ATE85976T1 - Pharmakologisch aktive derivate von tryptophan und diese enthaltende pharmazeutische zusammensetzungen. - Google Patents
Pharmakologisch aktive derivate von tryptophan und diese enthaltende pharmazeutische zusammensetzungen.Info
- Publication number
- ATE85976T1 ATE85976T1 AT86900106T AT86900106T ATE85976T1 AT E85976 T1 ATE85976 T1 AT E85976T1 AT 86900106 T AT86900106 T AT 86900106T AT 86900106 T AT86900106 T AT 86900106T AT E85976 T1 ATE85976 T1 AT E85976T1
- Authority
- AT
- Austria
- Prior art keywords
- group
- substituted
- tryptophan
- pharmaceutical compositions
- compositions containing
- Prior art date
Links
- QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical class C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 230000001575 pathological effect Effects 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000000051 benzyloxy group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O* 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 210000003169 central nervous system Anatomy 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 230000000968 intestinal effect Effects 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/20—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals substituted additionally by nitrogen atoms, e.g. tryptophane
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT68241/84A IT1179866B (it) | 1984-12-12 | 1984-12-12 | Derivati del triptofano farmaceuticamente attivi e composizioni farmaceutiche che li contengono |
| EP86900106A EP0237522B1 (de) | 1984-12-12 | 1985-12-05 | Pharmakologisch aktive derivate von tryptophan und diese enthaltende pharmazeutische zusammensetzungen |
| PCT/EP1985/000672 WO1986003489A1 (en) | 1984-12-12 | 1985-12-05 | Pharmaceutically active derivatives of tryptophan and pharmaceutical compositions containing them |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE85976T1 true ATE85976T1 (de) | 1993-03-15 |
Family
ID=11308641
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT86900106T ATE85976T1 (de) | 1984-12-12 | 1985-12-05 | Pharmakologisch aktive derivate von tryptophan und diese enthaltende pharmazeutische zusammensetzungen. |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US4870097A (de) |
| EP (1) | EP0237522B1 (de) |
| JP (1) | JPS62501292A (de) |
| AT (1) | ATE85976T1 (de) |
| AU (1) | AU589938B2 (de) |
| CA (1) | CA1256441A (de) |
| DE (1) | DE3587122T2 (de) |
| DK (1) | DK168564B1 (de) |
| ES (1) | ES8706630A1 (de) |
| IE (1) | IE58502B1 (de) |
| IT (1) | IT1179866B (de) |
| PT (1) | PT81674B (de) |
| WO (1) | WO1986003489A1 (de) |
| ZA (1) | ZA859526B (de) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4814463A (en) * | 1985-12-31 | 1989-03-21 | Biomeasure, Inc. | CCK antagonists |
| US4880938A (en) * | 1986-06-16 | 1989-11-14 | Merck & Co., Inc. | Amino acid analogs |
| US5089638A (en) * | 1986-06-16 | 1992-02-18 | Merck & Co., Inc. | Amino acid analogs as CCK-antagonists |
| SE8901149D0 (sv) * | 1989-04-03 | 1989-04-03 | Pharmacia Ab | Medel foer inducering respektive foerhindrande av pupillkonstriktion i oegat |
| US5360814A (en) * | 1991-02-28 | 1994-11-01 | Merrell Dow Pharmaceuticals Inc. | NMDA antagonists |
| AU643365B2 (en) * | 1991-02-28 | 1993-11-11 | Aventisub Ii Inc. | NMDA antagonists |
| US5484814A (en) * | 1991-02-28 | 1996-01-16 | Merrell Dow Pharmaceuticals Inc. | NMDA antagonists |
| US20030199523A1 (en) * | 2002-02-28 | 2003-10-23 | Snutch Terrance P. | Heterocyclic calcium in channel blockers |
| SI1549333T1 (sl) | 2002-09-20 | 2012-02-29 | Univ Pennsylvania | Analogi kompstatina z izboljĺ ano aktivnostjo |
| BRPI0617186A2 (pt) | 2005-10-08 | 2011-07-19 | Potentia Pharmaceuticals Inc | uso de análogo de compstatina, implante ocular, micropartìcula ou nanopartìcula, composição, composto multivalente, ácido nucléico, vetor de expressão, célula hospedeira recombinante, proteìna de fusão e método de produção e teste |
| US8168584B2 (en) | 2005-10-08 | 2012-05-01 | Potentia Pharmaceuticals, Inc. | Methods of treating age-related macular degeneration by compstatin and analogs thereof |
| RU2474586C2 (ru) | 2005-11-28 | 2013-02-10 | Дзе Трастиз Оф Дзе Юниверсити Оф Пенсильвания | Эффективные аналоги компстатина |
| WO2008097525A2 (en) | 2007-02-05 | 2008-08-14 | Potentia Pharmaceuticals, Inc. | Local complement inhibition for treatment of complement-mediated disorders |
| CA2760839C (en) | 2009-05-01 | 2019-02-12 | The Trustees Of The University Of Pennsylvania | Modified compstatin with peptide backbone and c-terminal modifications |
