DK168564B1 - Anvendelse af N-acylerede derivater af L-tryptophan til fremstilling af et lægemiddel til lindring af human smerte, farmaceutiske præparater indeholdende dem, samt sådanne nye farmaceutisk aktive derivater - Google Patents

Anvendelse af N-acylerede derivater af L-tryptophan til fremstilling af et lægemiddel til lindring af human smerte, farmaceutiske præparater indeholdende dem, samt sådanne nye farmaceutisk aktive derivater Download PDF

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Publication number
DK168564B1
DK168564B1 DK381486A DK381486A DK168564B1 DK 168564 B1 DK168564 B1 DK 168564B1 DK 381486 A DK381486 A DK 381486A DK 381486 A DK381486 A DK 381486A DK 168564 B1 DK168564 B1 DK 168564B1
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DK
Denmark
Prior art keywords
analgesic
tryptophan
compounds
derivatives
effect
Prior art date
Application number
DK381486A
Other languages
Danish (da)
English (en)
Other versions
DK381486D0 (da
DK381486A (da
Inventor
Francesco Makovec
Chiste Rolando
Angelo Luigi Rovati
Original Assignee
Rotta Research Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Rotta Research Lab filed Critical Rotta Research Lab
Publication of DK381486D0 publication Critical patent/DK381486D0/da
Publication of DK381486A publication Critical patent/DK381486A/da
Application granted granted Critical
Publication of DK168564B1 publication Critical patent/DK168564B1/da

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/20—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals substituted additionally by nitrogen atoms, e.g. tryptophane

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DK381486A 1984-12-12 1986-08-11 Anvendelse af N-acylerede derivater af L-tryptophan til fremstilling af et lægemiddel til lindring af human smerte, farmaceutiske præparater indeholdende dem, samt sådanne nye farmaceutisk aktive derivater DK168564B1 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
IT6824184 1984-12-12
IT68241/84A IT1179866B (it) 1984-12-12 1984-12-12 Derivati del triptofano farmaceuticamente attivi e composizioni farmaceutiche che li contengono
EP8500672 1985-12-05
PCT/EP1985/000672 WO1986003489A1 (en) 1984-12-12 1985-12-05 Pharmaceutically active derivatives of tryptophan and pharmaceutical compositions containing them

Publications (3)

Publication Number Publication Date
DK381486D0 DK381486D0 (da) 1986-08-11
DK381486A DK381486A (da) 1986-08-11
DK168564B1 true DK168564B1 (da) 1994-04-25

Family

ID=11308641

Family Applications (1)

Application Number Title Priority Date Filing Date
DK381486A DK168564B1 (da) 1984-12-12 1986-08-11 Anvendelse af N-acylerede derivater af L-tryptophan til fremstilling af et lægemiddel til lindring af human smerte, farmaceutiske præparater indeholdende dem, samt sådanne nye farmaceutisk aktive derivater

Country Status (14)

