DE3587122D1 - Pharmakologisch aktive derivate von tryptophan und diese enthaltende pharmazeutische zusammensetzungen. - Google Patents

Pharmakologisch aktive derivate von tryptophan und diese enthaltende pharmazeutische zusammensetzungen.

Info

Publication number
DE3587122D1
DE3587122D1 DE8686900106T DE3587122T DE3587122D1 DE 3587122 D1 DE3587122 D1 DE 3587122D1 DE 8686900106 T DE8686900106 T DE 8686900106T DE 3587122 T DE3587122 T DE 3587122T DE 3587122 D1 DE3587122 D1 DE 3587122D1
Authority
DE
Germany
Prior art keywords
group
substituted
tryptophane
pharmaceutical compositions
compositions containing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE8686900106T
Other languages
English (en)
Other versions
DE3587122T2 (de
Inventor
Francesco Makovec
Rolando Chiste
Luigi Rovati
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Rottapharm SpA
Original Assignee
Rotta Research Laboratorium SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rotta Research Laboratorium SpA filed Critical Rotta Research Laboratorium SpA
Publication of DE3587122D1 publication Critical patent/DE3587122D1/de
Application granted granted Critical
Publication of DE3587122T2 publication Critical patent/DE3587122T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/20—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals substituted additionally by nitrogen atoms, e.g. tryptophane

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DE8686900106T 1984-12-12 1985-12-05 Pharmakologisch aktive derivate von tryptophan und diese enthaltende pharmazeutische zusammensetzungen. Expired - Fee Related DE3587122T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT68241/84A IT1179866B (it) 1984-12-12 1984-12-12 Derivati del triptofano farmaceuticamente attivi e composizioni farmaceutiche che li contengono
PCT/EP1985/000672 WO1986003489A1 (en) 1984-12-12 1985-12-05 Pharmaceutically active derivatives of tryptophan and pharmaceutical compositions containing them

Publications (2)

Publication Number Publication Date
DE3587122D1 true DE3587122D1 (de) 1993-04-01
DE3587122T2 DE3587122T2 (de) 1993-07-15

Family

ID=11308641

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8686900106T Expired - Fee Related DE3587122T2 (de) 1984-12-12 1985-12-05 Pharmakologisch aktive derivate von tryptophan und diese enthaltende pharmazeutische zusammensetzungen.

Country Status (14)

