PT81674B - Processo para a preparacao de derivados n-acilados de l-triptofano farmaceuticamente activos, das composicoes farmaceuticas e de um produto farmaceutico que os contem, aplicaveis para aliviar a dor em seres humanos - Google Patents
Processo para a preparacao de derivados n-acilados de l-triptofano farmaceuticamente activos, das composicoes farmaceuticas e de um produto farmaceutico que os contem, aplicaveis para aliviar a dor em seres humanosInfo
- Publication number
- PT81674B PT81674B PT81674A PT8167485A PT81674B PT 81674 B PT81674 B PT 81674B PT 81674 A PT81674 A PT 81674A PT 8167485 A PT8167485 A PT 8167485A PT 81674 B PT81674 B PT 81674B
- Authority
- PT
- Portugal
- Prior art keywords
- derivatives
- group
- substituted
- acylated
- triptofan
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/20—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals substituted additionally by nitrogen atoms, e.g. tryptophane
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT68241/84A IT1179866B (it) | 1984-12-12 | 1984-12-12 | Derivati del triptofano farmaceuticamente attivi e composizioni farmaceutiche che li contengono |
Publications (2)
Publication Number | Publication Date |
---|---|
PT81674A PT81674A (en) | 1986-01-01 |
PT81674B true PT81674B (pt) | 1987-10-20 |
Family
ID=11308641
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT81674A PT81674B (pt) | 1984-12-12 | 1985-12-12 | Processo para a preparacao de derivados n-acilados de l-triptofano farmaceuticamente activos, das composicoes farmaceuticas e de um produto farmaceutico que os contem, aplicaveis para aliviar a dor em seres humanos |
Country Status (14)
Country | Link |
---|---|
US (1) | US4870097A (pt) |
EP (1) | EP0237522B1 (pt) |
JP (1) | JPS62501292A (pt) |
AT (1) | ATE85976T1 (pt) |
AU (1) | AU589938B2 (pt) |
CA (1) | CA1256441A (pt) |
DE (1) | DE3587122T2 (pt) |
DK (1) | DK168564B1 (pt) |
ES (1) | ES8706630A1 (pt) |
IE (1) | IE58502B1 (pt) |
IT (1) | IT1179866B (pt) |
PT (1) | PT81674B (pt) |
WO (1) | WO1986003489A1 (pt) |
ZA (1) | ZA859526B (pt) |
Families Citing this family (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4814463A (en) * | 1985-12-31 | 1989-03-21 | Biomeasure, Inc. | CCK antagonists |
US4880938A (en) * | 1986-06-16 | 1989-11-14 | Merck & Co., Inc. | Amino acid analogs |
US5089638A (en) * | 1986-06-16 | 1992-02-18 | Merck & Co., Inc. | Amino acid analogs as CCK-antagonists |
SE8901149D0 (sv) * | 1989-04-03 | 1989-04-03 | Pharmacia Ab | Medel foer inducering respektive foerhindrande av pupillkonstriktion i oegat |
US5360814A (en) * | 1991-02-28 | 1994-11-01 | Merrell Dow Pharmaceuticals Inc. | NMDA antagonists |
US5484814A (en) * | 1991-02-28 | 1996-01-16 | Merrell Dow Pharmaceuticals Inc. | NMDA antagonists |
DK0501378T3 (da) * | 1991-02-28 | 1995-03-20 | Merrell Dow Pharma | NMDA-antagonister |
US20030199523A1 (en) * | 2002-02-28 | 2003-10-23 | Snutch Terrance P. | Heterocyclic calcium in channel blockers |
US7989589B2 (en) | 2002-09-20 | 2011-08-02 | The Trustees Of The University Of Pennsylvania | Compstatin analogs with improved activity |
US8168584B2 (en) | 2005-10-08 | 2012-05-01 | Potentia Pharmaceuticals, Inc. | Methods of treating age-related macular degeneration by compstatin and analogs thereof |
DK1951279T3 (en) | 2005-10-08 | 2017-07-31 | Apellis Pharmaceuticals Inc | COMPSTATIN AND ANALOGUES THEREOF FOR EYE DISEASES |
US7888323B2 (en) | 2005-11-28 | 2011-02-15 | The Trustees Of The University Of Pennsylvania | Potent compstatin analogs |
US8580735B2 (en) | 2007-02-05 | 2013-11-12 | Apellis Pharmaceuticals, Inc. | Local complement inhibition for treatment of complement-mediated disorders |
ES2655389T3 (es) | 2009-05-01 | 2018-02-19 | The Trustees Of The University Of Pennsylvania | Compstatina modificada con esqueleto peptídico y modificaciones c-terminales |
CA2813049A1 (en) | 2010-09-23 | 2012-03-29 | The Trustees Of The University Of Pennsylvania | Modified compstatin with improved stability and binding properties |
EP2667711A4 (en) | 2011-01-26 | 2014-11-12 | Nico Worldwide Inc | MEANS FOR THE TREATMENT OF MIGRAINE |