Country Link
US (1) US4870097A (es)
EP (1) EP0237522B1 (es)
JP (1) JPS62501292A (es)
AT (1) ATE85976T1 (es)
AU (1) AU589938B2 (es)
CA (1) CA1256441A (es)
DE (1) DE3587122T2 (es)
DK (1) DK168564B1 (es)
ES (1) ES8706630A1 (es)
IE (1) IE58502B1 (es)
IT (1) IT1179866B (es)
PT (1) PT81674B (es)
WO (1) WO1986003489A1 (es)
ZA (1) ZA859526B (es)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4814463A (en) * 1985-12-31 1989-03-21 Biomeasure, Inc. CCK antagonists
US5089638A (en) * 1986-06-16 1992-02-18 Merck & Co., Inc. Amino acid analogs as CCK-antagonists
US4880938A (en) * 1986-06-16 1989-11-14 Merck & Co., Inc. Amino acid analogs
SE8901149D0 (sv) * 1989-04-03 1989-04-03 Pharmacia Ab Medel foer inducering respektive foerhindrande av pupillkonstriktion i oegat
US5360814A (en) * 1991-02-28 1994-11-01 Merrell Dow Pharmaceuticals Inc. NMDA antagonists
US5484814A (en) * 1991-02-28 1996-01-16 Merrell Dow Pharmaceuticals Inc. NMDA antagonists
ES2122098T3 (es) * 1991-02-28 1998-12-16 Merrell Pharma Inc Antagonistas del nmda.
US20030199523A1 (en) * 2002-02-28 2003-10-23 Snutch Terrance P. Heterocyclic calcium in channel blockers
EP2311479B1 (en) 2002-09-20 2014-07-23 The Trustees of The University of Pennsylvania Compstatin analogs with improved activity
US8168584B2 (en) 2005-10-08 2012-05-01 Potentia Pharmaceuticals, Inc. Methods of treating age-related macular degeneration by compstatin and analogs thereof
EP1951279B1 (en) 2005-10-08 2017-04-12 Apellis Pharmaceuticals, Inc. Compstatin and analogs thereof for eye disorders
ES2390828T3 (es) 2005-11-28 2012-11-16 The Trustees Of The University Of Pennsylvania Análogos potentes de la compstatina
HUE026001T2 (en) 2007-02-05 2016-04-28 Apellis Pharmaceuticals Inc Compstatin analogues for use in the treatment of the inflammatory condition of the respiratory system
PT2424557T (pt) 2009-05-01 2018-02-05 Univ Pennsylvania Compstatina modificada com estrutura peptídica e modificações no terminal c
US20140113874A1 (en) 2010-09-23 2014-04-24 The Trustees Of The University Of Pennsylvania Modified Compstatin With Improved Stability And Binding Properties
JP2014503592A (ja) 2011-01-26 2014-02-13 ニコ ワールドワイド，インコーポレイテッド 片頭痛の療法
JP6522337B2 (ja) 2011-05-11 2019-05-29 アペリス・ファーマシューティカルズ・インコーポレイテッドＡｐｅｌｌｉｓ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ，Ｉｎｃ． 細胞反応性、長時間作用型または標的化コンプスタチン類似体およびその使用
JP6618682B2 (ja) 2011-06-22 2019-12-11 アペリス・ファーマシューティカルズ・インコーポレイテッドＡｐｅｌｌｉｓ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ，Ｉｎｃ． 補体阻害剤による慢性障害の治療方法
CN110229216B (zh) 2011-09-07 2023-06-16 宾夕法尼亚州大学理事会 具有改善的药代动力学性质的坎普他汀类肽
SI3660033T1 (sl) 2012-11-15 2021-09-30 Apellis Pharmaceuticals, Inc. Analogi kompstatina z dolgotrajnim delovanjem in sorodni sestavki in postopki
WO2014152391A1 (en) 2013-03-15 2014-09-25 Apellis Pharmaceuticals, Inc. Cell-penetrating compstatin analogs and uses thereof
US10213476B2 (en) 2014-03-17 2019-02-26 The Trustees Of The University Of Pennsylvania Compstatin analogs with improved potency and pharmacokinetic properties
CA3001128A1 (en) 2015-10-07 2017-04-13 Apellis Pharmaceuticals, Inc. Use of long-acting compstatin analog for treating a complement-mediated eye disorder
JP2018534303A (ja) * 2015-11-12 2018-11-22 ザ・トラスティーズ・オブ・コロンビア・ユニバーシティ・イン・ザ・シティ・オブ・ニューヨーク ポリミキシン系抗生物質に対する耐性グラム陰性細菌感染を標的にする合理的薬物設計
KR20190139931A (ko) 2017-04-07 2019-12-18 아펠리스 파마슈티컬스 인코포레이티드 투여 요법 및 관련 조성물 및 방법
CA3061340A1 (en) 2017-04-25 2018-11-01 Temple Otorongo Llc Pharmaceutical composition comprising tryptophan and phyllokinin derivative for use in treating psychiatric and psychological conditions
MX2020010520A (es) 2018-04-06 2021-01-15 Univ Pennsylvania Analogos de compstatina con mayor solubilidad y mejores propiedades farmacocineticas.

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1055518B (it) * 1971-05-18 1982-01-11 Rotta Research Lab Derivatives del triptofano
US4482567A (en) * 1982-10-07 1984-11-13 Research Foundation For Mental Hygiene, Inc. N-hexanoyl to n-heptadecanoyl 5-hydroxy tryptophan-5-hydroxytryptophanamides and use as analgesics

Also Published As

Publication number Publication date
EP0237522B1 (en) 1993-02-24
IT8468241A1 (it) 1986-06-12
IT8468241A0 (it) 1984-12-12
DE3587122T2 (de) 1993-07-15
DK381486D0 (da) 1986-08-11
WO1986003489A1 (en) 1986-06-19
IE853029L (en) 1986-06-12
IT1179866B (it) 1987-09-16
ATE85976T1 (de) 1993-03-15
ES8706630A1 (es) 1987-06-01
ES549822A0 (es) 1987-06-01
AU5209986A (en) 1986-07-01
ZA859526B (en) 1986-08-27
PT81674A (en) 1986-01-01
EP0237522A1 (en) 1987-09-23
DE3587122D1 (de) 1993-04-01
US4870097A (en) 1989-09-26
DK381486A (da) 1986-08-11
CA1256441A (en) 1989-06-27
PT81674B (pt) 1987-10-20
JPS62501292A (ja) 1987-05-21
IE58502B1 (en) 1993-10-06
AU589938B2 (en) 1989-10-26

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Date Code Title Description
B1 Patent granted (law 1993)
PBP Patent lapsed