ATE85976T1 - Pharmakologisch aktive derivate von tryptophan und diese enthaltende pharmazeutische zusammensetzungen. - Google Patents

Pharmakologisch aktive derivate von tryptophan und diese enthaltende pharmazeutische zusammensetzungen.

Info

Publication number
ATE85976T1
ATE85976T1 AT86900106T AT86900106T ATE85976T1 AT E85976 T1 ATE85976 T1 AT E85976T1 AT 86900106 T AT86900106 T AT 86900106T AT 86900106 T AT86900106 T AT 86900106T AT E85976 T1 ATE85976 T1 AT E85976T1
Authority
AT
Austria
Prior art keywords
group
substituted
tryptophan
pharmaceutical compositions
compositions containing
Prior art date
Application number
AT86900106T
Other languages
English (en)
Inventor
Francesco Makovec
Rolando Chiste
Angelo Luigi Rovati
Original Assignee
Rotta Research Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rotta Research Lab filed Critical Rotta Research Lab
Application granted granted Critical
Publication of ATE85976T1 publication Critical patent/ATE85976T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/20—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals substituted additionally by nitrogen atoms, e.g. tryptophane
AT86900106T 1984-12-12 1985-12-05 Pharmakologisch aktive derivate von tryptophan und diese enthaltende pharmazeutische zusammensetzungen. ATE85976T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IT68241/84A IT1179866B (it) 1984-12-12 1984-12-12 Derivati del triptofano farmaceuticamente attivi e composizioni farmaceutiche che li contengono
PCT/EP1985/000672 WO1986003489A1 (en) 1984-12-12 1985-12-05 Pharmaceutically active derivatives of tryptophan and pharmaceutical compositions containing them
EP86900106A EP0237522B1 (de) 1984-12-12 1985-12-05 Pharmakologisch aktive derivate von tryptophan und diese enthaltende pharmazeutische zusammensetzungen

Publications (1)

Publication Number Publication Date
ATE85976T1 true ATE85976T1 (de) 1993-03-15

Family

ID=11308641

Family Applications (1)

Application Number Title Priority Date Filing Date
AT86900106T ATE85976T1 (de) 1984-12-12 1985-12-05 Pharmakologisch aktive derivate von tryptophan und diese enthaltende pharmazeutische zusammensetzungen.

Country Status (14)