MX356528B (es) | 2011-05-11 | 2018-06-01 | Apellis Pharmaceuticals Inc | Analogos de compstatina de celula reactiva, de acción prolongada u objetivos y usos de los mismos. |
US10039802B2 (en) | 2011-06-22 | 2018-08-07 | Apellis Pharmaceuticals, Inc. | Methods of treating chronic disorders with complement inhibitors |
HUE047375T2 (hu) | 2011-09-07 | 2020-04-28 | Univ Pennsylvania | Javított farmakokinetikai tulajdonságokkal rendelkezõ compstatin analógok |
ES2879430T3 (es) | 2012-11-15 | 2021-11-22 | Apellis Pharmaceuticals Inc | Análogos de compstatina de acción prolongada y composiciones y métodos relacionados |
WO2014152391A1 (en) | 2013-03-15 | 2014-09-25 | Apellis Pharmaceuticals, Inc. | Cell-penetrating compstatin analogs and uses thereof |
WO2015142701A1 (en) | 2014-03-17 | 2015-09-24 | The Trustees Of The University Of Pennsylvania | Compstatin analogs with improved potency and pharmacokinetic properties |
ES2974107T3 (es) | 2015-10-07 | 2024-06-25 | Apellis Pharmaceuticals Inc | Regímenes de dosificación |
WO2017083859A1 (en) * | 2015-11-12 | 2017-05-18 | The Trustees Of Columbia University In The City Of New York | Rational drug design targeting resistant gram-negative bacterial infections to polymyxin-class antibiotics |
JP2020516607A (ja) | 2017-04-07 | 2020-06-11 | アペリス・ファーマシューティカルズ・インコーポレイテッドApellis Pharmaceuticals,Inc. | 投与レジメンならびに関連組成物および方法 |
IL270179B2 (en) | 2017-04-25 | 2024-07-01 | Temple Otorongo Llc | A pharmaceutical preparation containing tryptophan and a phyllokinin derivative for the treatment of psychiatric and psychological disorders |
AU2019247467B2 (en) | 2018-04-06 | 2023-01-19 | The Trustees Of The University Of Pennsylvania | Compstatin analogs with increased solubility and improved pharmacokinetic properties |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1055518B (it) * | 1971-05-18 | 1982-01-11 | Rotta Research Lab | Derivatives del triptofano |
US4482567A (en) * | 1982-10-07 | 1984-11-13 | Research Foundation For Mental Hygiene, Inc. | N-hexanoyl to n-heptadecanoyl 5-hydroxy tryptophan-5-hydroxytryptophanamides and use as analgesics |
-
1984
- 1984-12-12 IT IT68241/84A patent/IT1179866B/it active
-
1985
- 1985-12-02 IE IE302985A patent/IE58502B1/en not_active IP Right Cessation
- 1985-12-05 JP JP61500191A patent/JPS62501292A/ja active Pending
- 1985-12-05 DE DE8686900106T patent/DE3587122T2/de not_active Expired - Fee Related
- 1985-12-05 WO PCT/EP1985/000672 patent/WO1986003489A1/en active IP Right Grant
- 1985-12-05 EP EP86900106A patent/EP0237522B1/en not_active Expired - Lifetime
- 1985-12-05 AU AU52099/86A patent/AU589938B2/en not_active Ceased
- 1985-12-05 AT AT86900106T patent/ATE85976T1/de active
- 1985-12-09 CA CA000497174A patent/CA1256441A/en not_active Expired
- 1985-12-11 ES ES549822A patent/ES8706630A1/es not_active Expired
- 1985-12-12 PT PT81674A patent/PT81674B/pt not_active IP Right Cessation
- 1985-12-12 ZA ZA859526A patent/ZA859526B/xx unknown
-
1986
- 1986-08-11 DK DK381486A patent/DK168564B1/da not_active IP Right Cessation
-
1988
- 1988-07-11 US US07/217,116 patent/US4870097A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
PT81674A (en) | 1986-01-01 |
ES549822A0 (es) | 1987-06-01 |
DE3587122D1 (de) | 1993-04-01 |
AU589938B2 (en) | 1989-10-26 |
IT8468241A1 (it) | 1986-06-12 |
DK381486D0 (da) | 1986-08-11 |
IE853029L (en) | 1986-06-12 |
CA1256441A (en) | 1989-06-27 |
IT1179866B (it) | 1987-09-16 |
DK168564B1 (da) | 1994-04-25 |
ES8706630A1 (es) | 1987-06-01 |
WO1986003489A1 (en) | 1986-06-19 |
US4870097A (en) | 1989-09-26 |
IT8468241A0 (it) | 1984-12-12 |
DK381486A (da) | 1986-08-11 |
ZA859526B (en) | 1986-08-27 |
ATE85976T1 (de) | 1993-03-15 |
JPS62501292A (ja) | 1987-05-21 |
EP0237522A1 (en) | 1987-09-23 |
AU5209986A (en) | 1986-07-01 |
DE3587122T2 (de) | 1993-07-15 |
IE58502B1 (en) | 1993-10-06 |
EP0237522B1 (en) | 1993-02-24 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
MM3A | Annulment or lapse |
Free format text: LAPSE DUE TO NON-PAYMENT OF FEES Effective date: 19950930 |