod eller andre ekstracellulaere kroppsvaesker
BG095622A BG60089B2 (bg) 1989-06-14 1991-12-12 Състав за отстраняване или инактивиране на вредни съставки в кръвта у хора и животни
OA60112A OA09646A (en) 1989-06-14 1991-12-13 A composition for removing or inactivating harmful components in blood or other extracellular body fluids
US07/806,206 US5314878A (en) 1989-06-14 1991-12-13 Composition for removing or inactivating harmful components in blood or other extracellular body fluids
FI915888A FI95139C (sv) 1989-06-14 1991-12-13 Analogiförfarande för framställning av en terapeutiskt användbar, kroneter-substituerad polysackarid
US08/205,629 US5514668A (en) 1989-06-14 1994-03-04 Composition for removing or inactivating harmful components in blood or other extracellular body fluids

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DK291389A DK169306B1 (da) 1989-06-14 1989-06-14 Middel til fjernelse eller inaktivering af uønskede komponenter i blod eller andre ekstracellulære legemsvæsker samt fremgangsmåde til fremstilling af dextran-O-carbonyl-benzo-18-crown-6 og af dextran-hydroxyethylbenzo-18-crown-6
DK291389 1989-06-14

Publications (3)

Publication Number Publication Date
DK291389D0 DK291389D0 (da) 1989-06-14
DK291389A DK291389A (da) 1990-12-15
DK169306B1 true DK169306B1 (da) 1994-10-10

Family

ID=8117054

Family Applications (2)

Application Number Title Priority Date Filing Date
DK291389A DK169306B1 (da) 1989-06-14 1989-06-14 Middel til fjernelse eller inaktivering af uønskede komponenter i blod eller andre ekstracellulære legemsvæsker samt fremgangsmåde til fremstilling af dextran-O-carbonyl-benzo-18-crown-6 og af dextran-hydroxyethylbenzo-18-crown-6
DK90917756.0T DK0481013T3 (da) 1989-06-14 1990-06-14 Middel til fjernelse eller inaktivering af skadelige komponenter i blod eller andre ekstracellulære legemsvæsker

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK90917756.0T DK0481013T3 (da) 1989-06-14 1990-06-14 Middel til fjernelse eller inaktivering af skadelige komponenter i blod eller andre ekstracellulære legemsvæsker

Country Status (21)

Country Link
US (2) US5314878A (sv)
EP (1) EP0481013B1 (sv)
JP (1) JPH04506211A (sv)
KR (1) KR920702624A (sv)
AT (1) ATE111739T1 (sv)
AU (1) AU635464B2 (sv)
BG (1) BG60089B2 (sv)
CA (1) CA2058442A1 (sv)
DE (1) DE69012818T2 (sv)
DK (2) DK169306B1 (sv)
ES (1) ES2062571T3 (sv)
FI (1) FI95139C (sv)
HU (1) HU208083B (sv)
IE (1) IE62998B1 (sv)
IL (1) IL94712A (sv)
MD (1) MD950010A (sv)
NO (1) NO914854D0 (sv)
NZ (1) NZ234034A (sv)
OA (1) OA09646A (sv)
WO (1) WO1990015610A1 (sv)
ZA (1) ZA904546B (sv)

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US6335160B1 (en) 1995-02-17 2002-01-01 Maxygen, Inc. Methods and compositions for polypeptide engineering
DE102008060549A1 (de) 2008-12-04 2010-06-10 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Wirkstoff-Peptid-Konstrukt zur extrazellulären Anreicherung
GB201506663D0 (en) * 2015-04-20 2015-06-03 Komplexis S R L In-vivo delivery of ion chelating ligands for therapy

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IE902131L (en) 1990-12-14
ZA904546B (en) 1991-04-24
HU208083B (en) 1993-08-30
IE902131A1 (en) 1991-01-02
WO1990015610A1 (en) 1990-12-27
IE62998B1 (en) 1995-03-08
IL94712A0 (en) 1991-04-15
FI95139B (sv) 1995-09-15
NZ234034A (en) 1991-11-26
DK291389A (da) 1990-12-15
IL94712A (en) 1994-11-28
US5514668A (en) 1996-05-07
NO914854L (no) 1991-12-10
MD950010A (ro) 1996-05-31
JPH04506211A (ja) 1992-10-29
FI95139C (sv) 1995-12-27
DK0481013T3 (da) 1995-04-10
DE69012818T2 (de) 1995-03-30
AU5940190A (en) 1991-01-08
FI915888A0 (sv) 1991-12-13
HU906647D0 (en) 1992-02-28
ES2062571T3 (es) 1994-12-16
EP0481013B1 (en) 1994-09-21
AU635464B2 (en) 1993-03-18
DE69012818D1 (de) 1994-10-27
OA09646A (en) 1993-04-30
DK291389D0 (da) 1989-06-14
KR920702624A (ko) 1992-10-06
HUT59011A (en) 1992-04-28
BG60089B2 (bg) 1993-10-29
US5314878A (en) 1994-05-24
CA2058442A1 (en) 1990-12-15
ATE111739T1 (de) 1994-10-15
NO914854D0 (no) 1991-12-10
EP0481013A1 (en) 1992-04-22

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B1 Patent granted (law 1993)
PBP Patent lapsed