Country Link
US (1) US4870097A (de)
EP (1) EP0237522B1 (de)
JP (1) JPS62501292A (de)
AT (1) ATE85976T1 (de)
AU (1) AU589938B2 (de)
CA (1) CA1256441A (de)
DE (1) DE3587122T2 (de)
DK (1) DK168564B1 (de)
ES (1) ES8706630A1 (de)
IE (1) IE58502B1 (de)
IT (1) IT1179866B (de)
PT (1) PT81674B (de)
WO (1) WO1986003489A1 (de)
ZA (1) ZA859526B (de)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4814463A (en) * 1985-12-31 1989-03-21 Biomeasure, Inc. CCK antagonists
US4880938A (en) * 1986-06-16 1989-11-14 Merck & Co., Inc. Amino acid analogs
US5089638A (en) * 1986-06-16 1992-02-18 Merck & Co., Inc. Amino acid analogs as CCK-antagonists
SE8901149D0 (sv) * 1989-04-03 1989-04-03 Pharmacia Ab Medel foer inducering respektive foerhindrande av pupillkonstriktion i oegat
ES2069921T3 (es) * 1991-02-28 1995-05-16 Merrell Dow Pharma Antagonistas del nmda.
US5360814A (en) * 1991-02-28 1994-11-01 Merrell Dow Pharmaceuticals Inc. NMDA antagonists
US5484814A (en) * 1991-02-28 1996-01-16 Merrell Dow Pharmaceuticals Inc. NMDA antagonists
US20030199523A1 (en) * 2002-02-28 2003-10-23 Snutch Terrance P. Heterocyclic calcium in channel blockers
SI1549333T1 (sl) 2002-09-20 2012-02-29 Univ Pennsylvania Analogi kompstatina z izboljĺ ano aktivnostjo
BRPI0617186A2 (pt) 2005-10-08 2011-07-19 Potentia Pharmaceuticals Inc uso de análogo de compstatina, implante ocular, micropartìcula ou nanopartìcula, composição, composto multivalente, ácido nucléico, vetor de expressão, célula hospedeira recombinante, proteìna de fusão e método de produção e teste
US8168584B2 (en) 2005-10-08 2012-05-01 Potentia Pharmaceuticals, Inc. Methods of treating age-related macular degeneration by compstatin and analogs thereof
PT1960422E (pt) 2005-11-28 2012-08-16 Univ Pennsylvania Análogos de compstatina potentes
EP2979729A3 (de) 2007-02-05 2016-05-11 Apellis Pharmaceuticals, Inc. Compstatin analoga zur behandlung von entzundungserkrankungen der atemwege
HUE035378T2 (en) 2009-05-01 2018-05-02 Univ Pennsylvania Compstatin with peptide framework and C-terminal modifications
CA2813049A1 (en) 2010-09-23 2012-03-29 The Trustees Of The University Of Pennsylvania Modified compstatin with improved stability and binding properties
CN103501609A (zh) 2011-01-26 2014-01-08 尼科环球有限公司 用于偏头痛的治疗
JP6522337B2 (ja) 2011-05-11 2019-05-29 アペリス・ファーマシューティカルズ・インコーポレイテッドＡｐｅｌｌｉｓ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ，Ｉｎｃ． 細胞反応性、長時間作用型または標的化コンプスタチン類似体およびその使用
CN103796667A (zh) 2011-06-22 2014-05-14 艾普莱斯制药公司 用补体抑制剂治疗慢性障碍的方法
JP6249949B2 (ja) 2011-09-07 2017-12-20 ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア 薬物動態特性の改善されたコンプスタチンアナログ
CA2891673A1 (en) 2012-11-15 2014-05-22 Apellis Pharmaceuticals, Inc. Cell-reactive, long-acting, or targeted compstatin analogs and related compositions and methods
WO2014152391A1 (en) 2013-03-15 2014-09-25 Apellis Pharmaceuticals, Inc. Cell-penetrating compstatin analogs and uses thereof
WO2015142701A1 (en) 2014-03-17 2015-09-24 The Trustees Of The University Of Pennsylvania Compstatin analogs with improved potency and pharmacokinetic properties
CN117503905A (zh) 2015-10-07 2024-02-06 阿佩利斯制药有限公司 给药方案
JP2018534303A (ja) * 2015-11-12 2018-11-22 ザ・トラスティーズ・オブ・コロンビア・ユニバーシティ・イン・ザ・シティ・オブ・ニューヨーク ポリミキシン系抗生物質に対する耐性グラム陰性細菌感染を標的にする合理的薬物設計
CA3059304A1 (en) 2017-04-07 2018-10-11 Apellis Pharmaceuticals, Inc. Dosing regimens and related compositions and methods
WO2018200381A1 (en) 2017-04-25 2018-11-01 Temple Otorongo Llc Pharmaceutical composition comprising tryptophan and phyllokinin derivative for use in treating psychiatric and psychological conditions
US11884747B2 (en) 2018-04-06 2024-01-30 The Trustees Of The University Of Pennsylvania Compstatin analogs with increased solubility and improved pharmacokinetic properties

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1055518B (it) * 1971-05-18 1982-01-11 Rotta Research Lab Derivatives del triptofano
US4482567A (en) * 1982-10-07 1984-11-13 Research Foundation For Mental Hygiene, Inc. N-hexanoyl to n-heptadecanoyl 5-hydroxy tryptophan-5-hydroxytryptophanamides and use as analgesics

Also Published As

Publication number Publication date
IE58502B1 (en) 1993-10-06
PT81674A (en) 1986-01-01
DK381486D0 (da) 1986-08-11
IE853029L (en) 1986-06-12
DE3587122D1 (de) 1993-04-01
EP0237522B1 (de) 1993-02-24
CA1256441A (en) 1989-06-27
DE3587122T2 (de) 1993-07-15
ZA859526B (en) 1986-08-27
DK168564B1 (da) 1994-04-25
AU5209986A (en) 1986-07-01
IT1179866B (it) 1987-09-16
JPS62501292A (ja) 1987-05-21
AU589938B2 (en) 1989-10-26
IT8468241A0 (it) 1984-12-12
PT81674B (pt) 1987-10-20
ES8706630A1 (es) 1987-06-01
US4870097A (en) 1989-09-26
WO1986003489A1 (en) 1986-06-19
IT8468241A1 (it) 1986-06-12
ES549822A0 (es) 1987-06-01
EP0237522A1 (de) 1987-09-23
DK381486A (da) 1986-08-11

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