Country Link
US (1) US4870097A (de)
EP (1) EP0237522B1 (de)
JP (1) JPS62501292A (de)
AT (1) ATE85976T1 (de)
AU (1) AU589938B2 (de)
CA (1) CA1256441A (de)
DE (1) DE3587122T2 (de)
DK (1) DK168564B1 (de)
ES (1) ES8706630A1 (de)
IE (1) IE58502B1 (de)
IT (1) IT1179866B (de)
PT (1) PT81674B (de)
WO (1) WO1986003489A1 (de)
ZA (1) ZA859526B (de)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4814463A (en) * 1985-12-31 1989-03-21 Biomeasure, Inc. CCK antagonists
US4880938A (en) * 1986-06-16 1989-11-14 Merck & Co., Inc. Amino acid analogs
US5089638A (en) * 1986-06-16 1992-02-18 Merck & Co., Inc. Amino acid analogs as CCK-antagonists
SE8901149D0 (sv) * 1989-04-03 1989-04-03 Pharmacia Ab Medel foer inducering respektive foerhindrande av pupillkonstriktion i oegat
US5360814A (en) * 1991-02-28 1994-11-01 Merrell Dow Pharmaceuticals Inc. NMDA antagonists
DE69201141T2 (de) * 1991-02-28 1995-05-11 Merrell Dow Pharma NMDA-Antagonisten.
US5484814A (en) * 1991-02-28 1996-01-16 Merrell Dow Pharmaceuticals Inc. NMDA antagonists
US20030199523A1 (en) * 2002-02-28 2003-10-23 Snutch Terrance P. Heterocyclic calcium in channel blockers
EP2311479B1 (de) 2002-09-20 2014-07-23 The Trustees of The University of Pennsylvania Compstatin-Analoga mit verbesserter Aktivität
US8168584B2 (en) 2005-10-08 2012-05-01 Potentia Pharmaceuticals, Inc. Methods of treating age-related macular degeneration by compstatin and analogs thereof
PL1951279T3 (pl) 2005-10-08 2017-12-29 Apellis Pharmaceuticals, Inc. Kompstatyna i jej analogi w zaburzeniach oczu
RU2474586C2 (ru) 2005-11-28 2013-02-10 Дзе Трастиз Оф Дзе Юниверсити Оф Пенсильвания Эффективные аналоги компстатина
PL2148691T3 (pl) 2007-02-05 2015-12-31 Apellis Pharmaceuticals Inc Analogi kompstatyny do stosowania w leczeniu stanów zapalnych układu oddechowego
HUE035378T2 (en) 2009-05-01 2018-05-02 Univ Pennsylvania Compstatin with peptide framework and C-terminal modifications
US20140113874A1 (en) 2010-09-23 2014-04-24 The Trustees Of The University Of Pennsylvania Modified Compstatin With Improved Stability And Binding Properties
WO2012103377A1 (en) 2011-01-26 2012-08-02 Nico Worldwide, Inc. Remedy for migraine headache
RU2653439C9 (ru) 2011-05-11 2018-10-16 Апеллис Фармасьютикалс, Инк. Клеточно-реактивные аналоги компстатина, аналоги компстатина длительного действия или аналоги компстатина нацеленного действия и их применение
AU2012272706B2 (en) 2011-06-22 2017-07-06 Apellis Pharmaceuticals, Inc. Methods of treating chronic disorders with complement inhibitors
DK2753636T3 (da) 2011-09-07 2020-02-03 Univ Pennsylvania Compstatinanaloger med forbedret farmakokinetiske egenskaber
EP3660033B9 (de) 2012-11-15 2022-06-22 Apellis Pharmaceuticals, Inc. Langwirkende compstatin-analoga sowie verwandte zusammensetzungen und verfahren
WO2014152391A1 (en) 2013-03-15 2014-09-25 Apellis Pharmaceuticals, Inc. Cell-penetrating compstatin analogs and uses thereof
US10213476B2 (en) 2014-03-17 2019-02-26 The Trustees Of The University Of Pennsylvania Compstatin analogs with improved potency and pharmacokinetic properties
EP3359555B1 (de) 2015-10-07 2023-12-20 Apellis Pharmaceuticals, Inc. Dosierpläne
EP3374027B1 (de) * 2015-11-12 2021-06-23 The Trustees of Columbia University in the City of New York Rationelles arzneimitteldesign zum targeting resistenter gramnegativer bakterieller infektionen gegen polymyxin-klasse-antibiotika
CA3059304A1 (en) 2017-04-07 2018-10-11 Apellis Pharmaceuticals, Inc. Dosing regimens and related compositions and methods
EP3615053A4 (de) 2017-04-25 2021-07-14 Temple Otorongo LLC Pharmazeutische zusammensetzung mit tryptophan- und phyllokininderivat zur verwendung in der behandlung von psychiatrischen und psychologischen störungen
HUE057693T2 (hu) 2018-04-06 2022-05-28 Univ Pennsylvania Fokozott oldhatóságú és javított farmakokinetikai tulajdonságú kompsztatin analógok

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1055518B (it) * 1971-05-18 1982-01-11 Rotta Research Lab Derivatives del triptofano
US4482567A (en) * 1982-10-07 1984-11-13 Research Foundation For Mental Hygiene, Inc. N-hexanoyl to n-heptadecanoyl 5-hydroxy tryptophan-5-hydroxytryptophanamides and use as analgesics

Also Published As

Publication number Publication date
PT81674B (pt) 1987-10-20
ES8706630A1 (es) 1987-06-01
IT8468241A0 (it) 1984-12-12
DK381486D0 (da) 1986-08-11
JPS62501292A (ja) 1987-05-21
IE853029L (en) 1986-06-12
DK168564B1 (da) 1994-04-25
AU589938B2 (en) 1989-10-26
IE58502B1 (en) 1993-10-06
PT81674A (en) 1986-01-01
ATE85976T1 (de) 1993-03-15
ES549822A0 (es) 1987-06-01
CA1256441A (en) 1989-06-27
IT1179866B (it) 1987-09-16
IT8468241A1 (it) 1986-06-12
AU5209986A (en) 1986-07-01
WO1986003489A1 (en) 1986-06-19
ZA859526B (en) 1986-08-27
EP0237522A1 (de) 1987-09-23
DK381486A (da) 1986-08-11
US4870097A (en) 1989-09-26
EP0237522B1 (de) 1993-02-24
DE3587122T2 (de) 1993-07-15

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee