KR920702624A - 혈액 또는 기타 세포외 체액중의 유해 성분을 제거하거나 이를 비활성화시키기 위한 조성물 - Google Patents

혈액 또는 기타 세포외 체액중의 유해 성분을 제거하거나 이를 비활성화시키기 위한 조성물

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KR920702624A
KR920702624A KR1019910701848A KR910701848A KR920702624A KR 920702624 A KR920702624 A KR 920702624A KR 1019910701848 A KR1019910701848 A KR 1019910701848A KR 910701848 A KR910701848 A KR 910701848A KR 920702624 A KR920702624 A KR 920702624A
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crown
composition
dextran
substituted
same
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헨리 마리누스 크리스텐션
한스 버그 안드레안센
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크리스텐센, 헨리 마리누스
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Abstract

내용 없음

Description

혈액 또는 기타 세포외 체액중의 유해 성분을 제거하거나 이를 비활성화시키기 위한 조성물
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (11)

  1. 크라운에테르가 다당류상에 치환되어 있고, 문제의 유해성분과 결합가능한 크라운에테프 화합물을 포함하는 것을 특징으로 하는, 사람 또는 동물의 혈액 또는 기타 세포의 체액중에서 비루스를 포함하는 유해성분을 제거하거나 이를 비활성화시키기 위한 조성물.
  2. 제1항에 있어서, 다당류가 덱스트라인 것을 특징으로 하는 조성물.
  3. 제1항 또는 제2항에 있어서, 다당류가 분자량 Mw가 1000~120.000 바람직하게 40.000-110.000인 덱스트라인 것을 특징으로 하는, 정맥 투여하기에 바람직한 수용성 조성물.
  4. 제 1항 또는 제 2항에 있어서, 크라운에테르프로 치환되어 있고 가교결합에 의해 수불용성으로된 덱스트란인으로 이루어진 조성물.
  5. 제2항 내지 제 4항중의 어느 한 항에 있어서, 크라운에테르 화합물이 크라운에테르로 치환된 덱스트란을 25중량%까지 차지하는 조성물.
  6. 전기한 항의 어느 한 항에 있어서, 크라운에테르 화합물이 코로난드 화합물이고 치환된 코로난드 그룹이 다음 구조식을 갖는 조성물.
    식중, Q는 다당류와 다리를 만들 수 있는 그룹으로서 1-20개의 탄소원자를 갖고 스페이서로서 제공될 수 있는 탄화수수사를, A1및 A2는 같거나 상이한바 각각 다음 구조식중 어느 하나의 그룹;
    n1및 n2는 같거나 상이한바 각각 0-20의 정수일수 있는데, 단 n1및 n2모두 동시에 0일수 없고, Y는 같거나 상이한바.또는, X는 같거나 상이한바, 각각 수소, 파마코포어 또는 코로난드 화합물에서의 통상적인 치환체, Z는 X와 동일하거나, 각 개별 화합물에 있어서 실제적인 X와 무관하거나 또는 하나 이상의 X와Z쌍은 코로난드 고리에서 C-원자 혹은 Y와 함께 하나 또는 두 개의 탄화수소 고리 또는 복소환식 고리, 바람직하게 벤젠 또는 피리딘 고리를 이룸.
  7. 제 6항에 있어서, Y가 질소 또는 인이고 여기에 결합된 X가 수소인 것을 특징으로 하는 조성물.
  8. 제6항에 있어서, 다음 구조식의 O-카보닐벤조-18-크라운-6-그룹으로 치환된 덱스트란으로 이루어진 것을 특징으로 하는 조성물.
  9. 제6항에 있어서, 다음 구조식의 O-하이드록시에틸벤조-18-크라운-6-그룹으로 치환된 덱스트란으로 이루어진 것을 특징으로 하는 조성물.
  10. 피리딘/디메틸포름아미드중의 덱스트란을 4'-클로로카보닐벤조-18-크라운-6과 방응시키는 것을 특징으로 하는 제 8항의 조성물에 사용하기 위한 덱스트란-카보닐벤조-18-크라운-6를 제조하는 방법.
  11. 수성염기 매체중의 덱스트란을 4'-(2''-브로모-1''-하이드록시에틸)-크라운-6 과 방응시키는 것을 특징으로 하는 제 9항의 조성물에 사용하기 위한 텍스트란-하이드록시에틸벤조-18-크라운-6를 제조하는 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개되는 것임.
KR1019910701848A 1989-06-14 1990-06-14 혈액 또는 기타 세포외 체액중의 유해 성분을 제거하거나 이를 비활성화시키기 위한 조성물 KR920702624A (ko)

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DK291389A DK169306B1 (da) 1989-06-14 1989-06-14 Middel til fjernelse eller inaktivering af uønskede komponenter i blod eller andre ekstracellulære legemsvæsker samt fremgangsmåde til fremstilling af dextran-O-carbonyl-benzo-18-crown-6 og af dextran-hydroxyethylbenzo-18-crown-6
DK2913/89 1989-06-14
PCT/DK1990/000151 WO1990015610A1 (en) 1989-06-14 1990-06-14 A composition for removing or inactivating harmful components in blood or other extracellular body fluids

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BG60089B2 (bg) 1993-10-29
IE902131A1 (en) 1991-01-02
IE902131L (en) 1990-12-14
ES2062571T3 (es) 1994-12-16
DE69012818T2 (de) 1995-03-30
JPH04506211A (ja) 1992-10-29
EP0481013A1 (en) 1992-04-22
EP0481013B1 (en) 1994-09-21
DK169306B1 (da) 1994-10-10
US5314878A (en) 1994-05-24
AU5940190A (en) 1991-01-08
US5514668A (en) 1996-05-07
CA2058442A1 (en) 1990-12-15
MD950010A (ro) 1996-05-31
HUT59011A (en) 1992-04-28
HU208083B (en) 1993-08-30
NO914854L (no) 1991-12-10
NZ234034A (en) 1991-11-26
FI95139C (fi) 1995-12-27
DK291389D0 (da) 1989-06-14
IL94712A (en) 1994-11-28
ZA904546B (en) 1991-04-24
ATE111739T1 (de) 1994-10-15
IL94712A0 (en) 1991-04-15
FI915888A0 (fi) 1991-12-13
DK291389A (da) 1990-12-15
DK0481013T3 (da) 1995-04-10
OA09646A (en) 1993-04-30
WO1990015610A1 (en) 1990-12-27
IE62998B1 (en) 1995-03-08
HU906647D0 (en) 1992-02-28
FI95139B (fi) 1995-09-15
NO914854D0 (no) 1991-12-10
DE69012818D1 (de) 1994-10-27
AU635464B2 (en) 1993-03-18

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