| WO2012040259A2 (en) | 2010-09-23 | 2012-03-29 | The Trustees Of The University Of Pennsylvania | Modified compstatin with improved stability and binding properties |
| CN103501609A (zh) | 2011-01-26 | 2014-01-08 | 尼科环球有限公司 | 用于偏头痛的治疗 |
| RU2653439C9 (ru) | 2011-05-11 | 2018-10-16 | Апеллис Фармасьютикалс, Инк. | Клеточно-реактивные аналоги компстатина, аналоги компстатина длительного действия или аналоги компстатина нацеленного действия и их применение |
| US10039802B2 (en) | 2011-06-22 | 2018-08-07 | Apellis Pharmaceuticals, Inc. | Methods of treating chronic disorders with complement inhibitors |
| PT2753636T (pt) | 2011-09-07 | 2020-01-21 | Univ Pennsylvania | Análogos de compstatina com propriedades farmacocinéticas melhoradas |
| ES2780674T3 (es) | 2012-11-15 | 2020-08-26 | Apellis Pharmaceuticals Inc | Análogos de compstatina de acción prolongada y composiciones y métodos relacionados |
| WO2014152391A1 (en) | 2013-03-15 | 2014-09-25 | Apellis Pharmaceuticals, Inc. | Cell-penetrating compstatin analogs and uses thereof |
| WO2015142701A1 (en) | 2014-03-17 | 2015-09-24 | The Trustees Of The University Of Pennsylvania | Compstatin analogs with improved potency and pharmacokinetic properties |
| FI3359555T3 (fi) | 2015-10-07 | 2024-03-20 | Apellis Pharmaceuticals Inc | Annostusohjeet |
| EP3374027B1 (de) * | 2015-11-12 | 2021-06-23 | The Trustees of Columbia University in the City of New York | Rationelles arzneimitteldesign zum targeting resistenter gramnegativer bakterieller infektionen gegen polymyxin-klasse-antibiotika |
| US11040107B2 (en) | 2017-04-07 | 2021-06-22 | Apellis Pharmaceuticals, Inc. | Dosing regimens and related compositions and methods |
| WO2018200381A1 (en) | 2017-04-25 | 2018-11-01 | Temple Otorongo Llc | Pharmaceutical composition comprising tryptophan and phyllokinin derivative for use in treating psychiatric and psychological conditions |
| WO2019118938A1 (en) | 2017-12-15 | 2019-06-20 | Apellis Pharmaceuticals, Inc. | Dosing regimens and related compositions and methods |
| PL3645550T3 (pl) | 2018-04-06 | 2022-04-04 | The Trustees Of The University Of Pennsylvania | Analogi kompstatyny o zwiększonej rozpuszczalności i ulepszonych właściwościach farmakokinetycznych |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1055518B (it) * | 1971-05-18 | 1982-01-11 | Rotta Research Lab | Derivatives del triptofano |
| US4482567A (en) * | 1982-10-07 | 1984-11-13 | Research Foundation For Mental Hygiene, Inc. | N-hexanoyl to n-heptadecanoyl 5-hydroxy tryptophan-5-hydroxytryptophanamides and use as analgesics |
-
1984
- 1984-12-12 IT IT68241/84A patent/IT1179866B/it active
-
1985
- 1985-12-02 IE IE302985A patent/IE58502B1/en not_active IP Right Cessation
- 1985-12-05 AT AT86900106T patent/ATE85976T1/de active
- 1985-12-05 EP EP86900106A patent/EP0237522B1/de not_active Expired - Lifetime
- 1985-12-05 AU AU52099/86A patent/AU589938B2/en not_active Ceased
- 1985-12-05 JP JP61500191A patent/JPS62501292A/ja active Pending
- 1985-12-05 WO PCT/EP1985/000672 patent/WO1986003489A1/en not_active Ceased
- 1985-12-05 DE DE8686900106T patent/DE3587122T2/de not_active Expired - Fee Related
- 1985-12-09 CA CA000497174A patent/CA1256441A/en not_active Expired
- 1985-12-11 ES ES549822A patent/ES8706630A1/es not_active Expired
- 1985-12-12 PT PT81674A patent/PT81674B/pt not_active IP Right Cessation
- 1985-12-12 ZA ZA859526A patent/ZA859526B/xx unknown
-
1986
- 1986-08-11 DK DK381486A patent/DK168564B1/da not_active IP Right Cessation
-
1988
- 1988-07-11 US US07/217,116 patent/US4870097A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| IT1179866B (it) | 1987-09-16 |
| IE58502B1 (en) | 1993-10-06 |
| ZA859526B (en) | 1986-08-27 |
| JPS62501292A (ja) | 1987-05-21 |
| WO1986003489A1 (en) | 1986-06-19 |
| DK168564B1 (da) | 1994-04-25 |
| EP0237522A1 (de) | 1987-09-23 |
| PT81674A (en) | 1986-01-01 |
| IT8468241A0 (it) | 1984-12-12 |
| EP0237522B1 (de) | 1993-02-24 |
| AU5209986A (en) | 1986-07-01 |
| US4870097A (en) | 1989-09-26 |
| ES549822A0 (es) | 1987-06-01 |
| IE853029L (en) | 1986-06-12 |
| AU589938B2 (en) | 1989-10-26 |
| DK381486A (da) | 1986-08-11 |
| CA1256441A (en) | 1989-06-27 |
| DK381486D0 (da) | 1986-08-11 |
| PT81674B (pt) | 1987-10-20 |
| DE3587122T2 (de) | 1993-07-15 |
| DE3587122D1 (de) | 1993-04-01 |
| IT8468241A1 (it) | 1986-06-12 |
| ES8706630A1 (es) | 1987-06-01 |
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